{"id":39746,"date":"2016-09-10T14:43:03","date_gmt":"2016-09-10T06:43:03","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=39746"},"modified":"2016-09-11T10:32:38","modified_gmt":"2016-09-11T02:32:38","slug":"adv-mater-%e6%b8%a9%e5%92%8c%e6%ba%b6%e6%b6%b2%e5%88%b6%e5%a4%87%e8%b6%85%e5%b0%8f%e5%8a%9f%e8%83%bd%e5%8c%96cu2%e2%88%92xse%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%e4%bd%9c%e4%b8%ba%e7%99%8c%e7%97%87","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=39746","title":{"rendered":"Adv. Mater. \u6e29\u548c\u6eb6\u6db2\u5236\u5907\u8d85\u5c0f\u529f\u80fd\u5316Cu2\u2212xSe\u7eb3\u7c73\u9897\u7c92\u4f5c\u4e3a\u764c\u75c7\u591a\u6a21\u5f0f\u9020\u5f71\u5bfc\u5411\u5149\u70ed\u6cbb\u7597\u7684\u8bca\u7597\u5242"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/b><\/p>\n

2016\u5e748\u670825\u65e5\uff0cAdvanced Materials\u7f51\u7ad9\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a\u201dAmbient Aqueous Synthesis of Ultrasmall PEGylated Cu2\u2212xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer\u201d\u7684\u6587\u7ae0\u3002\u8be5\u6587\u7ae0\u7684\u7b2c\u4e00\u4f5c\u8005\u662f\u82cf\u5dde\u5927\u5b66\u7684S. Zhang\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u82cf\u5dde\u5927\u5b66\u7684Z. Li\u3002\u8fd9\u7bc7\u6587\u7ae0\u7684\u4e3b\u8981\u5de5\u4f5c\u662f\u5229\u7528\u6e29\u548c\u7684\u6eb6\u6db2\u5408\u6210\u8def\u7ebf\u5236\u5907\u4e86\u591a\u6a21\u5f0f\u9020\u5f71\u5bfc\u5411\u7684\u5149\u70ed\u7eb3\u7c73\u8bca\u7597\u5242\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011
\n<\/strong>
\n\u8fd1\u5e74\u6765\uff0c\u4ece\u80fd\u6e90\u9886\u57df\u5982\u70ed\u7535\u8f6c\u6362\u3001\u9502\u79bb\u5b50\u7535\u6c60\u5230\u751f\u7269\u533b\u5b66\u9886\u57df\u5982\u5149\u58f0\u9020\u5f71\u3001\u5149\u70ed\u6cbb\u7597\u7b49\uff0c\u94dc\u7684\u786b\u65cf\u5316\u5408\u7269\uff08Cu2\u2212xE, E=S, Se\uff0cTe\uff09\u4ee5\u5176\u590d\u6742\u7684\u6676\u4f53\u7ed3\u6784\u4ee5\u53ca\u53ef\u53d8\u7ec4\u5206\u542b\u91cf\u7b49\u6027\u8d28\u53d7\u5230\u7814\u7a76\u4eba\u5458\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u7279\u522b\u662f\u5728\u751f\u7269\u8bca\u7597\u65b9\u9762\uff0c\u76f8\u8f83\u8d77\u4f20\u7edf\u7684\u5149\u70ed\u8bd5\u5242\uff0cCu2\u2212xE\u7531\u4e8e\u94dc\u7f3a\u4e4f\uff08copper deficiency\uff09\u5f15\u8d77\u7684\u5728\u8fd1\u7ea2\u5916\u8303\u56f4\u7684\u5c40\u57df\u8868\u9762\u7b49\u79bb\u6fc0\u5143\u5171\u632f\uff08LSPRs\uff09\u80fd\u591f\u5b9e\u73b0\u66f4\u5c0f\u5c3a\u5ea6\u7684\u7eb3\u7c73\u7ed3\u6784\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u94dc\u548c\u7852\u62e5\u6709\u8f83\u9ad8\u7684X\u5c04\u7ebf\u8870\u51cf\u7cfb\u6570\uff08attenuation coefficient\uff09\uff0c\u5728CT\u9020\u5f71\u65b9\u9762\u6709\u7740\u5de8\u5927\u7684\u7814\u7a76\u6f5c\u529b\uff0c\u7136\u800c\u76ee\u524d\u5173\u4e8e\u8d85\u5c0fCu2\u2212xSe\u7eb3\u7c73\u9897\u7c92\u7684\u7814\u7a76\u5374\u8fd8\u672a\u5c55\u5f00\u3002<\/p>\n

\u82cf\u5dde\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5229\u7528\u6e29\u548c\u7684\u6c34\u6eb6\u6db2\u6765\u53d1\u5c55\u5236\u5907\u5177\u6709\u6c34\u6eb6\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\u7279\u70b9\u7684\u8d85\u5c0fCu2\u2212xSe\u7eb3\u7c73\u9897\u7c92\u3002\u8fd9\u79cd\u9897\u7c92\u7684\u7c92\u5f84\u57283.6 \u00b1 0.3 nm\u8303\u56f4\u5185\uff0c\u53ef\u7528\u4e8e\u5305\u62ec\u5149\u58f0\uff08PA\uff09\u3001\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\uff08CT\uff09\u4ee5\u53ca\u5355\u5149\u5b50\u53d1\u5c04\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\uff08SPECT\uff09\u5728\u5185\u7684\u591a\u79cd\u9020\u5f71\u6a21\u5f0f\u3002\u636e\u7814\u7a76\u4eba\u5458\u4ecb\u7ecd\uff0c\u5c3a\u5ea6\u57285nm\u4ee5\u4e0b\u3001\u7528\u4e8e\u9ad8\u6548\u591a\u6a21\u5f0f\u9020\u5f71\u5bfc\u5411\u5149\u70ed\u6cbb\u7597\u7684Cu2\u2212xSe\u7eb3\u7c73\u6750\u6599\u76ee\u524d\u8fd8\u672a\u89c1\u8bf8\u62a5\u9053\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u65b9\u68481\uff1a\u591a\u529f\u80fdCu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92\u7684\u5408\u6210\u53ca\u5176\u5728\u5149\u58f0\u9020\u5f71\u3001CT\u9020\u5f71\u3001SPECT\u9020\u5f71\u4ee5\u53ca\u764c\u75c7\u5149\u70ed\u6cbb\u7597\u4e2d\u7684\u5e94\u7528
\n<\/strong><\/p>\n

\"\u65b9\u68481\"<\/strong>
\n\u56fe1\uff1aCu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92\u7684\u8868\u5f81<\/strong><\/p>\n

\"\u56fe1\"<\/p>\n

a)\u900f\u5c04\u7535\u5b50\u663e\u5fae\u56fe\u50cf\uff1b \u00a0 \u00a0 \u00a0b)\u9ad8\u5206\u8fa8\u900f\u5c04\u7535\u5b50\u663e\u5fae\u56fe\u50cf\uff1b<\/p>\n

c)XRD\u56fe\u50cf\u6bd4\u8f83\uff1b \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0d)\u94dc\u539f\u5b50\u7684\u9ad8\u5206\u8fa8XPS\u8c31\u5206\u6790\uff1b<\/p>\n

e)\u6c34\u5408\u7c92\u5f84\uff1b \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0f)\u4e0d\u540c\u94dc\u6d53\u5ea6\u4e0b\u7684\u7eb3\u7c73\u9897\u7c92\u6c34\u6eb6\u6db2\u7684\u7d2b\u5916-\u53ef\u89c1-\u8fd1\u7ea2\u5916\u5438\u6536\u8c31\u3002<\/p>\n

\u56fe2\uff1aCu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92\u7684\u4f53\u5916\u6027\u80fd\u6d4b\u8bd5<\/strong><\/p>\n

\"\u56fe2\"<\/p>\n

a)808\u7eb3\u7c73\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u94dc\u6d53\u5ea6\u6761\u4ef6\u4e0bCu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92\u6c34\u6eb6\u6db2\u5206\u6563\u4f53\u5149\u70ed\u5347\u6e29\u66f2\u7ebf\uff1b<\/p>\n

b)08\u7eb3\u7c73\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u4e0d\u540c\u94dc\u6d53\u5ea6\u6761\u4ef6\u4e0bCu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92\u6c34\u6eb6\u6db2\u5206\u6563\u4f53\u7684\u7ea2\u5916\u70ed\u56fe\u50cf\uff1b<\/p>\n

c)\u4e0d\u540cCu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92\u6d53\u5ea6\u57f9\u517b\u6db2\u57f9\u517b24\u5c0f\u65f6\u540e\u76844T1\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u6027\uff1b<\/p>\n

d)\u4e0d\u540c\u94dc\u6d53\u5ea6Cu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92\u6eb6\u6db2\u4e2d\uff0c\u7ecf\u8fc7\u4f53\u5916\u5149\u70ed\u6d88\u9664\u76844T1\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\u56fe3\uff1aCu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92\u7684\u4f53\u5185\u9020\u5f71\u6027\u80fd\u6d4b\u8bd5<\/strong><\/p>\n

\"\u56fe3\"<\/p>\n

a)Cu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92(500 \u03bcg mL\u22121, 200 \u03bcL)\u5c3e\u9759\u8109\u6ce8\u5c04\u524d\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u4f53\u5185\u80bf\u7624\u5149\u58f0\u56fe\u50cf\uff1b<\/p>\n

b)Cu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92(2.5mg mL\u22121, 200 \u03bcL)\u7624\u5185\u6ce8\u5c04\u540e\u7684\u4f53\u5185\u80bf\u7624CT\u56fe\u50cf\uff1b<\/p>\n

c)\u9759\u8109\u6ce8\u5c04Cu2-xSe-PEG-99mTc\u6eb6\u6db2\u540e\u7684\u4f53\u5185SPECT\u56fe\u50cf\uff1b<\/p>\n

d)\u9759\u8109\u6ce8\u5c04Cu2-xSe-PEG-SH\u540e\u7684\u7eb3\u7c73\u9897\u7c92\u8840\u6db2\u5faa\u73af\u5206\u6790<\/p>\n

e)\u9759\u8109\u6ce8\u5c04Cu2-xSe-PEG-SH\u540e\u7684\u7eb3\u7c73\u9897\u7c92\u4f53\u5185\u751f\u7269\u5206\u5e03\u56fe\uff1b<\/p>\n

\u56fe4\uff1aCu2-xSe-PEG-SH\u7eb3\u7c73\u9897\u7c92\u7684\u4f53\u5185\u80bf\u7624\u5149\u70ed\u6cbb\u7597<\/strong><\/p>\n

\"\u56fe4\"<\/p>\n

a)\u7eb3\u7c73\u9897\u7c92(500 \u03bcg mL\u22121, 200 \u03bcL)\u9759\u8109\u6ce8\u5c04\u4ee5\u53ca808\u7eb3\u7c73\u6ce2\u957f\u6fc0\u5149\u7167\u5c04\u6cbb\u7597\u540e\u7684\u80bf\u7624\u7ea2\u5916\u70ed\u5b66\u56fe\u50cf\uff1b<\/p>\n

b)\u7eb3\u7c73\u9897\u7c92(500 \u03bcg mL\u22121, 200 \u03bcL)\u9759\u8109\u6ce8\u5c04\u4ee5\u53ca808\u7eb3\u7c73\u6ce2\u957f\u6fc0\u5149\u7167\u5c04\u6cbb\u7597\u540e\u7684\u80bf\u7624\u6e29\u5ea6\u66f2\u7ebf\uff1b<\/p>\n

c)\u6cbb\u75973\u5929\u4ee5\u540e\u7684\u5c0f\u9f20\u80bf\u7624\u90e8\u4f4d\u7684H&E\u67d3\u8272\u5207\u7247\uff1b<\/p>\n

d)\u5f52\u4e00\u5316\u5230\u539f\u59cb\u80bf\u7624\u4f53\u79ef\u7684\u76f8\u5bf9\u80bf\u7624\u4f53\u79ef\u7edf\u8ba1\u56fe\uff1b \u00a0 \u00a0 \u00a0 \u00a0\u00a0e)\u5c0f\u9f20\u5b58\u6d3b\u66f2\u7ebf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011
\n<\/strong>
\n\u8be5\u6587\u7ae0\u62a5\u9053\u7684\u7ec4\u5206\u53ef\u53d8\u7684\u8d85\u5c0f\u7eb3\u7c73\u9897\u7c92\uff0c\u5728\u4f53\u5185\u548c\u4f53\u5916\u5b9e\u9a8c\u4e2d\u5747\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u80bf\u7624\u8bca\u7597\u6027\u80fd\u3002\u5982\u5728\u5149\u58f0\u9020\u5f71\u548c\u5149\u70ed\u6cbb\u7597\u4e2d\u8868\u73b0\u51fa\u9ad8\u6548\u7684\u5149\u70ed\u8f6c\u6362\u6548\u7387\uff1b\u5728CT\u9020\u5f71\u4e2d\u8868\u73b0\u51fa\u9ad8X\u5c04\u7ebf\u8870\u51cf\u7cfb\u6570\u3002\u7531\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u7ecf\u8fc7PEG\u529f\u80fd\u5316\u7684Cu2\u2212xSe\u7eb3\u7c73\u9897\u7c92\u662f\u5b9e\u73b0\u764c\u75c7\u591a\u6a21\u5f0f\u8bca\u7597\u7684\u7406\u60f3\u6750\u6599\u3002<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u5b66\u4e60\u5c0f\u7ec4\u9648\u4e16\u96c4\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aAmbient Aqueous Synthesis of Ultrasmall PEGylated Cu2\u2212xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer<\/a>\uff08Adv. Mater., 2016, DOI: 10.1002\/adma.201602193\uff09<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u503c\u6b64\u6559\u5e08\u8282\u4e4b\u9645\uff0c\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u795d\u613f\u5168\u5929\u4e0b\u8001\u5e08\uff1a<\/strong><\/span><\/p>\n

\u8eab\u4f53\u5065\u5eb7\uff0c\u5de5\u4f5c\u987a\u5229\uff0c\u5fc3\u60f3\u4e8b\u6210\uff0c\u9616\u5bb6\u6b22\u4e50\uff01<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 2016\u5e748\u670825\u65e5\uff0cAdvanced Materials\u7f51\u7ad9\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a\u201dAmbient Aqueous Synthesis of Ultrasm…<\/p>\n","protected":false},"author":382,"featured_media":39768,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75],"class_list":["post-39746","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-biomaterial"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/39746"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/382"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39746"}],"version-history":[{"count":4,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/39746\/revisions"}],"predecessor-version":[{"id":40060,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/39746\/revisions\/40060"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/media\/39768"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=39746"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=39746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}