{"id":230376,"date":"2021-12-06T06:30:30","date_gmt":"2021-12-05T22:30:30","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=230376"},"modified":"2021-12-05T20:11:40","modified_gmt":"2021-12-05T12:11:40","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e5%b1%b1%e4%b8%9c%e5%b8%88%e8%8c%83%e5%a4%a7%e5%ad%a6angew%ef%bc%9a%e4%b8%80%e9%94%85%e6%b3%95%e5%88%b6%e5%a4%87%e9%93%9c%e5%9f%ba%e7%ba%b3%e7%b1%b3","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=230376","title":{"rendered":"\u5c71\u4e1c\u5e08\u8303\u5927\u5b66Angew\uff1a\u4e00\u9505\u6cd5\u5236\u5907\u94dc\u57fa\u7eb3\u7c73\u9897\u7c92\u7528\u4e8e\u589e\u5f3aCDT"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u5316\u5b66\u52a8\u529b\u7597\u6cd5\uff08CDT\uff09\u4f5c\u4e3a\u4e00\u79cd\u5f88\u6709\u524d\u9014\u7684\u80bf\u7624\u6cbb\u7597\u65b9\u6cd5\uff0c\u56e0\u5176\u5177\u6709\u9ad8\u5ea6\u9009\u62e9\u6027\u548c\u5185\u6e90\u6027\u523a\u6fc0\u6fc0\u6d3b\u7684\u4f18\u70b9\u800c\u5907\u53d7\u5173\u6ce8\uff0c\u53ef\u5b9e\u73b0\u80bf\u7624\u7684\u539f\u4f4d\u6cbb\u7597\u3002\u5728CDT\u8fc7\u7a0b\u4e2d\uff0c\u5229\u7528Fenton\u53cd\u5e94\u6216\u7c7bFenton\u53cd\u5e94\u751f\u6210\u6bd2\u6027\u00b7OH\uff0c\u7834\u574f\u7ec6\u80de\u6c27\u5316\u8fd8\u539f\u7a33\u6001\uff0c\u8bf1\u5bfc\u7ec6\u80de\u6b7b\u4ea1\u3002\u4e0e\u5149\u52a8\u529b\u7597\u6cd5\u548c\u5149\u70ed\u7597\u6cd5\u76f8\u6bd4\uff0cCDT\u8fc7\u7a0b\u4e2d\u4e0d\u9700\u8981\u5149\u7b49\u5916\u90e8\u80fd\u91cf\u8f93\u5165\uff0c\u53ef\u4ee5\u6709\u6548\u514b\u670d\u5149\u7a7f\u900f\u7ec4\u7ec7\u7684\u9650\u5236\uff0c\u66f4\u9002\u5408\u4e8e\u6df1\u90e8\u80bf\u7624\u7684\u6cbb\u7597\u3002\u5c3d\u7ba1\u5df2\u7ecf\u5f00\u53d1\u51fa\u4e0d\u540c\u7684CDT\u7eb3\u7c73\u5236\u5242\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\uff0c\u4f46\u4ecd\u7136\u8feb\u5207\u9700\u8981\u65b0\u7684\u66f4\u7b80\u5355\u7684\u7b56\u7565\u6765\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002\u5728CDT\u4e2d\uff0c\u6d3b\u6027\u6c27\uff08ROS\uff09\u7684\u4ea7\u751f\u6c34\u5e73\u5bf9\u8bc4\u4ef7\u7597\u6548\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u7136\u800c\uff0c\u80bf\u7624\u7ec6\u80de\u4e2d\u9ad8\u6c34\u5e73\u7684\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u6d88\u8017\u6d3b\u6027\u6c27\uff0c\u76f4\u63a5\u964d\u4f4e\u6cbb\u7597\u6548\u7387\u3002\u4ece\u4e34\u5e8a\u5e94\u7528\u6765\u770b\uff0c\u5f00\u53d1\u5408\u6210\u7b80\u5355\u3001\u529f\u80fd\u591a\u6837\u3001\u6548\u7387\u66f4\u9ad8\u7684CDT\u8bd5\u5242\u4ecd\u7136\u662f\u7814\u7a76\u8005\u8ffd\u6c42\u7684\u76ee\u6807\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5c71\u4e1c\u5e08\u8303\u5927\u5b66\u5510\u6ce2\u6559\u6388\u3001\u5f20\u536b\u6559\u6388<\/strong>\u8054\u5408\uff0c\u91c7\u7528\u4e00\u9505\u6cd5\u8bbe\u8ba1\u5e76\u5408\u6210\u4e86\u591a\u529f\u80fd\u78b3\u57fa\u7eb3\u7c73\u9897\u7c92\u8d1f\u8f7d\u5206\u6563Cu2+<\/sup>\uff08Cu-Cys-CBNPs\uff09\u3002\u4f5c\u4e3a\u652f\u6491\u6750\u6599\u7684CBNP\u5145\u5206\u5206\u6563Cu2+<\/sup>\uff0c\u4f7f\u4e4b\u4e0eGSH\u53cd\u5e94\uff0c\u901a\u8fc7\u7c7bFenton\u53cd\u5e94\u4ea7\u751f\u6bd2\u6027\u8f83\u5927\u7684\u00b7OH\uff0c\u5e76\u63d0\u9ad8CDT\u7684\u6548\u7387\u3002\u7ed3\u679c\u8868\u660e\uff0c\u901a\u8fc7\u6d88\u8017\u7ec6\u80de\u5185\u6297\u6c27\u5316\u5242GSH\uff0c\u5206\u6563\u5728CBNPs\u4e0a\u7684Cu2+<\/sup>\u53ef\u4ee5\u8fd8\u539f\u4e3aCu+<\/sup>\u3002\u540c\u65f6\uff0c\u751f\u6210\u7684Cu+<\/sup>\u80fd\u4e0e\u80bf\u7624\u7ec4\u7ec7\u4e2d\u8fc7\u91cf\u751f\u6210\u7684H2<\/sub>O2<\/sub>\u53cd\u5e94\u751f\u6210\u00b7OH\uff0c\u800cCu+<\/sup>\u88ab\u6c27\u5316\u4e3aCu2+<\/sup>\uff0c\u7ee7\u7eed\u6d88\u8017\u80bf\u7624\u7ec6\u80de\u4e2d\u7684GSH\u3002GSH\u6d88\u8017\u4e0e\u00b7OH\u4ea7\u751f\u7684\u534f\u540c\u6548\u5e94\u53ef\u663e\u8457\u589e\u52a0\u7ec6\u80de\u5185ROS\u6c34\u5e73\uff0c\u5f15\u8d77DNA\u635f\u4f24\uff0c\u6700\u7ec8\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002\u80bf\u7624\u6cbb\u7597\u7ed3\u679c\u8868\u660e\uff0cCu-Cys-CBNPs\u80fd\u591f\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u5e76\u5728\u4f53\u5185\u8868\u73b0\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6027\u80fd\u3002\u8fdb\u4e00\u6b65\u5c0f\u9f20\u7684\u53cc\u5149\u5b50\u6210\u50cf\u663e\u793a\uff0cCu-Cys-CBNPs\u53ef\u4ee5\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff08BBB\uff09\uff0c\u8fd9\u7ed9\u8111\u90e8\u80bf\u7624\u7684\u6cbb\u7597\u5e26\u6765\u4e86\u5e0c\u671b\u3002\u8be5\u8bba\u6587\u4ee5\u9898\u4e3a\u201cOne-Pot Synthesis of Multifunctional Carbon-Based Nanoparticle Supported Dispersed Cu2+<\/sup> Disrupts Redox Homeostasis to Enhance CDT<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aAngew. Chem. Int. Ed.<\/strong>\u4e0a\u3002<\/p>\n

\"\"<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001<\/strong>CBNPs<\/strong>\u7684\u7406\u5316\u6027\u8d28\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a-b\uff09Cu-Cys CBNPs\u7684TEM\u3001\u9ad8\u5206\u8fa8TEM\u56fe\u50cf\u53caDLS\u56fe\u50cf\u3002<\/p>\n

\uff08c-d\uff09Cu-Cys CBNPs\u7684XPS\u53caCu 2p\u9ad8\u5206\u8fa8XPS\u8c31\u56fe\u3002<\/p>\n

\uff08e-g\uff09Cu-Cys CBNPs\u7684\u7ea2\u5916\u56fe\u50cf\u3001\u7d2b\u5916-\u53ef\u89c1\u5149\u5438\u6536\u5149\u8c31\u4ee5\u53ca\u8367\u5149\u5149\u8c31\u3002<\/p>\n

\u56fe\u4e8c\u3001<\/strong>Cu-Cys CBNPs<\/strong>\u5bf9<\/strong>GSH<\/strong>\u6d88\u8017<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u4e0d\u540c\u6750\u6599\u5bf9GSH\u7684\u6d88\u8017\u5bf9\u6bd4\u3002<\/p>\n

\uff08b\uff09\u4e0d\u540c\u6d53\u5ea6Cu-Cys CBNPs\u5bf9GSH\u7684\u6d88\u8017\u5bf9\u6bd4\u3002<\/p>\n

\uff08c\uff09Cu-Cys CBNPs\u4e0eGSH\u53cd\u5e94\u540eCu 2p\u9ad8\u5206\u8fa8XPS\u8c31\u56fe\u3002<\/p>\n

\uff08d\uff09Cu-Cys CBNPs\u4e0e\u4e0d\u540c\u6d53\u5ea6GSH\u53cd\u5e94\u540e\u8367\u5149\u5149\u8c31\u3002<\/p>\n

\uff08e\uff09\u4e0d\u540c\u6d53\u5ea6Cu-Cys CBNPs\u5bf9MB\u7684\u964d\u89e3\u3002<\/p>\n

\uff08f\uff09Cu-Cys CBNPs\u4e0eGSH\u53cd\u5e94\u540e\u518d\u4e0eH2<\/sub>O2<\/sub>\u53cd\u5e94\u540e\u7684Cu 2p\u9ad8\u5206\u8fa8XPS\u8c31\u56fe\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>Cu-Cys-CBNPs<\/strong>\u5bf9\u7ec6\u80de\u5185\u542b\u5def\u57fa\u86cb\u767d\u8d28\u7684\u5f71\u54cd<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u901a\u8fc7rdTOP-ABPP\u65b9\u6cd5\u7814\u7a76Cu-Cys-CBNPs\u5bf9SMMC-7721\u7ec6\u80de\u4e2d\u86cb\u767d\u8d28\u5def\u57fa\u7684\u5f71\u54cd\u3002<\/p>\n

\uff08b\uff09\u6bd4\u8f83Cys-CBNPs\uff08100 \u03bcg\/mL\uff09\u548cCu-Cys-CBNPs\uff08100 \u03bcg\/mL\uff09\u5bf9SMMC-7721\u7ec6\u80de\u4e2d\u86cb\u767d\u8d28\u5def\u57fa\u7684\u5f71\u54cd\u3002<\/p>\n

\uff08c\uff09\u7528rdTOP-ABPP\u65b9\u6cd5\u9274\u5b9a\u7684\u86cb\u767d\u8d28\u7684Venn\u56fe\u3002<\/p>\n

\uff08d\uff09GO\uff08\u57fa\u56e0\u672c\u4f53\uff09\u529f\u80fd\u5206\u6790\u56fe\u3002<\/p>\n

\uff08e\uff09\u4e0eCys-CBNPs\u548cCu-Cys-CBNPs\u5b75\u80b2\u540eSMMC-7721\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\u56fe\u56db\u3001Cu-Cys-CBNPs\u5bf9\u7ec6\u80de\u5b58\u6d3b\u7684\u5f71\u54cd<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u7528JC-1\uff08\u7ea2\u8272\uff0cJ-\u805a\u96c6\u4f53\uff1b\u7eff\u8272\uff0c\u5355\u4f53\uff09\u67d3\u8272\u7684SMMC-7721\u7ec6\u80de\u4e2d\u0394\u03c8m\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u3002<\/p>\n

\uff08b\uff09\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u57280\u5c0f\u65f6\u300124\u5c0f\u65f6\u300148\u5c0f\u65f6\u548c72\u5c0f\u65f6\u540e\u7684\u7ec6\u80de\u751f\u957f\u548c\u589e\u6b96\u56fe\u50cf\u3002<\/p>\n

\uff08c\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4b\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u7ec6\u80de\u51cb\u4ea1\u60c5\u51b5\u3002<\/p>\n

\u56fe\u4e94\u3001\u4f53\u5185\u6297\u80bf\u7624\u5b9e\u9a8c\u7814\u7a76<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5c0f\u9f20\u80bf\u7624\u79fb\u690d\u548c\u4f53\u5185\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

\uff08b\uff09\u6cbb\u7597\u671f\u95f4\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u60c5\u51b5\u3002<\/p>\n

\uff08c\uff09\u6cbb\u7597\u671f\u95f4\u5c0f\u9f20\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u60c5\u51b5\u3002<\/p>\n

\uff08d\uff09\u4e0d\u540c\u5904\u7406\u540e\u4e3b\u8981\u5668\u5b98\u548c\u7ec4\u7ec7\u7684\u5207\u7247\u56fe\u50cf\u3002<\/p>\n

\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u901a\u8fc7\u4e00\u9505\u6cd5\u5f00\u53d1\u4e86\u78b3\u57fa\u7eb3\u7c73\u9897\u7c92\u5206\u6563\u7684Cu2+<\/sup>\u7eb3\u7c73\u9897\u7c92\uff08Cu-cys-CBNPs\uff09\uff0c\u5b83\u4e0d\u4ec5\u80fd\u6d88\u8017GSH\uff0c\u5f71\u54cd\u86cb\u767d\u8d28\u5def\u57fa\uff0c\u800c\u4e14\u80fd\u4ea7\u751f\u00b7OH\uff0c\u7834\u574f\u7ec6\u80de\u6c27\u5316\u8fd8\u539f\u7a33\u6001\u3002\u4f53\u5185\u7814\u7a76\u8868\u660e\uff0cCu-cys-CBNPs\u5177\u6709\u826f\u597d\u7684CDT\u6548\u5e94\uff0c\u5e76\u80fd\u6709\u6548\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u8fd9\u4e9b\u4f18\u5f02\u7684\u7279\u6027\u4e3aCu-cys-CBNPs\u6210\u4e3a\u4e00\u79cd\u6709\u6548\u7684\u6297\u80bf\u7624\u836f\u7269\u5960\u5b9a\u4e86\u57fa\u7840\u3002\u6b64\u5916\uff0cCu-cys-CBNPs\u5177\u6709\u51fa\u4e4e\u610f\u6599\u7684\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\u7684\u80fd\u529b\uff0c\u53ef\u80fd\u88ab\u7528\u4e8e\u6cbb\u7597\u8111\u80bf\u7624\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5408\u6210\u8fc7\u7a0b\u4e2d\u53f6\u9178\u548c\u5417\u5549\u7684\u63ba\u6742\u8d4b\u4e88\u4e86\u7eb3\u7c73\u9897\u7c92\u4f18\u8d8a\u7684\u9776\u5411\u6027\uff0c\u4ece\u800c\u7b80\u5355\u5730\u5b9e\u73b0\u4e86\u7eb3\u7c73\u6750\u6599\u7684\u529f\u80fd\u5316\u3002\u8fd9\u9879\u5de5\u4f5c\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u524d\u9014\u7684\u6297\u80bf\u7624\u836f\u7269\uff0c\u5e76\u4e3a\u6784\u5efa\u591a\u529f\u80fd\u7eb3\u7c73\u5e73\u53f0\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u7b56\u7565\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aOne-Pot Synthesis of Multifunctional Carbon-Based Nanoparticle Supported Dispersed Cu2+<\/sup> Disrupts Redox Homeostasis to Enhance CDT<\/a> (Angew. Chem. Int. Ed. <\/em>2021<\/strong>, DOI: 10.1002\/anie.202114373)<\/p>\n

\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com<\/a><\/p>\n

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