{"id":245207,"date":"2022-12-28T07:54:06","date_gmt":"2022-12-27T23:54:06","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=245207"},"modified":"2022-12-28T11:36:02","modified_gmt":"2022-12-28T03:36:02","slug":"%e5%b1%b1%e4%b8%9c%e5%a4%a7%e5%ad%a6%e5%8f%b6%e7%a3%8a-%e7%bf%9f%e5%85%89%e5%96%9c%ef%bc%8c%e6%b5%8e%e5%8d%97%e5%a4%a7%e5%ad%a6%e5%bc%a0%e4%ba%9a%e5%bd%ac%e3%80%8aacta-biomaterialia%e3%80%8b%ef%bc%9a","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=245207","title":{"rendered":"\u5c71\u4e1c\u5927\u5b66\u53f6\u78ca\/\u7fdf\u5149\u559c&#038;\u6d4e\u5357\u5927\u5b66\u5f20\u4e9a\u5f6cActa Biomaterialia\uff1a\u76d0\u654f\u611f\u7eaf\u4e24\u6027\u79bb\u5b50\u7269\u7406\u6c34\u51dd\u80f6\u7528\u4e8e\u9884\u9632\u672f\u540e\u7ec4\u7ec7\u7c98\u8fde"},"content":{"rendered":"<p><strong><b>\u3010\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n<p>\u8179\u819c\u7c98\u8fde\uff08PA\uff09\u662f\u672f\u540e\u5e38\u89c1\u4f46\u4e25\u91cd\u7684\u4e34\u5e8a\u95ee\u9898\uff0c\u53ef\u5f15\u8d77\u590d\u6742\u7684\u7efc\u5408\u5f81\uff0c\u5305\u62ec\u6162\u6027\u8179\u75db\uff0c\u80a0\u6897\u963b\uff0c\u5973\u6027\u4e0d\u80b2\u3002\u636e\u62a5\u9053\uff0c\u624b\u672f\u540e\u590d\u53d1\u7c98\u8fde\u7684\u98ce\u9669\u53ef\u80fd\u9ad8\u8fbe90%\uff0c\u8fd9\u4f1a\u7ed9\u60a3\u8005\u5e26\u6765\u4e25\u91cd\u7684\u540e\u679c\u548c\u75db\u82e6\uff0c\u751a\u81f3\u9700\u8981\u7b2c\u4e8c\u6b21\u624b\u672f\u3002\u5176\u4e2d\uff0c\u4f20\u7edf\u7597\u6cd5\u4e2d\u4f7f\u7528\u590d\u6742\u5316\u5b66\u5408\u6210\u65b9\u6cd5\u7684\u6c34\u51dd\u80f6\uff0c\u901a\u5e38\u4f7f\u7528\u70b9\u51fb\u5316\u5b66\u6216\u70ed\u54cd\u5e94\u6c34\u51dd\u80f6\u3002\u590d\u6742\u7684\u5408\u6210\u5de5\u827a\u548c\u82db\u523b\u7684\u6761\u4ef6\u9650\u5236\u4e86\u5b83\u4eec\u7684\u5e94\u7528\u3002\u56e0\u6b64\uff0c\u4e34\u5e8a\u8feb\u5207\u9700\u8981\u4e00\u79cd\u6613\u4e8e\u5236\u5907\uff0c\u64cd\u4f5c\u7b80\u5355\uff0c\u5b89\u5168\u6709\u6548\u7684\u6297\u7c98\u8fde\u5c4f\u969c\uff0c\u9632\u6b62\u672f\u540e\u7c98\u8fde\u548c\u590d\u53d1\u6027\u7c98\u8fde\u7684\u53d1\u751f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong><b>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n<p>\u9488\u5bf9\u6b64\u95ee\u9898\uff0c\u5c71\u4e1c\u5927\u5b66\u836f\u5b66\u9662\u53f6\u78ca\u526f\u7814\u7a76\u5458\u56e2\u961f\u7b49\u901a\u8fc7\u7b80\u5355\u7684\u65b9\u6cd5\u5236\u5907\u4e86\u4e00\u79cd\u76d0\u6eb6\u6db2\u654f\u611f\u578b\u7684\u7269\u7406\u6c34\u51dd\u80f6\uff0c\u8be5\u6c34\u51dd\u80f6\u5236\u5907\u65b9\u6cd5\u7b80\u5355\uff0c\u901a\u8fc7\u751f\u7406\u76d0\u6c34\u548c\u7279\u5b9a\u6d53\u5ea6\u7684\u805a\u5408\u7269\u7c89\u672b\u5171\u6df7\u5373\u53ef\u5f97\u5230\u6c34\u51dd\u80f6\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u968f\u7740\u79bb\u5b50\u6d53\u5ea6\u7684\u589e\u52a0\uff0c\u7269\u7406\u6c34\u51dd\u80f6\u53ef\u4ee5\u5b8c\u5168\u89e3\u79bb\uff0c\u4f7f\u5176\u6210\u4e3a\u9884\u9632\u7c98\u8fde\u7684\u7edd\u4f73\u5019\u9009\u8005\u3002\u5728\u8179\u58c1-\u76f2\u80a0\u6a21\u578b\u4e2d\uff0c\u4e24\u6027\u79bb\u5b50PSBMA\u6c34\u51dd\u80f6\u663e\u793a\u51fa\u4f18\u5f02\u7684\u6297\u7c98\u9644\u6027\u80fd\u3002\u6b64\u5916\uff0c\u5206\u5b50\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u8be5\u6c34\u51dd\u80f6\u53ef\u4ee5\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u6297\u7ea4\u7ef4\u5316\u5e76\u6062\u590d\u53d7\u635f\u8868\u9762\u7684\u5149\u6ed1\u5ea6\uff0c\u4ece\u800c\u4ea7\u751f\u4f18\u5f02\u7684\u7c98\u9644\u9884\u9632\u6548\u679c\u3002\u603b\u4e4b\uff0c\u57fa\u4e8e\u7eaf\u4e24\u6027\u79bb\u5b50\u6750\u6599\u7684PSBMA\u662f\u4e00\u79cd\u5408\u6210\u65b9\u6cd5\u7b80\u5355\uff0c\u5e76\u4e14\u6613\u4e8e\u64cd\u4f5c\u7684\u5b9e\u7528\u6027\u578b\u6c34\u51dd\u80f6\uff0c\u5176\u5177\u6709\u5de8\u5927\u4e34\u5e8a\u8f6c\u5316\u6f5c\u529b\uff0c\u662f\u9884\u9632\u672f\u540e\u7ec4\u7ec7\u7c98\u8fde\u7684\u4e00\u79cd\u7406\u60f3\u7684\u9694\u79bb\u6750\u6599\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-245208\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72471-17.png\" alt=\"\" width=\"1001\" height=\"494\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72471-17.png 1001w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72471-17-300x148.png 300w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72471-17-768x379.png 768w\" sizes=\"(max-width: 1001px) 100vw, 1001px\" \/><\/p>\n<p>\u76f8\u5173\u6210\u679c\u4ee5Salt Sensitive Purely Zwitterionic Physical Hydrogel for Prevention of Postoperative Tissue Adhesion\u4e3a\u6807\u9898\u53d1\u8868\u5728\u4e2d\u79d1\u9662\u4e00\u533a\u300aActa\u00a0Biomaterialia\u300b\uff08IF\uff1a10.6\uff09\u5b66\u672f\u671f\u520a\u4e0a\u3002\u901a\u8baf\u4f5c\u8005\u4f9d\u6b21\u662f\u6d4e\u5357\u5927\u5b66\u5f20\u4e9a\u5f6c\u526f\u6559\u6388\uff0c\u5c71\u4e1c\u5927\u5b66\u7fdf\u5149\u559c\u6559\u6388\u548c\u53f6\u78ca\u526f\u7814\u7a76\u5458\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong><b>\u3010\u6838\u5fc3\u521b\u65b0\u70b9\u3011<\/b><\/strong><\/p>\n<ol>\n<li>\u672c\u6587\u62a5\u9053\u57fa\u4e8e\u7eaf\u4e24\u6027\u79bb\u5b50\u6750\u6599\u7684PSBMA\u7269\u7406\u6c34\u51dd\u80f6\u7684\u5236\u5907\u65b9\u6cd5\u53ca\u5176\u7528\u4e8e\u6297\u80a0\u9ecf\u8fde\u7684\u5e94\u7528\u3002\u8fd9\u79cdPSBMA\u805a\u5408\u7269\u53ef\u4ee5\u6839\u636e\u79bb\u5b50\u6d53\u5ea6\u7684\u4e0d\u540c\u5b9a\u5236\u6210\u52a8\u6001\u7269\u7406\u7f51\u7edc\uff0c\u5177\u6709\u51fa\u8272\u7684\u9632\u6c61\u80fd\u529b\u3002\u968f\u7740\u79bb\u5b50\u7684\u6d78\u6da6\uff0c\u7269\u7406\u6c34\u51dd\u80f6\u5c06\u5b8c\u5168\u89e3\u79bb\uff0c\u4f7f\u5176\u6210\u4e3a\u9884\u9632\u7c98\u8fde\u7684\u7edd\u4f73\u5019\u9009\u8005\u3002<\/li>\n<li>\u5236\u5907\u7684\u6c34\u51dd\u80f6\u53ef\u6ce8\u5c04\uff0c\u6613\u4e8e\u4f7f\u7528\u3002\u5b83\u53ef\u4ee5\u77ac\u95f4\u7c98\u9644\u5e76\u56fa\u5b9a\u5728\u4e0d\u89c4\u5219\u8868\u9762\u4e0a\uff0c\u8fd9\u79cd\u5177\u6709\u5de8\u5927\u4e34\u5e8a\u8f6c\u5316\u6f5c\u529b\u7684\u79bb\u5b50\u654f\u611f\u3001\u9632\u6c61\u8d85\u5206\u5b50\u6c34\u51dd\u80f6\u662f\u9884\u9632\u672f\u540e\u7ec4\u7ec7\u7c98\u8fde\u7684\u4e00\u79cd\u6709\u524d\u9014\u7684\u9694\u79bb\u6750\u6599\u3002<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><strong><b>\u3010<\/b><\/strong><strong><b>\u6570\u636e\u6982\u89c8\u3011<\/b><\/strong><\/p>\n<p><strong><b>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-245209\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72472-16.png\" alt=\"\" width=\"1055\" height=\"1320\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72472-16.png 1055w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72472-16-240x300.png 240w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72472-16-768x961.png 768w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72472-16-818x1024.png 818w\" sizes=\"(max-width: 1055px) 100vw, 1055px\" \/><\/b><\/strong><\/p>\n<p>\u539f\u7406\u56fe1\u00a0(a)\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u4ea4\u8054\u7f51\u7edcPSBMA\u6c34\u51dd\u80f6\u793a\u610f\u56fe\u3002(b)\u76f2\u80a0\u4fa7\u58c1\u6a21\u578b\u7684\u5efa\u7acb\u53ca\u6709\u65e0PSBMA\u6c34\u51dd\u80f6\u5904\u7406\u7684\u4e0d\u540c\u6548\u679c\u3002(c) PSBMA\u6c34\u51dd\u80f6\u9884\u9632\u672f\u540e\u8179\u8154\u7c98\u8fde\u7684\u4f5c\u7528\u53ca\u5206\u5b50\u673a\u5236\u793a\u610f\u56fe\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-245210\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72473-13.png\" alt=\"\" width=\"944\" height=\"802\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72473-13.png 944w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72473-13-300x255.png 300w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72473-13-768x652.png 768w\" sizes=\"(max-width: 944px) 100vw, 944px\" \/><\/p>\n<p>\u56fe1\u00a0(a) PSBMA\u6c34\u51dd\u80f6\u5185\u90e8\u7ed3\u6784\u3002(b)PSBMA\u6c34\u51dd\u80f6\u7684\u5149\u5b66\u7167\u7247\u3002PSBMA\u6c34\u51dd\u80f6\u7684\u6d41\u53d8\u5b66\u8868\u5f81\uff1a(c)\u9891\u7387\u626b\u63cf\u66f2\u7ebf(0.1-100 Hz\uff0c\u5e94\u53d8\u4e3a1%)\u4ee5\u53ca(d)\u65f6\u95f4\u626b\u63cf\u66f2\u7ebf(1hz\uff0c\u5e94\u53d81%\uff0c0-300s)\u3002(e) 0.01 ~ 1000 s<sup>\u22121<\/sup>\u8303\u56f4\u5185\u7684\u526a\u5207\u901f\u7387-\u626b\u63cf\u66f2\u7ebf\u3002(f) PSBMA\u6c34\u51dd\u80f6\u7684\u4f53\u5916\u964d\u89e3\u3002(g) PSBMA\u6c34\u51dd\u80f6\u7684\u6eb6\u80c0\u7279\u6027\u3002(h) PSBMA\u6c34\u51dd\u80f6\u5bf9BSA\u7684\u5438\u9644\u6027\u80fd\u6d4b\u8bd5\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-245211\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72474-13.png\" alt=\"\" width=\"827\" height=\"794\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72474-13.png 827w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72474-13-300x288.png 300w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72474-13-768x737.png 768w\" sizes=\"(max-width: 827px) 100vw, 827px\" \/><\/p>\n<p>\u56fe2\u00a0\u7528\u6c34\u51dd\u80f6\u63d0\u53d6\u7269\u5bf9(a) 4T1\u7ec6\u80de\u548c(b) L929\u7ec6\u80de\u57f9\u517b12\u300124\u548c48\u5c0f\u65f6\u540e\u7684\u7ec6\u80de\u6d3b\u529b\u3002(c) L929\u7ec6\u80de\u7528\u4e0d\u540c\u8d28\u91cf\u5206\u6570\u6c34\u51dd\u80f6\u63d0\u53d6\u7269\u57f9\u517b24\u5c0f\u65f6\u540e\u7684Calcein-AM\/PI\u67d3\u8272\u56fe\u50cf\uff08\u6bd4\u4f8b\u5c3a\u4e3a70 \u03bcm\uff09\u3002(d)\u6c34\u51dd\u80f6\u4e2d\u7ec6\u80de\u7684\u751f\u957f\uff08\u6bd4\u4f8b\u5c3a\u4e3a200 \u03bcm\uff09\u3002(e)L929\u7ec6\u80de\u5728PSBMA\u6c34\u51dd\u80f6\u4e0a\u7684\u7c98\u9644\u60c5\u51b5\u968f\u65f6\u95f4\u53d8\u5316\u7684\u5149\u5b66\u56fe\u50cf\uff08\u6bd4\u4f8b\u5c3a\u4e3a100 \u03bcm\uff09\u3002<\/p>\n<p><strong><b>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-245212\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72475-11.png\" alt=\"\" width=\"1024\" height=\"1335\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72475-11.png 1024w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72475-11-230x300.png 230w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72475-11-768x1001.png 768w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72475-11-785x1024.png 785w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/b><\/strong><\/p>\n<p>\u56fe3\u00a0(a)\u7a0b\u5e8f\u65f6\u95f4\u8868\u793a\u610f\u56fe\u3002(b)\u4e0d\u540c\u65b9\u6cd5\u5904\u7406\u5927\u9f20\u7b2c7\u300114\u5929\u7c98\u9644\u8bc4\u5206(n=6)\u3002(c)\u672f\u540e\u7b2c7\u5929\u548c\u7b2c14\u5929\uff0c\u6a21\u578b\u8179\u819c\u7c98\u8fde\u3001HA\u6c34\u51dd\u80f6\u548cPSBMA\u6c34\u51dd\u80f6\u7684\u7167\u7247\u3002(d)\u672f\u540e7\u5929\u548c14\u5929\uff0c\u751f\u7406\u76d0\u6c34\u3001HA\u6c34\u51dd\u80f6\u548cPSBMA\u6c34\u51dd\u80f6\u5904\u7406\u6807\u672c\u7684\u7ec4\u7ec7\u5b66\u8bc4\u4ef7\u3002CE\uff1a\u76f2\u80a0\u9ecf\u819c\uff1bAW\uff1a\u8179\u58c1\u3002\u6bd4\u4f8b\u5c3a\u4e3a200 \u03bcm\u3002** p &lt; 0.01\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-245213\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72476-4.png\" alt=\"\" width=\"1027\" height=\"816\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72476-4.png 1027w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72476-4-300x238.png 300w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72476-4-768x610.png 768w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72476-4-1024x814.png 1024w\" sizes=\"(max-width: 1027px) 100vw, 1027px\" \/><\/p>\n<p>\u56fe4\u00a0(a)\u7a0b\u5e8f\u65f6\u95f4\u8868\u793a\u610f\u56fe\u3002(b)\u7c98\u8fde\u6eb6\u89e3\u540e\u7b2c7\u5929\uff0c\u6a21\u578b\u8179\u819c\u7c98\u8fde\u3001HA\u548cPSBMA\u6c34\u51dd\u80f6\u7684\u7167\u7247\u3002(c, d)\u7c98\u8fde\u677e\u89e3\u540e7 \u5929\uff0c\u7528\u751f\u7406\u76d0\u6c34\u3001HA\u6c34\u51dd\u80f6\u548cPSBMA\u6c34\u51dd\u80f6\u5904\u7406\u6807\u672c\u7684\u7ec4\u7ec7\u5b66\u8bc4\u4ef7\uff08\u6bd4\u4f8b\u5c3a\u4e3a200 \u03bcm\uff09\u3002(e)\u7c98\u8fde\u677e\u89e3\u540e7\u5929\uff0c\u5404\u7ec4\u6cbb\u7597\u540e\u7c98\u8fde\u8bc4\u5206\uff08n=6\uff09\u3002(f)\u6743\u91cd\u53d8\u5316\u66f2\u7ebf\u3002CE\uff1a\u76f2\u80a0\u9ecf\u819c\uff1bAW\uff1a\u8179\u58c1\u3002** p &lt; 0.01\u3002<\/p>\n<p><strong><b>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-245214\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72477-1.png\" alt=\"\" width=\"948\" height=\"957\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72477-1.png 948w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72477-1-150x150.png 150w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72477-1-297x300.png 297w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72477-1-768x775.png 768w\" sizes=\"(max-width: 948px) 100vw, 948px\" \/><\/b><\/strong><\/p>\n<p>\u56fe5\u00a0PSBMA\u6c34\u51dd\u80f6\u5bf9\u672f\u540e\u7b2c7\u5929\u300114\u5929\u53ca\u7c98\u8fde\u677e\u89e3\u540e\u7b2c7\u5929\u8840\u6e05\u4e2d\u7ec6\u80de\u56e0\u5b50TGF-\u03b21\u3001IL-6\u3001IL-1\u03b2\u8868\u8fbe\u7684\u5f71\u54cd\uff1a(a-c) TGF -\u03b21\uff0c(d-f)IL-6\u4ee5\u53ca(g-i) IL-1\u03b2\u3002ns:\u65e0\u663e\u8457\u5dee\u5f02\uff1b* p &lt; 0.05\uff1b* * p &lt; 0.01\uff1b* * * p &lt; 0.001\uff1b* * * * p &lt; 0.0001\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-245215\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72478-1.png\" alt=\"\" width=\"1044\" height=\"1497\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72478-1.png 1044w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72478-1-209x300.png 209w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72478-1-768x1101.png 768w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2022\/12\/\u56fe\u72478-1-714x1024.png 714w\" sizes=\"(max-width: 1044px) 100vw, 1044px\" \/><\/p>\n<p>\u56fe6\u00a0(a)\u672f\u540e\u7b2c7\u5929DAPI(\u84dd\u8272)\u3001Smad7-Fluor 594\uff08\u7ea2\u8272\uff09\u548cSmad3-Alexa Fluor488\uff08\u7eff\u8272\uff09\u514d\u75ab\u8367\u5149\u67d3\u8272\u56fe\u50cf\uff08\u6bd4\u4f8b\u5c3a\u4e3a200 \u03bcm\uff09\u3002(b) Smad3\u548c(c) Smad7\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff08MFI\uff09\u3002(d)\u672f\u540e\u7b2c7\u5929\u548c\u7c98\u8fde\u677e\u89e3\u540e\u7b2c7\u5929\u6062\u590d\u7684\u8179\u58c1\u548c\u76f2\u80a0\u8868\u9762\u7684\u5149\u5b66\u56fe\u50cf\uff08\u6bd4\u4f8b\u5c3a\u4e3a100 \u03bcm\uff09\u3002CE\uff1a\u76f2\u80a0\u9ecf\u819c\uff1bAW\uff1a\u8179\u58c1\u3002\u6240\u6709\u6570\u636e\u4ee5\u5747\u6570\u00b1\u6807\u51c6\u5dee\u8868\u793a\uff08n=3\uff09\uff1b* * p &lt; 0.01\uff1b* * * * p &lt; 0.0001\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong><b>\u3010<\/b><\/strong><strong><b>\u6210\u679c\u603b\u7ed3\u3011<\/b><\/strong><\/p>\n<p>\u5728\u8fd9\u9879\u5de5\u4f5c\u4e2d\uff0c\u7814\u7a76\u8005\u5236\u5907\u4e86\u4e00\u7cfb\u5217\u5177\u6709\u6297\u86cb\u767d\u8d28\u5438\u9644\u548c\u964d\u89e3\u6027\u80fd\u7684\u76d0\u654f\u81ea\u7ec4\u88c5\u7269\u7406\u6c34\u51dd\u80f6PSBMA\u3002\u805a\u5408\u7269\u7c89\u672b\u5728\u4e00\u5b9a\u7684\u6d53\u5ea6\u4e0b\u53ef\u4ee5\u5728\u751f\u7406\u76d0\u6c34\u4e2d\u81ea\u7ec4\u88c5\u5f62\u6210\u53ef\u6ce8\u5c04\u7269\u7406\u6c34\u51dd\u80f6\u3002\u4f53\u5916\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u6c34\u51dd\u80f6\u5177\u6709\u4f18\u5f02\u7684\u6297\u86cb\u767d\u8d28\u5438\u9644\u548c\u6297\u6210\u7ea4\u7ef4\u7ec6\u80de\u7c98\u9644\u6027\u80fd\u3002\u5728\u5927\u9f20\u8179\u58c1\u76f2\u80a0\u635f\u4f24\u6a21\u578b\u4e2d\uff0cPSBMA\u6c34\u51dd\u80f6\u663e\u793a\u51fa\u4f18\u5f02\u7684\u6297\u7c98\u8fde\u6548\u679c\u3002PSBMA\u6c34\u51dd\u80f6\u4f5c\u4e3a\u9632\u6b62\u7c98\u8fde\u7684\u7269\u7406\u5c4f\u969c\uff0c\u5176\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u548c\u64cd\u4f5c\u65b9\u4fbf\u6027\u53ef\u6ee1\u8db3\u4e34\u5e8a\u5e94\u7528\u7684\u9700\u6c42\uff0c\u5177\u6709\u5e7f\u9614\u7684\u4e34\u5e8a\u8f6c\u5316\u524d\u666f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.actbio.2022.12.045\">https:\/\/doi.org\/10.1016\/j.actbio.2022.12.045<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5bfc\u8bfb\u3011 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