{"id":233019,"date":"2022-02-16T06:04:32","date_gmt":"2022-02-15T22:04:32","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=233019"},"modified":"2022-02-15T22:51:18","modified_gmt":"2022-02-15T14:51:18","slug":"%e5%a4%8d%e6%97%a6%e5%a4%a7%e5%ad%a6nature%e5%ad%90%e5%88%8a%ef%bc%9a4%e5%88%86%e9%92%9f%e5%8d%b3%e5%8f%af%e5%87%ba%e6%a0%b8%e7%ae%97%e7%bb%93%e6%9e%9c","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=233019","title":{"rendered":"\u590d\u65e6\u5927\u5b66Nature\u5b50\u520a\uff1a4\u5206\u949f\u5373\u53ef\u51fa\u6838\u9178\u7ed3\u679c"},"content":{"rendered":"

\u5f15\u8a00<\/strong><\/p>\n

\u56e0\u4e3a\u8bb8\u591a\u4e0e\u75be\u75c5\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\u7684\u4e30\u5ea6\u6781\u4f4e\uff0c\u6240\u4ee5\u5bf9\u751f\u7269\u6eb6\u6db2\u4e2d\u75d5\u91cf\u5206\u6790\u7269\u8fdb\u884c\u8d85\u7cbe\u786e\u5206\u6790\u5bf9\u4e8e\u751f\u7269\u7814\u7a76\u3001\u7cbe\u51c6\u533b\u5b66\u548c\u65e9\u671f\u8bca\u65ad\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u8fd9\u79cd\u7cbe\u786e\u7684\u5206\u6790\u63a5\u8fd1\u751f\u7269\u4f20\u611f\u5668\u7684\u6781\u9650\uff0c\u4e0d\u53ef\u907f\u514d\u5730\u4f1a\u53d7\u5230\u5927\u91cf\u975e\u7279\u5f02\u6027\u86cb\u767d\u8d28\u3001\u6838\u9178\u6216\u5176\u4ed6\u80cc\u666f\u751f\u7269\u5206\u5b50\u7684\u5f71\u54cd\u3002\u76ee\u524d\uff0c\u4e00\u4e9b\u6280\u672f\u53ef\u4ee5\u901a\u8fc7\u4f7f\u7528\u7eb3\u7c73\u5c3a\u5ea6\u7684\u4f20\u611f\u5668\uff0c\u5229\u7528\u5fae\u5c0f\u7684\u6d4b\u8bd5\u4f53\u79ef\u548c\u8d85\u5c0f\u7684\u8bc6\u522b\u622a\u9762\u6765\u5b9e\u73b0\u5355\u4e2a\u6216\u5c11\u6570\u5206\u5b50\u7684\u68c0\u6d4b\uff0c\u4f46\u5b83\u4eec\u5728\u5b8f\u89c2\u6eb6\u6db2\u7f3a\u4e4f\u5206\u5b50\u6c34\u5e73\u7684\u7075\u654f\u5ea6\u3002\u5c3d\u7ba1\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u65f6\u95f4\u4e2d\u79d1\u7814\u4eba\u5458\u505a\u51fa\u4e86\u5927\u91cf\u7684\u52aa\u529b\uff0c\u4f46\u662f\u8d85\u7cbe\u51c6\u7684\u751f\u7269\u68c0\u6d4b\u4ecd\u7136\u662f\u5316\u5b66\u548c\u751f\u7269\u79d1\u5b66\u4e2d\u7684\u4e00\u4e2a\u5173\u952e\u95ee\u9898\u3002\u7279\u522b\u662f\u57282019\u51a0\u72b6\u75c5\u6bd2\u75c5(COVID-19)\u5927\u6d41\u884c\u548c\u5176\u4ed6\u5927\u89c4\u6a21\u6d41\u884c\u75c5\u7684\u80cc\u666f\u4e0b\uff0c\u8d85\u7cbe\u51c6\u7684\u751f\u7269\u68c0\u6d4b\u5c24\u4e3a\u91cd\u8981\u3002\u7531\u4e8e\u5728\u5f85\u6d4b\u6eb6\u6db2\u4e2d\u68c0\u6d4b\u8d85\u4f4e\u6d53\u5ea6\u7684\u76ee\u6807\u5206\u5b50\u5b58\u5728\u6311\u6218\u6027\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u5c06\u76f4\u63a5\u7684SARS-CoV-2\u6838\u9178\u68c0\u6d4b\u65b9\u6cd5\u5e94\u7528\u4e8eCOVID-19\u7684\u4e34\u5e8a\u8bca\u65ad\u3002\u76ee\u524d\u5df2\u7ecf\u5efa\u7acb\u7684\u65b9\u6cd5\uff0c\u5373\u57fa\u4e8e\u5b9a\u91cf\u9006\u8f6c\u5f55\u805a\u5408\u9176\u94fe\u53cd\u5e94(quantitative reverse-transcription polymerase chain reaction, qRT-PCR)\u7684\u6280\u672f\uff0c\u8fd9\u79cd\u6280\u672f\u7684\u7075\u654f\u5ea6\u6709\u9650\uff0c\u800c\u4e14\u9700\u8981\u6838\u9178\u63d0\u53d6\u548c\u6269\u589e\u7a0b\u5e8f\uff0c\u9700\u8981\u719f\u7ec3\u7684\u6280\u672f\u4eba\u5458\u3001\u7279\u5b9a\u7684\u5b9e\u9a8c\u5ba4\u548c\u8bbe\u5907\uff0c\u5904\u7406\u65f6\u95f4\u8f83\u957f(>2 h<\/em>)\uff1b\u56e0\u6b64\uff0c\u73b0\u573a\u548c\u5373\u65f6\u68c0\u6d4bSARS-CoV-2\u6838\u9178\u4ecd\u7136\u662f\u4e00\u4e2a\u969c\u788d\u3002\u5c3d\u7ba1\u76ee\u6807\u6269\u589e\u5927\u4e8e106<\/sup>\u500d\uff0cqRT-PCR\u68c0\u6d4b\u6781\u9650(limit of detection, LoD)\u901a\u5e38\u662f\u6bcf\u5fae\u5347\u7ea60.2-1\u62f7\u8d1d(~0.3 \u00d7 10\u2212<\/sup>18<\/sup>\u00a0~ 1.7 \u00d7 10\u2212<\/sup>18<\/sup>\u00a0M<\/em>)\u3002\u7b80\u5355\u3001\u5feb\u901f\u548c\u8d85\u7cbe\u786e\u7684\u6838\u9178\u68c0\u6d4b\u65b9\u6cd5\u5c06\u6709\u52a9\u4e8e\u51cf\u7f13SARS-CoV-2\u7684\u5feb\u901f\u4f20\u64ad\u3002<\/p>\n

\u5fae\u673a\u7535\u7cfb\u7edf(Microelectromechanical systems, MEMS)\u662f\u4e00\u79cd\u5178\u578b\u7684\u96c6\u6210\u5ea6\u9ad8\u3001\u4f53\u79ef\u5c0f\u3001\u6210\u672c\u4f4e\u3001\u6548\u7387\u9ad8\u3001\u5177\u6709\u5546\u4e1a\u5316\u53ef\u884c\u6027\u7684\u7cfb\u7edf\u3002MEMS\u96c6\u6210\u4e86\u5fae\u7c73\u7ea7\u7684\u673a\u68b0\u5143\u4ef6\uff0c\u7ed3\u5408\u5fae\u7535\u5b50\u5b66\u77e5\u8bc6\uff0c\u5c06\u673a\u68b0\u3001\u5316\u5b66\u3001\u751f\u7269\u6216\u5176\u4ed6\u4f20\u611f\u54cd\u5e94\u8f6c\u6362\u4e3a\u7535\u4fe1\u53f7\u3002\u901a\u8fc7\u4e0e\u573a\u6548\u5e94\u6676\u4f53\u7ba1(field-effect transistors, FETs)\u7684\u96c6\u6210\uff0cMEMS\u53ef\u4ee5\u5236\u9020\u8d85\u7075\u654f\u7684\u751f\u7269\u4f20\u611f\u5668\uff0c\u56e0\u4e3aFETs\u5c06\u9ad8\u6548\u7684\u4f20\u611f\u5668\u4e0e\u4fe1\u53f7\u653e\u5927\u5668\u7ed3\u5408\u5728\u4e00\u8d77\uff0c\u5176\u4e2d\u4e00\u4e2a\u5c0f\u7684\u53c2\u6570\u53d8\u5316\u5c31\u4f1a\u5f15\u8d77\u901a\u9053\u7535\u6d41\u7684\u663e\u8457\u53d8\u5316\u3002\u7531\u4e8e\u66f4\u5c0f\u7684\u5c3a\u5bf8\uff0c\u53ef\u4f7f\u68c0\u6d4b\u5177\u6709\u66f4\u9ad8\u7684\u7075\u654f\u5ea6\u548c\u5206\u8fa8\u7387\uff0c\u901a\u8fc7\u5c06\u7279\u5f81\u5c3a\u5bf8\u5c0f\u578b\u5316\u5230\u4e9a\u5fae\u7c73\u5c3a\u5ea6\uff0c\u7eb3\u7c73\u673a\u7535\u7cfb\u7edf(nanoelectromechanical systems, NEMS)\u5728\u63d0\u9ad8\u4f20\u611f\u6027\u80fd\u7684\u540c\u65f6\u964d\u4f4e\u4e86\u6210\u672c\u3001\u4f53\u79ef\u3001\u91cd\u91cf\u548c\u529f\u8017\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7cfb\u7edf\u7684\u6027\u80fd\u4ecd\u7136\u8fdc\u8fdc\u4f4e\u4e8e\u8bb8\u591a\u751f\u7269\u7cfb\u7edf\uff0c\u5728\u751f\u7269\u7cfb\u7edf\u4e2d\uff0c\u751f\u7269\u8bc6\u522b\u548c\u53cd\u5e94\u901a\u5e38\u901a\u8fc7\u7cbe\u786e\u7684\u5206\u5b50\u6c34\u5e73\u673a\u5236\u53d1\u751f\u3002<\/p>\n

\u5bf9\u4e8e\u57fa\u4e8eMEMS\u3001NEMS\u548cFETs\u7684\u751f\u7269\u4f20\u611f\u5668\uff0c\u5982\u679c\u4e0d\u8bbe\u8ba1\u4f20\u611f\u754c\u9762\u548c\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u64cd\u7eb5\u7cfb\u7edf\uff0c\u5728\u7f13\u51b2\u6db2\u6216\u7a00\u91ca\u7684\u751f\u7269\u6db2\u4e2d\u7075\u654f\u5ea6\u5f88\u5c11\u80fd\u8fbe\u523010-17<\/sup>\u00a0M<\/em>\u00a0(100\u5fae\u5347\u4e2d\u7ea6600\u62f7\u8d1d)\u3002\u5982\u679c\u5728\u590d\u6742\u548c\u9ad8\u79bb\u5b50\u5f3a\u5ea6\u7684\u751f\u7269\u6db2\u4f53\u4e2d\u66f4\u96be\u8fbe\u5230\u8fd9\u79cd\u7075\u654f\u5ea6\u3002\u8fd1\u5e74\u6765\uff0c\u4e00\u4e9b\u4f9d\u8d56\u4e8e\u5316\u5b66\u7ed3\u5408\u8bf1\u5bfc\u51e0\u4f55\u53d8\u5316\u7684\u5206\u5b50\u5c3a\u5ea6\u7cfb\u7edf\u5df2\u88ab\u5f00\u53d1\u7528\u4e8e\u5316\u5b66\u4f20\u611f\u3002\u4f46\u5176\u68c0\u6d4b\u7075\u654f\u5ea6\u4e00\u822c\u572810-14<\/sup>~10-6<\/sup>\u00a0M<\/em>\u3002<\/p>\n

\u7814\u7a76\u8fdb\u5c55<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u6765\u81ea\u590d\u65e6\u5927\u5b66\u9b4f\u5927\u7a0b<\/strong>\u56e2\u961f\u4e0e\u6731\u53ec\u82b9<\/strong>\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5408\u4f5c<\/strong>\u5728Nat Biomed Eng<\/em>\u4e0a\u53d1\u8868\u6587\u7ae0\uff0c\u9898\u4e3a\u201cRapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples<\/strong>\u201d\u3002\u00a0\u9b4f\u5927\u7a0b\u56e2\u961f\u62a5\u9053\u4e86\u4e00\u4e2a\u5206\u5b50\u7cfb\u7edf\u7528\u4e8e\u751f\u7269\u6db2\u4f53\u4e2d\u672a\u6269\u589e\u7684\u91d1\u5c5e\u79bb\u5b50(Hg2+<\/sup>)\u3001\u86cb\u767d\u8d28(Thrombin)\u3001\u751f\u7269\u5c0f\u5206\u5b50(ATP)\u4ee5\u53ca\u65b0\u51a0\u75c5\u6bd2\u6838\u9178(RNA\u548ccDNA)\u7684\u5feb\u901f\u548c\u8d85\u7075\u654f\u7684\u673a\u7535\u68c0\u6d4b(\u5728100\u5fae\u5347\u4e2d\u53ef\u68c0\u6d4b\u52301\u52302\u62f7\u8d1d)\u3002\u6b64\u5916\uff0c\u8be5\u56e2\u961f\u5c06\u7528\u4e8e\u68c0\u6d4bSARS-CoV-2\u7684\u673a\u7535\u751f\u7269\u4f20\u611f\u5668\u96c6\u6210\u5230\u4e00\u4e2a\u4fbf\u643a\u5f0f\u539f\u578b\u8bbe\u5907\u4e2d\uff0c\u5e76\u8868\u660e\u5b83\u57284\u5206\u949f\u5185\u5373\u53ef\u68c0\u6d4b\u5230SARS-CoV-2 RNA\u7684\u4fe1\u53f7\u54cd\u5e94\uff0c\u65e0\u9700\u63d0\u53d6RNA\u6216\u6838\u9178\u6269\u589e\u3002<\/p>\n

\"\"<\/p>\n

\u56fe\u6587\u4ecb\u7ecd<\/strong><\/p>\n

\u56fe1.\u00a0MolEMS\u548cMolEMS g-FET\u00a92022 Springer Nature<\/p>\n

\"\"a. MEMS\u6216NEMS\u751f\u7269\u68c0\u6d4b\u539f\u7406\u56fe<\/p>\n

b. MolEMS\u53ca\u5176\u9759\u7535\u9a71\u52a8\u539f\u7406\u56fe<\/p>\n

c. MolEMS g-FET\u7684\u5668\u4ef6\u88c5\u7f6e\u56fe<\/p>\n

d, e. \u8be5\u88c5\u7f6e\u7684\u7167\u7247(d)\u548c\u5149\u5b66\u663e\u5fae\u955c\u56fe\u50cf(e)<\/p>\n

f. \u77f3\u58a8\u70ef\u4e0eMolEMSs\u4fee\u9970\u540e\u7684AFM\u56fe\u50cf<\/p>\n

g-i. \u7528Cy3-17bp-15T MolEMSs\u4fee\u9970\u7684\u77f3\u58a8\u70ef\u7684\u8367\u5149\u5f3a\u5ea6\u56fe\u50cf\uff0cV<\/em>lg<\/sub>\u4e3a0.9 V<\/em>\u00a0(g)\u30010 V<\/em>\u00a0(h)\u548c\u22121.1 V<\/em>\u00a0(i)<\/p>\n

\u56fe2. \u8d85\u7075\u654f\u7684\u751f\u7269\u68c0\u6d4b\u548c\u957f\u671f\u7a33\u5b9a\u6027\u00a92022 Springer Nature<\/p>\n

\"\"<\/p>\n

a-c. \u5728V<\/em>lg<\/sub>\u00a0=\u22120.5 V<\/em>\u00a0(a,c)\uff0c 0 V<\/em>\u00a0(b,c)\u548c0.5 V<\/em>\u00a0(b,c)\u65f6\uff0cTBA\u529f\u80fd\u5316MolEMS\u4fee\u9970\u7684g-FET\u57281\u00d7 TRB\u7f13\u51b2\u6db2\u4e2d\u6dfb\u52a0\u51dd\u8840\u9176(\u4ece5 \u00d7 10\u2212<\/sup>18<\/sup>\u00a0M<\/em>\u52305 \u00d7 10\u2212<\/sup>10<\/sup>\u00a0M<\/em>)\u7684\u5b9e\u65f6\u2206I<\/em>ds<\/sub>\u54cd\u5e94(a,b)\u548c\u2206I<\/em>ds<\/sub>\u00a0\u54cd\u5e94(c)<\/p>\n

d. MolEMS\u7684\u4f20\u611f\u673a\u7406<\/p>\n

e. \u5728\u5168\u8840\u6e05\u4e2d(\u9ed1\u8272\u3001\u7eff\u8272)\u548c\u57281\u00d7 TRB\u7f13\u51b2\u6db2\u4e2d\u4f9d\u6b21\u52a0\u5165\u51dd\u8840\u9176(\u7ea2\u8272)\u6216\u5168\u8840\u6e05\u4e2d(\u84dd\u8272)\uff0cTBA\u529f\u80fd\u5316MolEMS\u4fee\u9970\u7684g-FET\u88c5\u7f6e\u7684\u2206I<\/em>ds<\/sub>\/I<\/em>ds0<\/sub>\u4e0et\u7684\u5173\u7cfb\u66f2\u7ebf<\/p>\n

\u56fe3.\u901a\u7528\u6027\u3001\u7279\u5f02\u6027\u6027\u548c\u63a2\u9488\u7ed3\u6784\u8bbe\u8ba1\u00a92022 Springer Nature<\/p>\n

\"\"<\/p>\n

a, b.\u00a0\u4e0d\u540c\u6d53\u5ea6\u7684ATP (1\u00d7 AM)\u3001Hg2+<\/sup>\u00a0(1\u00d7 TM)\u3001ATP(\u5168\u8840\u6e05)\u548css-DNA-T(\u5168\u8840\u6e05)\u5728MolEMS\u4e0e\u76f8\u5e94\u63a2\u9488\u9759\u7535\u4f5c\u7528\u4e0b\u7684|\u2206I<\/em>ds<\/sub>\/I<\/em>ds0<\/sub>| (a)\u548c\u5b9e\u65f6\u2206I<\/em>ds<\/sub>\/I<\/em>ds0<\/sub>\u00a0(b)\u54cd\u5e94<\/p>\n

c. MolEMS g- FETs\u5bf9\u6dfb\u52a0\u76ee\u6807\u5206\u6790\u7269(5 \u00d7 10\u2212<\/sup>16<\/sup>M<\/em>)\u548c\u975e\u76ee\u6807\u5206\u6790\u7269(5 \u00d7 10\u2212<\/sup>15<\/sup>M<\/em>)\u7684|\u2206I<\/em>ds<\/sub>\/I<\/em>ds0<\/sub>|\u54cd\u5e94<\/p>\n

d. \u56db\u79cdDNA\u7ed3\u6784\u793a\u610f\u56fe<\/p>\n

e. \u5f53\u4f7f\u7528\u4e0d\u540c\u7684DNA\u7ed3\u6784(V<\/em>ds<\/sub>= 50 mV<\/u>)\u65f6\uff0cdirac\u70b9\u4f4d\u79fb\u4f5c\u4e3a\u51dd\u8840\u9176\u6d53\u5ea6\u7684\u51fd\u6570\u53d8\u5316\u91cf<\/p>\n

\u56fe4. SARS-CoV-2\u6838\u9178\u68c0\u6d4b\u00a92022 Springer Nature<\/p>\n

\"\"a. \u91c7\u7528qRT-PCR\u548cMolEMS g- FETs\u6280\u672f\u68c0\u6d4bSARS-CoV-2\u6838\u9178\u7684\u5de5\u4f5c\u6d41\u7a0b<\/p>\n

b. \u57fa\u56e0\u7ec4\u56fe\u8c31\u663e\u793a\u63a2\u9488\u548c\u6837\u54c11-5\u6240\u7528\u7684\u9009\u5b9a\u5e8f\u5217(\u53ca\u5176\u76f8\u5bf9\u4f4d\u7f6e)\u3002<\/p>\n

c. \u5728\u5168\u4eba\u5de5\u553e\u6db2\u4e2d\u52a0\u5165\u6837\u672c1\u548c\u6837\u672c2(\u4ece0.1\u5230500\u62f7\u8d1d\/\u5fae\u5347)(\u6280\u672f\u6837\u672c)\u540e\u7684|\u2206I<\/em>ds<\/sub>\/I<\/em>ds0<\/sub>|\u54cd\u5e94<\/p>\n

d. \u6dfb\u52a0F1, 6% P1\u548c100% P1(\u751f\u7269\u6837\u672c)\u7684\u2206I<\/em>ds<\/sub>\/I<\/em>ds0<\/sub>\u4e0et\u7684\u5173\u7cfb\u66f2\u7ebf<\/p>\n

e. \u5bf9\u5e94\u4e8e\u6bcf\u4e2a\u4e34\u5e8a\u6837\u672c\u7684|\u2206I<\/em>ds<\/sub>\/I<\/em>ds0<\/sub>|\u54cd\u5e94<\/p>\n

f. \u5728VTM\u4e2d\u7a00\u91caP32\u6d53\u5ea6\u4ece0.01\u62f7\u8d1d\/\u5fae\u5347\u5230100% P32(\u751f\u7269\u6837\u672c)\u7684\u2206I<\/em>ds<\/sub>\/I<\/em>ds0<\/sub>\u4e0et\u7684\u5173\u7cfb\u66f2\u7ebf<\/p>\n

g. \u5728VTM\u4e2d\u7a00\u91ca\u7684P27-P33 (\u751f\u7269\u6837\u672c)\u7684|\u2206I<\/em>ds<\/sub>\/I<\/em>ds0<\/sub>|\u54cd\u5e94\u548cCt\u503c<\/p>\n

h. MolEMS(\u672c\u5de5\u4f5c)\u4e0e\u91c7\u7528qRT-PCR\u3001US CDC\u6216\u4e2d\u56fdNMPA\u6279\u51c6\u7684qRT-PCR\u3001RT-LAMP\u3001CRISPR\u3001RPA\u3001SPR\u548cEC\u68c0\u6d4bSARS-CoV-2\u6838\u9178\u68c0\u6d4b\u7684\u6bd4\u8f83<\/p>\n

\u5c0f\u7ed3<\/strong><\/p>\n

\u4e0eMEMS\u548cNEMS\u76f8\u6bd4\uff0cMolEMS\u964d\u4f4e\u4e86\u6210\u672c\u3001\u4f53\u79ef\u548c\u91cd\u91cf\uff0c\u5e76\u5b9e\u73b0\u4e86\u5206\u5b50\u6c34\u5e73\u7684\u8c03\u63a7\u3002\u5728\u9759\u7535\u9a71\u52a8\u4e0b\uff0cMolEMS\u5141\u8bb8\u5728\u9ad8\u79bb\u5b50\u5f3a\u5ea6\u7f13\u51b2\u6db2\u6216\u751f\u7269\u6db2\u4e2d\u5bf9\u86cb\u767d\u8d28\u3001\u5c0f\u5206\u5b50\u3001\u79bb\u5b50\u548c\u6838\u9178\u8fdb\u884c\u7279\u5f02\u6027\u68c0\u6d4b\uff0c\u751a\u81f3\u5728\u8fde\u7eed\u66b4\u9732\u4e8e\u5168\u8840\u6e0515\u5929\u540e\u4e5f\u53ef\u4ee5\u8fdb\u884c5\u00d710-20<\/sup>\u00a0M<\/em>\u7684\u68c0\u6d4b\u3002MolEMS\u662f\u4e00\u79cd\u8d85\u7075\u654f\u7684\u751f\u7269\u4f20\u611f\u5668\uff0c\u4e14\u5177\u6709\u4f18\u5f02\u7684\u9632\u6c61\u6027\u3001\u68c0\u6d4b\u9009\u62e9\u6027\u3001\u7a33\u5b9a\u6027\u548c\u901a\u7528\u6027\u3002MolEMS g-FETs\u53ef\u4ee5\u76f4\u63a5\u68c0\u6d4b\u5728\u9f3b\u54bd\u62ed\u5b50\u6837\u672c\u4e2d\u672a\u6269\u589e\u7684SARS-CoV-2\u6838\u9178\uff0c\u4e14\u68c0\u6d4b\u6d53\u5ea6\u4f4e\u81f3\u6bcf\u5fae\u5347\u7ea60.02\u62f7\u8d1d\u3002\u8be5\u8bbe\u5907\u5b9e\u73b0\u4e86\u5feb\u901f\u548c\u65e0\u6807\u7b7e\u68c0\u6d4b\uff0c\u5e76\u6613\u4e8e\u64cd\u4f5c\u3002\u7279\u522b\u662f\u5728\u4e34\u5e8a\u6837\u672c\u4e2d\uff0cMolEMS\u68c0\u6d4bCOVID-19\u7684\u65f6\u95f4\u7ea6\u4e3a0.1-4 \u5206\u949f(\u6bd4qRT-PCR\u5feb)\uff0c\u65e0\u9700RNA\u63d0\u53d6\u548c\u6269\u589e\u8fc7\u7a0b\u3002\u7ed3\u5408\u4fbf\u643a\u5f0f\u7cfb\u7edf\u53ef\u4ee5\u5728\u673a\u573a\u3001\u8bca\u6240\u548c\u5f53\u5730\u6025\u8bca\u79d1\uff0c\u751a\u81f3\u5728\u5bb6\u91cc\u8fdb\u884c\u73b0\u573a\u548c\u5373\u65f6\u68c0\u6d4b\u3002\u9664\u4e86COVID-19, MolEMS\u7684\u5f00\u53d1\u8fd8\u53ef\u4ee5\u5728\u51e0\u5206\u949f\u5185\u5bf9\u5176\u4ed6\u75be\u75c5\u8fdb\u884c\u8d85\u7cbe\u786e\u8bca\u65ad\uff0c\u800c\u4e0d\u9700\u8981\u901a\u5e38\u9700\u8981\u6570\u5c0f\u65f6\u6216\u6570\u5929\u7684\u76ee\u6807\u7eaf\u5316\u3001\u6269\u589e\u6216\u57f9\u517b\u8fc7\u7a0b\u3002\u6b64\u5916\uff0cMolEMS\u7684\u8bbe\u8ba1\u539f\u5219\u53ef\u4ee5\u7528\u4e8e\u751f\u7269\u4f20\u611f\u4e4b\u5916\u7684\u5176\u4ed6\u673a\u7535\u8bbe\u5907\u548c\u529f\u80fd\u7cfb\u7edf\u7684\u8bbe\u8ba1\uff0c\u5177\u6709\u66f4\u9ad8\u7684\u7cbe\u5ea6\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aRapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples<\/a>. 2022, Nature Biomedical Engineering<\/em>, DOI: 10.1038\/s41551-021-00833-7.<\/p>\n

\u672c\u6587\u7531\u7eb3\u7c73\u5c0f\u767d\u4f9b\u7a3f<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"

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