{"id":69070,"date":"2017-03-08T06:30:24","date_gmt":"2017-03-07T22:30:24","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=69070"},"modified":"2017-03-07T19:46:26","modified_gmt":"2017-03-07T11:46:26","slug":"david-kaplan%e6%95%99%e6%8e%88acc-chem-res-%e6%9c%80%e6%96%b0%e7%bb%bc%e8%bf%b0%ef%bc%9a%e5%8d%8f%e5%90%8c%e6%95%b4%e5%90%88%e5%ae%9e%e9%aa%8c%e5%92%8c%e6%a8%a1%e6%8b%9f%e6%96%b9%e6%b3%95%e4%bb%8e","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=69070","title":{"rendered":"David L. Kaplan\u6559\u6388Acc. Chem. Res. \u6700\u65b0\u7efc\u8ff0\uff1a\u534f\u540c\u6574\u5408\u5b9e\u9a8c\u548c\u6a21\u62df\u65b9\u6cd5\u4ece\u5934\u8bbe\u8ba1\u4e1d\u57fa\u6750\u6599"},"content":{"rendered":"

\u3010\u5f15\u8bed\u3011<\/strong><\/p>\n

\u5982\u4eca\uff0c\u4ece\u536b\u751f\u4fdd\u5065\u5230\u65b0\u578b\u751f\u7269\u7eb3\u7c73\u5668\u4ef6\uff0c\u5177\u6709\u53ef\u8c03\u529f\u80fd\u5316\u6027\u80fd\u7684\u751f\u7269\u6750\u6599\u5728\u5b8c\u6210\u7279\u5b9a\u4efb\u52a1\u7684\u5e94\u7528\u9886\u57df\u5b58\u5728\u7740\u5e7f\u9614\u7684\u524d\u666f\u3002\u8fd9\u5176\u4e2d\uff0c\u4e3a\u4e86\u5b9e\u73b0\u53ef\u63a7\u529f\u80fd\u5316\u7684\u805a\u5408\u7269\u6750\u6599\uff0c\u5c06\u5929\u7136\u7269\u8d28\u5851\u5f62\u6210\u4eba\u5de5\u4ea7\u54c1\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u7b56\u7565\u3002\u4e1d\u662f\u8282\u80a2\u52a8\u7269\u7684\u81ea\u8eab\u5206\u6ccc\u7269\uff0c\u5728\u7ef4\u6301\u751f\u547d\u65b9\u9762\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002\u800c\u9274\u4e8e\u5176\u5728\u673a\u68b0\u6027\u80fd\u3001\u751f\u7269\u76f8\u5bb9\u6027\u3001\u53ef\u751f\u7269\u964d\u89e3\u6027\u7b49\u65b9\u9762\u7684\u7279\u70b9\uff0c\u4e1d\u86cb\u767d\u53ef\u88ab\u4f5c\u4e3a\u751f\u7269\u6750\u6599\u7cfb\u7edf\u53ef\u8c03\u63a7\u8bbe\u8ba1\u7684\u539f\u578b\u3002\u8fd1\u671f\uff0c\u7f8e\u56fd\u5854\u592b\u8328\u5927\u5b66\u7684David L. Kaplan\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u5728\u8457\u540d\u7efc\u8ff0\u7c7b\u671f\u520aAccounts of Chemical Research<\/strong>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cSynergistic Integration of Experimental and Simulation Approaches for the de Novo Design of Silk-Based Materials\u201d<\/strong>\u7684\u7efc\u8ff0\u6587\u7ae0\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u603b\u7ed3\u6982\u8ff0\u4e86\u4e1d\u57fa\u86cb\u767d\u8d28\u7cfb\u7edf\u8ba4\u77e5\u548c\u529f\u80fd\u5316\u7814\u7a76\u65b9\u9762\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u5e76\u91cd\u70b9\u5173\u6ce8\u4e86\u5982\u4f55\u5c06\u5b9e\u9a8c\u548c\u6a21\u62df\u65b9\u6cd5\u6574\u5408\u5e94\u7528\u4e8e\u751f\u7269\u805a\u5408\u7269\u7684\u8bbe\u8ba1\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u00a0\u7efc\u8ff0\u5bfc\u89c8\u56fe<\/strong><\/p>\n

1. \u6982\u51b5<\/strong><\/p>\n

\u4e1d\u662f\u4e00\u79cd\u7cbe\u81f4\u7684\u805a\u5408\u7269\u6750\u6599\uff0c\u4e5f\u662f\u4e00\u79cd\u9ad8\u5ea6\u6a21\u5757\u5316\u7684\u86cb\u767d\u8d28\u805a\u5408\u7269\u3002\u5b83\u5177\u6709\u9ad8\u5ea6\u7684\u5185\u90e8\u91cd\u590d\u5e8f\u5217\uff0c\u4fa7\u94fe\u8fd8\u5b58\u5728\u7740\u975e\u91cd\u590d\u6027\u7684N-\u6216\u8005C-\u672b\u7aef\u533a\u57df\u3002\u5728\u5185\u90e8\u91cd\u590d\u5e8f\u5217\u4e2d\uff0cpoly(Gly-Ala)\u4ee5\u53capoly-Ala\u57fa\u5e8f\uff08motif\uff09\u80fd\u591f\u5f62\u6210\u758f\u6c34\u7684\u03b2\u7ed3\u6784\uff08\u03b2\u7ed3\u6784\uff09\u7ed3\u6676\u533a\uff0c\u800c\u5bcc\u542b\u7518\u6c28\u9178\uff08glycine\uff09\u7684\u57fa\u5e8f\u5219\u5f62\u6210\u4eb2\u6c34\u7684\u975e\u7ed3\u6676\u533a\uff08\u5982\u03b2\u8f6c\u89d2\u6216\u8005\u65e0\u89c4\u5377\u66f2\u7b49\uff09\u3002\u8fd9\u4e9b\u57fa\u5e8f\u81ea\u7ec4\u88c5\u5f62\u6210\u5206\u7ea7\u6784\u9020\uff0c\u800c\u5728\u8fd9\u4e00\u6784\u9020\u4e2d\u6709\u5e8f\u4ea4\u8054\u7684\u03b2\u7ed3\u6784\u7eb3\u7c73\u6676\u88ab\u9650\u5236\u5728\u5f39\u6027\u7684\u86cb\u767d\u8d28\u57fa\u8d28\u4e2d\uff0c\u6700\u7ec8\u4f7f\u5f97\u4e1d\u7ea4\u7ef4\u6210\u4e3a\u6700\u575a\u97e7\u4e5f\u662f\u6700\u5177\u591a\u6837\u5316\u7684\u6750\u6599\u4e4b\u4e00\u3002<\/p>\n

\u5229\u7528\u91cd\u7ec4DNA\u6280\u672f\uff08recombinant DNA technology\uff09\u4eff\u6548\u548c\u53d1\u5c55\u6a21\u5757\u5316\u4e1d\u6a21\u677f\u7684\u601d\u8def\u4e3a\u4ece\u5206\u5b50\u6c34\u5e73\u5efa\u6784\u6750\u6599\u63d0\u4f9b\u4e86\u65b0\u7684\u53ef\u80fd\u3002\u6b64\u5916\uff0c\u9664\u4e86\u6539\u53d8\u57fa\u56e0\u5e8f\u5217\uff0c\u901a\u8fc7\u751f\u7269\u5408\u6210\u540e\u52a0\u5de5\uff08post-biosynthesis processing\uff09\u4e5f\u80fd\u5b9e\u73b0\u5bf9\u6750\u6599\u7ec4\u88c5\u7684\u8c03\u63a7\u3002\u5728\u8fc7\u53bb\u7684\u5341\u591a\u5e74\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u5728\u5229\u7528\u91cd\u7ec4\u4e1d\u6a21\u62df\u80bd\uff08recombinant silk mimetic peptides\uff09\u6765\u8bbe\u8ba1\u548c\u52a0\u5de5\u751f\u7269\u805a\u5408\u7269\u7684\u9886\u57df\u53d6\u5f97\u4e86\u957f\u8db3\u7684\u8fdb\u6b65\uff0c\u5bf9\u5206\u5b50\u91cf\u3001\u7ed3\u6784\u57df\u5c3a\u5bf8\uff08domain sizes\uff09\u4ee5\u53ca\u4eb2\u758f\u6c34\u5206\u533a\u7b49\u56e0\u7d20\u5728\u86cb\u767d\u8d28\u81ea\u7ec4\u88c5\u8fc7\u7a0b\u7b49\u65b9\u9762\u6240\u626e\u6f14\u7684\u89d2\u8272\u6709\u4e86\u66f4\u52a0\u6df1\u523b\u7684\u8ba4\u8bc6\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u901a\u8fc7\u5f15\u5165\u5176\u4ed6\u86cb\u767d\u8d28\u7684\u5173\u952e\u6a21\u5757\uff08key modules\uff09\u6216\u8005\u529f\u80fd\u5316\u57fa\u56e2\uff0c\u91cd\u7ec4DNA\u6280\u672f\u53ef\u4ee5\u4ece\u5934\u5408\u6210\uff08de novo<\/em>\uff09\u4e1d\u57fa\u751f\u7269\u6750\u6599\u3002<\/p>\n

\u591a\u5c3a\u5ea6\u6750\u6599\u6a21\u62df\uff08multiscale material simulations\uff09\u53ef\u4ee5\u63d0\u4f9b\u6750\u6599\u6027\u80fd\u6539\u53d8\u7684\u5185\u5728\u673a\u7406\u4fe1\u606f\u3002\u5728\u6750\u6599\u8bbe\u8ba1\u9636\u6bb5\u7684\u65e9\u671f\u5f15\u5165\u8ba1\u7b97\u6a21\u578b\u662f\u4ece\u5206\u5b50\u6784\u5efa\u6a21\u5757\u5e76\u4ea7\u751f\u529f\u80fd\u7684\u6709\u6548\u65b9\u6cd5\uff0c\u8fd9\u662f\u4e00\u79cd\u6709\u76ee\u6807\u529f\u80fd\u5bfc\u5411\u7684\u6750\u6599\u8bbe\u8ba1\u7684\u534f\u540c\u65b9\u6cd5\u3002\u8fd9\u4e00\u65b9\u6cd5\u4e5f\u540c\u6837\u9002\u5408\u4f5c\u4e3a\u805a\u5408\u7269\u5408\u91d1\u4ee5\u53ca\u805a\u5408\u7269\u590d\u5408\u6750\u6599\u7cfb\u7edf\u7684\u521b\u65b0\u8def\u7ebf\u56fe\u3002<\/p>\n

2. \u5b9e\u9a8c\u65b9\u6cd5\u548c\u591a\u5c3a\u5ea6\u5efa\u6a21\u7684\u6574\u5408\u7528\u4e8e\u751f\u7269\u805a\u5408\u7269\u7684\u8bbe\u8ba1<\/strong><\/p>\n

2.1 <\/strong>\u4e1d\u57fa\u6750\u6599\u7684\u751f\u7269\u5408\u6210<\/strong><\/p>\n

\u8bbe\u8ba1\u751f\u4ea7\u91cd\u7ec4\u4e1d\u57fa\u751f\u7269\u6750\u6599\uff08recombinant silks\uff09\u7684\u4e3b\u8981\u6b65\u9aa4\u5305\u62ec\u57fa\u56e0\u8bbe\u8ba1\u3001\u514b\u9686\u3001\u8868\u8fbe\u4ee5\u53ca\u86cb\u767d\u8d28\u7eaf\u5316\u3002\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\u7684\u4e1d\u86cb\u767d\u7684\u4e3b\u8981\u4f18\u52bf\u5728\u4e8e\u5e8f\u5217\u7684\u53ef\u4fee\u6574\u6027\uff08tailorability\uff09\u3001\u86cb\u767d\u8d28\u5316\u5b66\u7684\u591a\u6837\u6027\u4ee5\u53ca\u86cb\u767d\u8d28\u5c3a\u5bf8\u7684\u53ef\u63a7\u6027\u3002\u91cd\u7ec4DNA\u6280\u672f\u867d\u7136\u662f\u7814\u7a76\u5e8f\u5217-\u529f\u80fd\u5173\u7cfb\u7684\u6709\u6548\u5de5\u5177\uff0c\u4f46\u5728\u751f\u4ea7\u9ad8\u5206\u5b50\u91cf\u4e1d\u6750\u6599\u6216\u8005\u89c4\u6a21\u5316\u751f\u4ea7\u4e1d\u86cb\u767d\u65f6\u7684\u4f5c\u7528\u5374\u5341\u5206\u6709\u9650\u3002<\/p>\n

2.2 <\/strong>\u5408\u6210\u540e\u52a0\u5de5<\/strong><\/p>\n

\u5fae\u6d41\u4f53\u4ee5\u53ca\u6e7f\u6cd5\u7eba\u4e1d\uff08wet spinning\uff09\u6280\u672f\u662f\u6a21\u4eff\u81ea\u7136\u7eba\u4e1d\u8fc7\u7a0b\u800c\u53d1\u5c55\u8d77\u6765\u7684\uff0c\u5982\u4eca\u4e5f\u88ab\u5f00\u53d1\u7528\u4e8e\u5236\u5907\u91cd\u7ec4\u4e1d\u7ea4\u7ef4\u3002\u800c\u5316\u5b66\u7269\u7406\u6539\u6027\uff0c\u5305\u62ec\u7532\u9187\u84b8\u6c7d\u5904\u7406\u4ee5\u53ca\u9176\u4ea4\u8054\u53cd\u5e94\u7b49\u5747\u80fd\u591f\u4fc3\u4f7f\u9ad8\u5206\u5b50\u94fe\u7ec4\u88c5\u5f62\u6210\u4e8c\u7ea7\u7ed3\u6784\u6216\u8005\u805a\u5408\u7269\u7f51\u7edc\u4ee5\u589e\u5f3a\u6750\u6599\u6027\u80fd\u3002\u6b64\u5916\uff0c\u52a0\u5de5\u53c2\u6570\u7684\u6539\u53d8\u8fde\u540c\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u53d8\u5316\u4e5f\u80fd\u591f\u62d3\u5bbd\u65b0\u578b\u529f\u80fd\u805a\u5408\u7269\u6750\u6599\u7684\u8bbe\u8ba1\u601d\u8def\u3002<\/p>\n

2.3 <\/strong>\u591a\u5c3a\u5ea6\u5efa\u6a21\u4e0e\u9a8c\u8bc1<\/strong><\/p>\n

\u5bf9\u6750\u6599\u7279\u6027\u5efa\u6a21\u7684\u5e38\u89c1\u65b9\u6cd5\u5305\u62ec\u5c0f\u80bd\u7684\u5206\u5b50\u52a8\u529b\u5b66\u5efa\u6a21\uff08MD\uff09\u3001\u86cb\u767d\u8d28\u805a\u5408\u7269\u7684\u526f\u672c\u4ea4\u6362\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\uff08REMD\uff09\u3001\u7eb3\u7c73\u5c3a\u5ea6\u7684\u591a\u5206\u5b50\u7cfb\u7edf\u3001\u4ecb\u89c2\u5c3a\u5ea6\u7684\u7c97\u7c92\u5316\u5efa\u6a21\uff08CG\uff09\u7b49\u3002\u9690\u6027\u6eb6\u5242\u6e29\u5ea6\uff08implicit solvent temperature\uff09\u526f\u672c\u4ea4\u6362\u5206\u5b50\u52a8\u529b\u5b66\u53ca\u5176\u968f\u540e\u7684\u663e\u6027\u6eb6\u5242\u5e38\u89c4\u5206\u5b50\u52a8\u529b\u5b66\uff08explicit solvent conventional molecular dynamics\uff09\u4e5f\u53ef\u88ab\u7528\u4e8e\u7814\u7a76\u539f\u5b50\u5c3a\u5ea6\u7684\u7cfb\u7edf\u52a8\u529b\u5b66\u4ee5\u53ca\u7ed3\u6784\u7279\u6027\u3002<\/p>\n

\u5b9e\u9a8c\u8868\u5f81\u901a\u5e38\u4e0e\u6a21\u62df\u65b9\u6cd5\u4e00\u9053\u4e0d\u4ec5\u53ef\u4ee5\u7528\u4f5c\u5b9e\u9645\u7ed3\u679c\u7684\u9a8c\u8bc1\u624b\u6bb5\uff0c\u4e5f\u80fd\u4e3a\u6a21\u62df\u6a21\u578b\u7684\u4fee\u6b63\u63d0\u4f9b\u53cd\u9988\u3002\u5728\u539f\u5b50\u6216\u8005\u7eb3\u7c73\u5c3a\u5ea6\uff0c\u6d4b\u91cf\u6676\u4f53\u7ed3\u6784\u3001\u4e8c\u7ea7\u7ed3\u6784\u6216\u8005\u5316\u5b66\u7ed3\u6784\u7684\u5b9e\u9a8c\u65b9\u6cd5\u80fd\u591f\u4e3a\u786e\u5b9a\u539f\u5b50\u6027\u8d28\u63d0\u4f9b\u6709\u6548\u7684\u4fe1\u606f\u3002\u800c\u5728\u66f4\u5927\u7684\u5c3a\u5ea6\u4e0a\uff0c\u6d4b\u91cf\u5149\u5b66\u3001\u70ed\u5b66\u4ee5\u53ca\u673a\u68b0\u6027\u80fd\u7684\u5b9e\u9a8c\u65b9\u6cd5\u53c8\u80fd\u63d0\u4f9b\u5173\u4e8e\u5b8f\u89c2\u7269\u7406\u6027\u8d28\u7684\u4fe1\u606f\u3002\u800c\u6b63\u662f\u8fd9\u4e9b\u4fe1\u606f\u6784\u6210\u4e86\u5bf9\u6a21\u62df\u6a21\u578b\u7684\u53cd\u9988\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>1 \u57fa\u56e0\u5de5\u7a0b\u3001\u805a\u5408\u7269\u52a0\u5de5\u3001\u591a\u5c3a\u5ea6\u5efa\u6a21\u4ee5\u53ca\u529f\u80fd\u8bc4\u4f30\u7684\u534f\u540c\u6574\u5408\u7528\u4e8e\u65b0\u578b\u529f\u80fd\u5316\u751f\u7269\u6750\u6599\u7684\u8bbe\u8ba1<\/strong><\/p>\n

3. \u5b9e\u4f8b<\/strong>1<\/strong>\uff1a\u8718\u86db\u4e1d\u8bbe\u8ba1\u539f\u7406\u53ef\u7528\u4e8e\u5236\u9020\u5f3a\u52b2\u7684\u751f\u7269\u805a\u5408\u7269<\/strong><\/p>\n

\u5c3d\u7ba1\u8718\u86db\u4e1d\u62e5\u6709\u5f88\u597d\u7684\u673a\u68b0\u6027\u80fd\uff0c\u4f46\u8718\u86db\u4e1d\u53ca\u5176\u4eff\u751f\u6750\u6599\u7684\u6279\u91cf\u751f\u4ea7\u4f9d\u65e7\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\u3002\u91cd\u7ec4DNA\u6280\u672f\u662f\u8718\u86db\u4e1d\u5408\u6210\u7684\u624b\u6bb5\u4e4b\u4e00\uff0c\u540c\u65f6\u4e5f\u4e3a\u7406\u89e3\u8718\u86db\u4e1d\u7684\u5e8f\u5217\u8bbe\u8ba1\u3001\u81ea\u7ec4\u88c5\u673a\u5236\u4ee5\u53ca\u7eba\u4e1d\u8fc7\u7a0b\u5960\u5b9a\u4e86\u57fa\u7840\u3002\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u53ef\u4ee5\u751f\u7269\u5408\u6210\u91cd\u7ec4\u8718\u86db\u4e1d\uff0c\u5b83\u4eec\u7684\u5206\u5b50\u91cf\u3001\u7ed3\u6784\u57df\u5c3a\u5bf8\u7b49\u7279\u5f81\u4e0d\u540c\uff0c\u66f4\u6709\u5229\u4e8e\u7406\u89e3\u5e8f\u5217-\u529f\u80fd\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u4ece\u800c\u4fc3\u8fdb\u9ad8\u673a\u68b0\u5f3a\u5ea6\u7684\u4e1d\u57fa\u6750\u6599\u7684\u53d1\u5c55\u3002<\/p>\n

\u53ef\u6269\u5c55\u5efa\u6a21\u3001\u751f\u7269\u5408\u6210\u4ee5\u53ca\u52a0\u5de5\u5904\u7406\u7684\u6574\u5408\u52a0\u6df1\u4e86\u5bf9\u4e0e\u5929\u7136\u8718\u86db\u4e1d\u76f8\u4f3c\u7684\u4e1d\u7ea4\u7ef4\u5f62\u6210\u8fc7\u7a0b\u7684\u7406\u89e3\u3002\u6bd4\u5982\u501f\u52a9\u8fd9\u4e00\u7efc\u5408\u65b9\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u758f\u6c34\u6027A\u57df\uff08hydrophobic A domain\uff09\u4f53\u79ef\u5360\u6bd4\u8d8a\u5927\u7684\u91cd\u7ec4\u8718\u86db\u4e1d\u5176\u03b2\u7ed3\u6784\u542b\u91cf\u5c31\u8d8a\u9ad8\uff0c\u5176\u673a\u68b0\u521a\u5ea6\uff08mechanical stiffness\uff09\u4e5f\u5c31\u8d8a\u9ad8\uff0c\u5e76\u4e14\u8fd9\u4e00\u7ed3\u6784\u66f4\u503e\u5411\u4e8e\u81ea\u805a\u96c6\uff08self-associate\uff09\u800c\u5f62\u6210\u5206\u5b50\u95f4\u7ed3\u6784\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>2<\/strong> \u6574\u5408\u5efa\u6a21\u548c\u5b9e\u9a8c\u65b9\u6cd5\u751f\u4ea7\u91cd\u7ec4\u8718\u86db\u4e1d<\/strong><\/p>\n

4. \u5b9e\u4f8b<\/strong>2<\/strong>\uff1a\u751f\u7269\u6750\u6599\u754c\u9762\u7684\u4f18\u5316\u8bbe\u8ba1<\/strong><\/p>\n

\u6709\u673a-\u65e0\u673a\u754c\u9762\u662f\u7ec4\u7ec7\u4fee\u590d\u548c\u518d\u751f\u9886\u57df\u751f\u7269\u6750\u6599\u529f\u80fd\u7684\u4e00\u90e8\u5206\u3002\u4e3a\u4e86\u514b\u670d\u6765\u81ea\u751f\u7269\u77ff\u5316\u754c\u9762\u7684\u6311\u6218\u4ee5\u53ca\u5bf9\u575a\u786c\u751f\u7269\u6750\u6599\u884d\u751f\u51fa\u6765\u7684\u9700\u6c42\uff0c\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u5bf9\u4e1d\u6750\u6599\u8fdb\u884c\u6539\u6027\u53ef\u4ee5\u63a7\u5236\u751f\u7269\u77ff\u5316\u8fc7\u7a0b\u3002\u76f8\u5173\u7684\u7814\u7a76\u5df2\u7ecf\u9610\u660e\u4e86\u5305\u62ec\u57df\u7c7b\u578b\uff08domain types\uff09\u548c\u57df\u5206\u5e03\uff08domain distributions\uff09\u5728\u5185\u7684\u4e00\u7cfb\u5217\u4e0e\u77ff\u5316\u76f8\u5173\u7684\u7279\u6027\u4e0e\u673a\u68b0\u6027\u80fd\u9ad8\u5ea6\u5bc6\u5207\u76f8\u5173\u7684\u5173\u7cfb\u3002\u7406\u89e3\u8fd9\u4e9b\u5173\u952e\u56e0\u7d20\u5f71\u54cd\u751f\u7269\u77ff\u5316\u7684\u673a\u7406\u80fd\u591f\u5bf9\u4e1d\u57fa\u6750\u6599\u8fdb\u884c\u5408\u7406\u7684\u8bbe\u8ba1\uff0c\u4ece\u800c\u521b\u9020\u51fa\u65b0\u578b\u7684\u65e0\u673a\u6709\u673a\u6742\u5316\u7cfb\u7edf\u3002\u5efa\u6a21-\u5b9e\u9a8c\u65b9\u6cd5\u7684\u6574\u5408\u80fd\u591f\u9ad8\u6548\u8fa8\u6790\u5173\u952e\u53c2\u6570\u5728\u6750\u6599\u8bbe\u8ba1\u63a7\u5236\u529f\u80fd\u7684\u8fc7\u7a0b\u4e2d\u8d77\u5230\u7684\u4f5c\u7528\u3002\u901a\u8fc7\u5bf9\u6a21\u578b\u7684\u6574\u5408\uff0c\u53ef\u4ee5\u5bf9\u5305\u62ec\u86cb\u767d\u8d28\u6298\u53e0\u3001\u5e26\u7535\u5355\u5143\u7684\u6392\u5217\u4ee5\u53ca\u52a0\u5de5\u53c2\u6570\u7b49\u5728\u5185\u7684\u5173\u952e\u56e0\u7d20\u5728\u4fc3\u8fdb\u751f\u7269\u77ff\u5316\u65b9\u9762\u626e\u6f14\u7684\u89d2\u8272\u6709\u66f4\u6df1\u523b\u7684\u7406\u89e3\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>3 \u6574\u5408\u5efa\u6a21\u548c\u5b9e\u9a8c\u65b9\u6cd5\u8bbe\u8ba1\u751f\u7269\u77ff\u5316\u754c\u9762<\/strong><\/p>\n

5. \u5b9e\u4f8b<\/strong>3<\/strong>\uff1a\u52a8\u6001\u6750\u6599\uff1a\u7c7b\u4e1d\u5f39\u6027\u86cb\u767d<\/strong><\/p>\n

\u62e5\u6709\u72ec\u7279\u6027\u80fd\u7684\u4e1d\u6750\u6599\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u54cd\u5e94\u6027\u590d\u5408\u6750\u6599\u7684\u539f\u6750\u6599\u3002\u6bd4\u5982\u5c06\u4e1d-\u5f39\u6027\u86cb\u767d\uff08elastin\uff09\u590d\u5408\u7269\u7528\u4e8e\u53ef\u63a7\u7684\u6613\u53d8\u6027\u8bbe\u8ba1\u3002\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\uff0c\u8695\u4e1d\u7684\u5e8f\u5217GAGAGS\u4e0e\u7c7b\u5f39\u6027\u86cb\u767d\u591a\u80bd\uff08ELPs\uff09\u7684\u5e8f\u5217GXGVP\u878d\u5408\uff0c\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u8fdb\u884c\u7f16\u7801\u5c31\u80fd\u8868\u8fbe\u7c7b\u4e1d\u5f39\u6027\u86cb\u767d\uff08SELPs\uff09\uff0c\u968f\u540eSELPs\u53ef\u4f5c\u4e3a\u6a21\u677f\u7528\u4e8e\u523a\u6fc0\u54cd\u5e94\u6750\u6599\u7684\u5236\u5907\u3002\u8fd9\u4e00\u6750\u6599\u8bbe\u8ba1\u7684\u57fa\u7840\u5373\u662f\u4e1d\u7684\u5f3a\u52b2\u673a\u68b0\u6027\u80fd\u548c\u5f39\u6027\u86cb\u767d\u7684\u52a8\u6001\u7279\u6027\u3002\u53e6\u5916\uff0c\u8ba1\u7b97\u6a21\u578b\u7684\u52a0\u5165\u53ef\u4ee5\u6709\u6548\u51cf\u5c11\u8bd5\u9519\u7ed3\u679c\u7684\u4ea7\u751f\u3002\u591a\u5c3a\u5ea6\u5206\u5b50\u6a21\u578b\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u7528\u4e8e\u7c7b\u5f39\u6027\u86cb\u767d\u591a\u80bd\u3001\u5f39\u6027\u86cb\u767d\u539f\uff08tropoelastin\uff09\u3001\u4e1d\u86cb\u767d\u4ee5\u53caSELPs\u7684\u7814\u7a76\u3002\u8fd9\u4e9b\u6a21\u578b\u80fd\u591f\u63cf\u8ff0\u54cd\u5e94\u6e29\u5ea6\u7684\u7ed3\u6784\u8f6c\u53d8\u4ee5\u53ca\u673a\u68b0\u6027\u80fd\u53d8\u5316\u7684\u5206\u5b50\u673a\u5236\u3002\u5728\u672a\u6765\uff0c\u8fd8\u53ef\u4ee5\u5229\u7528\u8fd9\u4e9b\u6a21\u578b\u5c06\u76f8\u53d8\u6548\u5e94\u653e\u5927\u5230\u5b8f\u89c2\u5c3a\u5ea6\uff0c\u7528\u4e8e\u65b0\u578b\u523a\u6fc0\u54cd\u5e94\u578b\u6750\u6599\u7684\u8bbe\u8ba1\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>4 \u6574\u5408\u5efa\u6a21\u548c\u5b9e\u9a8c\u65b9\u6cd5\u8bbe\u8ba1\u523a\u6fc0\u54cd\u5e94\u578b\u6750\u6599<\/strong><\/p>\n

\u00a0\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n

\u5177\u6709\u53ef\u8c03\u529f\u80fd\u5316\u6027\u80fd\u7684\u751f\u7269\u6750\u6599\u5728\u836f\u7269\u9012\u9001\u3001\u7ec4\u7ec7\u5de5\u7a0b\u3001\u52a8\u6001\u751f\u7269\u6750\u6599\u690d\u5165\u4f53\u3001\u6750\u6599\u6d82\u5c42\u548c\u673a\u68b0\u5668\u4ef6\u7b49\u9886\u57df\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002\u4e1d\u5177\u6709\u7f16\u7801\u86cb\u767d\u8d28\u5e8f\u5217\u63a7\u5236\u7684\u57fa\u56e0\u57fa\u7840\u3001\u4f18\u5f02\u7684\u673a\u68b0\u6027\u80fd\u3001\u751f\u7269\u76f8\u5bb9\u6027\u4ee5\u53ca\u751f\u7269\u53ef\u964d\u89e3\u6027\u7b49\u7279\u70b9\uff0c\u662f\u4f5c\u4e3a\u8054\u5408\u5b9e\u9a8c\u548c\u5efa\u6a21\u65b9\u6cd5\u201c\u4ece\u5934\u8bbe\u8ba1\u201d\u529f\u80fd\u5316\u751f\u7269\u6750\u6599\u7684\u7406\u60f3\u539f\u578b\u3002\u5c3d\u7ba1\u5229\u7528\u4e1d\u6a21\u62df\u80bd\u53ef\u4ee5\u4ece\u5206\u5b50\u6a21\u5757\u5f00\u59cb\u8bbe\u8ba1\uff0c\u4f46\u8fd9\u79cd\u4e1d\u6750\u6599\u5176\u673a\u68b0\u6027\u80fd\u4f9d\u7136\u52a3\u4e8e\u5929\u7136\u4e1d\u6750\u6599\u3002\u8fd9\u5176\u4e2d\u4e00\u90e8\u5206\u662f\u7531\u4e8e\u4eba\u5de5\u6750\u6599\u7684\u5206\u5b50\u91cf\u8f83\u4f4e\uff0c\u5e76\u4e14\u86cb\u767d\u8d28\u4e2d\u7684\u4e00\u4e9b\u5173\u952e\u7ed3\u6784\u57df\u5728\u5236\u5907\u8fc7\u7a0b\u4e2d\u5bb9\u6613\u88ab\u622a\u65ad\uff08truncation\uff09\u7684\u7f18\u6545\u3002\u5b9e\u9a8c\u548c\u8ba1\u7b97\u7684\u6574\u5408\u6784\u6210\u4e86\u534f\u540c\u53cd\u9988\u56de\u8def\uff0c\u6709\u5229\u4e8e\u52a0\u6df1\u5bf9\u673a\u7406\u7684\u7406\u89e3\uff0c\u4ece\u800c\u4f18\u5316\u6750\u6599\u8bbe\u8ba1\u5e76\u514b\u670d\u73b0\u6709\u7f3a\u9677\u3002<\/p>\n

\u6587\u732e\u8fde\u63a5\uff1a<\/strong>Synergistic Integration of Experimental and Simulation Approaches<\/a>\u00a0for the de Novo Design of Silk-Based Materials<\/a> (Acc. Chem. Res., 2017, DOI: 10.1021\/acs.accounts.6b00616)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u751f\u7269\u6750\u6599\u7ec4cailiaoniuer\u63d0\u4f9b\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8bed\u3011 \u5982\u4eca\uff0c\u4ece\u536b\u751f\u4fdd\u5065\u5230\u65b0\u578b\u751f\u7269\u7eb3\u7c73\u5668\u4ef6\uff0c\u5177\u6709\u53ef\u8c03\u529f\u80fd\u5316\u6027\u80fd\u7684\u751f\u7269\u6750\u6599\u5728\u5b8c\u6210\u7279\u5b9a\u4efb\u52a1\u7684\u5e94\u7528\u9886\u57df\u5b58\u5728\u7740\u5e7f\u9614\u7684\u524d\u666f\u3002\u8fd9\u5176\u4e2d\uff0c\u4e3a\u4e86\u5b9e\u73b0\u53ef\u63a7\u529f\u80fd\u5316\u7684\u805a\u5408\u7269\u6750\u6599\uff0c\u5c06\u5929…<\/p>\n","protected":false},"author":1076,"featured_media":69076,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[533],"tags":[],"class_list":["post-69070","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zongshu"],"_links":{"self":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/69070"}],"collection":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/users\/1076"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=69070"}],"version-history":[{"count":4,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/69070\/revisions"}],"predecessor-version":[{"id":69138,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/posts\/69070\/revisions\/69138"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=\/wp\/v2\/media\/69076"}],"wp:attachment":[{"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=69070"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=69070"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.cailiaoniu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=69070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}