{"id":263209,"date":"2024-11-05T07:42:03","date_gmt":"2024-11-04T23:42:03","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=263209"},"modified":"2024-11-04T17:55:39","modified_gmt":"2024-11-04T09:55:39","slug":"synergistic-gas-therapy-and-targeted-interventional-ablation-with-size-controllable-arsenic-sulfide-as2s3-nanoparticles-for-effective-elimination-of-localized-cancer-pain","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=263209","title":{"rendered":"Synergistic Gas Therapy and Targeted Interventional Ablation With Size-Controllable Arsenic Sulfide (As2S3) Nanoparticles for Effective Elimination of Localized Cancer Pain"},"content":{"rendered":"

\"\"<\/p>\n

\u4e00\u3001<\/strong>\u00a0<\/strong>\u3010\u5bfc\u8bfb\u3011 \u00a0<\/strong><\/p>\n

\u8fd9\u7bc7\u6587\u7ae0\u63a2\u8ba8\u4e86\u4e00\u79cd\u521b\u65b0\u5730\u5229\u7528\u5c3a\u5bf8\u53ef\u63a7\u7684\u786b\u5316\u7837\uff08As2<\/sub>S3<\/sub>\uff09\u7eb3\u7c73\u9897\u7c92\u8054\u5408\u6c14\u4f53\u6cbb\u7597\u548c\u9776\u5411\u4ecb\u5165\u6d88\u878d\u7684\u7b56\u7565\uff0c\u6765\u5b9e\u73b0\u5c40\u90e8\u764c\u75db\u7684\u6709\u6548\u6d88\u9664\u3002\u764c\u75db\u7684\u5904\u7406\u662f\u5168\u7403\u6027\u533b\u5b66\u96be\u9898\uff0c\u800c\u6587\u7ae0\u4e2d\u63d0\u51fa\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6cd5\u4e3a\u5c40\u90e8\u764c\u75db\u7684\u6d88\u9664\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u4e0d\u540c\u5206\u5b50\u91cf\u7684\u900f\u660e\u8d28\u9178\uff08HA\uff09\u4f5c\u4e3a\u8d85\u5206\u5b50\u9aa8\u67b6\uff0c\u4e0e\u7837\u79bb\u5b50\uff08As3+<\/sup>\uff09\u5171\u7ec4\u88c5\u5f62\u6210HA-As3+<\/sup>\u4e2d\u95f4\u4f53\uff0c\u518d\u4e0e\u786b\u79bb\u5b50\u53cd\u5e94\u751f\u6210\u5c3a\u5bf8\u53ef\u63a7\u7684HA-As2<\/sub>S3<\/sub>\u7eb3\u7c73\u9897\u7c92\uff08\u56fe1\uff09\u3002\u900f\u660e\u8d28\u9178\u7684\u5206\u5b50\u91cf\u53ef\u4ee5\u63a7\u5236\u9897\u7c92\u7684\u6700\u7ec8\u5c3a\u5bf8\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u7b80\u4fbf\u4e14\u73af\u4fdd\u3002\u751f\u6210\u7684HA-As2<\/sub>S3<\/sub>\u7eb3\u7c73\u9897\u7c92\u5728\u9178\u6027\u73af\u5883\u4e2d\u91ca\u653e\u7837\u79bb\u5b50\u548c\u786b\u5316\u6c22\uff08H2<\/sub>S\uff09\u6c14\u4f53\u3002\u7837\u79bb\u5b50\u80fd\u591f\u76f4\u63a5\u635f\u4f24\u80bf\u7624\u7ebf\u7c92\u4f53\uff0c\u4ea7\u751f\u5927\u91cf\u6d3b\u6027\u6c27\uff08ROS\uff09\uff0c\u800cH2<\/sub>S\u6c14\u4f53\u5219\u53ef\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u8fc7\u6c27\u5316\u6c22\u9176\u548c\u7ebf\u7c92\u4f53\u590d\u5408\u7269IV\u6d3b\u6027\uff0c\u963b\u6b62ROS\u7684\u5206\u89e3\u5e76\u7834\u574f\u7ebf\u7c92\u4f53\u547c\u5438\u94fe\uff0c\u589e\u5f3a\u7837\u7eb3\u7c73\u836f\u7269\u5f15\u8d77\u7684\u7ebf\u7c92\u4f53\u635f\u4f24\uff08\u56fe2\uff09\u3002\u8fd9\u6837\u4e00\u6765\uff0cH2<\/sub>S\u9ad8\u6548\u7684\u4fc3\u8fdb\u4e86\u7837\u7eb3\u7c73\u836f\u7269\u8bf1\u5bfc\u7684\u80bf\u7624\u7ebf\u7c92\u4f53\u635f\u4f24\uff0c\u4ece\u800c\u5b9e\u73b0\u4e86\u6709\u6548\u7684\u80bf\u7624\u5c40\u90e8\u6d88\u878d\uff0c\u5e76\u5728\u5c0f\u9f20\u5b9e\u9a8c\u4e2d\u6210\u529f\u89e3\u9664\u4e86\u764c\u75db\u3002<\/p>\n

\u00a0<\/strong><\/p>\n

\u4e8c\u3001\u3010\u6210\u679c\u63a0\u5f71\u3011<\/strong><\/p>\n

1.\u5229\u7528\u4e0d\u540c\u5206\u5b50\u91cf\u7684\u900f\u660e\u8d28\u9178\uff08HA\uff09\u4f5c\u4e3a\u8d85\u5206\u5b50\u9aa8\u67b6\uff0c\u5b9e\u73b0\u4e86\u5bf9HA-As2<\/sub>S3<\/sub>\u7eb3\u7c73\u9897\u7c92\u5927\u5c0f\u7684\u7cbe\u51c6\u63a7\u5236\u3002\u8fd9\u79cd\u65b9\u6cd5\u5373\u7b80\u5355\u53c8\u73af\u4fdd\uff0c\u540c\u65f6\u4e5f\u9002\u7528\u4e8e\u5236\u5907\u5176\u4ed6\u5c3a\u5bf8\u53ef\u63a7\u7684\u91d1\u5c5e\u786b\u5316\u7269\u7eb3\u7c73\u9897\u7c92\u3002<\/p>\n

2.\u8bc1\u660e\u4e86H2<\/sub>S\u6c14\u4f53\u548c\u7837\u79bb\u5b50\u5728\u589e\u5f3a\u7ebf\u7c92\u4f53\u635f\u4f24\u548c\u7ebf\u7c92\u4f53\u5185ROS\u751f\u6210\u65b9\u9762\u7684\u534f\u540c\u4f5c\u7528\u3002<\/p>\n

3.\u6709\u6548\u6d88\u9664\u4e86\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u5c40\u90e8\u764c\u75c7\u75bc\u75db\u4e14\u65e0\u660e\u663e\u6bd2\u526f\u4f5c\u7528\u3002<\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0\u4e09\u3001\u3010\u6838\u5fc3\u521b\u65b0\u70b9\u3011<\/strong><\/p>\n

\u6587\u7ae0\u7684\u521b\u65b0\u70b9\u4e3b\u8981\u4f53\u73b0\u5728\u5229\u7528H2<\/sub>S\u6c14\u4f53\u534f\u540c\u7837\u79bb\u5b50\u5f15\u8d77\u7684\u7ebf\u7c92\u4f53\u635f\u4f24\uff0c\u5b9e\u73b0\u4e86\u66f4\u9ad8\u6548\u7684\u80bf\u7624\u6740\u4f24\u4f5c\u7528\u53ca\u764c\u75db\u6d88\u9664\u3002\u4e0e\u4ec5\u80fd\u6682\u65f6\u7f13\u89e3\u75c7\u72b6\u7684\u4f20\u7edf\u764c\u75db\u6cbb\u7597\u65b9\u6cd5\u4e0d\u540c\uff0c\u8fd9\u79cd\u8054\u5408\u6cbb\u7597\u7b56\u7565\u4e0d\u4ec5\u80fd\u591f\u6d88\u9664\u80bf\u7624\uff0c\u8fd8\u80fd\u901a\u8fc7\u76f4\u63a5\u4f5c\u7528\u4e8e\u7ebf\u7c92\u4f53\u5b9e\u73b0\u6301\u4e45\u7684\u75bc\u75db\u7f13\u89e3\u3002\u5728\u4f53\u5185\u5b9e\u9a8c\u4e2d\uff0c\u5728\u8d85\u58f0\u5f15\u5bfc\u4e0b\u76f4\u63a5\u5c06HA-As2<\/sub>S3<\/sub>\u7eb3\u7c73\u9897\u7c92\u6ce8\u5c04\u5230\u80bf\u7624\u5185\u90e8\uff0c\u4f7f\u5f97\u836f\u7269\u5728\u80bf\u7624\u5c40\u90e8\u533a\u57df\u957f\u65f6\u95f4\u6ede\u7559\u5e76\u7f13\u6162\u91ca\u653e\uff0c\u786e\u4fdd\u4e86\u9ad8\u6d53\u5ea6\u7684\u5c40\u90e8\u836f\u7269\u6c34\u5e73\uff0c\u540c\u65f6\u51cf\u5c11\u4e86\u5168\u8eab\u6bd2\u6027\uff08\u56fe3\uff09\u3002\u8fdb\u4e00\u6b65\u7684\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u7eb3\u7c73\u9897\u7c92\u80fd\u591f\u6709\u6548\u6d88\u9664\u80bf\u7624\u75bc\u75db\uff0c\u5305\u62ec\u81ea\u53d1\u6027\u75bc\u75db\u3001\u673a\u68b0\u6027\u75db\u89c9\u8fc7\u654f\u548c\u51b7\u654f\u53cd\u5e94\uff08\u56fe4\uff09\u3002\u8fd9\u79cd\u7eb3\u7c73\u836f\u7269\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u5b89\u5168\u6027\uff0c\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u672a\u5f15\u8d77\u663e\u8457\u7684\u4f53\u91cd\u53d8\u5316\u6216\u4e3b\u8981\u5668\u5b98\u7684\u7ec4\u7ec7\u635f\u4f24\u3002<\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0\u56db\u3001\u3010\u6570\u636e\u6982\u89c8\u3011 <\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\u56fe1 <\/strong>HA-As2<\/sub>S3<\/sub>\u7eb3\u7c73\u9897\u7c92\u5408\u6210\u793a\u610f\u56fe\uff08A\uff09\u53ca\u7269\u7406\u8868\u5f81\u7ed3\u679c\u3002B\uff0cC\uff0cD)10 kDa HA\u4e0e\u7837\u79bb\u5b50\u5728\u4e0d\u540c\u7684HA\/As3+<\/sup>\u6bd4\u4f8b\u4e0b\u5408\u6210\u7684HA-As2<\/sub>S3<\/sub>NPs\u7684DLS\u548czeta\u7535\u4f4d\u5206\u6790\u4ee5\u53ca\u900f\u5c04\u7535\u955c\uff08TEM\uff09\u6210\u50cf\u3002\u6bd4\u4f8b\u5c3a\uff1a 200 nm\u3002\u5f53\u6bd4\u4f8b\u4e3a1:50\u7684\u65f6\u5019\u4e3a\u6700\u4f73\u5408\u6210\u6bd4\u3002 E) HA-As2<\/sub>S3<\/sub>NPs\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\u3002F\uff0cG)\u9ad8\u5206\u5b50\u91cfHA\uff08200kDa\u3001500kDa\u300115MDa\uff09\u5728HA\/As3+<\/sup>\u6bd4\u4f8b\u4e3a1:50\u65f6\u5f62\u6210\u7684\u7eb3\u7c73\u7c92\u7684DLS\u5206\u6790\u548cTEM\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a\uff1a 200 nm\u3002<\/p>\n

\"\"<\/p>\n

\u56fe2 \u00a0<\/strong>HA-As2<\/sub>S3<\/sub>\u7eb3\u7c73\u9897\u7c92\u6297\u80bf\u7624\u6cbb\u7597\u673a\u5236\u56fe<\/p>\n

\"\"<\/p>\n

\u56fe3 <\/strong>HA-As2<\/sub>S3<\/sub>\u7eb3\u7c73\u9897\u7c92\u4f53\u5185\u6297\u80bf\u7624\u6cbb\u7597\u7ed3\u679c<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>4<\/strong>\u00a0<\/strong>HA-As2<\/sub>S3<\/sub>\u7eb3\u7c73\u9897\u7c92\u6d88\u9664\u5c40\u90e8\u764c\u75c7\u75bc\u75db<\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

\u4e94\u3001\u3010\u6210\u679c\u542f\u793a\u3011<\/strong><\/p>\n

\u8fd9\u9879\u7814\u7a76\u901a\u8fc7\u5f00\u53d1\u57fa\u4e8eH2<\/sub>S\u7684\u534f\u540c\u6cbb\u7597\u5e73\u53f0\uff0c\u4e3a\u5c40\u90e8\u80bf\u7624\u6d88\u878d\u548c\u764c\u75db\u6d88\u9664\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u663e\u793a\u4e86\u826f\u597d\u7684\u4e34\u5e8a\u8f6c\u5316\u6f5c\u529b\u3002\u8fd9\u79cd\u521b\u65b0\u7684\u7eb3\u7c73\u9897\u7c92\u4e0d\u4ec5\u80fd\u591f\u6709\u6548\u6d88\u878d\u80bf\u7624\uff0c\u8fd8\u80fd\u591f\u6709\u6548\u7684\u89e3\u9664\u764c\u75db\uff0c\u6709\u671b\u6210\u4e3a\u764c\u75c7\u75bc\u75db\u7ba1\u7406\u7684\u65b0\u65b9\u5411\u3002<\/p>\n

\u539f\u6587\u8be6\u60c5<\/strong>\uff1ahttps:\/\/doi.org\/10.1002\/smll.202407197<\/p>\n

 <\/p>\n

\u672c\u6587\u7531\u5357\u65b9\u533b\u79d1\u5927\u5b66\u68c0\u9a8c\u4e0e\u751f\u7269\u6280\u672f\u5b66\u9662\u5206\u5b50\u514d\u75ab\u7814\u7a76\u6240\u5f20\u9e4f\u98de\u8bfe\u9898\u7ec4\u4f9b\u7a3f<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e00\u3001\u00a0\u3010\u5bfc\u8bfb\u3011 \u00a0 \u8fd9\u7bc7\u6587\u7ae0\u63a2\u8ba8\u4e86\u4e00\u79cd\u521b\u65b0\u5730\u5229\u7528\u5c3a\u5bf8\u53ef\u63a7\u7684\u786b\u5316\u7837\uff08As2S3\uff09\u7eb3\u7c73\u9897\u7c92\u8054\u5408\u6c14\u4f53\u6cbb\u7597\u548c\u9776\u5411\u4ecb\u5165\u6d88\u878d\u7684\u7b56\u7565\uff0c\u6765\u5b9e\u73b0\u5c40\u90e8\u764c\u75db\u7684\u6709\u6548\u6d88\u9664\u3002\u764c\u75db\u7684\u5904\u7406\u662f\u5168…<\/p>\n","protected":false},"author":14360,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-263209","post","type-post","status-publish","format-standard","hentry","category-keji"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/263209"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/14360"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=263209"}],"version-history":[{"count":1,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/263209\/revisions"}],"predecessor-version":[{"id":263215,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/263209\/revisions\/263215"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=263209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=263209"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=263209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}