{"id":221018,"date":"2021-04-24T06:48:28","date_gmt":"2021-04-23T22:48:28","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=221018"},"modified":"2021-04-23T19:48:55","modified_gmt":"2021-04-23T11:48:55","slug":"%e6%96%b0%e5%8a%a0%e5%9d%a1%e5%9b%bd%e7%ab%8b%e5%a4%a7%e5%ad%a6%e9%99%88%e5%b0%8f%e5%85%83%e3%80%81nih-wang-zhantong%e3%80%81%e7%a6%8f%e5%b7%9e%e5%a4%a7%e5%ad%a6%e6%9e%97%e7%ab%8b%e6%a3%aeadv-sci","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=221018","title":{"rendered":"\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u9648\u5c0f\u5143\u3001NIH Wang Zhantong\u3001\u798f\u5dde\u5927\u5b66\u6797\u7acb\u68eeAdv. Sci.:\u5149\u52a8\u529b-\u5316\u5b66\u52a8\u529b\u7ea7\u8054\u53cd\u5e94\u7528\u4e8e\u6709\u6548\u7684\u836f\u7269\u8f93\u9001\u548c\u589e\u5f3a\u7684\u8054\u5408\u7597\u6cd5"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u5316\u5b66\u7597\u6cd5\u4ecd\u7136\u662f\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u91cd\u8981\u65b9\u6cd5\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u5e38\u89c4\u5168\u8eab\u7ed9\u836f\u7684\u5316\u5b66\u7597\u6cd5\u5e38\u5e38\u4f1a\u56e0\u6cbb\u7597\u836f\u7269\u7684\u975e\u7279\u5f02\u6027\u751f\u7269\u5206\u5e03\u800c\u5bfc\u81f4\u751f\u7269\u5229\u7528\u5ea6\u4f4e\u548c\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002\u7eb3\u7c73\u836f\u7269\u7531\u4e8e\u53ef\u88ab\u52a8\u548c\u4e3b\u52a8\u9776\u5411\u80bf\u7624\u800c\u6781\u5177\u524d\u666f\u3002\u7279\u522b\u5730\uff0c\u523a\u6fc0\u54cd\u5e94\u6027\u7eb3\u7c73\u836f\u7269\u53ef\u4ee5\u5b9e\u73b0\u6309\u9700\u91ca\u653e\u836f\u7269\uff0c\u8fd9\u53ef\u4ee5\u8fdb\u4e00\u6b65\u63d0\u9ad8\u6cbb\u7597\u836f\u7269\u7684\u751f\u7269\u5229\u7528\u5ea6\u3002\u53ef\u54cd\u5e94\u67d0\u4e9b\u523a\u6fc0\u5e76\u5b9e\u73b0\u7ed3\u6784\u7834\u574f\u7684\u7eb3\u7c73\u8f7d\u4f53\u7684\u8bbe\u8ba1\u662f\u5f00\u53d1\u523a\u6fc0\u54cd\u5e94\u6027\u7eb3\u7c73\u836f\u7269\u7684\u5e38\u7528\u65b9\u6cd5\u3002\u591a\u79cdpH\u548c\u8c37\u80f1\u7518\u80bd\u54cd\u5e94\u6027\u7eb3\u7c73\u8f7d\u4f53\u5df2\u88ab\u5f00\u53d1\u5e76\u7528\u4e8e\u6297\u80bf\u7624\u836f\u7269\u9012\u9001\u3002\u7136\u800c\uff0c\u7531\u4e8e\u80bf\u7624\u7ec6\u80de\u4e0e\u6b63\u5e38\u7ec6\u80de\u4e4b\u95f4\u7684\u7ec6\u80de\u5185\u73af\u5883\u5dee\u5f02\u6709\u9650\uff08\u9178\u6027\u5185\u4f53\/\u6eb6\u9176\u4f53\u548c\u9ad8\u8c37\u80f1\u7518\u80bd\u6d53\u5ea6\uff09\uff0cpH\u548c\u8c37\u80f1\u7518\u80bd\u54cd\u5e94\u6027\u7eb3\u7c73\u8f7d\u4f53\u7684\u9009\u62e9\u6027\u4ecd\u7136\u53d7\u5230\u9650\u5236\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u542b\u6709\u6d3b\u6027\u6c27\uff08ROS\uff09\u654f\u611f\u5316\u5b66\u952e\u7684\u54cd\u5e94\u6027\u7eb3\u7c73\u836f\u7269\u5907\u53d7\u5173\u6ce8\u3002\u7531\u4e8e\u6b63\u5e38\u7ec6\u80de\u4e2d\u7684ROS\u6c34\u5e73\u76f8\u5bf9\u8f83\u4f4e\uff0c\u56e0\u6b64ROS\u54cd\u5e94\u578b\u7eb3\u7c73\u836f\u7269\u5177\u6709\u66f4\u9ad8\u7684\u9009\u62e9\u6027\u3002\u6b64\u5916\uff0cROS\u8fd8\u53ef\u4ee5\u7528\u4f5c\u6cbb\u7597\u5242\u4ee5\u589e\u5f3a\u5316\u5b66\u7597\u6cd5\u7684\u6cbb\u7597\u529f\u6548\uff0c\u5b9e\u73b0\u8054\u5408\u6cbb\u7597\u3002\u5df2\u6709\u591a\u79cd\u4ea7\u751fROS\u7684\u7b56\u7565\u88ab\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\uff0c\u4f8b\u5982\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\uff0c\u5316\u5b66\u52a8\u529b\u7597\u6cd5\u548c\u58f0\u52a8\u529b\u7597\u6cd5\u3002\u5176\u4e2d\uff0cPDT\u91c7\u7528\u5149\u6fc0\u53d1\u5149\u654f\u5242\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\u6740\u4f24\u764c\u7ec6\u80de\uff0c\u662f\u4e00\u79cd\u5c40\u90e8\u6cbb\u7597\u7b56\u7565\u3002\u5c06PDT\u548cROS\u89e6\u53d1\u7684\u836f\u7269\u91ca\u653e\u7684\u7ec4\u5408\u5df2\u88ab\u8bc1\u660e\u5177\u6709\u6297\u80bf\u7624\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u5177\u6709\u5149\u52a8\u529b\u7597\u6cd5\u548c\u6d3b\u6027\u6c27\uff08ROS\uff09\u89e6\u53d1\u7684\u836f\u7269\u91ca\u653e\u80fd\u529b\u7684\u7eb3\u7c73\u836f\u7269\u6709\u671b\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u3002\u7136\u800c\uff0c\u5728\u89e6\u53d1\u836f\u7269\u91ca\u653e\u8fc7\u7a0b\u4e2d\uff0c\u5927\u591a\u6570\u57fa\u4e8eROS\u54cd\u5e94\u6027\u7eb3\u7c73\u8f7d\u4f53\u7684\u7eb3\u7c73\u836f\u7269\u5728\u836f\u7269\u91ca\u653e\u8fc7\u7a0b\u4e2d\u9700\u8981\u4e25\u91cd\u7684\u6d88\u8017ROS\uff0c\u5bfc\u81f4\u8054\u5408\u6cbb\u7597\u6548\u679c\u4e0d\u4f73\u3002\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u9648\u5c0f\u5143\u3001NIH Wang Zhantong\u3001\u798f\u5dde\u5927\u5b66\u6797\u7acb\u68ee<\/b><\/strong>\u63d0\u51fa\u4e86\u4e00\u79cd\u5149\u52a8\u529b\u5b66-\u5316\u5b66\u52a8\u529b\u5b66\u7ea7\u8054\u7b56\u7565\uff0c\u7528\u4e8e\u8bbe\u8ba1\u836f\u7269\u9012\u9001\u7eb3\u7c73\u7cfb\u7edf\u3002\u901a\u8fc7\u4e24\u4eb2\u6027\u805a\u4e59\u4e8c\u9187-\u805a\u4e9a\u6cb9\u9178\u548cPEG-HPPH-Fe\u7684\u81ea\u7ec4\u88c5\u5236\u5907\u8d1f\u8f7d\u963f\u9709\u7d20\u7684ROS\u54cd\u5e94\u805a\u5408\u7269\u56ca\u6ce1\uff08DOX-RPS\uff09\u3002 RPS\u53ef\u4ee5\u901a\u8fc7\u88ab\u52a8\u9776\u5411\u4f5c\u7528\u5c06\u836f\u7269\u6709\u6548\u5730\u9012\u9001\u81f3\u80bf\u7624\u90e8\u4f4d\u3002\u5728\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u5149\u654f\u5242HPPH\u53ef\u4ee5\u6709\u6548\u751f\u6210ROS\uff0c\u8fdb\u800c\u5f15\u8d77\u4e9a\u6cb9\u9178\u94fe\u7684\u539f\u4f4d\u6c27\u5316\u548c\u968f\u540e\u7684RPS\u7ed3\u6784\u7834\u574f\uff0c\u4ece\u800c\u89e6\u53d1\u836f\u7269\u91ca\u653e\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728HPPH-Fe\u7684\u50ac\u5316\u4e0b\uff0cROS\u5c06\u901a\u8fc7\u5316\u5b66\u52a8\u529b\u5b66\u8fc7\u7a0b\u4ece\u4e9a\u6cb9\u9178\u8fc7\u6c27\u5316\u7269\u4e2d\u518d\u751f\u3002\u56e0\u6b64\uff0c\u53ef\u4ee5\u5728\u6ca1\u6709ROS\u8fc7\u5ea6\u6d88\u8017\u7684\u60c5\u51b5\u4e0b\u5b9e\u73b0ROS\u89e6\u53d1\u7684\u836f\u7269\u91ca\u653e\u3002\u4f53\u5916\u548c\u4f53\u5185\u7ed3\u679c\u8bc1\u5b9e\u4e86ROS\u7684\u4ea7\u751f\uff0c\u89e6\u53d1\u4e86\u836f\u7269\u91ca\u653e\u884c\u4e3a\u4ee5\u53caDOX-RPS\u7684\u6709\u6548\u6297\u80bf\u7624\u4f5c\u7528\u3002\u8fd9\u79cd\u5149\u52a8\u529b-\u5316\u5b66\u52a8\u529b\u7ea7\u8054\u7b56\u7565\u4e3a\u589e\u5f3a\u8054\u5408\u7597\u6cd5\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u524d\u9014\u7684\u65b9\u6cd5\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201c<\/strong>Photodynamic-Chemodynamic Cascade Reactions for efficient Drug Delivery and Enhanced Combination Therapy<\/strong>\u201d<\/strong>\u53d1\u8868\u5728Adv. Sci.<\/b><\/strong>\u4e0a<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>1.<\/b><\/strong>\u901a\u8fc7\u5149\u52a8\u529b-\u5316\u5b66\u52a8\u529b\u7ea7\u8054\u53cd\u5e94\u8fdb\u884c\u836f\u7269\u9012\u9001\u548c\u5316\u5b66-ROS\u8054\u5408\u6cbb\u7597\u7684DOX-RPS\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a\uff09\u7eb3\u7c73DOX-RPS\u901a\u8fc7\u88ab\u52a8\u9776\u5411\u79ef\u7d2f\u5230\u80bf\u7624\u7ec4\u7ec7\u4e2d b\uff09\u6fc0\u5149\u7167\u5c04\u540e\uff0cHPPH\u901a\u8fc7\u5149\u52a8\u529b\u53cd\u5e94\u751f\u6210ROS c\uff09ROS\u8fdb\u4e00\u6b65\u5c06\u4e9a\u6cb9\u9178\u6c27\u5316\u6210LAP d\uff09\u4ea7\u751f\u7684LAP\u5206\u5b50\u6539\u53d8RPS\u7684\u7ed3\u6784\uff0c\u4ece\u800c\u4f7f\u836f\u7269\u91ca\u653e e\uff09\u5728HPPH-Fe\u7684\u5b58\u5728\u4e0b\uff0cROS\u901a\u8fc7\u7c7bFenton\u53cd\u5e94\u518d\u751f<\/p>\n

\u56fe2.<\/b><\/strong>\u7269\u7406\u6027\u8d28\u8868\u5f81<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a\uff09DOX-RPS\u7684\u7c92\u5f84\u548cTEM\u56fe\u50cf\uff08\u63d2\u56fe\uff09 b\uff09DOX-RPS\u548cDOX-NRPS\u7684\u80f6\u4f53\u7a33\u5b9a\u6027\uff08n = 3\uff09 c\uff09HPPH\uff0cDOX\uff0cDOX-RPS\u548cDOX-NRPS\u7684\u5438\u6536\u5149\u8c31 d\uff09\u5728\u6709\u6216\u6ca1\u6709\u6fc0\u5149\u7167\u5c04\u7684\u60c5\u51b5\u4e0b\uff0c\u5728\u5b58\u5728RPS1\u7684\u60c5\u51b5\u4e0b\uff0cSOSG\u7684FL\u5149\u8c31 e\uff09\u6fc0\u5149\u89e6\u53d1LAP\u751f\u6210\u7684\u673a\u7406 f\uff09\u6709\u6216\u6ca1\u6709\u6fc0\u5149\u7167\u5c04\u7684RPS1\u76841H NMR\u5149\u8c31<\/p>\n

\u56fe<\/strong>3.\u5149\u7269\u7406\u6027\u8d28\u8868\u5f81<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a\uff09\u5728\u6ca1\u6709\u6216\u6ca1\u6709\u6fc0\u5149\u7167\u5c04\u65f6\u95f4\u7684\u60c5\u51b5\u4e0b\uff0cDOX-RPS\u7684\u4f53\u5916DOX\u91ca\u653e\u66f2\u7ebf b\uff09\u5728\u6ca1\u6709\u6216\u6ca1\u6709\u6fc0\u5149\u7167\u5c04\u65f6\u95f4\u7684\u60c5\u51b5\u4e0b\uff0cDOX-NRPS\u7684\u4f53\u5916DOX\u91ca\u653e\u66f2\u7ebf c\uff09\u5728\u6709\u6216\u6ca1\u6709Fe2+\u7684RPS1\u6216\u6fc0\u5149\u9884\u8f90\u7167\u7684RPS1\u5b58\u5728\u4e0b\uff0cTMB\u7684\u5438\u6536\u5149\u8c31\uff085\u5206\u949f\uff09 d\uff09\u6fc0\u5149\u9884\u8f90\u7167\u7684RPS1\u5bf9TMB\u6c27\u5316\u7684\u6bd4\u8f83 e\uff09\u5728\u6709\u6216\u6ca1\u6709Fe2+\u7684\u60c5\u51b5\u4e0b\uff0c\u5728\u5b58\u5728NRPS1\u6216\u6fc0\u5149\u9884\u8f90\u7167NRPS1\uff085\u5206\u949f\uff09\u7684\u60c5\u51b5\u4e0b\uff0cTMB\u7684\u5438\u6536\u5149\u8c31 f\uff09\u6fc0\u5149\u9884\u8f90\u7167NRPS1\u5bf9TMB\u6c27\u5316\u7684\u6bd4\u8f83<\/p>\n

\u56fe<\/b><\/strong>4.\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

a\uff09\u7528DCFDA\u548cRPS1\u5b75\u80b2\u7684U87MG\u7ec6\u80de\u7684FCM\u5206\u6790\uff0c\u7136\u540e\u8fdb\u884c\u6fc0\u5149\u7167\u5c04 b\uff09\u7528DCFH-DA\u548c\u6fc0\u5149\u9884\u8f90\u7167\u7684RPS1\u5b75\u80b2\u7684U87MG\u7ec6\u80de\u7684FCM\u5206\u6790 c\uff09\u5728\u6709\u6216\u6ca1\u6709\u6fc0\u5149\u7167\u5c04\u7684\u60c5\u51b5\u4e0b\uff0c\u4e0d\u540c\u6837\u54c1\u5904\u7406\u8fc7\u7684U87MG\u7ec6\u80de\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf d\uff09\u4e0d\u540c\u6837\u54c1\u5904\u7406\u8fc7\u7684U87MG\u7ec6\u80de\u5b75\u80b248 h\u7684\u5b58\u6d3b\u7387<\/p>\n

\u56fe<\/b><\/strong>5<\/b><\/strong>.<\/b><\/strong>\u4f53\u5185\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a\uff09\u9759\u8109\u6ce8\u5c0489<\/sup>Zr\u6807\u8bb0\u7684DOX-RPS\u540e\u7684U87MG\u8377\u7624\u5c0f\u9f20\u7684PET\u56fe\u50cf b\uff09\u6ce8\u5c04\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u5fc3\u810f\u548c\u809d\u810f\u4e2d89<\/sup>Zr\u6807\u8bb0\u7684DOX-RPS\u7684\u5206\u5e03 c\uff09\u6ce8\u5c04\u540e1\u30014\u300124\u300148\u548c72 h\u6444\u53d689<\/sup>Zr\u6807\u8bb0\u7684DOX-RPS\u7684\u80bf\u7624 d\uff09\u6ce8\u5c04\u540e72 h\u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u7684\u751f\u7269\u5206\u5e03<\/p>\n

\u56fe<\/strong>6.\u6d3b\u4f53\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/p>\n

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\u3010<\/b><\/strong>\u5c0f\u7ed3<\/b><\/strong>\u3011<\/b><\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5<\/b><\/strong>\uff1aPhotodynamic-Chemodynamic Cascade Reactions for efficient Drug Delivery and Enhanced Combination Therapy. Adv. Sci., <\/em>202<\/strong>1<\/strong>, DOI:10.1002\/advs.202002927<\/p>\n

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