{"id":256821,"date":"2023-12-29T08:56:36","date_gmt":"2023-12-29T00:56:36","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=256821"},"modified":"2023-12-29T08:56:36","modified_gmt":"2023-12-29T00:56:36","slug":"%e4%b8%a4%e9%99%a2%e9%99%a2%e5%a3%ab%ef%bc%8c%e5%86%8d%e5%8f%91science%ef%bc%81","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=256821","title":{"rendered":"\u4e24\u9662\u9662\u58eb\uff0c\u518d\u53d1Science\uff01"},"content":{"rendered":"<p><strong>\u4e00\u3001\u3010\u79d1\u5b66\u80cc\u666f\u3011<\/strong><\/p>\n<p>\u5408\u6210\u590d\u6742\u6709\u673a\u5206\u5b50\u7684\u80fd\u529b\u5bf9\u4e8e\u53d1\u73b0\u548c\u5236\u9020\u529f\u80fd\u6027\u5316\u5408\u7269\uff08\u5305\u62ec\u5c0f\u5206\u5b50\u836f\u7269\uff09\u81f3\u5173\u91cd\u8981\u3002\u8fd9\u4e00\u8fc7\u7a0b\u901a\u5e38\u662f\u901a\u8fc7\u7f13\u6162\u3001\u8d39\u529b\u3001\u53cd\u590d\u7684\u8bbe\u8ba1-\u5236\u9020-\u6d4b\u8bd5-\u5206\u6790\uff08Design-make-test-analyze, DMTA\uff09\u5faa\u73af\u8fdb\u884c\u7684\u3002\u65b0\u5174\u7684\u673a\u5668\u5b66\u4e60\uff08ML\uff09\u5de5\u5177\u53ef\u4ee5\u751f\u6210\u65b0\u7684\u5019\u9009\u5206\u5b50\uff0c\u9884\u6d4b\u5176\u6027\u8d28\uff0c\u5e76\u901a\u8fc7\u8ba1\u7b97\u673a\u8f85\u52a9\u5408\u6210\u89c4\u5212\uff08Computer-aided synthesis planning, CASP\uff09\u63d0\u51fa\u53cd\u5e94\u8def\u5f84\u3002\u5316\u5b66\u81ea\u52a8\u5316\u65b9\u9762\u7684\u8fdb\u6b65\u53ef\u4ee5\u5728\u4eba\u5de5\u8bbe\u7f6e\u4e4b\u540e\uff0c\u4ee5\u6700\u5c11\u7684\u4eba\u5de5\u5e72\u9884\u5b9e\u73b0\u5316\u5b66\u5408\u6210\u548c\u8868\u5f81\u3002\u5c06\u4ee5\u4e0a\u6d41\u7a0b\u4ee5\u53ca\u5316\u5408\u7269\u7eaf\u5316\u3001\u8868\u5f81\u6574\u5408\u5230DMTA\u5de5\u4f5c\u6d41\u7a0b\u4e2d\uff0c\u53ef\u4ee5\u5f00\u53d1\u51fa\u81ea\u4e3b\u5316\u5b66\u53d1\u73b0\u5e73\u53f0\uff0c\u65e0\u9700\u4eba\u5de5\u91cd\u65b0\u914d\u7f6e\u5373\u53ef\u5728\u4e0d\u540c\u7684\u5316\u5b66\u7a7a\u95f4\u4e2d\u8fd0\u884c\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u6f14\u793a\u5f3a\u8c03\u4e86\u96c6\u6210\u9884\u6d4b\u5de5\u5177\u548c\u5316\u5b66\u81ea\u52a8\u5316\u7684\u6f5c\u529b\uff0c\u4f46\u5b83\u4eec\u7684\u4e13\u4e1a\u5b9e\u65bd\u9650\u5236\u4e86\u6267\u884c\u7684\u5316\u5b66\u7c7b\u578b\u3001\u53ef\u5b9e\u73b0\u7684\u7ed3\u6784\u7c7b\u578b\uff0c\u7279\u522b\u662f\u8fd9\u4e9b\u5e73\u53f0\u53ef\u4ee5\u63a2\u7d22\u7684\u5316\u5b66\u7a7a\u95f4\u3002\u57282019\u5e74\uff0c\u9ebb\u7701\u7406\u5de5\u5b66\u9662Klavs F. 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-256825\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2023\/12\/science.adi1407-f1.jpg\" alt=\"\" width=\"600\" height=\"737\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2023\/12\/science.adi1407-f1.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2023\/12\/science.adi1407-f1-244x300.jpg 244w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>1\u00a0 <\/strong><strong>\u7efc\u5408\u5e73\u53f0\u4ee5\u53ca\u5e73\u53f0\u9884\u6d4b\u5e76\u6210\u529f\u6267\u884c\u7684\u53cd\u5e94\u6982\u8ff0<\/strong><strong> \u00a9 2023 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-256824\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2023\/12\/science.adi1407-f6.jpg\" alt=\"\" width=\"600\" height=\"362\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2023\/12\/science.adi1407-f6.jpg 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2023\/12\/science.adi1407-f6-300x181.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>2\u00a0 <\/strong><strong>\u6a21\u578b\u5f00\u53d1\u6848\u4f8b\u7814\u7a76<\/strong><strong> \u00a9 2023 AAAS<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u4e09\u3001\u3010<\/strong><strong>\u521b\u65b0\u70b9<\/strong><strong>\u3011<\/strong><\/p>\n<p>\u672c\u7814\u7a76\u5f00\u53d1\u4e86\u4e00\u4e2a\u7531\u96c6\u6210\u673a\u5668\u5b66\u4e60\u5de5\u5177\u9a71\u52a8\u7684\u95ed\u73af\u81ea\u4e3b\u5206\u5b50\u53d1\u73b0\u5e73\u53f0\uff0c\u4ee5\u52a0\u901f\u8bbe\u8ba1\u5177\u6709\u6240\u9700\u7279\u6027\u7684\u5206\u5b50\u3002\u5728\u5b9e\u9645\u5e94\u7528\u4e2d\uff0c\u5c55\u793a\u4e86\u9488\u5bf9\u5438\u6536\u6ce2\u957f\u3001\u4eb2\u6cb9\u6027\u548c\u5149\u6c27\u5316\u7a33\u5b9a\u6027\u7684\u4e24\u4e2a\u67d3\u6599\u7c7b\u5206\u5b50\u6848\u4f8b\u7814\u7a76\uff0c\u5728\u63a2\u7d22\u8f83\u5c11\u7684\u7ed3\u6784-\u6027\u8d28\u7a7a\u95f4\u5185\u53d1\u73b0\u4e869\u4e2a\u6027\u80fd\u6700\u597d\u7684\u5206\u5b50\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56db\u3001\u3010\u79d1\u5b66\u542f\u8fea\u3011<\/strong><\/p>\n<p>\u7efc\u8ff0\uff0c\u672c\u7814\u7a76\u5c55\u793a\u4e86\u4e00\u4e2aDMTA\u5faa\u73af\uff0c\u5b83\u53ef\u4ee5\u63a2\u7d22\u5316\u5b66\u7a7a\u95f4\u5e76\u5229\u7528\u5df2\u77e5\u5316\u5b66\u7ed3\u6784\uff0c\u800c\u65e0\u9700\u4eba\u5de5\u5b9e\u9a8c\u3002\u8be5\u5e73\u53f0\u63d0\u51fa\u3001\u5408\u6210\u5e76\u8868\u5f81\u4e86303\u4e2a\u672a\u62a5\u9053\u7684\u67d3\u6599\u7c7b\u5206\u5b50\uff0c\u5b83\u4eec\u5206\u5e03\u5728\u56db\u4e2a\u63a2\u7d22\u652f\u67b6\u548c\u4e00\u4e2a\u5229\u7528\u652f\u67b6\u4e0a\u3002\u8be5\u96c6\u6210\u5e73\u53f0\u53ef\u901a\u8fc7\u641c\u7d22\u5177\u6709\u6240\u9700\u6027\u8d28\u7684\u7ed3\u6784\uff08\u547d\u4e2d\uff09\u6765\u63a2\u7d22\u672a\u77e5\u7684\u7ed3\u6784-\u6027\u8d28\u7a7a\u95f4\uff0c\u5e76\u53ef\u901a\u8fc7\u4f18\u5316\u6709\u5e0c\u671b\u7684\u5019\u9009\u7ed3\u6784\uff08\u5148\u5bfc\uff09\u6765\u5229\u7528\u5df2\u8868\u5f81\u7684\u7ed3\u6784-\u6027\u8d28\u7a7a\u95f4\u3002\u95ed\u73af\u96c6\u6210\u5e73\u53f0\u7684\u8fdb\u4e00\u6b65\u53d1\u5c55\u6709\u671b\u52a0\u901f\u5206\u5b50\u53d1\u73b0\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u539f\u6587\u8be6\u60c5\uff1ahttps:\/\/www.science.org\/doi\/10.1126\/science.adi1407<\/p>\n<p>\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001\u3010\u79d1\u5b66\u80cc\u666f\u3011 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