{"id":64144,"date":"2017-02-15T06:30:30","date_gmt":"2017-02-14T22:30:30","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=64144"},"modified":"2017-02-13T20:20:06","modified_gmt":"2017-02-13T12:20:06","slug":"jacs%e5%9f%ba%e4%ba%8e%e8%82%bd-%e5%8d%9f%e5%95%89%e8%87%aa%e7%bb%84%e8%a3%85%e7%9a%84%e5%85%89%e7%83%ad%e7%ba%b3%e7%b1%b3%e7%82%b9%e7%94%a8%e4%ba%8e%e6%8a%97%e7%99%8c%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=64144","title":{"rendered":"JACS\uff1a\u57fa\u4e8e\u80bd-\u535f\u5549\u81ea\u7ec4\u88c5\u7684\u5149\u70ed\u7eb3\u7c73\u70b9\u7528\u4e8e\u6297\u764c\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

\u5149\u70ed\u6cbb\u7597\uff08PTT\uff09\u7531\u4e8e\u5177\u6709\u6e29\u548c\u3001\u6cbb\u7597\u7a0b\u5e8f\u7b80\u4fbf\u3001\u6cbb\u7597\u65f6\u95f4\u77ed\u3001\u6062\u590d\u901f\u5ea6\u5feb\u7b49\u4f18\u70b9\u5e7f\u6cdb\u5e94\u7528\u4e8e\u80bf\u7624\u7684\u6cbb\u7597\u4e2d\u3002\u5728\u5149\u70ed\u6cbb\u7597\u4e2d\u5149\u654f\u5242\u7684\u4f7f\u7528\u81f3\u5173\u91cd\u8981\uff0c\u5149\u654f\u5242\u4e0d\u4ec5\u53ef\u4ee5\u5c06\u5149\u80fd\u8f6c\u53d8\u4e3a\u70ed\u91cf\u6d88\u878d\u764c\u75c7\u7ec6\u80de\uff0c\u800c\u4e14\u7528\u4e8e\u5149\u58f0\uff08PA\uff09\u6210\u50cf\u4e2d\u6bd4\u4f20\u7edf\u7684\u6210\u50cf\u6280\u672f\u6709\u66f4\u9ad8\u7684\u5206\u8fa8\u7387\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u51fa\u73b0\u8fc7\u5404\u79cd\u65e0\u673a\u548c\u805a\u5408\u7269\u5149\u654f\u5242\u4f46\u662f\u7531\u4e8e\u751f\u7269\u5b89\u5168\u6027\u7b49\u95ee\u9898\u5728\u4e34\u5e8a\u4e2d\u4e00\u76f4\u5f97\u4e0d\u5230\u8f83\u597d\u7684\u6548\u679c\u3002\u56e0\u6b64\uff0c\u8bbe\u8ba1\u548c\u521b\u9020\u51fa\u4e00\u79cd\u7406\u60f3\u7684\u5149\u654f\u6750\u6599\u8fd8\u9762\u4e34\u7740\u5f88\u5927\u7684\u6311\u6218\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u6765\u81ea\u4e2d\u79d1\u9662\u8fc7\u7a0b\u5de5\u7a0b\u6240\u7684\u95eb\u5b66\u6d77\u7814\u7a76\u5458\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5728\u591a\u80bd\u548c\u535f\u5549\u7684\u751f\u7269\u7ec4\u7ec7\u4e2d\u53d7\u5230\u542f\u53d1\uff0c\u901a\u8fc7\u5149\u654f\u535f\u5549\u7684\u80bd\u81ea\u7ec4\u88c5\u91c7\u7528\u8d85\u5206\u5b50\u7b56\u7565\u6784\u6210\u5149\u70ed\u7eb3\u7c73\u70b9\u3002\u535f\u5549\u7684\u81ea\u7ec4\u88c5\u7279\u6027\u8bf1\u53d1J\u805a\u5408\u7269\u4f5c\u4e3a\u7eb3\u7c73\u70b9\u7684\u57fa\u7840\u7ed3\u6784\uff0c\u4f7f\u7eb3\u7c73\u70b9\u7684\u7ed3\u6784\u80fd\u6291\u5236\u8367\u5149\u6563\u5c04\u548c\u5355\u7ebf\u6001\u6c27\u7684\u4ea7\u751f\uff0c\u4ece\u800c\u4f7f\u5149\u5230\u70ed\u7684\u8f6c\u53d8\u5177\u6709\u66f4\u9ad8\u7684\u6548\u7387\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u80bd-\u535f\u5549\uff08TPP-G-FF\uff09\u81ea\u7ec4\u88c5\u5230\u5149\u70ed\u80bd-\u535f\u5549\u7eb3\u7c73\u70b9\uff08PPP-NDs\uff09\u7684\u8fc7\u7a0b\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

a) PP-G-FF\u7684\u5206\u5b50\u7ed3\u6784\u548c\u81ea\u7ec4\u88c5\u8fc7\u7a0b\u56fe\u89e3<\/p>\n

b) PPP-NDs\u5728\u6d53\u5ea6\u4e3a0.2mg.mL-1<\/sup>\u6c34\u4e2d\u7684\u52a8\u6001\u5149\u6563\u5c04\uff08DLS\uff09\u5c3a\u5bf8\u5206\u5e03<\/p>\n

c) PPP-NDs\u7684\u900f\u5c04\u7535\u955c\uff08TEM\uff09\u56fe\u50cf<\/p>\n

d,e) PPP-NDs\u7684\u539f\u5b50\u529b\u663e\u5fae\u955c\uff08AFM\uff09\u56fe\u50cf<\/p>\n

\u56fe2 \u00a0PPP-NDs\u7684\u7a33\u5b9a\u6027\u80fd<\/b><\/strong><\/p>\n

\"\"<\/p>\n

 <\/p>\n

a) \u65b0\u8fd1\u51c6\u5907\u7684\u548c\u8001\u5316\u7684PPP-NDs\u52a8\u6001\u5149\u6563\u5c04\uff08DLS\uff09\u5c3a\u5bf8\u8f6e\u5ed3\u5bf9\u6bd4<\/p>\n

b) PPP-NDs\u5728\u542b\u6709\u6c2f\u5316\u94a0\uff08NaCl\uff09\u6c34\u6eb6\u6db2\u4e2d\u7684\u7d2b\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31\uff08UV-vis\uff09<\/p>\n

c) PPP-NDs\u5728\u6c34\u4e2d\u548c\u542b\u6709\u6c28\u57fa\u9178\u548c\u8461\u8404\u7cd6\u7684\u57f9\u517b\u57fa\uff08DMEM\uff09\u4e2d\u52a8\u6001\u5149\u6563\u5c04\uff08DLS\uff09\u5c3a\u5bf8\u8f6e\u5ed3<\/p>\n

d) \u4e0d\u540c\u6d53\u5ea6\u7684PP-NDs\u52a8\u6001\u5149\u6563\u5c04\uff08DLS\uff09\u5c3a\u5bf8\u8f6e\u5ed3\u5bf9\u6bd4<\/p>\n

\u56fe3 \u00a0PPP-NDs\u7684\u5149\u70ed\u548c\u5149\u58f0\u6027\u80fd<\/strong><\/p>\n

\"\"<\/p>\n

a) PPP-NDs\u5728\u6c34\u4e2d\u4e0d\u540c\u5149\u5f3a\u5ea6\u4f5c\u7528\u5728\u6e29\u5ea6\u7684\u5347\u9ad8\u66f2\u7ebf<\/p>\n

b) PPP-NDs\u5728\u6c34\u4e2d\u4f7f\u7528635nm\u7684\u6fc0\u5149\u8f90\u5c04\u4e0b\u7684\u5149\u70ed\u6548\u7387\uff0c\u8f90\u5c04\u5341\u5206\u949f\u540e\u5173\u95ed\u6fc0\u5149<\/p>\n

c) \u65f6\u95f4\u5bf9\u6e29\u5ea6\u7684\u81ea\u7136\u5bf9\u6570\u5728\u51b7\u5374\u671f\u7684\u56fe\u8868<\/p>\n

d) PPP-NDs\u5728\u4e0d\u540c\u6d53\u5ea6\u6c34\u4e2d\u7684\u5149\u58f0\uff08PA\uff09\u56fe\u50cf<\/p>\n

e\uff09\u5c0f\u9f20\u5728\u9759\u8109\u6ce8\u5c04PPP-NDs\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u5149\u58f0\uff08PA\uff09\u56fe\u50cf<\/p>\n

\u56fe4 \u00a0PPP-NDs\u7684\u8840\u6db2\u6d41\u901a\u60c5\u51b5\u548c\u751f\u7269\u7ec4\u7ec7\u7684\u5206\u5e03<\/strong><\/p>\n

\"\"<\/p>\n

a) \u5728\u9759\u8109\u6ce8\u5c04PPP-NDs\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684PPP-NDs\u5728\u8840\u6db2\u4e2d\u7684\u6d53\u5ea6\u66f2\u7ebf<\/p>\n

b) \u5728\u9759\u8109\u6ce8\u5c04PPP-NDs\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684PPP-NDs\u5728\u5668\u5b98\u548c\u80bf\u7624\u7684\u6d53\u5ea6\u56fe\u8868<\/p>\n

\u56fe5 \u5728\u5c0f\u9f20\u4f53\u5185\u8fdb\u884c\u5149\u70ed\u6cbb\u7597\u6548\u679c\u5206\u6790<\/strong><\/p>\n

\"\"<\/p>\n

a) \u9759\u8109\u6ce8\u5c04PPP-NDs\u7684\u5c0f\u9f20\u5728\u6301\u7eed\u7684\u6fc0\u5149\u8f90\u5c04\u4e0b\u7684\u7ea2\u5916\u5149\u8c31\uff08IR\uff09\u56fe\u50cf<\/p>\n

b) \u968f\u7740\u8f90\u5c04\u65f6\u95f4\u7684\u589e\u52a0\u80bf\u7624\u4f4d\u7f6e\u5e73\u5747\u6e29\u5ea6\u53d8\u5316\u66f2\u7ebf<\/p>\n

c) \u4e0d\u540c\u7ec4\u5c0f\u9f20\u7684\u80bf\u7624\u6570\u91cf<\/p>\n

d) \u4e0d\u540c\u7ec4\u5c0f\u9f20\u7684\u4f53\u91cd<\/p>\n

e) \u5206\u522b\u6765\u81ea\u63a7\u5236\u7ec4\u548c\u5149\u70ed\u6cbb\u7597\u7ec4\u7684\u7ecf\u82cf\u6728\u7d2b\u548c\u66d9\u7ea2\u67d3\u8272\u7684\u5fc3\u810f\u3001\u813e\u810f\u3001\u80be\u810f\u3001\u809d\u810f\u548c\u80ba\u7684\u5bf9\u6bd4\u56fe<\/p>\n

\u3010\u5c0f\u7ed3<\/strong>\u3011<\/p>\n

\u8be5\u65b9\u6cd5\u9996\u6b21\u5b9e\u73b0\u4e86\u901a\u8fc7\u80bd-\u535f\u5549\u81ea\u7ec4\u88c5\u5149\u70ed\u7eb3\u7c73\u70b9\u6765\u8fdb\u884c\u5149\u70ed\u6cbb\u7597\uff0c\u5728\u5149\u70ed\u8f6c\u6362\u7387\u4e0a\u63d0\u9ad8\u4e8654.2%\u3002\u4e3a\u8d85\u5206\u5b50\u6cbb\u7597\u4e0a\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u7684\u524d\u77bb\u6027\u7684\u8bbe\u8ba1\u65b9\u6848\uff0c\u5e76\u5728\u751f\u7269\u4e34\u5e8a\u533b\u5b66\u4e2d\u5f97\u5230\u5f88\u597d\u7684\u5e94\u7528\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aBiological Photothermal Nanodots Based on Self-Assembly of Peptide\u2013Porphyrin Conjugates for Antitumor Therapy<\/a><\/strong>(JACS.\uff0c2017\uff0cDOI:10.1021\/jacs.6b11382)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u674e\u4f26\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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