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  • **CAT\u6837\u6d3b\u6027\uff1a**\u4fc3\u8fdb\u8fc7\u6c27\u5316\u6c22\u5206\u89e3\u4e3a\u6c34\u548c\u6c27\u6c14\u3002<\/li>\n<\/ul>\n\n\n\n

    \u5728\u76f8\u5e94\u5b9e\u9a8c\u6761\u4ef6\u4e0b\uff0cK-SAC\u7684\u8d85\u6c27\u9634\u79bb\u5b50\u6e05\u9664\u80fd\u529b\u660e\u663e\u9ad8\u4e8e\u4e0d\u542b\u94be\u7684\u6c2e\u63ba\u6742\u78b3\u5bf9\u7167\uff0c\u5e76\u8868\u73b0\u51fa\u8f83\u5f3a\u7684\u8fc7\u6c27\u5316\u6c22\u5206\u89e3\u80fd\u529b\u3002\u6750\u6599\u5728\u5ba4\u6e29\u73af\u5883\u50a8\u5b586\u4e2a\u6708<\/strong>\u540e\u4ecd\u80fd\u4fdd\u6301\u76f8\u5e94\u6d3b\u6027\uff0c\u63d0\u793a\u5176\u5177\u6709\u4e00\u5b9a\u7684\u50ac\u5316\u7a33\u5b9a\u6027\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe2\uff5cK-SAC\u7684ROS\u7ea7\u8054\u6e05\u9664\u80fd\u529b\u53ca\u7406\u8bba\u673a\u5236\u3002<\/strong>
    K-SAC\u540c\u65f6\u8868\u73b0\u51faSOD\u6837\u548cCAT\u6837\u6d3b\u6027\uff0c\u53ef\u4f9d\u6b21\u4fc3\u8fdb\u8d85\u6c27\u9634\u79bb\u5b50\u548c\u8fc7\u6c27\u5316\u6c22\u7684\u6e05\u9664\u3002\u81ea\u7531\u80fd\u8ba1\u7b97\u548c\u7535\u5b50\u7ed3\u6784\u5206\u6790\u7528\u4e8e\u89e3\u91caK\u2013N\u6d3b\u6027\u4e2d\u5fc3\u4e0e\u53cd\u5e94\u4e2d\u95f4\u4f53\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n\n\n\n

    \u56db\u3001\u7406\u8bba\u8ba1\u7b97\u63ed\u793a\uff1as\u533a\u5143\u7d20\u4e5f\u53ef\u80fd\u53c2\u4e0e\u6297\u6c27\u5316\u50ac\u5316<\/strong><\/strong><\/p>\n\n\n\n

    \u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba\u8ba1\u7b97\u663e\u793a\uff0cK\u2013N\u5c40\u90e8\u914d\u4f4d\u4e2d\u5fc3\u80fd\u591f\u8c03\u8282\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u5438\u9644\u548c\u53cd\u5e94\u81ea\u7531\u80fd\u53d8\u5316\uff0c\u4f7f\u6a21\u578b\u4e2d\u7684SOD\u6837\u548cCAT\u6837\u53cd\u5e94\u5728\u70ed\u529b\u5b66\u4e0a\u66f4\u52a0\u6709\u5229\u3002<\/p>\n\n\n\n

    \u7535\u5b50\u7ed3\u6784\u5206\u6790\u8fdb\u4e00\u6b65\u63d0\u793a\uff0c\u94be\u4e0e\u5468\u56f4\u914d\u4f4d\u6c2e\u539f\u5b50\u4e4b\u95f4\u53d1\u751f\u660e\u663e\u7684\u7535\u8377\u91cd\u65b0\u5206\u5e03\u3002\u4e0e\u901a\u5e38\u4f9d\u8d56d\u8f68\u9053\u53c2\u4e0e\u5438\u9644\u7684\u8fc7\u6e21\u91d1\u5c5e\u5355\u539f\u5b50\u50ac\u5316\u5242\u4e0d\u540c\uff0cK-SAC\u4e2d\u94be\u76844s\u53ca3p\u8f68\u9053\u53ef\u80fd\u53c2\u4e0e\u5176\u4e0e\u542b\u6c27\u4e2d\u95f4\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n\n\n\n

    \u8fd9\u9879\u7ed3\u679c\u7684\u610f\u4e49\u5e76\u4e0d\u5c40\u9650\u4e8e\u53d1\u73b0\u4e00\u79cd\u65b0\u7684\u6297\u6c27\u5316\u6750\u6599\u3002\u5b83\u8fd8\u63d0\u793a\uff1a<\/p>\n\n\n\n

    \u901a\u8fc7\u7cbe\u786e\u8bbe\u8ba1\u5c40\u90e8\u914d\u4f4d\u73af\u5883\uff0c\u4f20\u7edf\u4e0a\u88ab\u8ba4\u4e3a\u50ac\u5316\u6d3b\u6027\u6709\u9650\u7684s\u533a\u5143\u7d20\uff0c\u4e5f\u6709\u53ef\u80fd\u6210\u4e3a\u751f\u7269\u50ac\u5316\u6750\u6599\u4e2d\u7684\u539f\u5b50\u7ea7\u6d3b\u6027\u4e2d\u5fc3\u3002<\/strong><\/p>\n\n\n\n

    \u4e94\u3001K-SAC\u5982\u4f55\u627e\u5230\u80ba\u90e8\u5de8\u566c\u7ec6\u80de\uff1f<\/strong><\/strong><\/p>\n\n\n\n

    \u7ecf\u8367\u5149\u6807\u8bb0\u540e\uff0cK-SAC\u7ed9\u836f\u540e\u7684\u4fe1\u53f7\u4e3b\u8981\u51fa\u73b0\u5728\u80ba\u90e8\uff0c\u5e76\u4e0eF4\/80\u9633\u6027\u5de8\u566c\u7ec6\u80de\u51fa\u73b0\u660e\u663e\u5171\u5b9a\u4f4d\u3002\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0c\u9aa8\u9ad3\u6765\u6e90\u5de8\u566c\u7ec6\u80de\u548c\u8179\u8154\u5de8\u566c\u7ec6\u80de\u5747\u53ef\u6444\u53d6K-SAC\u3002<\/p>\n\n\n\n

    \u7814\u7a76\u8ba4\u4e3a\uff0c\u8fd9\u79cd\u6444\u53d6\u4e3b\u8981\u6765\u81ea\u88ab\u52a8\u673a\u5236\uff1a\u7ea6200\u7eb3\u7c73\u7684\u7c92\u5f84\u3001\u4ecb\u5b54\u7ed3\u6784\uff0c\u4ee5\u53ca\u708e\u75c7\u73af\u5883\u4e2d\u6d3b\u5316\u5de8\u566c\u7ec6\u80de\u8f83\u5f3a\u7684\u541e\u566c\u80fd\u529b\uff0c\u5171\u540c\u4fc3\u8fdb\u4e86\u6750\u6599\u5185\u5316\u3002<\/p>\n\n\n\n

    \u56e0\u6b64\uff0cK-SAC\u5e76\u4e0d\u662f\u901a\u8fc7\u6297\u4f53\u6216\u914d\u4f53\u8bc6\u522b\u5b9e\u73b0\u4e3b\u52a8\u9776\u5411\uff0c\u800c\u662f\u5229\u7528\u80ba\u90e8\u708e\u75c7\u73af\u5883\u53ca\u5de8\u566c\u7ec6\u80de\u7684\u5929\u7136\u541e\u566c\u7279\u5f81\u5b9e\u73b0\u76f8\u5bf9\u5bcc\u96c6\u3002<\/p>\n\n\n\n

    \u968f\u540e\uff0c\u7814\u7a76\u4eba\u5458\u5728\u8102\u591a\u7cd6\u8bf1\u5bfc\u548c\u76f2\u80a0\u7ed3\u624e\u7a7f\u5b54\u8bf1\u5bfc\u7684\u4e24\u79cd\u6025\u6027\u80ba\u635f\u4f24\u6a21\u578b\u4e2d\u8bc4\u4ef7\u6cbb\u7597\u6548\u679c\u3002\u7ed3\u679c\u663e\u793a\uff0cK-SAC\u5904\u7406\u53ef\u51cf\u8f7b\u80ba\u6ce1\u58c1\u589e\u539a\u548c\u708e\u75c7\u7ec6\u80de\u6d78\u6da6\uff0c\u964d\u4f4e\u80ba\u635f\u4f24\u8bc4\u5206\u53ca\u80ba\u7ec4\u7ec7IL-1\u03b2\u6c34\u5e73\u3002<\/p>\n\n\n\n

    \u5f53\u4f7f\u7528\u6c2f\u81a6\u9178\u8102\u8d28\u4f53\u6e05\u9664\u5de8\u566c\u7ec6\u80de\u540e\uff0cK-SAC\u5bf9\u80ba\u635f\u4f24\u7684\u4fdd\u62a4\u4f5c\u7528\u660e\u663e\u51cf\u5f31\uff0c\u8fdb\u4e00\u6b65\u652f\u6301\u5de8\u566c\u7ec6\u80de\u5728\u5176\u6cbb\u7597\u6548\u5e94\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe3\uff5cK-SAC\u7684\u80ba\u90e8\u5bcc\u96c6\u3001\u5de8\u566c\u7ec6\u80de\u6444\u53d6\u53ca\u6297\u6025\u6027\u80ba\u635f\u4f24\u6548\u679c\u3002<\/strong>
    \u6d3b\u4f53\u53ca\u79bb\u4f53\u6210\u50cf\u663e\u793aK-SAC\u4fe1\u53f7\u4e3b\u8981\u5206\u5e03\u4e8e\u80ba\u90e8\uff1b\u514d\u75ab\u8367\u5149\u548c\u7535\u955c\u7ed3\u679c\u652f\u6301\u5de8\u566c\u7ec6\u80de\u6444\u53d6\u3002K-SAC\u53ef\u6539\u5584LPS\u53caCLP\u8bf1\u5bfc\u5c0f\u9f20\u7684\u80ba\u7ec4\u7ec7\u75c5\u7406\u8868\u73b0\uff0c\u964d\u4f4e\u80ba\u635f\u4f24\u8bc4\u5206\u548cIL-1\u03b2\u6c34\u5e73\u3002<\/p>\n\n\n\n

    \u516d\u3001\u6e05\u9664ROS\u4e4b\u540e\uff0c\u7126\u4ea1\u901a\u8def\u53d1\u751f\u4e86\u4ec0\u4e48\uff1f<\/strong><\/strong><\/p>\n\n\n\n

    RNA\u6d4b\u5e8f\u5206\u6790\u63d0\u793a\uff0cK-SAC\u5904\u7406\u540e\u591a\u6761\u7126\u4ea1\u76f8\u5173\u901a\u8def\u53d7\u5230\u6291\u5236\u3002<\/p>\n\n\n\n

    \u8fdb\u4e00\u6b65\u7684\u7ec6\u80de\u5b9e\u9a8c\u663e\u793a\uff0c\u5728LPS\u548cATP\u8bf1\u5bfc\u7684\u5de8\u566c\u7ec6\u80de\u7126\u4ea1\u6a21\u578b\u4e2d\uff0cK-SAC\u964d\u4f4e\u4e86\u7898\u5316\u4e19\u5576\u67d3\u8272\u4fe1\u53f7\uff0c\u51cf\u8f7b\u4e86\u7ec6\u80de\u819c\u901a\u900f\u6027\u589e\u52a0\u548c\u7ec6\u80de\u6b7b\u4ea1\u3002\u7535\u955c\u89c2\u5bdf\u663e\u793a\uff0cK-SAC\u5904\u7406\u540e\u7ec6\u80de\u819c\u7834\u88c2\u3001\u7126\u4ea1\u5c0f\u4f53\u5f62\u6210\u53ca\u7ebf\u7c92\u4f53\u635f\u4f24\u5747\u6709\u6240\u51cf\u8f7b\u3002<\/p>\n\n\n\n

    \u5728\u5206\u5b50\u5c42\u9762\uff0cK-SAC\u964d\u4f4e\u4e86caspase-1\u6d3b\u5316\u3001\u5168\u957fGSDMD\u53ca\u5176\u6210\u5b54\u76f8\u5173N\u7aef\u7247\u6bb5\u7684\u6c34\u5e73\uff0c\u800c\u5bf9caspase-3\u548cGSDME\u901a\u8def\u7684\u5f71\u54cd\u76f8\u5bf9\u6709\u9650\uff0c\u63d0\u793a\u5176\u4f5c\u7528\u4e3b\u8981\u4e0ecaspase-1\/GSDMD\u76f8\u5173\u7126\u4ea1\u8f74\u6709\u5173\u3002<\/p>\n\n\n\n

    \u4e0e\u6b64\u540c\u65f6\uff0cK-SAC\u964d\u4f4e\u4e86\u7ec6\u80de\u5185\u603bROS\u548c\u7ebf\u7c92\u4f53ROS\uff0c\u5e2e\u52a9\u7ef4\u6301\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\uff0c\u5e76\u51cf\u5c11IL-1\u03b2\u548cIL-18\u91ca\u653e\u3002GSDMD\u5c0f\u5e72\u6270RNA\u548c\u7126\u4ea1\u6291\u5236\u5242\u5b9e\u9a8c\u4e5f\u652f\u6301K-SAC\u7684\u4fdd\u62a4\u4f5c\u7528\u4e0eGSDMD\u76f8\u5173\u3002<\/p>\n\n\n\n

    \u6362\u53e5\u8bdd\u8bf4\uff0cK-SAC\u5e76\u4e0d\u662f\u7b80\u5355\u5730\u201c\u5438\u6536\u201d\u67d0\u4e00\u79cd\u81ea\u7531\u57fa\uff0c\u800c\u662f\u901a\u8fc7\u8fde\u7eed\u7684\u6297\u6c27\u5316\u50ac\u5316\uff0c\u51cf\u8f7b\u7ebf\u7c92\u4f53\u635f\u4f24\u548c\u708e\u75c7\u5c0f\u4f53\u76f8\u5173\u4fe1\u53f7\uff0c\u4ece\u4e0a\u6e38\u524a\u5f31\u7126\u4ea1\u53d1\u751f\u7684\u6761\u4ef6\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe4\uff5cK-SAC\u6291\u5236\u5de8\u566c\u7ec6\u80deGSDMD\u76f8\u5173\u7126\u4ea1\u5e76\u4fdd\u62a4\u7ebf\u7c92\u4f53\u3002<\/strong>
    \u8f6c\u5f55\u7ec4\u3001\u514d\u75ab\u8367\u5149\u3001\u7535\u955c\u3001Western blot\u53ca\u708e\u75c7\u56e0\u5b50\u68c0\u6d4b\u5171\u540c\u663e\u793a\uff0cK-SAC\u964d\u4f4e\u7ec6\u80de\u5185ROS\u548c\u7ebf\u7c92\u4f53ROS\uff0c\u6291\u5236caspase-1\/GSDMD\u76f8\u5173\u7126\u4ea1\u4fe1\u53f7\uff0c\u5e76\u51cf\u5c11IL-1\u03b2\u548cIL-18\u91ca\u653e\u3002<\/p>\n\n\n\n

    \u4e03\u3001\u9664\u4e86\u6291\u5236\u6210\u5b54\uff0c\u7ec6\u80de\u819c\u8fd8\u80fd\u5426\u5f97\u5230\u201c\u4fee\u8865\u201d\uff1f<\/strong><\/strong><\/p>\n\n\n\n

    GSDMD\u5728\u7ec6\u80de\u819c\u4e0a\u5f62\u6210\u5b54\u9053\u5e76\u4e0d\u610f\u5473\u7740\u7ec6\u80de\u4e00\u5b9a\u4f1a\u7acb\u5373\u7834\u88c2\u3002\u7ec6\u80de\u81ea\u8eab\u62e5\u6709\u4e00\u5957\u819c\u635f\u4f24\u4fee\u590d\u7cfb\u7edf\uff0c\u5176\u4e2dESCRT\u590d\u5408\u4f53\u53ef\u4ee5\u53c2\u4e0e\u79fb\u9664\u6216\u4fee\u590d\u53d7\u635f\u819c\u533a\u57df\u3002<\/p>\n\n\n\n

    \u7814\u7a76\u53d1\u73b0\uff0cK-SAC\u5904\u7406\u540e\uff0cESCRT-III\u76f8\u5173\u7ec4\u5206CHMP2A\u3001CHMP6\u4ee5\u53ca\u8c03\u8282\u56e0\u5b50VPS4A\/B\u8868\u8fbe\u5347\u9ad8\uff1b\u540c\u65f6\uff0c\u7ec6\u80de\u5185\u9499\u79bb\u5b50\u6d41\u5165\u51cf\u5c11\uff0c\u63d0\u793a\u819c\u901a\u900f\u6027\u548c\u5b8c\u6574\u6027\u5f97\u5230\u6539\u5584\u3002<\/p>\n\n\n\n

    \u8102\u8d28\u7ec4\u5b66\u5206\u6790\u8fd8\u663e\u793a\uff0cK-SAC\u5904\u7406\u540e\uff0c\u7126\u4ea1\u5de8\u566c\u7ec6\u80de\u4e2d\u7684\u591a\u7c7b\u819c\u7ed3\u6784\u8102\u8d28\u53d1\u751f\u53d8\u5316\uff0c\u5176\u4e2d\u5305\u62ec\u78f7\u8102\u9170\u80c6\u78b1\u3001\u78f7\u8102\u9170\u4e59\u9187\u80fa\u548c\u9798\u78f7\u8102\u7b49\uff0c\u5e76\u4f34\u6709\u542b\u4e0d\u9971\u548c\u8102\u80aa\u9178\u78f7\u8102\u6bd4\u4f8b\u53d8\u5316\u3002<\/p>\n\n\n\n

    \u8fd9\u4e9b\u7ed3\u679c\u63d0\u793a\uff0cK-SAC\u7684\u4f5c\u7528\u53ef\u80fd\u4e0d\u4ec5\u5305\u62ec\u51cf\u5c11GSDMD\u6210\u5b54\uff0c\u8fd8\u4e0eESCRT\u76f8\u5173\u819c\u4fee\u590d\u53cd\u5e94\u548c\u819c\u78f7\u8102\u7ec4\u6210\u8c03\u6574\u76f8\u8054\u7cfb\u3002<\/p>\n\n\n\n

    \u9700\u8981\u5f3a\u8c03\u7684\u662f\uff0c\u76ee\u524d\u7ed3\u679c\u652f\u6301\u7684\u662f\u8fd9\u4e9b\u53d8\u5316\u4e4b\u95f4\u7684\u5173\u8054\u53ca\u53ef\u80fd\u8054\u7cfb<\/strong>\u3002ESCRT\u53d8\u5316\u548c\u8102\u8d28\u91cd\u5851\u662f\u5426\u662fK-SAC\u6539\u5584\u819c\u5b8c\u6574\u6027\u7684\u5fc5\u8981\u73af\u8282\uff0c\u4ecd\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u529f\u80fd\u963b\u65ad\u5b9e\u9a8c\u9a8c\u8bc1\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe5\uff5cK-SAC\u4e0eESCRT\u76f8\u5173\u819c\u4fee\u590d\u53cd\u5e94\u53ca\u819c\u78f7\u8102\u53d8\u5316\u3002<\/strong>
    K-SAC\u51cf\u5c11\u7126\u4ea1\u7ec6\u80de\u7684\u9499\u79bb\u5b50\u6d41\u5165\uff0c\u4e0a\u8c03\u591a\u79cdESCRT\u76f8\u5173\u56e0\u5b50\uff0c\u5e76\u6539\u53d8PC\u3001PE\u3001SM\u7b49\u819c\u7ed3\u6784\u8102\u8d28\u53ca\u4e0d\u9971\u548c\u78f7\u8102\u7ec4\u6210\uff0c\u8fd9\u4e9b\u53d8\u5316\u4e0e\u819c\u5b8c\u6574\u6027\u6539\u5584\u76f8\u4f34\u968f\u3002<\/p>\n\n\n\n

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    \u540c\u65f6\uff0c\u80ba\u6e7f\u5e72\u91cd\u6bd4\u4e0b\u964d\uff0c\u63d0\u793a\u80ba\u6c34\u80bf\u548c\u80ba\u6ce1\u2014\u6bdb\u7ec6\u8840\u7ba1\u5c4f\u969c\u635f\u4f24\u5f97\u5230\u7f13\u89e3\u3002\u80ba\u7ec4\u7ec7Western blot\u7ed3\u679c\u8fdb\u4e00\u6b65\u663e\u793a\uff0cNLRP3\u3001caspase-1\u3001GSDMD\u53ca\u6210\u719fIL-1\u03b2\u7b49\u7126\u4ea1\u76f8\u5173\u5206\u5b50\u53d7\u5230\u6291\u5236\u3002<\/p>\n\n\n\n

    \u8fd9\u4e9b\u7ed3\u679c\u4e0e\u4f53\u5916\u7814\u7a76\u5f62\u6210\u4e86\u8f83\u4e3a\u5b8c\u6574\u7684\u8bc1\u636e\u94fe\uff1a<\/p>\n\n\n\n

    \u6297\u6c27\u5316\u50ac\u5316\u964d\u4f4eROS\u79ef\u7d2f\uff0c\u51cf\u8f7b\u7ebf\u7c92\u4f53\u635f\u4f24\u548c\u708e\u75c7\u5c0f\u4f53\u6d3b\u5316\uff0c\u6291\u5236GSDMD\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u7126\u4ea1\uff0c\u5e76\u6700\u7ec8\u7f13\u89e3\u80ba\u90e8\u708e\u75c7\u548c\u5c4f\u969c\u635f\u4f24\u3002<\/strong><\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe6\uff5cK-SAC\u5728\u5c0f\u9f20\u80ba\u7ec4\u7ec7\u4e2d\u6291\u5236\u5de8\u566c\u7ec6\u80de\u7126\u4ea1\u548c\u6c27\u5316\u5e94\u6fc0\u3002<\/strong>
    K-SAC\u964d\u4f4e\u80ba\u7ec4\u7ec7F4\/80\u3001GSDMD\u548cROS\u4fe1\u53f7\uff0c\u6539\u5584\u80ba\u6e7f\u5e72\u91cd\u6bd4\uff0c\u5e76\u6291\u5236NLRP3\/caspase-1\/GSDMD\u76f8\u5173\u7126\u4ea1\u86cb\u767d\u8868\u8fbe\u3002<\/p>\n\n\n\n

    \u4e5d\u3001\u8fd9\u9879\u7814\u7a76\u7684\u56db\u4e2a\u4e3b\u8981\u521b\u65b0\u70b9<\/strong><\/strong><\/p>\n\n\n\n

    1. \u5c06\u751f\u7406\u4e30\u5bcc\u7684\u94be\u5143\u7d20\u7528\u4e8e\u5355\u539f\u5b50\u6297\u6c27\u5316\u50ac\u5316<\/strong><\/strong><\/p>\n\n\n\n

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    2. \u6784\u5efaSOD\/CAT\u6837\u7ea7\u8054ROS\u6e05\u9664\u4f53\u7cfb<\/strong><\/strong><\/p>\n\n\n\n

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    3. \u5c06\u50ac\u5316\u6750\u6599\u4e0eGSDMD\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u7126\u4ea1\u8054\u7cfb\u8d77\u6765<\/strong><\/strong><\/p>\n\n\n\n

    \u7814\u7a76\u4e0d\u6b62\u89c2\u5bdf\u80ba\u7ec4\u7ec7\u708e\u75c7\u4e0b\u964d\uff0c\u8fd8\u4ece\u8f6c\u5f55\u7ec4\u3001\u86cb\u767d\u3001\u7ec6\u80de\u819c\u3001\u7ebf\u7c92\u4f53\u548c\u708e\u75c7\u56e0\u5b50\u591a\u4e2a\u5c42\u9762\u5206\u6790K-SAC\u5bf9\u5de8\u566c\u7ec6\u80de\u7126\u4ea1\u7684\u5f71\u54cd\u3002<\/p>\n\n\n\n

    4. \u5c06\u201c\u51cf\u5c11\u819c\u635f\u4f24\u201d\u4e0e\u201c\u589e\u5f3a\u819c\u4fee\u590d\u7ebf\u7d22\u201d\u7ed3\u5408<\/strong><\/strong><\/p>\n\n\n\n

    \u9664\u6291\u5236\u7126\u4ea1\u6210\u5b54\u5916\uff0c\u7814\u7a76\u8fd8\u89c2\u5bdf\u5230ESCRT\u76f8\u5173\u56e0\u5b50\u53ca\u819c\u78f7\u8102\u7ec4\u6210\u7684\u53d8\u5316\uff0c\u4e3a\u901a\u8fc7\u50ac\u5316\u6750\u6599\u7ef4\u62a4\u7ec6\u80de\u819c\u5b8c\u6574\u6027\u63d0\u4f9b\u4e86\u65b0\u7684\u7814\u7a76\u65b9\u5411\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe7\uff5cK-SAC\u8c03\u63a7\u6025\u6027\u80ba\u635f\u4f24\u7684\u603b\u4f53\u673a\u5236\u793a\u610f\u56fe\u3002<\/strong>
    K-SAC\u901a\u8fc7SOD\u548cCAT\u6837\u50ac\u5316\u6d3b\u6027\u6e05\u9664\u8fc7\u91cfROS\uff0c\u4fdd\u62a4\u7ebf\u7c92\u4f53\u5e76\u51cf\u5f31NLRP3\/caspase-1\/GSDMD\u76f8\u5173\u7126\u4ea1\u4fe1\u53f7\uff1b\u4e0e\u6b64\u540c\u65f6\uff0cESCRT\u76f8\u5173\u53cd\u5e94\u548c\u819c\u78f7\u8102\u53d8\u5316\u4e0e\u819c\u5b8c\u6574\u6027\u6539\u5584\u76f8\u8054\u7cfb\uff0c\u6700\u7ec8\u51cf\u8f7b\u6025\u6027\u80ba\u635f\u4f24\u4e2d\u7684\u708e\u75c7\u7ea7\u8054\u548c\u6c27\u5316\u5e94\u6fc0\u3002<\/p>\n\n\n\n

    \u5341\u3001\u54ea\u4e9b\u7814\u7a76\u8005\u53ef\u4ee5\u5173\u6ce8\u8fd9\u9879\u5de5\u4f5c\uff1f<\/strong><\/strong><\/p>\n\n\n\n

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    **\u6297\u6c27\u5316\u50ac\u5316\u9886\u57df\uff1a**\u63d0\u4f9b\u4e86SOD\/CAT\u6837\u7ea7\u8054\u50ac\u5316\u548c\u957f\u671f\u6d3b\u6027\u4fdd\u6301\u7684\u6750\u6599\u8bbe\u8ba1\u601d\u8def\u3002<\/p>\n\n\n\n

    **\u5de8\u566c\u7ec6\u80de\u4e0e\u7126\u4ea1\u7814\u7a76\u9886\u57df\uff1a**\u5efa\u7acb\u4e86ROS\u8c03\u63a7\u3001\u7ebf\u7c92\u4f53\u635f\u4f24\u3001caspase-1\/GSDMD\u4fe1\u53f7\u548c\u708e\u75c7\u56e0\u5b50\u91ca\u653e\u4e4b\u95f4\u7684\u6750\u6599\u5e72\u9884\u8bc1\u636e\u94fe\u3002<\/p>\n\n\n\n

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    \u540e\u7eed\u4ecd\u9700\u8fdb\u4e00\u6b65\u56de\u7b54\uff1a<\/p>\n\n\n\n

      \n
    • K-SAC\u5728\u4f53\u5185\u7684\u957f\u671f\u84c4\u79ef\u3001\u964d\u89e3\u4e0e\u6e05\u9664\u8fc7\u7a0b\uff1b<\/li>\n\n\n\n
    • \u91cd\u590d\u7ed9\u836f\u53ca\u66f4\u957f\u89c2\u5bdf\u5468\u671f\u4e0b\u7684\u5b89\u5168\u6027\uff1b<\/li>\n\n\n\n
    • K-SAC\u5bf9\u4e0d\u540c\u6765\u6e90\u548c\u4e0d\u540c\u72b6\u6001\u5de8\u566c\u7ec6\u80de\u4e9a\u7fa4\u7684\u5f71\u54cd\uff1b<\/li>\n\n\n\n
    • \u4e2d\u6027\u7c92\u7ec6\u80de\u53ca\u5176\u4ed6\u80ba\u90e8\u514d\u75ab\u7ec6\u80de\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\uff1b<\/li>\n\n\n\n
    • ESCRT\u76f8\u5173\u53cd\u5e94\u548c\u819c\u8102\u53d8\u5316\u662f\u5426\u4e3a\u6cbb\u7597\u4f5c\u7528\u6240\u5fc5\u9700\uff1b<\/li>\n\n\n\n
    • \u9002\u5408\u91cd\u75c7\u53ca\u673a\u68b0\u901a\u6c14\u573a\u666f\u7684\u7ed9\u836f\u8bbe\u5907\u548c\u7ed9\u836f\u65b9\u6848\uff1b<\/li>\n\n\n\n
    • \u6750\u6599\u89c4\u6a21\u5316\u751f\u4ea7\u53ca\u8d28\u91cf\u63a7\u5236\u95ee\u9898\u3002<\/li>\n<\/ul>\n\n\n\n

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      \u4f5c\u8005\u53ca\u56e2\u961f\u4ecb\u7ecd<\/strong><\/strong><\/p>\n\n\n\n

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      \u540c\u6d4e\u5927\u5b66\u902f\u5411\u96e8\u3001\u65bd\u70dc\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff1b\u674e\u53ef\u3001\u5415\u6b23\u548c\u65bd\u5251\u6797\u6559\u6388\u4e3a\u901a\u8baf\u4f5c\u8005\u3002<\/p>\n\n\n\n

      \u8bba\u6587\u4fe1\u606f<\/strong><\/strong><\/p>\n\n\n\n


      Lu, X., Shi, X., Jian, Y. et al.<\/em> A potassium-based single-atom catalyst enables acute lung injury immunotherapy in mice by inhibiting macrophage pyroptosis. Nature Communications<\/em> 17, 9400 (2026). https:\/\/doi.org\/10.1038\/s41467-026-76331-8<\/p>\n","protected":false},"excerpt":{"rendered":"

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