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class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"949\" height=\"519\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/0.png\" alt=\"\" class=\"wp-image-269717\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4e8c\u3001\u3010\u521b\u65b0\u6210\u679c\u3011<\/strong><\/h2>\n\n\n\n<p>\u4e3a\u4e86\u89e3\u51b3\u4e0a\u8ff0\u96be\u70b9\uff0c\u7f8e\u56fd\u534e\u76db\u987f\u5927\u5b66David Baker\u6559\u6388\uff0cIndrek Kalvet\u6559\u6388\uff0c\u745e\u58eb\u82cf\u9ece\u4e16\u8054\u90a6\u7406\u5de5\u5b66\u9662Donald 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design of metallohydrolases\u201d\u4e3a\u9898\u53d1\u8868\u5728\u56fd\u9645\u5b66\u672f\u671f\u520a\u300aNature\u300b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1268\" height=\"1187\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/1.png\" alt=\"\" class=\"wp-image-269718\" \/><\/figure>\n\n\n\n<p>\u56fe1. RFdiffusion2 \u8bbe\u8ba1\u65b9\u6cd5\u3002\u00a9 2025 Springer Nature Limited<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1268\" height=\"1186\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/2.png\" alt=\"\" class=\"wp-image-269719\" style=\"width:840px;height:auto\" \/><\/figure>\n\n\n\n<p>\u56fe2. \u6d3b\u6027\u8868\u5f81\u4e0ePLACER\u6d3b\u6027\u4e2d\u5fc3\u9884\u7ec4\u7ec7\u8bc4\u4f30\u3002<a>\u00a9 2025 Springer Nature Limited<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1268\" height=\"1029\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/3.png\" alt=\"\" class=\"wp-image-269720\" \/><\/figure>\n\n\n\n<p>\u56fe3. ZETA_1\u9176\u7684\u6d3b\u6027\u8868\u5f81\u3002\u00a9 2025 Springer Nature Limited<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1269\" height=\"1775\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/4.png\" alt=\"\" class=\"wp-image-269721\" style=\"width:840px;height:auto\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/4.png 1269w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/4-1098x1536.png 1098w\" sizes=\"(max-width: 1269px) 100vw, 1269px\" \/><\/figure>\n\n\n\n<p>\u56fe4. \u7b2c\u4e8c\u8f6e\u8bbe\u8ba1\u9176\u7684\u8868\u5f81\u3002\u00a9 2025 Springer Nature Limited<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1057\" height=\"893\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/5.png\" alt=\"\" class=\"wp-image-269722\" \/><\/figure>\n\n\n\n<p>\u56fe5. ZETA_2\u7684\u6676\u4f53\u7ed3\u6784\u4e0e\u8bbe\u8ba1\u6a21\u578b\u9ad8\u5ea6\u76f8\u4f3c\u3002\u00a9 2025 Springer Nature Limited<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4e09\u3001\u3010\u79d1\u5b66\u542f\u8fea\u3011<\/strong><\/h2>\n\n\n\n<p>\u8fd9\u9879\u5de5\u4f5c\u4e3a\u9176\u5de5\u7a0b\u4e0e\u8ba1\u7b97\u751f\u7269\u5b66\u9886\u57df\u5e26\u6765\u91cd\u8981\u79d1\u5b66\u542f\u8fea\u3002\u8bc1\u5b9e\u4e86\u751f\u6210\u5f0fAI\u4e0e\u91cf\u5b50\u5316\u5b66\u7684\u6df1\u5ea6\u878d\u5408\uff0c\u53ef\u7a81\u7834\u4f20\u7edf\u9176\u8bbe\u8ba1\u7684\u53c2\u6570\u5c40\u9650\uff0c\u5f62\u6210\u4ece\u7406\u8bba\u6d3b\u6027\u4e2d\u5fc3\u5230\u529f\u80fd\u86cb\u767d\u7684\u9ad8\u6548\u8f6c\u5316\u8303\u5f0f\uff0c\u4e3a\u590d\u6742\u9176\u5206\u5b50\u4ece\u5934\u8bbe\u8ba1\u63d0\u4f9b\u53ef\u63a8\u5e7f\u6846\u67b6\u3002\u660e\u786e\u4e86\u201c\u9884\u7ec4\u7ec7\u5316\u6d3b\u6027\u4e2d\u5fc3\u201d\u4e3a\u9ad8\u6d3b\u6027\u8bbe\u8ba1\u9176\u7684\u6838\u5fc3\u7279\u5f81\uff0c\u4e3a\u8bbe\u8ba1\u65b9\u6848\u9ad8\u901a\u91cf\u7b5b\u9009\u63d0\u4f9b\u5173\u952e\u7406\u8bba\u4f9d\u636e\u3002\u9a8c\u8bc1\u4e86AI\u80fd\u9ad8\u6548\u751f\u6210\u5e8f\u5217\u4e0e\u7ed3\u6784\u65b0\u9896\u4e14\u529f\u80fd\u6709\u6548\u7684\u86cb\u767d\u8d28\u9aa8\u67b6\uff0c\u65e2\u4e3a\u5b9a\u5236\u5316\u4eba\u5de5\u9176\u5f00\u53d1\u5f00\u8f9f\u65b0\u8def\u5f84\uff0c\u4e5f\u4e3a\u7814\u7a76\u86cb\u767d\u8d28\u201c\u7ed3\u6784-\u529f\u80fd\u201d\u5173\u7cfb\u63d0\u4f9b\u4e86\u4eba\u5de5\u8bbe\u8ba1\u6a21\u578b\u3002<\/p>\n\n\n\n<p>\u539f\u6587\u4fe1\u606f\uff1aKim, D., Woodbury, S.M., Ahern, W. et al. Computational design of metallohydrolases. Nature (2025).<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41586-025-09746-w\">https:\/\/doi.org\/10.1038\/s41586-025-09746-w<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001\u3010\u79d1\u5b66\u80cc\u666f\u3011 \u91d1\u5c5e\u6c34\u89e3\u9176\u4f5c\u4e3a\u4e00\u7c7b\u4f9d\u8d56\u91d1\u5c5e\u79bb\u5b50\uff08\u5982Zn2+\u3001Fe3+\uff09\u5b9e\u73b0\u50ac\u5316\u529f\u80fd\u7684\u9176\u5206\u5b50\uff0c\u5728\u751f\u7269\u4ee3\u8c22\u4e0e\u73af\u5883\u6c61\u67d3\u7269\u964d\u89e3\u4e2d\u5177\u6709\u4e0d\u53ef\u66ff\u4ee3\u7684\u4f5c\u7528\u3002\u5728\u73af\u5883\u6cbb\u7406\u9886\u57df\uff0c\u8be5&#8230;<\/p>\n","protected":false},"author":186431,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[293],"class_list":["post-269716","post","type-post","status-publish","format-standard","hentry","category-keji","tag-nature"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/269716"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/186431"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=269716"}],"version-history":[{"count":1,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/269716\/revisions"}],"predecessor-version":[{"id":269723,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/269716\/revisions\/269723"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=269716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=269716"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=269716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}