{"id":238977,"date":"2022-06-28T06:19:41","date_gmt":"2022-06-27T22:19:41","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=238977"},"modified":"2022-06-27T18:19:48","modified_gmt":"2022-06-27T10:19:48","slug":"science%ef%bc%9a%e9%95%8d%e5%82%ac%e5%8c%96%e6%b0%a2%e5%8c%96%e5%81%b6%e8%81%94%e5%ae%9e%e7%8e%b0%e5%a4%9a%e7%a7%8d%e8%83%ba%e7%9a%84%e7%ae%80%e6%98%93%e5%88%b6%e5%a4%87","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=238977","title":{"rendered":"Science\uff1a\u954d\u50ac\u5316\u6c22\u5316\u5076\u8054\u5b9e\u73b0\u591a\u79cd\u80fa\u7684\u7b80\u6613\u5236\u5907"},"content":{"rendered":"<p><strong>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p>\u5728\u8fc7\u53bb\u7684\u4e00\u4e2a\u4e16\u7eaa\u91cc\uff0c\u80fa\u7684\u5546\u4e1a\u751f\u4ea7\u4e0d\u65ad\u589e\u957f\u3002\u9884\u8ba1\u5728\u672a\u6765\u5341\u5e74\u5185\uff0c\u5168\u7403\u80fa\u5e02\u573a\u5c06\u4ee5\u6bcf\u5e74\u7ea68%\u7684\u901f\u5ea6\u589e\u957f\u3002\u76ee\u524d\u80fa\u5e7f\u6cdb\u7528\u4e8e\u6d88\u8d39\u54c1\u3001\u9ad8\u7ea7\u5316\u5b66\u54c1\u3001\u836f\u54c1\u3001\u519c\u7528\u5316\u5b66\u54c1\u548c\u805a\u5408\u7269\u7684\u5236\u9020\uff0c\u5982\u5927\u591a\u6570\u519c\u7528\u5316\u5b66\u54c1\u548c\u5927\u591a\u6570\u7545\u9500\u836f\u7269\u4e2d\u90fd\u542b\u6709\u80fa\u90e8\u5206\uff0c\u8fd9\u4e9b\u90e8\u5206\u901a\u5e38\u5728\u5176\u4f5c\u7528\u65b9\u5f0f\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<p>\u5bf9\u80fa\u9700\u6c42\u7684\u63d0\u5347\u4f7f\u5f97\u5fc5\u987b\u91c7\u7528\u66f4\u7ecf\u6d4e\u548c\u53ef\u6301\u7eed\u7684\u65b9\u6cd5\u6765\u6539\u8fdb\u5176\u5408\u6210\u65b9\u6cd5\u3002\u76ee\u524d\uff0c\u8148\u7c7b\u548c\u785d\u57fa\u82b3\u70c3\u7684\u50ac\u5316\u52a0\u6c22\u53cd\u5e94\u4e3b\u8981\u7528\u4e8e\u5236\u5907\u8102\u80aa\u65cf\u4f2f\u80fa\u548c\u82b3\u9999\u65cf\u4f2f\u80fa\uff0c\u800c\u7fb0\u57fa\u5316\u5408\u7269\u7684\u8fd8\u539f\u80fa\u5316\u53cd\u5e94\u3001\u9187\u7684\u80fa\u5316\u53cd\u5e94\uff0c\u7528\u80fa\u53d6\u4ee3\u5364\u4ee3\u5316\u5408\u7269\uff0c\u4ee5\u53ca\u70ef\u70c3\u7684\u52a0\u6c22\u80fa\u5316\u4e3b\u8981\u7528\u4e8e\u5236\u9020\u4ef2\u80fa\u548c\u53d4\u80fa\u3002\u5728\u6240\u6709\u5df2\u77e5\u7684\u65b9\u6cd5\u4e2d\uff0c\u8148\u7684\u50ac\u5316\u6c22\u5316\u662f\u751f\u4ea7\u82c4\u57fa\u4f2f\u80fa\u548c\u8102\u80aa\u65cf\u4f2f\u80fa\u7684\u4e00\u79cd\u7ecf\u6d4e\u4e14\u539f\u5b50\u7ecf\u6d4e\u7684\u5de5\u4e1a\u5de5\u827a\uff0c\u5982\u5c3c\u9f99\u3001\u9ad8\u6027\u80fd\u5851\u6599\u3001\u8868\u9762\u6d3b\u6027\u5242\u3001\u4e73\u5316\u5242\u548c\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u6279\u91cf\u5de5\u4e1a\u751f\u4ea7\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u8bb8\u591a\u82b3\u9999\u65cf\u3001\u6742\u73af\u548c\u8102\u80aa\u65cf\u8148\u5f88\u5bb9\u6613\u83b7\u5f97\u5e76\u4ee5\u5546\u4e1a\u89c4\u6a21\u751f\u4ea7\u3002\u6b64\u5916\uff0c\u5df2\u4ece\u9646\u5730\u548c\u6d77\u6d0b\u6765\u6e90\u4e2d\u5206\u79bb\u51fa100\u591a\u79cd\u5929\u7136\u5b58\u5728\u7684\u8148\u3002\u56e0\u6b64\uff0c\u8148\u7684\u76f4\u63a5\u50ac\u5316\u52a0\u6c22\u5236\u5907\u4f2f\u80fa\u5728\u5b66\u672f\u548c\u5de5\u4e1a\u5408\u6210\u4e2d\u4e00\u76f4\u5907\u53d7\u5173\u6ce8\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u7531\u4e8e\u9009\u62e9\u6027\u8f83\u4f4e\uff0c\u901a\u8fc7\u4ea4\u53c9\u5076\u8054\u4ece\u8148\u4e2d\u5408\u6210\u5404\u79cd\u4ef2\u80fa\u548c\u53d4\u80fa\uff0c\u5305\u62ecN-\u7532\u80fa\uff0c\u662f\u4e00\u9879\u6781\u5177\u6311\u6218\u6027\u7684\u5de5\u4f5c\u3002<\/p>\n<p><strong>\u4e8c\u3001\u3010\u6210\u679c\u63a0\u5f71\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u5fb7\u56fd\u83b1\u5e03\u5c3c\u8328\u50ac\u5316\u7814\u7a76\u6240<\/strong><strong>Rajenahally V. Jagadeesh<\/strong><strong>\u6559\u6388\u3001<\/strong><strong>Matthias Beller<\/strong><strong>\u6559\u6388<\/strong>\u7b49\u4eba\u62a5\u9053\u4e86\u4e00\u79cd\u5747\u76f8\u954d\u50ac\u5316\u5242\uff0c\u7528\u4e8e\u7cfb\u5217\u82b3\u9999\u65cf\u3001\u6742\u82b3\u9999\u65cf\u548c\u8102\u80aa\u65cf\u8148\u4e0e\u4f2f\u80fa\u548c\u4ef2\u80fa\u6216\u6c28\u7684\u6c22\u5316\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u3002\u8fd9\u4e00\u4e00\u822c\u6c22\u5316\u65b9\u6848\u901a\u8fc7\u76f4\u63a5\u548c\u9ad8\u9009\u62e9\u6027\u5730\u5408\u6210\u8d85\u8fc7230\u79cd\u529f\u80fd\u5316\u548c\u7ed3\u6784\u591a\u6837\u7684\u80fa\uff08\u5305\u62ec\u836f\u7269\u5206\u5b50\u548c\u624b\u6027\u5206\u5b50\uff09\uff0c\u4ee5\u53ca<sup>15<\/sup>N\u540c\u4f4d\u7d20\u6807\u8bb0\u5e94\u7528\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201c<strong>Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520a<strong><em>Science<\/em><\/strong>\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-238978\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/0-4.jpg\" alt=\"\" width=\"600\" height=\"262\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/0-4.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/0-4-300x131.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u4e09\u3001\u3010\u6838\u5fc3\u521b\u65b0\u70b9\u3011<\/strong><\/p>\n<p>1\u3001\u5236\u5907\u4e86\u4e00\u76f4\u954d\u5747\u76f8\u50ac\u5316\u5242\uff0c\u53ef\u4ee5\u5c06\u4e00\u7cfb\u5217\u82b3\u65cf\u3001\u6742\u82b3\u65cf\u548c\u8102\u80aa\u65cf\u8148\u4e0e\u4f2f\u80fa\u548c\u4ef2\u80fa\u6216\u6c28\u8fdb\u884c\u6c22\u5316\u4ea4\u53c9\u5076\u8054\u3002<\/p>\n<p>2\u3001\u6c22\u5316\u5076\u8054\u65b9\u6cd5\u76f4\u63a5\u548c\u9ad8\u9009\u62e9\u6027\u5408\u6210 &gt; 230\u79cd\u529f\u80fd\u5316\u548c\u7ed3\u6784\u591a\u6837\u7684\u80fa\u3002<\/p>\n<p><strong>\u56db\u3001\u3010\u6570\u636e\u6982\u89c8\u3011<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-238979\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/1-11.jpg\" alt=\"\" width=\"600\" height=\"394\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/1-11.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/1-11-300x197.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>1 <\/strong><strong>\u8148\u4e0e\u5404\u7ea7\u80fa\u50ac\u5316\u8fd8\u539f\u4ea4\u53c9\u5076\u8054\u53cd\u5e94<\/strong><strong> \u00a9 2022 AAAS<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-238980\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/2-11.jpg\" alt=\"\" width=\"600\" height=\"653\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/2-11.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/2-11-276x300.jpg 276w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p><strong>\u56fe<\/strong><strong>2 <\/strong><strong>\u4e0d\u540c\u91d1\u5c5e<\/strong><strong>&#8211;<\/strong><strong>\u81a6\u914d\u4f53\u7528\u4e8e<\/strong><strong>4-<\/strong><strong>\u7532\u57fa\u82ef\u8148\u548c<\/strong><strong>4-<\/strong><strong>\u8334\u9999\u80fa\u7684\u6c22\u5316\u5076\u8054\u53ca\u50ac\u5316\u6548\u7387<\/strong><strong> \u00a9 2022 AAAS<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-238981\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/3-11.jpg\" alt=\"\" width=\"600\" height=\"759\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/3-11.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/3-11-237x300.jpg 237w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>3 <\/strong><strong>\u954d\u50ac\u5316\u8148\u4e0e\u80fa\u6c22\u5316\u4ea4\u53c9\u5076\u8054\u5236\u5907\u4ef2\u80fa\u548c\u53d4\u80fa<\/strong><strong> \u00a9 2022 AAAS<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-238982\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/4-11.jpg\" alt=\"\" width=\"600\" height=\"741\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/4-11.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/4-11-243x300.jpg 243w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>4 <\/strong><strong>\u954d\u50ac\u5316\u7684\u8148\u4e0e<\/strong><strong>N-<\/strong><strong>\u7532\u80fa\u4ee5\u53ca\u6c28\u7684\u6c22\u5316\u4ea4\u53c9\u5076\u8054\u53cd\u5e94<\/strong><strong> \u00a9 2022 AAAS<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-238983\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/5-12.jpg\" alt=\"\" width=\"600\" height=\"529\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/5-12.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/5-12-300x265.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>5 <\/strong><strong>\u624b\u6027\u80fa\u4ee5\u53ca\u76ee\u6807\u836f\u7269\u5206\u5b50\u7684\u5408\u6210<\/strong><strong> \u00a9 2022 AAAS<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-238984\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/6-9.jpg\" alt=\"\" width=\"600\" height=\"745\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/6-9.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/06\/6-9-242x300.jpg 242w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>6 <\/strong><strong>\u751f\u7269\u6d3b\u6027\u8148\u548c\u80fa\u7684\u540e\u671f\u529f\u80fd\u5316<\/strong><strong> \u00a9 2022 AAAS<\/strong><\/p>\n<p><strong>\u4e94\u3001\u3010\u6210\u679c\u542f\u793a\u3011<\/strong><\/p>\n<p>\u5747\u76f8\u954d-triphos\u50ac\u5316\u5242\u4f53\u7cfb\u5141\u8bb8\u5404\u79cd\u8148\u548c\u80fa\u6216\u6c28\u5728\u6c22\u6c14\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u6c22\u5316\u4ea4\u53c9\u5076\u8054\uff0c\u4ee5\u5236\u5907\u529f\u80fd\u5316\u548c\u7ed3\u6784\u591a\u6837\u7684\u82b3\u9999\u65cf\u3001\u6742\u73af\u548c\u8102\u80aa\u65cf\u4f2f\u80fa\u3001\u4ef2\u80fa\u548c\u53d4\u80fa\uff0c\u5305\u62ecN-\u7532\u57fa\u5316\u4ea7\u7269\u3002\u6839\u636e\u8fd9\u4e00\u5408\u6210\u65b9\u6848\uff0c\u8148\u662f\u5236\u5907\u5305\u62ec\u836f\u7269\u5728\u5185\u7684\u5e7f\u8c31\u6709\u4ef7\u80fa\u7684\u6709\u5438\u5f15\u529b\u7684\u8d77\u59cb\u6750\u6599\u3002\u6b64\u5916\uff0c\u672c\u65b9\u6cd5\u53ef\u4ee5\u7528\u4e8e\u751f\u547d\u79d1\u5b66\u5206\u5b50\u7684\u6709\u6548\u540e\u671f\u529f\u80fd\u5316\u3002\u7136\u800c\u76ee\u524d\u8be5\u65b9\u6cd5\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\uff0c\u5982\u8f83\u5c11\u7684\u4eb2\u6838\u80fa\u5e95\u7269\u4ee5\u53ca\u5b98\u80fd\u56e2\uff0c\u5982\u919b\u3001\u916e\u3001\u7094\u548c\u785d\u57fa\u7b49\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abn7565\" target=\"_blank\" rel=\"noopener\">Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis<\/a> (<em>Science <\/em><strong>2022<\/strong>, <em>376<\/em>, 1433-1441)<\/p>\n<p>\u672c\u6587\u7531\u8d5b\u6069\u65af\u4f9b\u7a3f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011 \u5728\u8fc7\u53bb\u7684\u4e00\u4e2a\u4e16\u7eaa\u91cc\uff0c\u80fa\u7684\u5546\u4e1a\u751f\u4ea7\u4e0d\u65ad\u589e\u957f\u3002\u9884\u8ba1\u5728\u672a\u6765\u5341\u5e74\u5185\uff0c\u5168\u7403\u80fa\u5e02\u573a\u5c06\u4ee5\u6bcf\u5e74\u7ea68%\u7684\u901f\u5ea6\u589e\u957f\u3002\u76ee\u524d\u80fa\u5e7f\u6cdb\u7528\u4e8e\u6d88\u8d39\u54c1\u3001\u9ad8\u7ea7\u5316\u5b66\u54c1\u3001\u836f\u54c1\u3001\u519c\u7528\u5316\u5b66\u54c1&#8230;<\/p>\n","protected":false},"author":36791,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[4875],"class_list":["post-238977","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-4875"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/238977"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/36791"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=238977"}],"version-history":[{"count":2,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/238977\/revisions"}],"predecessor-version":[{"id":239003,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/238977\/revisions\/239003"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=238977"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=238977"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=238977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}