{"id":269772,"date":"2025-12-07T06:44:00","date_gmt":"2025-12-06T22:44:00","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=269772"},"modified":"2025-12-07T00:47:24","modified_gmt":"2025-12-06T16:47:24","slug":"%e9%a6%96%e6%ac%a1%e5%ae%9e%e9%aa%8c%e6%b5%8b%e9%87%8f%ef%bc%81%e5%91%a8%e5%8d%8e%e6%96%8c%ef%bc%8cscience%ef%bc%81","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=269772","title":{"rendered":"\u9996\u6b21\u5b9e\u9a8c\u6d4b\u91cf\uff01\u5468\u534e\u658c\uff0cScience\uff01"},"content":{"rendered":"\n<p>\u5c0f\u827a<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>\u3010\u79d1\u5b66\u80cc\u666f\u3011<\/strong><\/p>\n\n\n\n<p>\u751f\u7269\u5206\u5b50\u51dd\u805a\u4f53\u662f\u4e00\u7c7b\u65e0\u819c\u533a\u5ba4\uff0c\u80fd\u591f\u5bcc\u96c6\u5927\u5206\u5b50\u5e76\u53c2\u4e0e\u591a\u79cd\u7ec6\u80de\u8fc7\u7a0b\u3002\u67d3\u8272\u8d28\u4f5c\u4e3a\u5b58\u50a8\u9057\u4f20\u4fe1\u606f\u7684DNA-\u7ec4\u86cb\u767d\u590d\u5408\u7269\uff0c\u5728\u4f53\u5916\u548c\u7ec6\u80de\u5185\u5747\u53ef\u53d1\u751f\u76f8\u5206\u79bb\u5f62\u6210\u51dd\u805a\u4f53\u3002\u7136\u800c\uff0c\u6838\u5c0f\u4f53\u5982\u4f55\u4ece\u5355\u4e2a\u5355\u5143\u9010\u6b65\u7ec4\u88c5\u5f62\u6210\u53ef\u89c1\u7684\u51dd\u805a\u4f53\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u5982\u4f55\u51b3\u5b9a\u51dd\u805a\u4f53\u7684\u6750\u6599\u6027\u8d28\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>\u3010\u521b\u65b0\u6210\u679c\u3011<\/strong><\/p>\n\n\n\n<p>\u8fd1\u65e5\uff0c<strong>\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3(UT Southwestern Medical Center) \u7684 Michael K. Rosen \u56e2\u961f\u5468\u534e\u658c\u7b49\u4eba\u8054\u5408\u5251\u6865\u5927\u5b66Rosana Collepardo-Guevara\u7b49\u7814\u7a76\u8005\u5728Science\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cMultiscale structure of chromatin condensates explains phase separation and material properties\u201d\u7684\u8bba\u6587\uff0c\u9996\u6b21\u5b9e\u73b0\u4e86\u4ece\u5355\u4e2a\u6838\u5c0f\u4f53\u300112 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class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"830\" height=\"365\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/image-1.jpg\" alt=\"\" class=\"wp-image-269773\" \/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center\"><strong>\u3010\u56fe\u6587\u89e3\u6790\u3011<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1007\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/image-6.jpeg\" alt=\"\" class=\"wp-image-269777\" \/><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>1 <\/strong><strong>\u8fde\u63a5\u5b50\u957f\u5ea6\u51b3\u5b9a\u76d0\u6d53\u5ea6\u4f9d\u8d56\u7684\u67d3\u8272\u8d28\u7ea4\u7ef4\u6298\u53e0\u6a21\u5f0f<\/strong><strong>\u00a9 2025 AAAS<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"780\" height=\"1199\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/image-5.jpeg\" alt=\"\" class=\"wp-image-269778\" \/><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>2 <\/strong><strong>\u7ec4\u86cb\u767d\u5c3e\u90e8\u76f8\u4e92\u4f5c\u7528\u6a21\u5f0f\u7684\u5dee\u5f02\u8c03\u63a7<\/strong><strong>\u00a9 2025 AAAS<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"683\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/image-2.jpeg\" alt=\"\" class=\"wp-image-269775\" \/><\/figure>\n\n\n\n<p><strong>\u56fe3 \u5728\u51dd\u805a\u76f8\u4e2d25 bp\u4e0e30 bp\u67d3\u8272\u8d28\u7684\u5206\u5b50\u7ed3\u6784\u5dee\u5f02<\/strong><a><strong>\u00a9 2025 AAAS<\/strong><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"780\" height=\"1066\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/image-4.jpeg\" alt=\"\" class=\"wp-image-269776\" \/><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>4 <\/strong><strong>\u8fde\u63a5\u5b50\u957f\u5ea6\u51b3\u5b9a\u51dd\u805a\u76f8\u4e2d\u5206\u5b50\u5185\u4e0e\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u5e73\u8861<\/strong><strong>\u00a9 2025 AAAS<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"721\" height=\"919\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/image-3.jpeg\" alt=\"\" class=\"wp-image-269774\" \/><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>5 <\/strong><strong>\u4ece\u7f51\u7edc\u8fde\u901a\u6027\u4e0e\u52a8\u6001\u7279\u6027\u89d2\u5ea6<\/strong><strong>25 bp<\/strong><strong>\u4e0e<\/strong><strong>30 bp<\/strong><strong>\u67d3\u8272\u8d28\u51dd\u805a\u4f53\u7684\u6750\u6599\u6027\u8d28\u6bd4\u8f83<\/strong><strong>\u00a9 2025 AAAS<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"935\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2025\/12\/image-7.jpeg\" alt=\"\" class=\"wp-image-269779\" \/><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>6 <\/strong><strong>\u5929\u7136\u67d3\u8272\u8d28\u5f62\u6210\u7c7b\u4f3c\u4e8e<\/strong><strong>25bp<\/strong><strong>\u67d3\u8272\u8d28\u51dd\u805a\u4f53\u7684\u79bb\u6563\u7ed3\u6784\u57df<\/strong><strong>\u00a9 2025 AAAS<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>\u3010\u79d1\u5b66\u542f\u8fea\u3011<\/strong><\/p>\n\n\n\n<p>\u901a\u8fc7\u4ece\u5355\u6838\u5c0f\u4f53\u5230\u5206\u5b50\u7f51\u7edc\u7684\u591a\u5c3a\u5ea6\u5b9e\u9a8c\u4e0e\u6a21\u62df\uff0c\u8be5\u9879\u7814\u7a76\u9610\u660eDNA\u8fde\u63a5\u5b50\u957f\u5ea6\u7684\u53d8\u5316\u80fd\u591f\u5f15\u5bfc\u67d3\u8272\u8d28\u51dd\u805a\u4f53\u5728\u7eb3\u7c73\u81f3\u5fae\u7c73\u5c3a\u5ea6\u4e0a\u7684\u7ed3\u6784\u7ec4\u7ec7\u4e0e\u529b\u5b66\u6027\u8d28\u300225 bp\u8fde\u63a5\u5b50\u4fc3\u8fdb\u5f62\u6210\u5f3a\u5206\u5b50\u95f4\u4f5c\u7528\u7f51\u7edc\uff0c\u4ea7\u751f\u7a33\u5b9a\u6027\u9ad8\u3001\u7c98\u5f39\u6027\u663e\u8457\u7684\u51dd\u805a\u4f53\uff1b30 bp\u8fde\u63a5\u5b50\u5219\u503e\u5411\u4e8e\u5206\u5b50\u5185\u5806\u53e0\uff0c\u5f62\u6210\u5f31\u8fde\u63a5\u3001\u9ad8\u52a8\u6001\u7684\u51dd\u805a\u4f53\u3002\u8fd9\u4e00\u591a\u5c3a\u5ea6\u7ed3\u6784\u6846\u67b6\u63ed\u793a\u4e86\u7ec6\u80de\u53ef\u80fd\u901a\u8fc7\u8c03\u63a7\u6838\u5c0f\u4f53\u95f4\u8ddd\u3001\u7ec4\u86cb\u767d\u4fee\u9970\u6216\u76f8\u5173\u56e0\u5b50\uff0c\u5b9e\u73b0\u67d3\u8272\u8d28\u6750\u6599\u72b6\u6001\u7684\u5207\u6362\uff0c\u4ece\u800c\u5f71\u54cd\u57fa\u56e0\u8c03\u63a7\u548c\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u3002\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u5408\u6210\u67d3\u8272\u8d28\u51dd\u805a\u4f53\u5728\u7ed3\u6784\u4e0a\u6a21\u62df\u4e86\u7ec6\u80de\u5185\u5929\u7136\u67d3\u8272\u8d28\u7684\u9ad8\u5bc6\u5ea6\u533a\u57df\uff0c\u4e3a\u7406\u89e3\u67d3\u8272\u8d28\u5728\u7ec6\u80de\u5185\u7684\u7ec4\u7ec7\u673a\u5236\u63d0\u4f9b\u4e86\u91cd\u8981\u4f9d\u636e\u3002<\/p>\n\n\n\n<p>\u539f\u6587\u8be6\u60c5\uff1aHuabin Zhou et al., Multiscale structure of chromatin condensates explains phase separation and material properties. Science390, eadv6588(2025). DOI:10.1126\/science.adv6588<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5c0f\u827a \u3010\u79d1\u5b66\u80cc\u666f\u3011 \u751f\u7269\u5206\u5b50\u51dd\u805a\u4f53\u662f\u4e00\u7c7b\u65e0\u819c\u533a\u5ba4\uff0c\u80fd\u591f\u5bcc\u96c6\u5927\u5206\u5b50\u5e76\u53c2\u4e0e\u591a\u79cd\u7ec6\u80de\u8fc7\u7a0b\u3002\u67d3\u8272\u8d28\u4f5c\u4e3a\u5b58\u50a8\u9057\u4f20\u4fe1\u606f\u7684DNA-\u7ec4\u86cb\u767d\u590d\u5408\u7269\uff0c\u5728\u4f53\u5916\u548c\u7ec6\u80de\u5185\u5747\u53ef\u53d1\u751f\u76f8\u5206\u79bb\u5f62&#8230;<\/p>\n","protected":false},"author":35295,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-269772","post","type-post","status-publish","format-standard","hentry","category-keji"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/269772"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/35295"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=269772"}],"version-history":[{"count":2,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/269772\/revisions"}],"predecessor-version":[{"id":269783,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/269772\/revisions\/269783"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=269772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=269772"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=269772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}