{"id":243015,"date":"2022-10-06T09:00:18","date_gmt":"2022-10-06T01:00:18","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=243015"},"modified":"2022-10-06T09:00:18","modified_gmt":"2022-10-06T01:00:18","slug":"%e6%b8%85%e5%8d%8e%e5%a4%a7%e5%ad%a6%ef%bc%8c%e6%9c%80%e6%96%b0nature%ef%bc%81-2","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=243015","title":{"rendered":"\u6e05\u534e\u5927\u5b66\uff0c\u6700\u65b0Nature\uff01"},"content":{"rendered":"<p><strong>\u3010\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p>\u771f\u6838\u751f\u7269\u4e2d\u7684\u8131\u6c27\u6838\u7cd6\u6838\u9178\u5305\u88f9\u5728\u7ec4\u86cb\u767d\u516b\u805a\u4f53\u5468\u56f4\u5f62\u6210\u6838\u5c0f\u4f53\uff08nucleosomes\uff09\uff0c\u5176\u662f\u67d3\u8272\u8d28\u7684\u57fa\u672c\u5355\u4f4d\u3002\u7ec4\u86cb\u767dH4\u7684N\u7aef\u4e0e\u9644\u8fd1\u7684\u6838\u5c0f\u4f53\u76f8\u4e92\u4f5c\u7528\uff0c\u5728\u9ad8\u9636\u67d3\u8272\u8d28\u7ed3\u6784\u7684\u5f62\u6210\u548c\u5f02\u67d3\u8272\u8d28\u6c89\u9ed8\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u9175\u6bcd\u4e2d\u7684NuA4\u53ca\u5176\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u7684\u540c\u6e90\u7269Tip60\u590d\u5408\u4f53\u662f\u50ac\u5316H4\u4e59\u9170\u5316\u7684\u5173\u952e\u9176\uff0c\u800cH4\u4e59\u9170\u5316\u53cd\u8fc7\u6765\u53c8\u8c03\u8282\u67d3\u8272\u8d28\u5305\u88c5\uff0c\u5e76\u5728\u8f6c\u5f55\u6fc0\u6d3b\u548cDNA\u4fee\u590d\u4e2d\u53d1\u6325\u4f5c\u7528\u3002NuA4\u5305\u542b13\u4e2a\u2009\u4e9a\u5355\u4f4d\uff0c\u5176\u4e2dEsa1\u662f\u4e59\u9170\u5316\u53cd\u5e94\u7684\u50ac\u5316\u4e9a\u5355\u4f4d\uff0cTra1\u662f\u4e0e\u591a\u79cd\u8f6c\u5f55\u6fc0\u6d3b\u5242\u6216\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408\uff0c\u4ee5\u62db\u52dfNuA4\u8fdb\u884c\u9776\u5411\u57fa\u56e0\u6fc0\u6d3b\u7684\u652f\u67b6\u4e9a\u5355\u4f4d\u3002Esa1\u4e0eEpl1\u3001Yng2\u548cEaf6\u76f8\u4e92\u4f5c\u7528\u5f62\u6210Piccolo\u4e9a\u590d\u5408\u7269\uff0c\u901a\u8fc7\u57fa\u4e8e\u4f4d\u7f6e\u7684\u673a\u5236\u5728\u6838\u5c0f\u4f53\u7684\u80cc\u666f\u4e0b\u5b9e\u73b0\u9009\u62e9\u6027H4\u4e59\u9170\u5316\uff08H4-Ac\uff09\u3002Tra1\u662f\u53e6\u4e00\u79cd\u8f6c\u5f55\u8f85\u6fc0\u6d3b\u7269HAT\u590d\u5408\u7269SAGA\u5171\u6709\u7684\u5171\u540c\u4e9a\u5355\u4f4d\uff0cSAGA\u50ac\u5316\u6838\u5c0f\u4f53\u4e0a\u7684H3\u4e59\u9170\u5316\u3002\u867d\u7136NuA4\u590d\u5408\u7269\u5177\u6709\u57fa\u672c\u91cd\u8981\u6027\uff0c\u4f46\u662f\u76ee\u524d\u53ef\u7528\u7684\u7ed3\u6784\u5206\u8fa8\u7387\u5f88\u4f4e\uff0cHAT\u590d\u5408\u7269\u5982\u4f55\u4e0e\u6838\u5c0f\u4f53\u5e95\u7269\u76f8\u4e92\u4f5c\u7528\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n<p> <strong>\u3010\u6210\u679c\u63a0\u5f71\u3011<\/strong><\/p>\n<p>\u57282022\u5e7410\u67085\u65e5\uff0c<strong>\u6e05\u534e\u5927\u5b66\u9648\u67f1\u6210\u6559\u6388\u548c\u674e\u96ea\u660e\u526f\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba<\/strong>\u62a5\u9053\u4e86\u917f\u9152\u9175\u6bcd\uff08<em>Saccharomyces cerevisiae<\/em>\uff09NuA4\u4e0e\u6838\u5c0f\u4f53\u7ed3\u5408\u7684\u51b7\u51bb\u7535\u955c\uff08cryo-electron microscopy\uff09\u7ed3\u6784\u3002NuA4\u7531\u4e24\u4e2a\u4e3b\u8981\u6a21\u5757\u7ec4\u6210:\u50ac\u5316\u7ec4\u86cb\u767d\u4e59\u9170\u8f6c\u79fb\u9176(HAT)\u6a21\u5757\u548c\u8f6c\u5f55\u6fc0\u6d3b\u7269\u7ed3\u5408(TRA)\u6a21\u5757\u3002\u6838\u5c0f\u4f53\u4e3b\u8981\u4e0eHAT\u6a21\u5757\u7ed3\u5408\uff0c\u4f4d\u4e8eTRA\u6a21\u5757\u7684\u591a\u57fa\u8868\u9762\u9644\u8fd1\uff0c\u8fd9\u5bf9NuA4\u7684\u6700\u4f73\u6d3b\u6027\u975e\u5e38\u91cd\u8981\u3002\u643a\u5e26\u4e0a\u6e38\u6fc0\u6d3b\u5e8f\u5217\u7684\u6838\u5c0f\u4f53\u8fde\u63a5\u5b50DNA\u671d\u5411Tra1\u4e9a\u57fa\u7684\u4fdd\u5b88\u8f6c\u5f55\u6fc0\u6d3b\u5b50\u7ed3\u5408\u8868\u9762\uff0c\u8868\u660eNuA4\u4f5c\u4e3a\u8f6c\u5f55\u5171\u6fc0\u6d3b\u5b50\u7684\u6f5c\u5728\u673a\u5236\u3002HAT\u6a21\u5757\u901a\u8fc7H2A-H2B\u9178\u6027\u8d34\u7247\u548c\u6838\u5c0f\u4f53DNA\u8bc6\u522b\u6838\u5c0f\u4f53\u7684\u76d8\u9762\uff0c\u5c06Esa1\u7684\u50ac\u5316\u53e3\u888b\u6295\u5c04\u5230H4\u7684n\u7aef\u5c3e\u90e8\uff0c\u652f\u6301\u5176\u5728H4\u9009\u62e9\u6027\u4e59\u9170\u5316\u4e2d\u7684\u529f\u80fd\u3002\u603b\u4e4b\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u8868\u660e\u4e86NuA4\u662f\u5982\u4f55\u7ec4\u88c5\u7684\uff0c\u5e76\u4e3a\u6838\u5c0f\u4f53\u8bc6\u522b\u548cHAT\u7684\u8f6c\u5f55\u5171\u6fc0\u6d3b\u63d0\u4f9b\u4e86\u673a\u5236\u89c1\u89e3\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201c<strong>Structure of the NuA4 acetyltransferase complex bound to the nucleosome<\/strong>\u201d\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aNature\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-243016\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/4-1.jpg\" alt=\"\" width=\"1008\" height=\"500\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/4-1.jpg 1008w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/4-1-300x149.jpg 300w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/4-1-768x381.jpg 768w\" sizes=\"(max-width: 1008px) 100vw, 1008px\" \/><\/p>\n<p><strong>\u3010\u6570\u636e\u6982\u89c8\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u7ed3\u5408\u6838\u5c0f\u4f53\u7684NuA4\u590d\u5408\u7269\u7684\u603b\u4f53\u7ed3\u6784<\/strong>\u00a92022 Springer Nature Limited<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-243017\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/1.webp_-1.jpg\" alt=\"\" width=\"800\" height=\"1099\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/1.webp_-1.jpg 800w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/1.webp_-1-218x300.jpg 218w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/1.webp_-1-768x1055.jpg 768w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/1.webp_-1-745x1024.jpg 745w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<p><strong>\u56fe\u4e8c\u3001TRA\u6a21\u5757\u7684\u7ed3\u6784<\/strong>\u00a92022 Springer Nature Limited<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-243018\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/2.webp_-1.jpg\" alt=\"\" width=\"800\" height=\"1058\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/2.webp_-1.jpg 800w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/2.webp_-1-227x300.jpg 227w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/2.webp_-1-768x1016.jpg 768w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/2.webp_-1-774x1024.jpg 774w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<p><strong>\u56fe\u4e09\u3001\u4e0e\u6838\u5c0f\u4f53\u7ed3\u5408\u7684HAT\u6a21\u5757\u7684\u7ed3\u6784<\/strong>\u00a92022 Springer Nature Limited<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-243019\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/3.webp_-1.jpg\" alt=\"\" width=\"800\" height=\"540\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/3.webp_-1.jpg 800w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/3.webp_-1-300x203.jpg 300w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/10\/3.webp_-1-768x518.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<p><strong>\u3010\u6210\u679c\u542f\u793a\u3011<\/strong><\/p>\n<p>\u603b\u4e4b\uff0c\u8be5\u53d1\u73b0\u901a\u8fc7\u591a\u79cd\u5143\u7d20\u7684\u534f\u540c\uff0c\u5305\u62ecTRA\u6a21\u5757\u7684ABS\u548cPBS\u4ee5\u53caDFL\u548cHAT\u6a21\u5757\u7684\u7cbe\u6c28\u9178\u951a\u3002PBS\u548cABS\u76f4\u63a5\u6216\u95f4\u63a5\u5730\u4e0e\u8fde\u63a5\u4f53DNA\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u5c06\u6838\u5c0f\u4f53\u62db\u52df\u5230TRA\u6a21\u5757\u7684\u8fb9\u7f18\uff0c\u4ee5\u4fbf\u7d27\u5bc6\u8fde\u63a5\u7684HAT\u6a21\u5757\u4e0e\u6838\u5c0f\u4f53\u7684\u76d8\u9762\u7ed3\u5408\uff0c\u4ece\u800c\u4ea7\u751fH4\u5c3e\u90e8\u7684\u9009\u62e9\u6027\u4e59\u9170\u5316\u3002\u6b64\u5916\uff0c\u7ec4\u86cb\u767d\u5c3e\u90e8\u7ed3\u5408\u7ed3\u6784\u57df\uff0c\u5982Yng2\u7684PHD\u7ed3\u6784\u57df\u548cYaf9\u7684YEATS\u7ed3\u6784\u57df\uff0c\u5728\u6838\u5c0f\u4f53\u5468\u56f4\u7a7a\u95f4\u6392\u5217\uff0c\u5141\u8bb8NuA4\u8bfb\u53d6\u7ec4\u86cb\u767d\u4fee\u9970\u4fe1\u53f7\u3002NuA4\u4e24\u4e2a\u4e3b\u8981\u6a21\u5757\u7684\u76f8\u5bf9\u53d6\u5411\u663e\u793a\u51fa\u5f88\u5927\u7a0b\u5ea6\u7684\u53ef\u5851\u6027\uff0c\u7136\u800c\uff0c\u8fd9\u53ef\u80fd\u63d0\u4f9b\u4e86\u5bf9\u4e0d\u540c\u8f6c\u5f55\u6fc0\u6d3b\u7269\u548c\u67d3\u8272\u8d28\u7ebf\u7d22\u7684\u53cd\u5e94\u6240\u9700\u7684\u9002\u5e94\u6027\u3002\u9664\u9175\u6bcdNuA4\u7684Eaf5\u5916\uff0c\u6240\u6709\u4e9a\u5355\u4f4d\u90fd\u4fdd\u5b58\u5728\u4eba\u7c7b\u7ec6\u80de\u7684Tip60\u590d\u5408\u4f53\u4e2d\uff0c\u8868\u660e\u8be5\u7ed3\u6784\u4e3a\u4eba\u7c7bTip60\u63d0\u4f9b\u4e86\u4e00\u4e2a\u826f\u597d\u7684\u6a21\u578b\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/doi.org\/10.1038\/s41586-022-05303-x\" target=\"_blank\" rel=\"noopener\">Structure of the NuA4 acetyltransferase complex bound to the nucleosome<\/a>.<\/strong> <em>Nature<\/em>, <strong>2022<\/strong>, DOI: 10.1038\/s41586-022-05303-x.<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4ebaCQR\u7f16\u8bd1\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5bfc\u8bfb\u3011 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