{"id":23683,"date":"2016-07-03T17:10:35","date_gmt":"2016-07-03T09:10:35","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=23683"},"modified":"2016-07-02T23:03:53","modified_gmt":"2016-07-02T15:03:53","slug":"science%e7%83%af%e7%83%83%e7%9a%84%e9%9d%9e%e5%af%b9%e7%a7%b0%e5%82%ac%e5%8c%96%e6%b0%9f%e5%8c%96%e7%94%9f%e6%88%90%e4%ba%8c%e6%b0%9f%e7%94%b2%e5%9f%ba%e9%b8%9f%e6%b0%a8%e9%85%b8%e7%ab%8b%e4%bd%93","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=23683","title":{"rendered":"Science:\u70ef\u70c3\u7684\u975e\u5bf9\u79f0\u50ac\u5316\u6c1f\u5316\u751f\u6210\u4e8c\u6c1f\u7532\u57fa\u9e1f\u6c28\u9178\u7acb\u4f53\u5f02\u6784\u4f53"},"content":{"rendered":"

\u3010<\/b><\/strong>\u5f15\u8a00<\/b><\/strong>\u3011<\/b><\/strong><\/span><\/p>\n

Science\u4e8e2016\u5e747\u67081\u65e5\u5728\u7ebf\u53d1\u8868\u4e86\u4e00\u7bc7Report\uff0c\u9898\u4e3a\u201cCatalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters\u201d\uff0c\u8bd1\u4e3a\u201c\u70ef\u70c3\u7684\u975e\u5bf9\u79f0\u50ac\u5316\u6c1f\u5316\u751f\u6210\u4e8c\u6c1f\u7532\u57fa\u9e1f\u6c28\u9178\u7acb\u4f53\u5f02\u6784\u4f53\u201d\u3002\u672c\u6587\u901a\u8baf\u4f5c\u8005\u662f\u54c8\u4f5b\u5927\u5b66\u5316\u5b66\u4e0e\u751f\u7269\u7cfb\u7684Eric N. Jacobsen\u6559\u6388\u3002<\/p>\n

\"eric_jacobsen_1\"<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n

\u6c1f\u70f7\u57fa\u5bf9\u5206\u5b50\u7269\u7406\u3001\u751f\u7269\u7279\u6027\u7684\u5f71\u54cd\uff0c\u542f\u53d1\u4e86\u7814\u7a76\u8005\uff0c\u529b\u4e89\u53d1\u73b0\u901a\u7528\u65b9\u6cd5\u4ee5\u4f7f\u8be5\u57fa\u56e2\u53ef\u63a7\u5f15\u5165\u6709\u673a\u5316\u5408\u7269\u3002\u5055\u4e8c\u6c1f\u57fa\u62161,1-\u4e8c\u6c1f\u57fa\uff0c\u6613\u4ece\u7b80\u5355\u7fb0\u57fa\u5316\u5408\u7269\u5236\u5f97\uff0c\u5df2\u7ecf\u663e\u73b0\u51fa\u4f5c\u4e3a\u591a\u79cd\u6781\u6027\u5b98\u80fd\u56e2\u7684\u5316\u5b66\u60f0\u6027\u7535\u5b50\u7b49\u6392\u4f53\u7684\u6709\u7528\u7279\u6027\u3002\u4e8c\u6c1f\u7532\u57fa\uff08CHF2<\/sub>\uff09\u8fd8\u6709\u53e6\u4e00\u4e2a\u7279\u5f81\uff0c\u5b83\u643a\u5e26\u6709\u4e00\u4e2a\u5f31\u9178\u5316\u7684C-H\u952e\uff0c\u8fd9\u4f7f\u5b83\u53ef\u4f5c\u4e3a\u4e00\u4e2a\u4eb2\u8102\u6027\u6c22\u952e\u4f9b\u4f53\uff0c\u8fdb\u4e00\u6b65\uff0c\u53ef\u4f5c\u4e3a\u9187\u548c\u786b\u9187\u7684\u751f\u7269\u5f02\u6784\u4f53\u3002\u56e0\u6b64\uff0c\u5728\u5206\u5b50\u4e2d\u5f15\u5165\u4e8c\u6c1f\u7532\u57fa\u53ef\u8d4b\u4e88\u5176\u8bf8\u591a\u4f18\u826f\u6027\u80fd\uff0c\u5982\u53ef\u8c03\u8282\u751f\u7269\u6709\u6548\u6027\u3001\u4ee3\u8c22\u7a33\u5b9a\u6027\u3001\u4eb2\u8102\u6027\uff0c\u540c\u65f6\u5f15\u5165\u6216\u4fdd\u6301\u4e86\u751f\u7269\u9776\u5b50\u7684\u5173\u952e\u8bc6\u522b\u5143\u7d20\u3002\u8fd9\u4e9b\u51b3\u5b9a\u4e86\u5176\u5728\u751f\u7269\u6210\u50cf\u3001\u751f\u7269\u533b\u836f\u7b49\u9886\u57df\u7684\u5de8\u5927\u6f5c\u529b\u548c\u79d1\u7814\u4ef7\u503c\u3002<\/p>\n

\u4f5c\u8005\u62a5\u9053\u4e86\u4e00\u79cd\u03b2-\u53d6\u4ee3\u82ef\u4e59\u70ef\u7684\u975e\u5bf9\u79f0\u53ef\u8fc1\u79fb\u50ac\u5316\u5055\u6c1f\u5316\u65b0\u65b9\u6cd5\uff0c\u6765\u5236\u5f97\u5e26\u6709\u4e8c\u6c1f\u7532\u57fa\u9e1f\u6c28\u9178\u4e09\u7ea7\u5f02\u6784\u4f53\u548c\u56db\u7ea7\u5f02\u6784\u4f53\u7684\u591a\u79cd\u4ea7\u7269\u3002\u53cd\u5e94\u5229\u7528\u5df2\u5546\u4e1a\u5316\u7684\u53cd\u5e94\u7269\uff08\u95f4\u6c2f\u8fc7\u6c27\u82ef\u7532\u9178\u3001\u6c1f\u5316\u6c22-\u5421\u54af\u7edc\u5408\u7269\uff09\u548c\u624b\u6027\u82b3\u57fa\u7898\u50ac\u5316\u5242\uff0c\u53cd\u5e94\u89c4\u6a211\u514b\u5de6\u53f3\u3002\u4f5c\u8005\u8fd8\u5bf9\u5176\u673a\u7406\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u53d6\u4ee3\u6548\u5e94\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u6e29\u5ea6\u4f9d\u8d56\u53d8\u5316\u8868\u660e\uff0c\u9633\u79bb\u5b50-\u03c0\u76f8\u4e92\u4f5c\u7528\u5728\u8be5\u50ac\u5316\u5242\u7684\u7acb\u4f53\u5206\u5316\u6548\u5e94\u4e2d\u626e\u6f14\u8005\u81f3\u5173\u91cd\u8981\u7684\u89d2\u8272\u3002<\/p>\n

\u3010\u56fe\u6587\u6982\u8ff0\u3011<\/b><\/strong><\/span><\/p>\n

\u56fe1 \u4e8c\u6c1f\u7532\u57fa\u5316\u65b9\u6cd5<\/strong><\/span><\/p>\n

\"F1.large\"<\/p>\n

A \u4e8c\u6c1f\u7532\u57fa\u662f\u9187\u548c\u5176\u4ed6\u8d28\u5b50\u5b98\u80fd\u5ea6\u7684\u751f\u7269\u5f02\u6784\u4f53
\nB-D \u5df2\u62a5\u9053\u7684\u5236\u5907\u4e8c\u6c1f\u7532\u57fa\u4ea7\u7269\u5bf9\u6620\u4f53\u7684\u65b9\u6cd5
\nE \u7528\u82b3\u57fa\u7898\u50ac\u5316\uff0c\u8089\u6842\u9178\u76d0\u884d\u751f\u7269\u7684\u5bf9\u6620\u4f53\u4e8c\u6c1f\u5316<\/p>\n

\u56fe2 \u03b2-\u53d6\u4ee3\u82ef\u4e59\u70ef\u7684\u5e95\u7269\u8303\u56f4<\/strong><\/span><\/p>\n

\"F2.large\"<\/p>\n

\u53cd\u5e94\u89c4\u6a211.04 mmol\uff0c\u7b49\u4ef7\u4e8e1.1-1.3 mmol\u95f4\u6c2f\u8fc7\u6c27\u82ef\u7532\u9178\u548c11.1 mmol\u805a\u82ef\u4e59\u70ef\u00b79HF\u3002<\/p>\n

\u56fe3 \u4e09\u53d6\u4ee3\u8089\u6842\u9178\u5355\u4f53\u884d\u751f\u7269\u7684\u5e95\u7269\u8303\u56f4\u548c\u4ea7\u54c1\u7cbe\u5236<\/strong><\/span><\/p>\n

\"F3.large\"<\/p>\n

A \u53cd\u5e94\u89c4\u6a211.04 mmol\uff0c\u7b49\u4ef7\u4e8e1.1-1.3 mmol\u95f4\u6c2f\u8fc7\u6c27\u82ef\u7532\u9178\u548c11.1 mmol\u805a\u82ef\u4e59\u70ef\u00b79HF\u3002
\nB \u542b\u4e8c\u6c1f\u7532\u57fa\u4ea7\u54c1\u7684\u591a\u6837\u5316\u3002<\/p>\n

a,SmI2<\/sub>\u7f6e\u4e8eTHF\u4e2d5min\uff0c\u7136\u540e\u5ba4\u6e29\u4e0b\u7528Et3<\/sub>N\u548cH2<\/sub>O\u5904\u7406.
\nb,BH3\u00b7\u4e8c\u7532\u57fa\u786b\u919a\u4e8e65\u2103\u7f6e\u4e8eTHF\u4e2d16\u5c0f\u65f6\uff0c\u63a5\u7740\u7f6e\u4e8eHCl\u4e2d.
\nc,\u4e9a\u785d\u9178\u53d4\u4e01\u916f80\u2103\u7f6e\u4e8eMeCN\u548cH2<\/sub>O\u4e2d48\u5c0f\u65f6.
\nd,PIFA\u4e8e\u5ba4\u6e29\u4e0b\u7f6e\u4e8eMeCN\u548cH2<\/sub>O\u4e2d36\u5c0f\u65f6\uff0c\u7136\u540e\u7f6e\u4e8eHCl\u4e2d.
\ne,i\u5ba4\u6e29\u4e0b\u628aNaOH\u7f6e\u4e8eH2<\/sub>O\u3001THF\u548cMeOH\u4e2d12\u5c0f\u65f6; ii(COCl)2<\/sub>\uff0cN,N-\u4e8c\u7532\u57fa\u7532\u9170\u80fa\u4e8e0\u2103\u4e0b\u7f6e\u4e8eCH2<\/sub>Cl2<\/sub>\u4e2d6\u5c0f\u65f6; iii\u6eb4\u4ee3\u82ef\u80fa\uff0cN,N-\u4e8c\u7532\u57fa\u6c28\u57fa\u5421\u5576\u4e8e\u5ba4\u6e29\u4e0b\u7f6e\u4e8eCH2<\/sub>Cl2<\/sub>\u4e2d24\u5c0f\u65f6.
\nf,i RuCl3\uff0cNaIO4\u4e8e\u5ba4\u6e29\u4e0b\u7f6e\u4e8eMeCN\u548cH2O\u4e2d24\u5c0f\u65f6\uff1bii COMU\u548cDIPEA\u4e8e\u5ba4\u6e29\u4e0b\u7f6e\u4e8eDMF\u4e2d72\u5c0f\u65f6\u3002
\ng,DIBAL\u4e8e0\u2103\u7f6e\u4e8eTHF\u4e2d1.5\u5c0f\u65f6.<\/p>\n

\u56fe4 \u50ac\u5316\u5242\u5bf9\u4e8e\u5bf9\u6620\u9009\u62e9\u6027\u7684\u53d6\u4ee3\u57fa\u6548\u5e94<\/strong><\/span><\/p>\n

\"F4.large\"<\/p>\n

A \u50ac\u5316\u5242\u5bf9\u6bd4\u53ef\u77e5\uff0c4a\u52305a\u8f6c\u5316\u7684\u5bf9\u6620\u9009\u62e9\u6027\u4e0e\u50ac\u5316\u5242\u53d6\u4ee3\u57fa\u7684\u03c0-\u4f9b\u4f53\u7279\u6027\u4e00\u81f4
\nB \u827e\u7433\u5206\u6790<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/span><\/p>\n

\u4e8c\u6c1f\u7532\u57fa\u5177\u6709\u72ec\u7279\u7684\u7a7a\u95f4\u6392\u5217\u548c\u7535\u5b50\u6027\u8d28\uff0c\u5728\u5206\u5b50\u8bc6\u522b\u8fdb\u7a0b\u4e2d\u53ef\u7528\u4f5c\u9187\u3001\u786b\u9187\u7b49\u6781\u6027\u5b98\u80fd\u56e2\u7684\u5316\u5b66\u60f0\u6027\u66ff\u4ee3\u54c1\u3002\u672c\u6587\u4f5c\u8005\u4e0d\u53ea\u53d1\u73b0\u4e86\u70ef\u70c3\u4e8c\u6c1f\u5316\u7684\u50ac\u5316\u65b0\u65b9\u6cd5\uff0c\u8fd8\u5bf9\u5176\u673a\u7406\u505a\u51fa\u4e86\u6709\u8bf4\u670d\u529b\u7684\u76f8\u5173\u7814\u7a76\u3002\u5bf9\u4e8e\u8be5\u50ac\u5316\u8fdb\u7a0b\u7684\u7acb\u4f53\u9009\u62e9\u6027\u6765\u8bf4\uff0c\u9633\u79bb\u5b50-\u03c0\u76f8\u4e92\u4f5c\u7528\u81f3\u5173\u91cd\u8981\u3002\u53ef\u4ee5\u9884\u89c1\uff0c\u5176\u5728\u751f\u7269\u533b\u836f\u3001\u751f\u7269\u6210\u50cf\u7b49\u9886\u57df\u5177\u6709\u5de8\u5927\u5e94\u7528\u524d\u666f\u3002<\/p>\n

\u6587\u732e\u5730\u5740\uff1aCatalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters<\/a><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5c0f\u5f3a\u51fa\u54c1\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 Science\u4e8e2016\u5e747\u67081\u65e5\u5728\u7ebf\u53d1\u8868\u4e86\u4e00\u7bc7Report\uff0c\u9898\u4e3a\u201cCatalytic, asymmetric difluorination of a…<\/p>\n","protected":false},"author":711,"featured_media":23684,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[155,42],"class_list":["post-23683","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","category-keji","tag-science","tag-gaofenzi"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/23683"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/711"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23683"}],"version-history":[{"count":9,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/23683\/revisions"}],"predecessor-version":[{"id":23978,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/23683\/revisions\/23978"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/media\/23684"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23683"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}