{"id":29991,"date":"2016-08-01T08:00:33","date_gmt":"2016-08-01T00:00:33","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=29991"},"modified":"2016-07-31T13:35:50","modified_gmt":"2016-07-31T05:35:50","slug":"%e9%a1%b6%e5%88%8a%e5%8a%a8%e6%80%81-nature%e5%ad%90%e5%88%8apnasafmnano-letters%e7%ad%89%e6%9c%9f%e5%88%8a%e7%94%9f%e7%89%a9%e6%9d%90%e6%96%99%e6%9c%80%e6%96%b0%e5%ad%a6%e6%9c%af%e8%bf%9b","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=29991","title":{"rendered":"\u9876\u520a\u52a8\u6001 | Nature\u5b50\u520a\/PNAS\/AFM\/Nano Letters\u7b49\u671f\u520a\u751f\u7269\u6750\u6599\u6700\u65b0\u5b66\u672f\u8fdb\u5c55\u6c47\u603b\u3010\u7b2c15\u671f\u3011"},"content":{"rendered":"<p><strong>1\u3001AFM\uff1a\u5149\u548cpH\u54cd\u5e94\u7684\u78b3\u9178\u9499@\u78f7\u8102@\u4e59\u9170\u5316\u53f3\u65cb\u82f7\u7cd6\u6742\u5316\u5e73\u53f0\u5728\u751f\u7269\u533b\u5b66\u65b9\u9762\u7684\u5e94\u7528<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-29993\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72471-22.jpg\" alt=\"\u56fe\u72471\" width=\"500\" height=\"341\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72471-22.jpg 500w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72471-22-300x205.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe1 \u78b3\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u52a0\u8f7d\u836f\u7269\u7684\u793a\u610f\u56fe<\/strong><\/p>\n<p>\u80fd\u591f\u52a0\u8f7d\u591a\u79cd\u836f\u7269\u7684\u8fd0\u8f93\u5e73\u53f0\u5bf9\u4e8e\u6cbb\u7597\u764c\u75c7\u548c\u5176\u5b83\u75be\u75c5\u6709\u91cd\u8981\u610f\u4e49\uff0c\u591a\u79cd\u6cbb\u7597\u65b9\u6cd5\u7ed3\u5408\u80fd\u591f\u964d\u4f4e\u591a\u91cd\u8010\u836f\u6027\u548c\u51cf\u5c11\u836f\u7269\u7684\u4f7f\u7528\u91cf\uff0c\u4f46\u662f\u76ee\u524d\u4f7f\u7528\u7684\u591a\u91cd\u836f\u7269\u8fd0\u8f93\u5e73\u53f0\u7684\u52a0\u8f7d\u91cf\u4f4e\u5e76\u4e14\u751f\u7269\u76f8\u5bb9\u6027\u5dee\u3002<\/p>\n<p>\u6700\u8fd1\u5317\u4eac\u79d1\u6280\u5927\u5b66\u3001\u54c8\u4f5b\u5927\u5b66\u7684\u6d77\u660e\u6f6d\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u5236\u5907\u4e86\u4e00\u4e2a\u80fd\u591f\u540c\u65f6\u8fd0\u8f93\u591a\u79cd\u836f\u7269\uff08\u5305\u62ec\u4eb2\u6c34\/\u758f\u6c34\u836f\u7269\u3001\u9176\u3001\u6297\u4f53\u3001\u91d1\u7eb3\u7c73\u7ebf\u7b49\uff09\u7684\u5e73\u53f0\uff0c\u6210\u529f\u6291\u5236\u4e86\u764c\u7ec6\u80de\u7684\u751f\u957f\u5e76\u4e14\u51cf\u5c11\u4e86\u526f\u4f5c\u7528\u3002\u8fd9\u79cd\u5e73\u53f0\u7684\u8f7d\u836f\u4e3b\u4f53\u662f\u78b3\u9178\u9499\u9897\u7c92\uff0c\u5e76\u4e14\u5728\u78b3\u9178\u9499\u7684\u5916\u9762\u5305\u88f9\u4e00\u5c42\u78f7\u8102\uff08POPC\uff09\u548c\u4e59\u9170\u5316\u53f3\u65cb\u82f7\u7cd6\uff08AcDX\uff09\u6df7\u5408\u7269\u3002POPC\u548cAcDX\u80fd\u591f\u589e\u5f3a\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u5e76\u4e14AcDX\u80fd\u591f\u5bf9pH\u505a\u51fa\u54cd\u5e94\u800c\u91ca\u653e\u52a0\u8f7d\u7684\u836f\u7269\uff0c\u4ed6\u4eec\u8fd8\u5728\u7eb3\u7c73\u9897\u7c92\u91cc\u9762\u52a0\u8f7d\u91d1\u7eb3\u7c73\u7ebf\uff0c\u91d1\u7eb3\u7c73\u7ebf\u80fd\u591f\u5728\u5149\u7684\u4f5c\u7528\u4e0b\u4fc3\u8fdb\u836f\u7269\u7684\u91ca\u653e\u548c\u589e\u5f3a\u7597\u6548\u3002\u8fd9\u79cd\u5e73\u53f0\u7684\u836f\u7269\u52a0\u8f7d\u91cf\u9ad8\u3001\u751f\u7269\u76f8\u5bb9\u6027\u597d\u3001\u5236\u5907\u7b80\u5355\uff0c\u5728\u751f\u7269\u533b\u5b66\u65b9\u9762\u6709\u91cd\u8981\u6f5c\u5728\u5e94\u7528\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adfm.201602715\/full\" target=\"_blank\">Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications<\/a>\uff08Advanced Functional Materials\uff0c2016\uff0cDOI:\u00a010.1002\/adfm.201602715\uff09<\/p>\n<p><strong>2\u3001ACS Nano\uff1a\u7ec6\u83cc\u52a9\u529b\u751f\u6210\u77f3\u58a8\u70ef\u8936\u76b1<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-29994\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72472-14.jpg\" alt=\"\u56fe\u72472\" width=\"500\" height=\"258\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72472-14.jpg 500w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72472-14-300x155.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe2 \u5229\u7528\u7ec6\u83cc\u5236\u9020\u8936\u76b1\u77f3\u58a8\u70ef\u7684\u793a\u610f\u56fe<\/strong><\/p>\n<p>\u8936\u76b1\u80fd\u591f\u5728\u77f3\u58a8\u70ef\u4e2d\u4ea7\u751f\u5c40\u90e8\u5e94\u529b\uff0c\u6539\u53d8\u77f3\u58a8\u70ef\u7684\u7535\u8377\u3001\u5076\u6781\u77e9\u7b49\u7684\u5206\u5e03\u4ece\u800c\u6539\u53d8\u77f3\u58a8\u70ef\u7684\u7535\u5b66\u3001\u5149\u5b66\u548c\u5316\u5b66\u6027\u80fd\uff0c\u4f46\u662f\u76f4\u63a5\u5728\u77f3\u58a8\u70ef\u4e0a\u5236\u9020\u53d7\u9650\u7684\u8936\u76b1\u8fd8\u5341\u5206\u56f0\u96be\u3002<\/p>\n<p>\u6700\u8fd1\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u829d\u52a0\u54e5\u5206\u6821\u7684Vikas Berry\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u5229\u7528\u7ec6\u83cc\u5728\u77f3\u58a8\u70ef\u4e2d\u5236\u9020\u4e86\u8936\u76b1\uff0c\u4ed6\u4eec\u9996\u5148\u5c06\u7ec6\u83cc\u56fa\u5b9a\u5728\u8868\u9762\u8986\u76d6SiO2\u7684Si\u57fa\u5e95\u4e0a\uff0c\u7136\u540e\u7528\u77f3\u58a8\u70ef\u76d6\u4f4f\u7ec6\u83cc\uff0c\u5728\u771f\u7a7a\u548c\u52a0\u70ed\u6761\u4ef6\u4e0b\u7ec6\u83cc\u7684\u6c34\u5206\u88ab\u84b8\u53d1\uff0c\u7ec6\u83cc\u6536\u7f29\u5bf9\u77f3\u58a8\u70ef\u4ea7\u751f\u5e94\u529b\uff0c\u5728\u5e94\u529b\u4f5c\u7528\u4e0b\u77f3\u58a8\u70ef\u4ea7\u751f\u8936\u76b1\u3002\u8fd9\u79cd\u8936\u76b1\u7684\u53d6\u5411\u548c\u957f\u5ea6\u53ef\u4ee5\u63a7\u5236\uff0c\u6709\u671b\u7528\u5728\u5176\u5b832D\u6750\u6599\u4e2d\u751f\u6210\u8936\u76b1\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.6b03214\" target=\"_blank\">Confined, Oriented, and Electrically Anisotropic Graphene Wrinkles on Bacteria<\/a>\uff08ACS Nano\uff0c2016\uff0cDOI:\u00a010.1021\/acsnano.6b03214\uff09<\/p>\n<p><strong>3\u3001ACS Nano\uff1a\u78f7\u8102\u53cc\u5c42\u5305\u88f9\u4ecb\u5b54\u7845\u7eb3\u7c73\u9897\u7c92\u8fd0\u8f93\u836f\u7269\u5230\u5355\u4e2a\u767d\u8840\u75c5\u7ec6\u80de<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-29995\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72473-12.jpg\" alt=\"\u56fe\u72473\" width=\"482\" height=\"615\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72473-12.jpg 482w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72473-12-235x300.jpg 235w\" sizes=\"(max-width: 482px) 100vw, 482px\" \/><br \/>\n<strong>\u56fe3 \u539f\u59cb\u7ec6\u80de\u7684\u7ed3\u6784\u793a\u610f\u56fe<\/strong><\/p>\n<p>\u5f88\u591a\u7eb3\u7c73\u8f7d\u4f53\u901a\u8fc7\u9ad8\u901a\u900f\u548c\u6ede\u7559\u6548\u5e94\uff08EPR\uff09\u5728\u80bf\u7624\u5bcc\u96c6\u4ece\u800c\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u4f46\u662f\u8840\u764c\uff08\u767d\u8840\u75c5\uff09\u7ec6\u80de\u4f1a\u5728\u8840\u6db2\u6216\u8005\u9aa8\u9ad3\u4e2d\u5faa\u73af\uff0c\u8fd9\u65f6EPR\u5c31\u4e0d\u80fd\u53d1\u6325\u4f5c\u7528\u4e86\uff0c\u56e0\u6b64\u8981\u6cbb\u7597\u8840\u764c\uff0c\u7eb3\u7c73\u7c92\u5b50\u9700\u8981\u80fd\u591f\u5b9a\u5411\u8bc6\u522b\u5e76\u4e14\u7c98\u9644\u5faa\u73af\u7684\u764c\u7ec6\u80de\u3002<\/p>\n<p>\u6700\u8fd1\u7f8e\u56fd\u65b0\u58a8\u897f\u54e5\u5927\u5b66\u7684C. Jeffrey Brinker\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u7814\u7a76\u4e86\u83b7\u5f97\u80fd\u7a33\u5b9a\u5b58\u5728\u7684\u5355\u5206\u6563\u201c\u539f\u59cb\u7ec6\u80de\u201d\u6240\u9700\u7684\u6761\u4ef6\uff08\u539f\u59cb\u7ec6\u80de\u7531\u78f7\u8102\u53cc\u5c42\u5305\u88f9\u4ecb\u5b54\u7845\u7eb3\u7c73\u9897\u7c92\u7ec4\u6210\uff09\uff0c\u5e76\u4e14\u7528\u6297\u4f53\u4fee\u9970\u83b7\u5f97\u7684\u201c\u539f\u59cb\u7ec6\u80de\u201d\uff0c\u6210\u529f\u4f7f\u201c\u539f\u59cb\u7ec6\u80de\u201d\u5b9a\u5411\u7c98\u9644\u5728\u8840\u764c\u7ec6\u80de\u4e0a\uff0c\u8fd9\u79cd\u539f\u59cb\u7ec6\u80de\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u767d\u8840\u75c5\u548c\u5176\u5b83\u4f20\u64ad\u75be\u75c5\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.6b02819\" target=\"_blank\">Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells<\/a>\uff08ACS Nano\uff0c2016\uff0cDOI:\u00a010.1021\/acsnano.6b02819\uff09<\/p>\n<p><strong>4\u3001Nature Materials\uff1a\u5c40\u90e8\u4e09\u91cd\u7597\u6cd5\u8ba9\u80bf\u7624\u6d88\u9000\u5e76\u4e14\u9632\u6b62\u518d\u53d1<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-29996\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72474-11.jpg\" alt=\"\u56fe\u72474\" width=\"500\" height=\"357\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72474-11.jpg 500w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72474-11-300x214.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe4 \u6c34\u51dd\u80f6\u7684\u7ec4\u6210<\/strong><\/p>\n<p>\u7ed3\u80a0\u76f4\u80a0\u764c\uff08CRC\uff09\u662f\u5f88\u5e38\u89c1\u764c\u75c7\uff0c\u76ee\u524d\u6cbb\u7597CRC\u4e3b\u8981\u4f9d\u9760\u624b\u672f\u5207\u9664\uff0c\u4f46\u662f\u8fd9\u79cd\u65b9\u6cd5\u98ce\u9669\u5f88\u5927\u3002<\/p>\n<p>\u6700\u8fd1\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u7684Jo\u00e3o Conde\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c Natalie Artzi\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u5c06\u57fa\u56e0\u3001\u836f\u7269\u548c\u5149\u70ed\u7597\u6cd5\u7ed3\u5408\u6210\u529f\u4f7f\u672a\u5207\u9664\u7684\u80bf\u7624\u6d88\u9000\u5e76\u4e14\u9632\u6b62\u5207\u9664\u540e\u7684\u80bf\u7624\u590d\u53d1\u3002\u4ed6\u4eec\u9996\u5148\u5c06\u6297\u764c\u836f\u5438\u9644\u5728\u91d1\u7eb3\u7c73\u68d2\u4e0a\uff0c\u5e76\u4e14\u5c06SiRNA\u5438\u9644\u5728\u7403\u5f62\u91d1\u7eb3\u7c73\u9897\u7c92\u4e0a\uff0c\u7136\u540e\u5c06\u4e8c\u8005\u52a0\u8f7d\u5728\u6c34\u51dd\u80f6\u4e0a\uff0c\u518d\u5c06\u6c34\u51dd\u80f6\u79fb\u690d\u5230\u80bf\u7624\u5904\uff0c\u91d1\u7eb3\u7c73\u68d2\u548c\u7eb3\u7c73\u9897\u7c92\u80fd\u88ab\u764c\u7ec6\u80de\u5b9a\u5411\u5438\u6536\uff0c\u5728\u8fd1\u7ea2\u5916\u5149\u7684\u4f5c\u7528\u4e0b\uff0c\u836f\u7269\u6216\u8005SiRNA\u88ab\u91ca\u653e\u6765\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u800c\u91d1\u7eb3\u7c73\u68d2\u672c\u8eab\u53d1\u70ed\u4e5f\u4f1a\u6740\u6b7b\u764c\u7ec6\u80de\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/www.nature.com\/nmat\/journal\/vaop\/ncurrent\/full\/nmat4707.html\" target=\"_blank\">Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model<\/a>\uff08Nature Materials\uff0c2016\uff0cDOI:\u00a010.1038\/nmat4707\uff09<\/p>\n<p><strong>5\u3001AFM\uff1a\u901a\u8fc7\u78c1\u70ed\u53cd\u5e94\u5feb\u901f\u91ca\u653e\u836f\u7269\u5c40\u90e8\u6fc0\u53d1\u795e\u7ecf\u6d3b\u52a8<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-29997\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72475-11.jpg\" alt=\"\u56fe\u72475\" width=\"500\" height=\"195\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72475-11.jpg 500w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72475-11-300x117.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe5 \u5728\u4ea4\u53d8\u78c1\u573a\u4e2d\uff0c\u7531\u4e8e\u78c1\u6ede\u5bfc\u81f4TRPV1\u8868\u9762\u91ca\u653eAITC\u3002\u901a\u8fc7GCaMP6s\u4e2d\u8367\u5149\u589e\u52a0\u73b0\u8c61\u68c0\u6d4b\u5230Ca2+\u8fdb\u5165\u795e\u7ecf\u5143\u3002<\/strong><\/p>\n<p>\u5728\u4ea4\u53d8\u78c1\u573a(AMFs)\u4e2d\u7531\u78c1\u6027\u7eb3\u7c73\u9897\u7c92(MNPs)\u5f15\u8d77\u7684\u78c1\u81f4\u635f\u8017\u53ef\u4f7f\u6750\u6599\u7528\u4f5c\u4f20\u611f\u5668\u54cd\u5e94\u5916\u90e8\u523a\u6fc0\uff0c\u8c03\u63a7\u7ec6\u80de\u4fe1\u606f\u4f20\u5bfc\uff0c\u5e38\u7528\u4e8e\u764c\u75c7\u7814\u7a76\u4e2d\u3002\u4eba\u4f53\u7ec4\u7ec7\u7684\u5f31\u78c1\u6027\u548c\u4f4e\u5bfc\u7535\u7387\u5141\u8bb8\u4ea4\u53d8\u78c1\u573a\u5230\u8fbe\u4eba\u4f53\u5185\u90e8\uff0cMNPs\u7684\u6ede\u540e\u73b0\u8c61\u4ea7\u751f\u7684\u70ed\u80fd\u53ef\u7528\u4e8e\u523a\u6fc0\u5927\u8111\u7ed3\u6784\uff0c\u5524\u8d77\u70ed\u654f\u795e\u7ecf\u5143\u7684\u6d3b\u52a8\u3002<\/p>\n<p>\u6700\u8fd1\uff0c\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u7684Polina Anikeeva\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u901a\u8fc7\u5c06\u5f02\u786b\u6c30\u9178\u70ef\u4e19\u916f(AITC\uff0c\u82a5\u672b\u7684\u4e00\u79cd\u523a\u6fc0\u6027\u7ec4\u5143)\u5206\u5b50\u4f7f\u7528\u5c40\u90e8\u4ea4\u53d8\u78c1\u573a\u611f\u5e94\u52a0\u70ed\u7ed1\u5b9a\u5230MNPs\u7684\u8868\u9762\u3002\u529f\u80fd\u5316\u7684MNPs\u9776\u5411\u795e\u7ecf\u5143\u8868\u9762\uff0c\u4f7f\u5176\u8868\u8fbeTRPV1 (\u4e00\u79cd\u9633\u79bb\u5b50\u901a\u9053)\u548cGCaMP6s(\u4e00\u79cd\u57fa\u56e0\u7f16\u7801\u7684Ca2+\u6307\u793a\u5242)\u3002\u7531\u4e8e\u78c1\u6ede\u4ea7\u751f\u70ed\u635f\u8017\uff0c\u5bfc\u81f4TRPV1\u8868\u9762\u91ca\u653e\u51faAITC\uff0c\u901a\u8fc7GCaMP6s\u7684\u8367\u5149\u589e\u52a0\u73b0\u8c61\u68c0\u6d4b\u5230Ca2+\u8fdb\u5165\u795e\u7ecf\u5143\uff0c\u5b8c\u6210\u5bf9\u795e\u7ecf\u5143\u7684\u523a\u6fc0\u3002\u8fd9\u79cd\u78c1\u70ed\u6548\u5e94\u523a\u6fc0\u795e\u7ecf\u5143\u7684\u6a21\u5f0f\u53ef\u901a\u8fc7\u63a7\u5236\u819c\u86cb\u767d\u7684\u529f\u80fd\u4ee5\u8c03\u8282\u7ec6\u80de\u4fe1\u53f7\u4f20\u9012\u3002\u4f7f\u7528AMFs\u4f5c\u4e3a\u523a\u6fc0\uff0c\u7531\u4e8e\u5b83\u4e0d\u968f\u7ec4\u7ec7\u6df1\u5ea6\u51fa\u73b0\u8870\u51cf\uff0c\u5f88\u9002\u7528\u4e8e\u8eab\u4f53\u5185\u90e8\u53ca\u5927\u8111\u7684\u9776\u5411\u523a\u6fc0\uff0c\u8fd8\u53ef\u5b9e\u73b0\u5bf9\u5916\u90e8\u523a\u6fc0\u5feb\u901f\u7684\u54cd\u5e94\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adfm.201602189\/full\" target=\"_blank\">Localized Excitation of Neural Activity via Rapid Magnetothermal Drug Release<\/a>\uff08Advanced Functional Materials\uff0c2016\uff0cDOI: 10.1002\/adfm.201602189\uff09<\/p>\n<p><strong>6\u3001ACS Nano\uff1a\u53efDNA\u7f16\u7a0b\u7684\u7eb3\u7c73\u7ed3\u6676\u7684\u52a8\u529b\u5b66\u7279\u6027<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-29998\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72476-9.jpg\" alt=\"\u56fe\u72476\" width=\"500\" height=\"415\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72476-9.jpg 500w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72476-9-300x249.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe6 A\u2212A\u81ea\u7ec4\u88c5\u4f53\u7cfb\u7684\u7c97\u7c92\u5ea6\u6a21\u578b <\/strong><br \/>\n<strong>\u9876\u90e8\uff1a\u5355\u94feDNA\u6a21\u578b\uff1b\u5e95\u90e8\uff1a\u4e24\u4e2a\u5355\u94feDNA-NP\u6742\u4ea4<\/strong><\/p>\n<p>DNA\u6742\u4ea4\u52a8\u529b\u5b66\u5bf9\u53efDNA\u7f16\u7a0b\u7684\u7eb3\u7c73\u7ed3\u6676\u5f88\u91cd\u8981\u3002DNA\u6742\u4ea4\u53cd\u5e94\u7684\u52a8\u6001\u7ed3\u6676\u8fc7\u7a0b\u901a\u8fc7\u5e73\u5747\u4f4d\u79fb\u3001\u6742\u4ea4\u7684\u767e\u5206\u6bd4\u548cDNA\u952e\u7684\u5bff\u547d\u6765\u8bc4\u5b9a\u3002DNA\u952e\u7684\u5bff\u547d\u4e0e\u6e29\u5ea6\u5bc6\u5207\u76f8\u5173\u3002\u4e3a\u4e86\u66f4\u597d\u5730\u7406\u89e3\u5f71\u54cdDNA \u78b1\u57fa\u914d\u5bf9\u548c\u7ed3\u6676\u52a8\u529b\u5b66\u8fc7\u7a0b\u7684\u5f71\u54cd\u56e0\u7d20\u3002\u7c97\u7c92\u5ea6\u7684\u5206\u5b50\u52a8\u529b\u5b66\u88ab\u7528\u4e8e\u63a2\u7d22DNA\u6742\u4ea4\u7684\u7ed3\u6784\u548c\u52a8\u6001\u6027\u80fd\u3002<\/p>\n<p>\u5357\u4eac\u5927\u5b66\u7684Rong Wang\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u7814\u7a76\u4e86DNA \u952e\u7684A-A\u81ea\u4e92\u8865\u5355\u7ec4\u5206\u4f53\u7cfb\u7684\u52a8\u6001\u5f62\u6210\u8fc7\u7a0b\u3002\u4ed6\u4eec\u53d1\u73b0\u4f4e\u7684DNA \u4f53\u79ef\u5206\u6570(\u03b7)\u53ef\u4ee5\u4fc3\u8fdb\u5f62\u6210HCP\u7ed3\u6784\u4ee5\u5b9e\u73b0\u6700\u5927\u5316DNA \u6742\u4ea4\u53cd\u5e94\u3002\u4f46\u66f4\u9ad8\u7684\u03b7\u4f1a\u5f62\u6210FCC\u7ed3\u6784\u3002\u975e\u5e38\u5bc6\u96c6\u7684DNA\u4f1a\u9650\u5236\u91cd\u7ec4\u8fdb\u7a0b\uff0c\u963b\u6b62\u9897\u7c92\u91cd\u6392\u3002\u968f\u7740\u6e29\u5ea6\u589e\u52a0\uff0c&lt;p(H)&gt;(\u6742\u4ea4\u7684\u5e73\u5747\u767e\u5206\u6bd4)\u51cf\u5c0f\uff0c\u53bb\u6742\u5316\u53cd\u5e94\u8d8a\u6765\u8d8a\u5feb\uff0c\u5bf9\u6742\u5316\u7387\u4ea7\u751f\u5f71\u54cd\u3002DNA\u952e\u7684\u5bff\u547d\u53d7\u5230DNA \u94fe\u4e0a\u7684\u9897\u7c92\u6570\u548c\u4f53\u79ef\u5206\u6570\u9650\u5236\uff0c\u7eb3\u7c73\u7ed3\u6676\u8fc7\u7a0b\u5b58\u5728\u9002\u5f53\u7684\u6e29\u5ea6\u533a\u95f4\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u5bf9\u6211\u4eec\u7406\u89e3DNA\u529f\u80fd\u5316\u7684\u7eb3\u7c73\u9897\u7c92(DNA-NP)\u7ed3\u6676\u52a8\u529b\u5b66\u53ca\u5176\u5f71\u54cd\u56e0\u7d20\u5f88\u6709\u5e2e\u52a9\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.6b02067\" target=\"_blank\">Dynamic Properties of DNA-Programmable Nanoparticle Crystallization<\/a> \uff08ACS Nano\uff0c2016\uff0cDOI: 10.1021\/acsnano.6b02067\uff09<\/p>\n<p><strong>7\u3001PNAS\uff1a\u65e0\u9176\u50ac\u5316\u4eff\u751f\u91cd\u6784\u5408\u6210\u78f7\u8102\u8102\u8d28\u4f53<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-29999\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72477-10.jpg\" alt=\"\u56fe\u72477\" width=\"500\" height=\"282\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72477-10.jpg 500w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72477-10-300x169.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe7 \u78f7\u8102\u819c\u7ed3\u6784\u7684\u91cd\u5851\u8fc7\u7a0b\u793a\u610f\u56fe <\/strong><\/p>\n<p>\u7ec6\u80de\u819c\u542b\u6709\u5927\u91cf\u7684\u78f7\u8102\u7c7b\u7269\u8d28\uff0c\u5176\u7ed3\u6784\u53ef\u901a\u8fc7\u9176\u91cd\u6784\u9170\u57fa\u94fe\u548c\u6781\u6027\u4eb2\u6c34\u57fa\u57fa\u56e2\u6765\u6539\u53d8\u3002\u8102\u8d28\u91cd\u6784\u5728\u819c\u751f\u7269\u5b66\u4e2d\u5341\u5206\u91cd\u8981\u3002\u5c3d\u7ba1\u4ee5\u4eba\u5de5\u819c\u4e3a\u6a21\u578b\u6765\u8c03\u8282\u539f\u751f\u7ec6\u80de\u819c\u5c5e\u6027\u7684\u76f8\u5173\u7814\u7a76\u5df2\u53d6\u5f97\u5f88\u5927\u8fdb\u5c55\uff0c\u4f46\u6a21\u62df\u7c7b\u8102\u819c\u91cd\u5851\u7684\u8fc7\u7a0b\u4f9d\u7136\u662f\u4e00\u4e2a\u96be\u9898\u3002<\/p>\n<p>\u6700\u8fd1\uff0c\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u7684Neal K. Devaraj\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u8bbe\u8ba1\u4e86\u4e00\u79cd\u4eba\u9020\u751f\u7269\u819c\u6765\u6a21\u62df\u539f\u751f\u78f7\u8102\u819c\u7684\u5408\u6210\u548c\u6539\u9020\u8fc7\u7a0b\u3002\u4ed6\u4eec\u5c06\u5929\u7136\u5316\u5b66\u8fde\u63a5(NCL)\u53cd\u5e94\u7528\u4e8e\u9170\u80fa\u57fa\u78f7\u8102\u7684\u539f\u4f4d\u81ea\u7ec4\u88c5\uff0c\u5f62\u6210\u819c\u56ca\u6ce1\u3002\u518d\u901a\u8fc7\u53ef\u9006\u7684\u5929\u7136\u5316\u5b66\u8fde\u63a5(RNCL)\u53cd\u5e94\u8fdb\u884c\u819c\u91cd\u6784\uff0c\u81ea\u53d1\u5730\u6539\u53d8\u819c\u7684\u7ec4\u6210\u4e0e\u5f62\u8c8c\u3002\u8be5\u65b9\u6cd5\u514b\u670d\u4e86\u539f\u751f\u8102\u8d28\u4f53\u8fdb\u884c\u8102\u8d28\u91cd\u6784\u7684\u52a8\u529b\u5b66\u969c\u788d\uff0c\u53ef\u4ee5\u8c03\u63a7\u78f7\u8102\u56ca\u6ce1\u7684\u5c3a\u5bf8\u548c\u5f62\u72b6\u3002\u57fa\u4e8eNCL\u7684\u8102\u8d28\u5408\u6210\u6cd5\u548c\u57fa\u4e8eRNCL\u7684\u8102\u8d28\u91cd\u6784\u6cd5\u76f8\u7ed3\u5408\uff0c\u663e\u793a\u51fa\u81ea\u53d1\u78f7\u8102\u5f15\u53d1\u819c\u91cd\u6784\u53d8\u5316\u7684\u80fd\u529b\uff0c\u9002\u7528\u4e8e\u7814\u7a76\u819c\u4ea4\u6362\u53ca\u819c\u7684\u91cd\u6784\u5bf9\u7ec6\u80de\u529f\u80fd\u4ea7\u751f\u7684\u5f71\u54cd\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/www.pnas.org\/content\/early\/2016\/07\/19\/1605541113.full\" target=\"_blank\">Nonenzymatic biomimetic remodeling of phospholipids in synthetic liposomes<\/a> \uff08Proceedings of the National Academy of Sciences\uff0c2016\uff0cDOI: 10.1073\/pnas.1605541113\uff09<\/p>\n<p><strong>8\u3001Nano Letters\uff1a\u5fae\u6db2\u6ef4\u7eb3\u7c73\u4f20\u611f\u5668\u63a2\u9488<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-30000\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72478-8.jpg\" alt=\"\u56fe\u72478\" width=\"500\" height=\"294\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72478-8.jpg 500w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2016\/07\/\u56fe\u72478-8-300x176.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe8 \u591a\u76f8\u5fae\u6d41\u4f53\u3001\u7eb3\u7c73\u7ebf\u79bb\u5b50\u654f\u611f\u573a\u6548\u5e94\u6676\u4f53\u7ba1(ISFET)\u4f20\u611f\u5668\u548c\u6db2\u6ef4\u5fae\u6d41\u63a7\u7cfb\u7edf\u7684\u96c6\u6210\u6982\u5ff5\u56fe<\/strong><\/p>\n<p>\u5b9e\u9a8c\u5ba4\u9ad8\u6027\u80fd\u81ea\u52a8\u5316\u6d4b\u8bd5\u5df2\u7ecf\u5b9e\u73b0\u4e86\u533b\u7597\u70b9\u8bca\u65ad\u548c\u667a\u80fd\u4fe1\u606f\u5904\u7406\u3002\u5fae\u578b\u7eb3\u7c73\u4f20\u611f\u5668\u548c\u6db2\u6ef4\u5fae\u6d41\u63a7\u5236\u7cfb\u7edf\u7684\u7ed3\u5408\u53ef\u66f4\u597d\u5730\u5206\u6790\u9ad8\u4f20\u8f93\u7387\u7684\u751f\u7269\u5316\u5b66\u8fc7\u7a0b\u3002\u8fd9\u79cd\u6db2\u6ef4\u5fae\u6d41\u63a7\u5236\u7cfb\u7edf\u53ef\u7528\u5355\u4e2a\u8bbe\u5907\u540c\u65f6\u76d1\u6d4b\u5927\u91cf\u72ec\u7acb\u7684\u53cd\u5e94\u5806\uff0c\u6bcf\u4e2a\u6db2\u6ef4\u90fd\u53ef\u8fdb\u884c\u72ec\u7acb\u7684\u751f\u5316\u5b9e\u9a8c\uff0c\u53ef\u5b9e\u73b0\u5e73\u884c\u6d4b\u91cf\u3002<\/p>\n<p>\u6700\u8fd1\uff0c\u5fb7\u56fd\u5fb7\u7d2f\u65af\u987f\u5de5\u4e1a\u5927\u5b66\u7684Larysa Baraban\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u5c06\u6db2\u6ef4\u5fae\u6d41\u63a7\u5236\u4e0e\u7845\u7eb3\u7c73\u7ebf\u573a\u6548\u5e94\u6676\u4f53\u7ba1(SiNW FET )\u76f8\u7ed3\u5408\uff0c\u4f7f\u7528\u5316\u5b66\u63a2\u9488\u72ec\u7acb\u68c0\u6d4b\u6db2\u6ef4\u4e2d\u7684\u7535\u6d41\u91cf\u3001\u6d4b\u5b9a\u6eb6\u6db2\u7684pH\u503c\u53ca\u7535\u6d41\u53d8\u5316\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u5229\u7528\u7ed3\u5408SiNW FET\u7684\u6db2\u6ef4\u5fae\u6d41\u4f53\u76d1\u6d4b\u4e73\u5316\u6db2\u6ef4\u4e2d\u7684\u7535\u6d41\u91cf\uff0c\u8fdb\u884c\u9ad8\u901a\u91cf\u68c0\u67e5\u548c\u4e73\u5316\u6db2\u6ef4\u5206\u6790\u3002\u4f7f\u7528\u79bb\u5b50\u654f\u611f\u573a\u6548\u5e94\u6676\u4f53\u7ba1(ISFETs)\u8ba8\u8bba\u4e86\u4e73\u6db2\u4f20\u611f\u7684\u7279\u70b9\uff0c\u4ee5\u53ca\u6db2\u6ef4\u5927\u5c0f\u5bf9\u4f20\u611f\u5668\u7684\u5f71\u54cd\u3002\u8fd9\u79cd\u5fae\u578b\u5668\u4ef6\uff0c\u5c06SiNW FET\u548c\u5fae\u6d41\u4f53\u96c6\u6210\u5728\u5355\u4e00\u82af\u7247\u4e0a\uff0c\u53ef\u8fdb\u884c\u8fde\u7eed\u7684\u4f53\u5916\u68c0\u6d4b\u3001\u5fae\u751f\u7269\u68c0\u6d4b\u3001\u836f\u7269\u7b5b\u9009\u4ee5\u53ca\u65e9\u671f\u75c5\u539f\u4f53\u7684\u68c0\u6d4b\u3002\u5355\u4e2a\u7684\u6db2\u6ef4\u4e5f\u53ef\u8868\u73b0\u51fa\u660e\u663e\u7684\u4fe1\u53f7\u53d8\u5316\uff0c\u7cbe\u5ea6\u8d85\u8d8a\u4e86\u5e38\u89c4\u68c0\u6d4b\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.nanolett.6b01707\" target=\"_blank\">Compact Nanowire Sensors Probe Microdroplets <\/a>\uff08Nano Letters\uff0c2016\uff0cDOI: 10.1021\/acs.nanolett.6b01707\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u5b66\u4e60\u5c0f\u7ec4CZM\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u6b22\u8fce\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u5b66\u4e60\u5c0f\u7ec4\uff0c\u4e00\u8d77\u63a2\u8ba8\u751f\u7269\u6750\u6599\u7684\u4e13\u4e1a\u95ee\u9898\uff0c\u5173\u6ce8\u751f\u7269\u6750\u6599\u7684\u6700\u65b0\u52a8\u6001\u3002\u52a0\u5165\u65b9\u5f0f\uff1a\uff081\uff09\u6dfb\u52a0\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\uff0c\u79c1\u4fe1\u7ba1\u7406\u5458\u201c\u9648\u662d\u94ed\uff08QQ\uff1a1982342885\uff09\u201d\u62a5\u540d\uff1b\uff082\uff09<a href=\"http:\/\/cailiaoren.mikecrm.com\/6qSdMU\" target=\"_blank\">\u70b9\u6b64\u5904\u62a5\u540d<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1\u3001AFM\uff1a\u5149\u548cpH\u54cd\u5e94\u7684\u78b3\u9178\u9499@\u78f7\u8102@\u4e59\u9170\u5316\u53f3\u65cb\u82f7\u7cd6\u6742\u5316\u5e73\u53f0\u5728\u751f\u7269\u533b\u5b66\u65b9\u9762\u7684\u5e94\u7528 \u56fe1 \u78b3\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u52a0\u8f7d\u836f\u7269\u7684\u793a\u610f\u56fe \u80fd\u591f\u52a0\u8f7d\u591a\u79cd\u836f\u7269\u7684\u8fd0\u8f93\u5e73\u53f0\u5bf9\u4e8e\u6cbb\u7597\u764c\u75c7&#8230;<\/p>\n","protected":false},"author":382,"featured_media":29998,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[67],"tags":[75],"class_list":["post-29991","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zhoubao","tag-biomaterial"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/29991"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/382"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29991"}],"version-history":[{"count":7,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/29991\/revisions"}],"predecessor-version":[{"id":30134,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/29991\/revisions\/30134"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/media\/29998"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29991"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}