{"id":272048,"date":"2026-05-29T08:26:00","date_gmt":"2026-05-29T00:26:00","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=272048"},"modified":"2026-05-28T22:27:58","modified_gmt":"2026-05-28T14:27:58","slug":"%e7%ba%b3%e7%b1%b3%e7%94%9f%e7%89%a9%e5%88%86%e5%ad%90%e5%87%9d%e8%81%9a%e4%bd%93%e7%94%a8%e4%ba%8e%e8%83%9e%e5%86%85%e8%87%b4%e7%97%85%e8%9b%8b%e7%99%bd%e9%99%8d%e8%a7%a3","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=272048","title":{"rendered":"\u7eb3\u7c73\u751f\u7269\u5206\u5b50\u51dd\u805a\u4f53\u7528\u4e8e\u80de\u5185\u81f4\u75c5\u86cb\u767d\u964d\u89e3"},"content":{"rendered":"\n<p>\u86cb\u767d\u964d\u89e3\u5242\u7684\u7814\u53d1\u9010\u6e10\u4ece\u5e7f\u8c31\u86cb\u767d\u5e72\u9884\u8fdb\u5165\u81f4\u75c5\u8868\u578b\u86cb\u767d\u9009\u62e9\u6027\u6e05\u9664\uff08phenotype-selective clearance\uff09\u3002\u7136\u800c\uff0c\u5bf9\u4e8e KRAS \u7b49\u7ecf\u5178\u81f4\u764c\u86cb\u767d\u800c\u8a00\uff0c\u5c24\u5176\u662f KRAS G12V\u7b49\u5355\u6c28\u57fa\u9178\u53d8\u5f02\u7684\u7a81\u53d8\u4f53\uff0c\u5982\u4f55\u5728\u4fdd\u7559\u91ce\u751f\u578b KRAS \u751f\u7406\u529f\u80fd\u7684\u540c\u65f6\u5b9e\u73b0\u81f4\u75c5\u8868\u578b\u7684\u964d\u89e3\uff0c\u662f\u7cbe\u51c6\u533b\u7597\u9886\u57df\u7684\u6311\u6218\u4e4b\u4e00\u3002<\/p>\n\n\n\n<p>\u8fd1\u671f, \u7f8e\u56fd\u897f\u5317\u5927\u5b66(Northwestern University) International Institute for Nanotechnology&nbsp;Prof. Shana Kelley \u56e2\u961f\u63d0\u51fa\u4e86\u4e00\u79cd\u57fa\u4e8e\u751f\u7269\u5206\u5b50\u51dd\u805a\u4f53\uff08biomolecular condensates\uff09\u7684\u65b0\u578b\u86cb\u767d\u964d\u89e3\u5de5\u5177\u3002\u7814\u7a76\u8005\u5229\u7528\u6db2-\u6db2\u76f8\u5206\u79bb\u6784\u5efa\u7eb3\u7c73\u7ea7\u201c\u4eba\u5de5\u7ec6\u80de\u5668\u201d\uff0c\u5c06\u6297\u4f53\u5c01\u88c5\u3001\u7a81\u53d8\u8bc6\u522b\u4e0e\u86cb\u767d\u9176\u4f53\u62db\u52df\u7b49\u529f\u80fd\u6574\u5408\u4e8e\u540c\u4e00\u751f\u7269\u5206\u5b50\u51dd\u805a\u4f53\u4e2d\uff0c\u5b9e\u73b0\u4e86\u5bf9 KRAS G12V \u7b49\u80de\u5185\u81f4\u75c5\u86cb\u767d\u7684\u9009\u62e9\u6027\u964d\u89e3,&nbsp;\u5728\u5929\u7136\u86cb\u767d\u7a33\u6001\u7f51\u7edc\u4e2d\u5b8c\u6210\u9776\u86cb\u767d\u6e05\u9664\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"377\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2026\/05\/2382c315a6ba396-31.png\" alt=\"\" class=\"wp-image-272049\"\/><\/figure>\n\n\n\n<p><strong>\u672c\u6587\u8981\u70b9<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u81f4\u75c5\u8868\u578b\u86cb\u767d\u9009\u62e9\u6027\u964d\u89e3: KRAS G12V \u4e0e\u91ce\u751f\u578b KRAS \u4ec5\u5b58\u5728\u5355\u6c28\u57fa\u9178\u5dee\u5f02\uff0c\u4f7f\u7a81\u53d8\u4f53\u9009\u62e9\u6027\u6e05\u9664\u6210\u4e3a\u7cbe\u51c6\u6cbb\u7597\u4e2d\u7684\u6838\u5fc3\u6311\u6218\u3002\u4f5c\u8005\u5229\u7528\u6db2-\u6db2\u76f8\u5206\u79bb\uff08liquid\u2013liquid phase separation, LLPS\uff09\u5bcc\u96c6 KRAS G12V \u7279\u5f02\u6027\u6297\u4f53\uff0c\u5e76\u901a\u8fc7\u591a\u915a-\u91d1\u5c5e\u7f51\u7edc\uff08metal\u2013phenolic network, MPN\uff09\u534a\u900f\u58f3\u5c42\u5c06\u51dd\u805a\u4f53\u7eb3\u7c73\u5316\u5e76\u63d0\u5347\u80f6\u4f53\u7a33\u5b9a\u6027\uff0c\u4ece\u800c\u5b9e\u73b0\u9ad8\u6548\u3001\u5747\u4e00\u7684\u80de\u8d28\u9012\u9001\uff0c\u4ee5\u53ca\u5bf9\u81f4\u75c5 KRAS \u7a81\u53d8\u4f53\u7684\u9009\u62e9\u6027\u8bc6\u522b\u4e0e\u964d\u89e3\u3002\u8be5\u4f53\u7cfb\u5728\u4f53\u5916\u6742\u5408\u5b50\u7ec6\u80de\u4e2d\u9009\u62e9\u6027\u964d\u89e3 KRAS G12V \u800c\u4fdd\u7559\u91ce\u751f\u578b KRAS\uff0c\u5e76\u5728\u4f53\u5185\u8bd5\u9a8c\u663e\u8457\u6291\u5236 KRAS G12V\u80bf\u7624\u751f\u957f\uff0c\u5b9e\u73b0\u201cdisease-causing phenotype\u2013restricted clearance\u201d.<\/li>\n\n\n\n<li>\u5229\u7528\u7ec6\u80de\u5185\u6e90\u6027\u86cb\u767d\u7a33\u6001\u7cfb\u7edf\u5b9e\u73b0\u964d\u89e3: \u4f20\u7edf\u86cb\u767d\u964d\u89e3\u5e73\u53f0\u591a\u4f9d\u8d56\u5916\u6e90\u6cdb\u7d20\u5316\u5de5\u7a0b\u6216 E3 ligase \u91cd\u7f16\u7a0b\uff0c\u96be\u4ee5\u9002\u914d\u4e0d\u540c\u7ec6\u80de\u73af\u5883. \u4f5c\u8005\u5728\u51dd\u805a\u4f53\u524d\u9a71\u80bd\u4e2d\u5f15\u5165 RRRG \u86cb\u767d\u9176\u4f53\u62db\u52df\u5e8f\u5217\uff0c\u76f4\u63a5\u8c03\u7528\u7ec6\u80de native proteasome disposal system\uff0c\u5b9e\u73b0 ubiquitin-independent degradation\u3002\u86cb\u767d\u9176\u4f53\u6291\u5236\u5b9e\u9a8c\u3001\u5206\u5b50\u5bf9\u63a5\u3001\u4e34\u8fd1\u6807\u8bb0\u7b49\u5206\u6790\u8868\u660e, \u51dd\u805a\u4f53\u53ef\u76f4\u63a5\u52df\u96c6\u5185\u6e90\u6027\u86cb\u767d\u9176\u4f53\u5e76\u89e6\u53d1\u9776\u86cb\u767d\u964d\u89e3\uff0c\u5c55\u793a\u51fa\u4e00\u79cd\u65e0\u9700\u57fa\u56e0\u6539\u9020\u3001\u53ef\u6a21\u5757\u5316\u6269\u5c55\u7684\u7ec6\u80de\u5185\u86cb\u767d\u964d\u89e3\u5de5\u5177<\/li>\n<\/ul>\n\n\n\n<p><strong>\u603b\u7ed3<\/strong>:<\/p>\n\n\n\n<p>\u672c\u6587\u63d0\u51fa\u4e00\u79cd\u57fa\u4e8e\u751f\u7269\u5206\u5b50\u51dd\u805a\u4f53\u7684\u7ec6\u80de\u5185\u86cb\u767d\u964d\u89e3\u7cfb\u7edf\uff0c\u901a\u8fc7\u6db2-\u6db2\u76f8\u5206\u79bb\u6784\u5efa\u6297\u4f53\u5bcc\u96c6\u578b\u7eb3\u7c73\u51dd\u805a\u4f53\uff0c\u5e76\u76f4\u63a5\u8c03\u7528\u7ec6\u80de\u5185\u6e90\u6027\u86cb\u767d\u9176\u4f53\u7cfb\u7edf\uff0c\u5b9e\u73b0 KRAS G12V \u7684\u81f4\u75c5\u8868\u578b\u9009\u62e9\u6027\u964d\u89e3\uff0c\u800c\u4fdd\u7559\u91ce\u751f\u578b KRAS \u529f\u80fd\uff0c\u4e3a\u201cundruggable\u201d\u80de\u5185\u81f4\u75c5\u86cb\u767d\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u7f16\u7a0b\u7684\u7cbe\u51c6\u6e05\u9664\u7b56\u7565\u3002<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e: Li, Y., Jin, Z., Ahmed, S. U., Das, J., Bleher, R., Chang, D., &#8230; &amp; Kelley, S. O. (2026). Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets.&nbsp;<em>Nature<\/em><em>&nbsp;Communications<\/em>.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"308\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2026\/05\/ce6e2814f207c93-29.png\" alt=\"\" class=\"wp-image-272050\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u86cb\u767d\u964d\u89e3\u5242\u7684\u7814\u53d1\u9010\u6e10\u4ece\u5e7f\u8c31\u86cb\u767d\u5e72\u9884\u8fdb\u5165\u81f4\u75c5\u8868\u578b\u86cb\u767d\u9009\u62e9\u6027\u6e05\u9664\uff08phenotype-selective clearance\uff09\u3002\u7136\u800c\uff0c\u5bf9\u4e8e KRAS \u7b49\u7ecf\u5178\u81f4\u764c\u86cb\u767d&#8230;<\/p>\n","protected":false},"author":31345,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-272048","post","type-post","status-publish","format-standard","hentry","category-keji"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/272048"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/31345"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=272048"}],"version-history":[{"count":1,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/272048\/revisions"}],"predecessor-version":[{"id":272051,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/272048\/revisions\/272051"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=272048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=272048"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=272048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}