{"id":223783,"date":"2021-06-25T06:30:25","date_gmt":"2021-06-24T22:30:25","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=223783"},"modified":"2021-06-24T09:57:40","modified_gmt":"2021-06-24T01:57:40","slug":"%e5%a4%a9%e6%b4%a5%e5%a4%a7%e5%ad%a6%e4%bb%b0%e5%a4%a7%e5%8b%87%e8%af%be%e9%a2%98%e7%bb%84nano-letters%ef%bc%9adna%e7%ba%b3%e7%b1%b3%e5%a4%8d%e5%90%88%e7%89%a9%e7%94%a8%e4%ba%8e%e8%bf%91%e7%ba%a2","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=223783","title":{"rendered":"\u5929\u6d25\u5927\u5b66\u4ef0\u5927\u52c7\u8bfe\u9898\u7ec4Nano\u00a0Letters\uff1aDNA\u7eb3\u7c73\u590d\u5408\u7269\u7528\u4e8e\u8fd1\u7ea2\u5916\u5149\u589e\u5f3a\u7684\u8131\u6c27\u6838\u9176\u4ecb\u5bfc\u57fa\u56e0\u6cbb\u7597"},"content":{"rendered":"<p>\u8fd1\u671f\uff0c\u5929\u6d25\u5927\u5b66\u5316\u5de5\u5b66\u9662\u4ef0\u5927\u52c7\u6559\u6388\u8bfe\u9898\u7ec4\u5728Nano Letters\uff08\u7eb3\u7c73\u5feb\u62a5\uff09\u4e0a\u53d1\u8868DNA\u7eb3\u7c73\u590d\u5408\u7269\u7528\u4e8e\u8fd1\u7ea2\u5916\u5149\u589e\u5f3a\u7684\u8131\u6c27\u6838\u9176\u4ecb\u5bfc\u57fa\u56e0\u6cbb\u7597\u3002\u7814\u7a76\u5f97\u5230\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u7b49\u8d44\u52a9\u652f\u6301\u3002<\/p>\n<p>\u6838\u9178\u836f\u7269\u53ef\u5b9e\u73b0\u5bf9\u57fa\u56e0\u7684\u9ad8\u6548\u7cbe\u51c6\u8c03\u63a7\uff0c\u6709\u671b\u5728\u57fa\u56e0\u6c34\u5e73\u8c03\u63a7\u7ec6\u80de\u529f\u80fd\uff0c\u7528\u4e8e\u91cd\u5927\u75be\u75c5\u6cbb\u7597\u3002\u8131\u6c27\u6838\u9176\uff08DNAzyme\uff09\u4f5c\u4e3a\u65b0\u578b\u6838\u9178\u836f\u7269\uff0c\u5177\u6709\u7a33\u5b9a\u6027\u9ad8\u548c\u76f8\u5bf9\u6210\u672c\u4f4e\u7684\u7279\u70b9\uff0c\u8fd1\u5e74\u6765\u53d7\u5230\u5e7f\u6cdb\u5173\u6ce8\u3002DNAzyme\u662f\u4e00\u79cd\u5177\u6709\u50ac\u5316\u529f\u80fd\u7684DNA\u5206\u5b50\uff0c\u80fd\u591f\u7279\u5f02\u6027\u8bc6\u522b\u5e76\u50ac\u5316\u5207\u5272\u9776\u6807\u4fe1\u4f7fRNA \uff08mRNA\uff09\uff0c\u8c03\u63a7\u9776\u6807\u57fa\u56e0\u8868\u8fbe\uff0c\u5728\u80bf\u7624\u57fa\u56e0\u6cbb\u7597\u9886\u57df\u8868\u73b0\u51fa\u826f\u597d\u7684\u5e94\u7528\u524d\u666f\u3002DNAzyme\u50ac\u5316\u6548\u7387\u53d7\u591a\u79cd\u56e0\u7d20\u5f71\u54cd\uff0c\u4f8b\u5982\u8f85\u56e0\u5b50\u6d53\u5ea6\u548c\u6e29\u5ea6\u7b49\u3002\u4f53\u5185\u73af\u5883\u590d\u6742\uff0c\u8f85\u56e0\u5b50\u6d53\u5ea6\u4f4e\uff0cDNAzyme\u5728\u4f53\u5185\u7684\u50ac\u5316\u6d3b\u6027\u96be\u4ee5\u8c03\u63a7\uff0c\u9650\u5236\u4e86DNAzyme\u7684\u5e94\u7528\u3002<\/p>\n<p>\u4ef0\u5927\u52c7\u6559\u6388\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u5177\u6709\u5149\u70ed\u8f6c\u6362\u6548\u5e94\u7684DNA\u7eb3\u7c73\u590d\u5408\u7269\uff08DP-PM\uff09\uff0c\u53ef\u901a\u8fc7\u5149\u63a7\u7b56\u7565\u8c03\u63a7DNAzyme\u7684\u4f53\u5185\u50ac\u5316\u6027\u80fd\uff0c\u589e\u5f3a\u80bf\u7624\u57fa\u56e0\u6cbb\u7597\u6548\u679c\uff08\u56fe1\uff09\u3002\u4f5c\u8005\u5229\u7528DNA\u6eda\u73af\u6269\u589e\u6280\u672f\u5236\u5907\u4e86\u4e00\u79cd\u542b\u6709\u5927\u91cfDNAzyme\u91cd\u590d\u5e8f\u5217\u7684DNA\u7eb3\u7c73\u7ec4\u88c5\u4f53\uff08DP\uff09\uff1b\u5229\u7528\u76d0\u9178\u591a\u5df4\u80fa\u4e0e\u9ad8\u9530\u9178\u94be\u7684\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\uff0c\u5408\u6210\u4e86\u5177\u6709\u805a\u591a\u5df4\u80fa\u6d82\u5c42\u7684\u4e8c\u6c27\u5316\u9530\u7eb3\u7c73\u7c92\u5b50\uff08PM\uff09\u3002PM\u901a\u8fc7\u03c0~\u03c0\u5806\u79ef\u548c\u6c22\u952e\u4f5c\u7528\u529b\u5728DP\u8868\u9762\u7ec4\u88c5\uff0c\u5f62\u6210\u7403\u5f62DNA\u7eb3\u7c73\u590d\u5408\u7269DP-PM\u3002DP-PM\u5177\u6709\u826f\u597d\u7684pH\u548c\u6e29\u5ea6\u7a33\u5b9a\u6027\uff0c\u54cd\u5e94\u7ec6\u80de\u5185\u9ad8\u6d53\u5ea6\u8c37\u80f1\u7518\u80bd\uff0c\u91ca\u653e\u51fa\u5927\u91cf\u91d1\u5c5e\u79bb\u5b50Mn<sup>2+<\/sup>\u3002Mn<sup>2+<\/sup>\u79bb\u5b50\u4f5c\u4e3a\u8f85\u56e0\u5b50\u6fc0\u6d3bDNAzyme\u50ac\u5316\u6d3b\u6027\uff0c\u5bf9\u9776\u6807Egr-1\u00a0mRNA\u8fdb\u884c\u7279\u5f02\u6027\u8bc6\u522b\u548c\u5207\u5272\uff0c\u964d\u4f4e\u65e9\u671f\u751f\u957f\u56e0\u5b50Egr-1\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u805a\u591a\u5df4\u80fa\u662f\u6027\u80fd\u4f18\u5f02\u7684\u5149\u70ed\u8f6c\u6362\u6750\u6599\uff0c\u53ef\u5c06\u8fd1\u7ea2\u5916\u5149\u8f6c\u5316\u6210\u70ed\u80fd\uff0c\u4f7f\u80bf\u7624\u90e8\u4f4d\u6e29\u5ea6\u5347\u9ad8\uff0c\u4ece\u800c\u63d0\u9ad8DNAzyme\u7684\u50ac\u5316\u6d3b\u6027\uff0c\u589e\u5f3aDNAzyme\u4ecb\u5bfc\u7684\u57fa\u56e0\u6cbb\u7597\u6548\u679c\u3002\u5c0f\u9f20\u6d3b\u4f53\u5b9e\u9a8c\u663e\u793a\uff0c\u805a\u591a\u5df4\u80fa\u5f15\u8d77\u7684\u70ed\u6548\u5e94\u4f1a\u5f15\u8d77\u80bf\u7624\u7ec6\u80de\u70ed\u5e94\u6fc0\uff0c\u4e0eDNAzyme\u4ecb\u5bfc\u7684\u57fa\u56e0\u6cbb\u7597\u8d77\u5230\u534f\u540c\u6297\u80bf\u7624\u6548\u679c\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-223784\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2021\/06\/\u56fe\u7247-1-23.png\" alt=\"\" width=\"509\" height=\"385\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2021\/06\/\u56fe\u7247-1-23.png 509w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2021\/06\/\u56fe\u7247-1-23-300x227.png 300w\" sizes=\"(max-width: 509px) 100vw, 509px\" \/><\/p>\n<p>\u56fe1.\u00a0\u00a0A) \u548cB\uff09DNA\u7eb3\u7c73\u590d\u5408\u7269\u7684\u5236\u5907\u8fc7\u7a0b\u793a\u610f\u56fe\uff1bC\uff09\u8fd1\u7ea2\u5916\u5149\u7167\u5c04\u4e0b\uff0c\u80bf\u7624\u7ec6\u80de\u5185DNAzyme\u57fa\u56e0\u8c03\u63a7\u548c\u6cbb\u7597\u793a\u610f\u56fe<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-223785\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2021\/06\/\u56fe\u7247-2-22.png\" alt=\"\" width=\"600\" height=\"219\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2021\/06\/\u56fe\u7247-2-22.png 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2021\/06\/\u56fe\u7247-2-22-300x110.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.nanolett.1c01727<\/p>\n<p><strong><b>\u4ef0\u5927\u52c7\u6559\u6388\u8bfe\u9898\u7ec4<\/b><\/strong>\u4ee5\u751f\u7269\u5927\u5206\u5b50DNA\u4e3a\u7814\u7a76\u4e3b\u7ebf\uff0c\u805a\u7126DNA\u751f\u7269\u529f\u80fd\u6750\u6599\u667a\u80fd\u5236\u9020\uff0c\u5229\u7528\u6750\u6599\u5316\u5b66\u7684\u624b\u6bb5\u7406\u89e3\u751f\u547d\u7cfb\u7edf\u8fd0\u884c\u673a\u5236\uff0c\u63a2\u7d22\u91cd\u5927\u75be\u75c5\u7684\u8bca\u65ad\u6cbb\u7597\u65b0\u9014\u5f84\u3002<\/p>\n<p><strong><b>\u8bfe\u9898\u7ec4\u4e3b\u9875<\/b><\/strong>\uff1a<a href=\"http:\/\/yanglab-dna.com\/\"><u>http:\/\/yanglab-dna.com\/<\/u><\/a><\/p>\n<p>\u672c\u6587\u7531\u4f5c\u8005\u6295\u7a3f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u671f\uff0c\u5929\u6d25\u5927\u5b66\u5316\u5de5\u5b66\u9662\u4ef0\u5927\u52c7\u6559\u6388\u8bfe\u9898\u7ec4\u5728Nano Letters\uff08\u7eb3\u7c73\u5feb\u62a5\uff09\u4e0a\u53d1\u8868DNA\u7eb3\u7c73\u590d\u5408\u7269\u7528\u4e8e\u8fd1\u7ea2\u5916\u5149\u589e\u5f3a\u7684\u8131\u6c27\u6838\u9176\u4ecb\u5bfc\u57fa\u56e0\u6cbb\u7597\u3002\u7814\u7a76\u5f97\u5230\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa&#8230;<\/p>\n","protected":false},"author":11454,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-223783","post","type-post","status-publish","format-standard","hentry","category-keji"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/223783"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/11454"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=223783"}],"version-history":[{"count":1,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/223783\/revisions"}],"predecessor-version":[{"id":223786,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/223783\/revisions\/223786"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=223783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=223783"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=223783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}