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\u4e09\u3001\u3010\u6838\u5fc3\u521b\u65b0\u70b9\u3011<\/h2>\n

\u5f15\u5165\u975e\u94c1\u91d1\u5c5e\u5355\u539f\u5b50\u50ac\u5316\u5242\uff08Ir\u548cRu SACs\uff09\u4f5c\u4e3a\u65b0\u578b\u7684\u7ec6\u83cc\u7c7b\u4f3c\u94c1\u6b7b\u4ea1\u7b56\u7565<\/p>\n

\u56db\u3001\u3010\u6570\u636e\u6982\u89c8\u3011\"\"\u56fe<\/strong>1\u00a0<\/strong>\u63cf\u8ff0\u4e86\u5728<\/strong>sp2<\/sup>c-COF<\/strong>\u5b54\u4e2d\u8fdb\u884c<\/strong>Ir<\/strong>\u548c<\/strong>Ru SACs<\/strong>\u7684\u534f\u540c\u5408\u6210\u7684\u65b9\u6848\u00a92023 The Authors<\/span><\/strong><\/h2>\n

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\u56fe2 sp2<\/sup>c-COF\u7684\u8868\u5f81\u7ed3\u679c\u3002a) BTHAN\u548cTA\u7684\u6700\u9ad8\u5360\u636e\u8f68\u9053\u548c\u6700\u4f4e\u672a\u5360\u636e\u8f68\u9053\u3002b) \u975e\u7a7f\u63d2\u5f0fsp2<\/sup>c-COF\u7684\u6269\u5c55\u7ed3\u6784\u3002c) sp2<\/sup>c-COF\u91cd\u590d\u5355\u5143\u7684\u9759\u7535\u52bf\u8868\u9762\u663e\u793a\u53ef\u80fd\u7684\u6d3b\u6027\u4f4d\u70b9\u3002d) sp2<\/sup>c-COF\u7684\u7535\u8377\u5bc6\u5ea6\u5dee\u5f02\uff0c\u5305\u62ec\u653e\u5927\u7684\u9876\u90e8\u548c\u4fa7\u9762\u89c6\u56fe\uff0c\u54c1\u7ea2\u548c\u9ec4\u8272\u5206\u522b\u8868\u793a\u7535\u5b50\u79ef\u7d2f\u548c\u8017\u7aed\u3002e) sp2<\/sup>c-COF\u7247\u6bb5\u5728\u6fc0\u53d1\u6001\u7684\u7a7a\u7a74\u548c\u7535\u5b50\u5206\u5e03\u70ed\u56fe\u3002f) \u7531\u4e8esp2<\/sup>c-COF\u7684\u5c40\u90e8\u6781\u5316\u4ea7\u751f\u7684\u5076\u6781\u77e9\u65b9\u5411\u3002g) sp2<\/sup>c-COF\u5728\u6fc0\u53d1\u6001\u7684\u7535\u5b50-\u7a7a\u7a74\u5206\u5e03\uff0c\u84dd\u8272\u548c\u7eff\u8272\u5206\u522b\u8868\u793a\u7535\u5b50\u79ef\u7d2f\u548c\u8017\u7aed\u3002h) sp2<\/sup>c-COF\u7684Pawley\u7cbe\u5316\u7ed3\u679c\uff1a\u5b9e\u9a8cXRD\u56fe\u6848\u663e\u793a\u4e3a\u9ed1\u8272\uff0cPawley\u7cbe\u5316\u56fe\u6848\u4e3a\u7ea2\u8272\uff0c\u4e8c\u8005\u5dee\u5f02\u4e3a\u84dd\u8272\uff0c\u4f7f\u7528AA\u5806\u79ef\u6a21\u5f0f\u7684\u6a21\u62df\u56fe\u6848\u4e3a\u7eff\u8272\u3002i) sp2<\/sup>c-COF\u7684AA\u5806\u79ef\u6a21\u578b\u6676\u4f53\u7ed3\u6784\u3002j) sp2<\/sup>c-COF\u572877K\u4e0b\u7684\u6c2e\u6c14\u5438\u9644-\u8131\u9644\u7b49\u6e29\u7ebf\u3002\u63d2\u56fe\uff1a\u901a\u8fc7\u5c06NLDFT\u6a21\u578b\u62df\u5408\u5230\u5438\u9644\u6570\u636e\u6765\u8ba1\u7b97\u7684\u5b54\u5f84\u5206\u5e03\u3002k) AA\u5806\u79ef\u7684sp2<\/sup>c-COF\u7684\u6a21\u62df\u5b54\u5f84\u5927\u5c0f\u3002l,m) sp2<\/sup>c-COF\u7684AFM\u56fe\u50cf\u53ca\u5176\u4e09\u7ef4\u5730\u5f62\u56fe\u50cf\u3002n,o) sp2<\/sup>c-COF\u7684\u8868\u9762\u7535\u4f4d\u56fe\u50cf\u53ca\u5176\u4e09\u7ef4\u7535\u4f4d\u7ebf\u5256\u9762\u56fe \u00a0\u00a9 2023 The Authors<\/span><\/strong><\/p>\n

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\u56fe3 \u00a0Ir\u548cRu SACs\u7684\u5f62\u6001\u3002a) sp2<\/sup>c-COF-Ir-ppy2<\/sub>\u548csp2<\/sup>c-COF-Ru-bpy2<\/sub>\u7684\u5408\u6210\u8def\u7ebf\u3002b-d) b) sp2<\/sup>c-COF\uff0cc) sp2<\/sup>c-COF-Ir-ppy2<\/sub>\uff0cd) sp2<\/sup>c-COF-Ru-bpy2<\/sub>\u7684FESEM\u56fe\u50cf\u3002e-g) e) sp2<\/sup>c-COF\uff0cf) sp2<\/sup>c-COF-Ir-ppy2<\/sub>\uff0cg) sp2<\/sup>c-COF-Ru-bpy2<\/sub>\u7684TEM\u548cHRTEM\u56fe\u50cf\u3002h-j) h) sp2<\/sup>c-COF\uff0ci) sp2<\/sup>c-COF-Ir-ppy2<\/sub>\uff0cj) sp2<\/sup>c-COF-Ru-bpy2<\/sub>\u4e2d\u9009\u62e9\u533a\u57df\u7684C\u3001N\u3001Ir\u548cRu\u5143\u7d20\u7684TEM-EDX\u6620\u5c04\u56fe\u50cf\uff08\u6697\u573a\u6a21\u5f0f\uff09\u3002k-m) k) sp2<\/sup>c-COF\uff0cl) sp2<\/sup>c-C\u00a0\u00a9 2023 The Authors<\/span><\/strong><\/p>\n

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\u56fe4 \u00a0Ir\u548cRu SACsOF-Ir-ppy2<\/sub>\uff0cm) sp2<\/sup>c-COF-Ru-bpy2<\/sub>\u7684SAC-HAADF-STEM\u56fe\u50cf\u3002\u7684\u7ed3\u6784\u3002a,b) sp2<\/sup>c-COF-Ir-ppy2<\/sub>\u548csp2<\/sup>c-COF-Ru-bpy2<\/sub>\u7684\u6807\u51c6\u5316Ir L3\u8fb9\u7f18XANES\u8c31\u56fe\u3002c,d) sp2<\/sup>c-COF-Ir-ppy2<\/sub>\u548csp2<\/sup>c-COF-Ru-bpy2<\/sub>\u7684FTEXAFS\u8c31\u56fe\u3002e,f) sp2<\/sup>c-COF-Ir-ppy2<\/sub>\u548csp2<\/sup>c-COF-Ru-bpy2<\/sub>\u7684WT\u8c31\u56fe\u3002g,h) sp2<\/sup>c-COF-Ir-ppy2<\/sub>\u548csp2<\/sup>c-COF-Ru-bpy2<\/sub>\u7684EXAFS\u62df\u5408\u66f2\u7ebf\uff08k\u7a7a\u95f4\uff09\u00a9 2023 The Authors<\/span><\/strong><\/p>\n

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\u56fe<\/strong>5\u00a0<\/strong>\u5149\u50ac\u5316<\/strong>ROS<\/strong>\u4ea7\u751f\u3002<\/strong>a-c) <\/strong>\u5728<\/strong>(a) sp2<\/sup>c-COF<\/strong>\uff0c<\/strong>(b) sp2<\/sup>c<\/strong>-COF-Ir-ppy2<\/sub><\/strong>\u548c<\/strong>(c)\u00a0<\/strong>sp2<\/sup>c-COF-Ru-bpy2<\/sub><\/strong>\u4e0a\u8bb0\u5f55\u7684<\/strong>TMB<\/strong>\u6c27\u5316\u7684<\/strong>UV-vis<\/strong>\u5438\u6536\u5149\u8c31\u3002<\/strong>d) sp2<\/sup>c -COF<\/strong>\uff0c<\/strong>sp2<\/sup>c -COF-Ir-ppy2<\/sub><\/strong>\u548c<\/strong>sp2<\/sup>c -COF-Ru-bpy2<\/sub><\/strong>\u4e0a<\/strong>DHE<\/strong>\u63a2\u9488\u7684\u8367\u5149\u53d1\u5c04\u5149\u8c31\u3002<\/strong>e) sp2<\/sup>c -COF<\/strong>\uff0c<\/strong>sp2<\/sup>c -COF-Ir-ppy2<\/sub><\/strong>\u548c<\/strong>sp2<\/sup>c -COF-Ru-bpy2<\/sub><\/strong>\u4e0a<\/strong>DPBF<\/strong>\u7684\u964d\u89e3\u3002\u6570\u636e\u8868\u793a\u4e3a\u5e73\u5747\u503c<\/strong>\u00b1<\/strong>\u6807\u51c6\u5dee\uff1b<\/strong>n = 3<\/strong>\u3002<\/strong>f) sp2<\/sup>c -COF<\/strong>\uff0c<\/strong>sp2<\/sup>c -COF-Ir-ppy2<\/sub><\/strong>\u548c<\/strong>sp2<\/sup>c -COF-Ru-bpy2<\/sub><\/strong>\u7684\u80fd\u5e26\u7ed3\u6784\u3002<\/strong>g-i) <\/strong>\u4e0d\u540c\u5904\u7406\u6761\u4ef6\u4e0b<\/strong>sp2<\/sup>c -COF<\/strong>\uff0c<\/strong>sp2<\/sup>c -COF-Ir-ppy2<\/sub><\/strong>\u548c<\/strong>sp2<\/sup>c -COF-Ru-bpy2<\/sub><\/strong>\u7684<\/strong>ESR<\/strong>\u5149\u8c31\u3002<\/strong>j) <\/strong>\u4e09\u79cd<\/strong>COFs<\/strong>\u7684\u5206\u5b50\u8f68\u9053\u56fe\u00a0\u00a9 2023 The Authors<\/span><\/strong><\/p>\n

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\u56fe<\/strong>6 \u00a0<\/strong>\u4eba\u4f53\u5916\u7c7b\u94c1\u6b7b\u73b0\u8c61\u3002<\/strong>a) <\/strong>\u83cc\u843d\u5f62\u6210\u5355\u4f4d\uff08<\/strong>CFU<\/strong>\uff09\u8ba1\u6570\uff0c<\/strong>b) <\/strong>\u626b<\/strong>\u63cf\u7535\u5b50\u663e\u5fae\u955c\uff08<\/strong>SEM<\/strong>\uff09\u56fe\u50cf\uff08\u523b<\/strong>\u5ea6\u5c3a<\/strong>=1 \u03bcm<\/strong>\uff09\uff0c<\/strong>c) E. coli<\/strong>\u548c<\/strong>S. aureus<\/strong>\u7ec6\u80de\u5728\u4e0d\u540c\u914d\u65b9\u5904\u7406\u4e0b\u7684\u7ec6\u80de\u5185<\/strong>ROS<\/strong>\u6c34\u5e73\uff1a<\/strong>(I) PBS<\/strong>\uff0c<\/strong>(II) sp2<\/sup>c-COF<\/strong>\uff0c<\/strong>(III) sp2<\/sup>c -COF-Ir-ppy2<\/sub><\/strong>\uff0c<\/strong>(IV) sp2<\/sup>c -COF-Ru-bpy2<\/sub><\/strong>\uff0c<\/strong>(V) sp2<\/sup>c\u00a0<\/strong>-COF+<\/strong>\u6fc0\u5149\uff0c<\/strong>(VI) sp2<\/sup>c -COF-Ir-ppy2<\/sub>+ H2<\/sub>O2<\/sub>+<\/strong>\u6fc0\u5149\uff0c<\/strong>(VII) sp2<\/sup>c -COF-Ru-bpy2<\/sub>+<\/strong>\u6fc0\u5149\u3002<\/strong>d,e) <\/strong>\u5728\u7ea2\u5149\u7167\u5c04\u4e0b\uff0c<\/strong>E. coli<\/strong>\u548c<\/strong>S. aureus<\/strong>\u7ec6\u80de\u5728<\/strong>PBS<\/strong>\uff0c<\/strong>sp2<\/sup>c-COF-Ir-ppy2<\/sub>+ H2<\/sub>O2<\/sub><\/strong>\u548c<\/strong>sp2<\/sup>c-COF-Ru-bpy2<\/sub><\/strong>\u5904\u7406\u540e\u7684\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08<\/strong>TEM<\/strong>\uff09\u56fe\u50cf\u3002\u523b\u5ea6\u5c3a<\/strong>=500 nm<\/strong>\u3002<\/strong>f) C11-BODIPY<\/strong>\u67d3\u6599\u67d3\u8272\u7684<\/strong>E. coli<\/strong>\u548c<\/strong>S. aureus<\/strong>\u7ec6\u80de\u5728\u7ea2\u5149\u7167\u5c04\u4e0b\u7ecf<\/strong>PBS<\/strong>\uff0c<\/strong>sp2<\/sup>c-COF-Ir-ppy2<\/sub>+ H2<\/sub>O2<\/sub><\/strong>\u548c<\/strong>sp2<\/sup>c-COF-Ru-bpy2<\/sub><\/strong>\u5904\u7406\u540e\u7684\u5171\u805a<\/strong>\u7126\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u955c\uff08<\/strong>CLSM<\/strong>\uff09\u56fe\u50cf\u3002\u523b\u5ea6\u5c3a<\/strong>=5 \u03bcm<\/strong>\u3002<\/strong>g) E. coli<\/strong>\u7ec6\u80de\u4e2d<\/strong>GPX4<\/strong>\u86cb\u767d\u8d28\u7684<\/strong>Western blot<\/strong>\u5206\u6790\uff0c\u5177\u6709\u4e0d\u540c\u6761\u4ef6\u3002\u6570\u636e\u8868\u793a\u5e73\u5747\u503c<\/strong>\u00b1<\/strong>\u6807\u51c6\u5dee\uff1b<\/strong>n = 3<\/strong>\u3002<\/strong>h) E. coli<\/strong>\u7ec6\u80de\u7684\u7ec6\u80de\u5185<\/strong>GSH<\/strong>\uff0c<\/strong>i) TrxR<\/strong>\uff0c<\/strong>j) <\/strong>\u548c<\/strong>ATP<\/strong>\u6c34\u5e73\uff0c\u5728<\/strong>I<\/strong>\uff0c<\/strong>V<\/strong>\uff0c<\/strong>VI<\/strong>\uff0c<\/strong>VII<\/strong>\u7ec4\u3002\u6570\u636e\u8868\u793a\u5e73\u5747\u503c<\/strong>\u00b1<\/strong>\u6807\u51c6\u5dee\uff1b<\/strong>n = 3<\/strong>\u3002<\/strong>k)<\/strong>\u7ec6\u80de\u819c\u635f\u4f24\u4e2d\u4f7f\u7528\u7684<\/strong>LPO<\/strong>\u7684\u793a\u610f\u56fe\u3002\u4f7f\u7528\u4e00\u65b9\u5dee\u5206\u6790\uff08<\/strong>ANOVA<\/strong>\uff09\u68c0\u9a8c\u8fdb\u884c\u7edf\u8ba1\u663e\u8457\u6027\u68c0\u9a8c\uff0c\u4f7f\u7528<\/strong>Bonferroni<\/strong>\u7684\u6bd4\u8f83\u68c0\u9a8c\uff0c\u7ed9\u51fa<\/strong>P<\/strong>\u503c\uff0c<\/strong>*<\/strong>\u8868\u793a<\/strong>P < 0.05<\/strong>\uff0c<\/strong>**<\/strong>\u8868\u793a<\/strong>P < 0.01\u00a0\u00a9 2023 The Authors<\/span><\/strong><\/p>\n

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\u56fe<\/strong>7 \u00a0MRSA<\/strong>\u8f6c\u5f55\u7ec4<\/strong>\u7684\u53d8\u5316\u3002<\/strong>a) <\/strong>\u4e0e<\/strong>Ctrl<\/strong>\u7ec4\u76f8\u6bd4\uff0c<\/strong>Ir SAC<\/strong>\u7ec4\u548c<\/strong>b) Ru SAC<\/strong>\u7ec4\u4e2d\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff08<\/strong>DEGs<\/strong>\uff09\u7684\u706b\u5c71\u56fe\u3002<\/strong>c,d) <\/strong>\u5728<\/strong>(a) Ir SAC<\/strong>\u548c<\/strong>(b) Ru SAC<\/strong>\u4e0e<\/strong>Ctrl<\/strong>\u7ec4\u76f8\u6bd4\uff0c\u4e0a\u8c03\u548c\u4e0b\u8c03\u7684\u57fa\u56e0\u672c\u4f53\u5bcc\u96c6\u5206\u6790\u3002<\/strong>e,f) Ctrl<\/strong>\u3001<\/strong>Ir SAC<\/strong>\u548c<\/strong>Ru SAC<\/strong>\u7684\u8102\u8d28\u8f6c\u8fd0\u4e0e\u4ee3\u8c22\u3001\u7ec6\u80de\u58c1<\/strong>\/<\/strong>\u819c<\/strong>\/<\/strong>\u5305<\/strong>\u819c\u751f\u7269\u5408\u6210\u3001\u80fd\u91cf\u751f\u4ea7\u4e0e\u8f6c\u6362\u4ee5\u53ca\u590d\u5236\u3001\u91cd\u7ec4\u548c\u4fee\u590d\u7684\u8868\u8fbe\u53d8\u5316\u3002\u6570\u636e\u8868\u793a\u4e3a<\/strong>log2<\/sub><\/strong>\u6298\u53e0\u53d8\u5316\uff1b<\/strong>n = 3<\/strong>\u3002<\/strong>g) <\/strong>\u57fa\u4e8e\u8f6c\u5f55\u7ec4\u5206\u6790\u7684<\/strong>Ir<\/strong>\u548c<\/strong>Ru SAC<\/strong>\u4ecb\u5bfc\u7684\u7ec6\u83cc\u7c7b\u94c1\u6b7b\u6837\u673a\u5236\u7684\u793a\u610f\u56fe\u3002\u4f7f\u7528\u4e00\u65b9\u5dee\u5206\u6790\uff08<\/strong>ANOVA<\/strong>\uff09\u68c0\u9a8c\u8fdb\u884c\u7edf\u8ba1\u663e\u8457\u6027\u68c0\u9a8c\uff0c\u4f7f\u7528<\/strong>Bonferroni<\/strong>\u7684\u6bd4\u8f83\u68c0\u9a8c\uff0c\u7ed9\u51fa<\/strong>P<\/strong>\u503c\uff0c<\/strong>*<\/strong>\u8868\u793a<\/strong>P < 0.05<\/strong>\uff0c<\/strong>**<\/strong>\u8868\u793a<\/strong>P < 0.01\u00a0\u00a9 2023 The Authors<\/span><\/strong><\/p>\n

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\u56fe<\/strong> 8 \u00a0<\/strong>\u4eba\u4f53\u7c7b\u94c1\u6b7b\u73b0\u8c61\u3002<\/strong>a) <\/strong>\u57fa\u4e8e<\/strong>COF<\/strong>\u7684<\/strong>SACs<\/strong>\u8bf1\u5bfc\u7684\u7ec6\u83cc<\/strong>\u7c7b\u94c1\u6b7b\u6837\u8bc4\u4f30\u7684\u793a\u610f\u56fe\u3002<\/strong>b)<\/strong>\u63a5\u53d7\u4e0d\u540c\u5904<\/strong>\u7406\u7684\u6b8b\u4f59\u4f24\u53e3\u9762\u79ef\u7684\u5b9a\u91cf\u5206\u6790\u3002<\/strong>c) <\/strong>\u7b2c<\/strong>3<\/strong>\u5929\u548c\u7b2c<\/strong>12<\/strong>\u5929\u4f7f\u7528\u7a00\u91ca\u6d82\u5e03\u6cd5\u6d4b\u91cf\u611f\u67d3\u4f24\u53e3\u5468\u56f4\u7684\u7ec6\u83cc\u8d1f\u8377\u3002<\/strong>d) <\/strong>\u5305\u542b<\/strong>DAPI<\/strong>\u3001<\/strong>DCFH-DA<\/strong>\u548c<\/strong>C11-BODIPY<\/strong>\u7684\u4f24\u53e3\u7ec4\u7ec7\u5207\u7247\u3002\u6bd4\u4f8b\u5c3a<\/strong>=100 \u03bcm<\/strong>\u3002<\/strong>e) <\/strong>\u4e0d\u540c<\/strong>COF<\/strong>\u5904\u7406\u540e\u4f24\u53e3\u90e8\u4f4d<\/strong>Ki67<\/strong>\u6807\u8bb0\u7684\u9633\u6027\u7ec6\u80de\u7684\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a<\/strong>=100 \u03bcm<\/strong>\u3002<\/strong>f) <\/strong>\u7b2c<\/strong>12<\/strong>\u5929\u611f\u67d3\u76ae\u80a4\u5207\u7247\u7684<\/strong>H&E<\/strong>\u548c<\/strong>Masson<\/strong>\u67d3\u8272\u3002\u6bd4\u4f8b\u5c3a<\/strong>=200 \u03bcm\u3002i\uff09\u5b83\u4eec\u5728\u7ea2\u5149\u7167\u5c04\u6216\u5b58\u5728H2<\/sub>O2<\/sub>\u7684\u6761\u4ef6\u4e0b\u8868\u73b0\u51fa\u9ad8\u6548\u7684ROS\u4ea7\u751f\u80fd\u529b\uff0c\u8fd9\u662f\u7531\u4e8e\u5b83\u4eec\u8f83\u7a84\u7684\u5e26\u9699\u548c\u7c7b\u8fc7\u6c27\u5316\u7269\u9176\u7684\u7eb3\u7c73\u9176\u6d3b\u6027\u00a0\u00a9 2023 The Authors<\/span><\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong> 9 \u00a0<\/strong>\u4eba\u4f53\u8113\u80bf\u6108\u5408\u8bc4\u4f30\u3002<\/strong>a) <\/strong>\u63cf\u8ff0<\/strong>MRSA<\/strong>\u611f\u67d3\u8113\u80bf\u6a21\u578b\u4e2d\u7684\u6cbb\u7597\u65b9\u6848\u7684\u793a\u610f\u56fe\u3002<\/strong>b) <\/strong>\u4e0d\u540c\u65f6\u95f4\u70b9\u611f\u67d3\u8113\u80bf<\/strong>\u7684\u5404\u7ec4\u4ee3\u8868\u6027\u56fe\u50cf\uff08\u6bd4\u4f8b\u5c3a<\/strong>=10 mm<\/strong>\uff09\u3002<\/strong>c) <\/strong>\u5728<\/strong>12<\/strong>\u5929\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u6b8b\u4f59\u75c5\u53d8\u9762\u79ef\u7684\u7edf\u8ba1\u56fe\u3002\u6570\u636e\u8868\u793a\u4e3a\u5e73\u5747\u503c<\/strong>\u00b1<\/strong>\u6807\u51c6\u5dee\uff1b<\/strong>n = 3<\/strong>\u3002<\/strong>d) <\/strong>\u7b2c<\/strong>3<\/strong>\u5929\u548c\u7b2c<\/strong>12<\/strong>\u5929\u611f\u67d3\u76ae\u80a4\u7ec4\u7ec7\u4e2d<\/strong>MRSA<\/strong>\u7684<\/strong>CFU<\/strong>\u3002\u6570\u636e\u8868\u793a\u4e3a\u5e73\u5747<\/strong>\u503c<\/strong>\u00b1<\/strong>\u6807\u51c6\u5dee\uff1b<\/strong>n = 3<\/strong>\u3002<\/strong>e) <\/strong>\u7b2c<\/strong>12<\/strong>\u5929\u75c5\u53d8\u90e8\u4f4d\u7684<\/strong>Wright<\/strong>\u67d3\u8272\u3002<\/strong>f) <\/strong>\u4e0d\u540c\u6cbb\u7597\u540e\u7b2c<\/strong>12<\/strong>\u5929\u75c5\u53d8\u90e8\u4f4d\u7684<\/strong>TNF-<\/strong>\ud835\udefc<\/strong>\u3001<\/strong>CD80<\/strong>\u3001<\/strong>CD163<\/strong>\u67d3\u8272\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u548c\u514d\u75ab\u8367\u5149\u56fe\u50cf\u3002<\/strong>\u6bd4\u4f8b\u5c3a<\/strong>=100 \u03bcm<\/strong>\u3002<\/strong>g) B<\/strong>\u7ec6\u80de\uff08<\/strong>C<\/strong>D19+<\/sup>\/CD21+<\/sup>\/CD45+<\/sup><\/strong>\uff09\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u3002<\/strong>h) TNF-<\/strong>\ud835\udefc<\/strong>\u9633\u6027\u533a\u57df\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\u7684\u5b9a\u91cf\u5316\u3002<\/strong>i\u2013j) CD80<\/strong>\u548c<\/strong>CD163<\/strong>\u9633\u6027\u533a\u57df\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\u7684\u5b9a\u91cf\u5316\u3002<\/strong>k) <\/strong>\u6765\u81ea<\/strong>(g)<\/strong>\u7684<\/strong>B<\/strong>\u7ec6\u80de\u767e\u5206\u6bd4\u8ba1<\/strong>\u7b97\u3002\u6570\u636e\u8868\u793a\u4e3a\u5e73\u5747\u503c<\/strong>\u00b1<\/strong>\u6807\u51c6\u5dee\uff1b<\/strong>n = 3<\/strong>\u3002\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7531\u4e00\u5143\u65b9\u5dee\u5206\u6790\u68c0<\/strong>\u9a8c\u548c<\/strong>Bonf<\/strong>erroni<\/strong>\u7684\u6bd4\u8f83\u68c0\u9a8c\u786e\u5b9a\uff0c\u7ed9\u51fa<\/strong>P<\/strong>\u503c\uff0c<\/strong>*<\/strong>\u8868\u793a<\/strong>P < 0.05<\/strong>\uff0c<\/strong>**<\/strong>\u8868\u793a<\/strong>P < 0.0<\/strong>1\u00a0\u00a9 2023 The Authors<\/span><\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>10\u00a0<\/strong>\u901a\u8fc7\u7ec6\u83cc\u7c7b\u4f3c\u94c1\u6b7b\u4ea1\u3001\u708e\u75c7\u76f8\u65e9\u671f\u7ec8\u6b62\u3001\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u6fc0\u6d3b\u9014\u5f84<\/strong>\u7684\u6cbb\u7597\u673a\u5236\u793a\u610f\u56fe\u00a0\u00a9 2023 The Authors<\/span><\/strong><\/p>\n

\u4e94\u3001\u3010\u6210\u679c\u542f\u793a\u3011<\/h2>\n

\u603b\u7ed3\u8d77\u6765\uff0c\u6211\u4eec\u63d0\u51fa\u4e86\u4e00\u79cd\u975e\u94c1\u7684\u7ec6\u83cc\u7c7b\u4f3c\u94c1\u6b7b\u4ea1\u7b56\u7565\u3002\u4e0e\u4f20\u7edf\u7684\u94c1\u57fa\u8bf1\u5bfc\u5242\u76f8\u6bd4\uff0c\u5177\u6709\u91d1\u5c5e-\u6c2e-\u78b3\u6865\u63a5\u7ed3\u6784\u7684\u9ad8\u6548Ir\u548cRu\u5355\u539f\u5b50\u50ac\u5316\u5242\u5177\u6709\u4ee5\u4e0b\u51e0\u4e2a\u4f18\u70b9\uff1a<\/p>\n

i\uff09\u5b83\u4eec\u53ef\u4ee5\u4f5c\u4e3a\u6709\u5229\u7684GSH\u6c27\u5316\u7269\u6a21\u62df\u7eb3\u7c73\u9176\uff0c\u589e\u5f3a\u5185\u6e90\u6027GSH\u7684\u8017\u7aed\uff0c\u4ece\u800c\u6291\u5236GPX4\u9176\u7684\u6d3b\u6027\u548c\u964d\u4f4eTrxR\u6c34\u5e73\uff0c\u8fdb\u800c\u7834\u574f\u6297\u6c27\u5316\u7cfb\u7edf\u5e76\u8fdb\u4e00\u6b65\u79ef\u7d2f\u8102\u8d28\u8fc7\u6c27\u5316\u7269\uff08LPO\uff09\u3002<\/p>\n

ii\uff09\u5b83\u4eec\u53ef\u4ee5\u4e25\u91cd\u7834\u574f\u7ec6\u83cc\u7684\u4ee3\u8c22\u80fd\u529b\u548c\u6b63\u5e38\u547c\u5438\uff0c\u5c06\u6709\u6c27\u547c\u5438\u8f6c\u53d8\u4e3a\u538c\u6c27\u547c\u5438\u3002<\/p>\n

iii\uff09\u5b83\u4eec\u5f15\u8d77\u4e25\u91cd\u7684\u6c27\u5316\u5e94\u6fc0\uff0c\u5bfc\u81f4\u7ec6\u83cc\u57fa\u56e0\u7cfb\u7edf\u548c\u86cb\u767d\u8d28\u8102\u9170\u5316\u7684\u635f\u574f\u3002\u5728\u7167\u5c04\u4e0b\uff0cIr\u548cRu SACs\u5728\u9769\u5170\u9633\u6027\u7ec6\u83cc\u3001\u9769\u5170\u9634\u6027\u7ec6\u83cc\u3001\u4e34\u5e8a\u5206\u79bb\u7684MRSA\u4e0a\u663e\u793a\u51fa\u6709\u6548\u7684\u6297\u83cc\u6d3b\u6027\uff0c\u5e76\u4e14\u80fd\u591f\u7834\u574f\u751f\u7269\u819c\u3002\u8fd9\u4e24\u79cd\u7c7b\u4f3c\u94c1\u6b7b\u4ea1\u7684\u8bf1\u5bfc\u5242\u5728\u4f53\u5916\u548c\u4f53\u5185\u90fd\u663e\u793a\u51fa\u4f4e\u6bd2\u6027\uff0c\u8868\u660e\u5728\u6f5c\u5728\u7684\u4e34\u5e8a\u5e94\u7528\u4e2d\u5177\u6709\u51fa\u8272\u7684\u751f\u7269\u5b89\u5168\u6027\u3002<\/p>\n

\u6700\u540e\uff0c\u5e94\u7528Ir\u548cRu SACs\u4e0d\u4ec5\u663e\u8457\u52a0\u901f\u4e86MRSA\u611f\u67d3\u7684\u521b\u4f24\u548c\u8113\u80bf\u7684\u6108\u5408\u8fc7\u7a0b\uff0c\u8fd8\u8bf1\u5bfc\u4e86\u7279\u5b9a\u75c5\u539f\u4f53\u7684\u514d\u75ab\u8bb0\u5fc6\u53cd\u5e94\uff0c\u964d\u4f4e\u4e86\u518d\u611f\u67d3\u7684\u98ce\u9669\u3002\u603b\u4f53\u800c\u8a00\uff0c\u6211\u4eec\u7684\u7814\u7a76\u9996\u6b21\u521b\u65b0\u5730\u4ecb\u7ecd\u5e76\u9a8c\u8bc1\u4e86\u57fa\u4e8eCOF\u7684\u975e\u94c1\u7ec6\u83cc\u7c7b\u4f3c\u94c1\u6b7b\u4ea1\u7b56\u7565\uff0c\u4e3a\u672a\u6765\u7684\u6297\u611f\u67d3\u6cbb\u7597\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u65b9\u5411\u3002<\/p>\n

 <\/p>\n

 <\/p>\n

\u539f\u6587\u8be6\u60c5\uff1a<\/strong><\/p>\n

Local inversion-symmetry breaking in a bismuthate high-Tc superconductor https:\/\/doi.org\/10.1038\/s41467-023-36348-9<\/p>\n

\u672c\u6587\u7531Andy\u4f9b\u7a3f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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