{"id":83595,"date":"2017-06-02T06:30:10","date_gmt":"2017-06-01T22:30:10","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=83595"},"modified":"2017-05-25T22:39:14","modified_gmt":"2017-05-25T14:39:14","slug":"jacs%ef%bc%9a%e5%85%b7%e6%9c%89%e8%87%aa%e4%bf%ae%e5%a4%8d%e3%80%81%e8%87%aa%e7%bb%84%e8%a3%85%e5%8a%9f%e8%83%bd%e7%9a%84%ce%b2-%e7%89%87%e5%a4%9a%e8%82%bd-%ce%b3%e8%81%9a%e8%b0%b7%e6%b0%a8%e9%85%b8","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=83595","title":{"rendered":"JACS\uff1a\u5177\u6709\u81ea\u4fee\u590d\u53ca\u81ea\u7ec4\u88c5\u529f\u80fd\u7684\u03b2-\u7247\u591a\u80bd-\u03b3\u805a\u8c37\u6c28\u9178\u6742\u5316\u6c34\u51dd\u80f6"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u5728\u751f\u7269\u7ec4\u7ec7\u5de5\u7a0b\u4e2d\u5e38\u7528\u5230\u751f\u7269\u652f\u6491\u6750\u6599\u6765\u7ed9\u7ec6\u80de\u63d0\u4f9b\u4e00\u5b9a\u7684\u673a\u68b0\u652f\u6491\uff0c\u540c\u65f6\u80fd\u591f\u4fdd\u6301\u5f88\u597d\u7684\u751f\u7269\u6d3b\u6027\u5982\u7ec6\u80de\u6d41\u52a8\u548c\u517b\u5206\u7684\u6269\u6563\u3002\u8fd9\u4e9b\u652f\u6491\u6750\u6599\u4e00\u822c\u90fd\u662f\u7531\u805a\u5408\u7269\u6216\u8005\u591a\u80bd\u51dd\u80f6\u7ec4\u6210\uff0c\u5171\u4ef7\u4ea4\u8054\u7684\u805a\u5408\u7269\u51dd\u80f6\u4e00\u822c\u53ef\u4ee5\u901a\u8fc7\u8c03\u6574\u4ea4\u8054\u5ea6\u6216\u8005\u5206\u5b50\u7ed3\u6784\u6765\u5f97\u5230\u5f88\u597d\u7684\u673a\u68b0\u6027\u80fd\uff0c\u4f46\u662f\u8fd9\u4e00\u7c7b\u7684\u6750\u6599\u90fd\u662f\u7531\u975e\u81ea\u7136\u5b58\u5728\u7684\u5355\u4f53\u5408\u6210\u7684\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u6539\u6027\u6216\u8005\u529f\u80fd\u5316\u624d\u80fd\u5728\u751f\u7269\u7cfb\u7edf\u4e2d\u5e94\u7528\u3002\u81ea\u7ec4\u88c5\u6c34\u51dd\u80f6\u751f\u7269\u6750\u6599\u662f\u4e00\u79cd\u80fd\u591f\u901a\u8fc7\u6ce8\u5c04\u4e14\u539f\u4f4d\u5f62\u6210\u7684\u53ef\u964d\u89e3\u3001\u751f\u7269\u76f8\u5bb9\u6027\u8f83\u597d\u7684\u6750\u6599\uff0c\u7531\u4e8e\u8fd9\u79cd\u6750\u6599\u5728\u8f83\u4f4e\u5e94\u529b\u4e0b\u4f1a\u9020\u6210\u673a\u68b0\u6027\u80fd\u7684\u635f\u5931\uff0c\u56e0\u6b64\u5f88\u96be\u6ee1\u8db3\u5728\u751f\u7269\u9886\u57df\u4e2d\u7684\u5e94\u7528\u3002\u800c\u5b9e\u73b0\u5bf9\u81ea\u7ec4\u88c5\u6c34\u51dd\u80f6\u673a\u68b0\u6027\u80fd\u7684\u6539\u6027\uff0c\u4f7f\u5176\u80fd\u591f\u5728\u751f\u7269\u533b\u7597\u548c\u7ec4\u7ec7\u652f\u6491\u6750\u6599\u9886\u57df\u4e2d\u5927\u663e\u8eab\u624b\u5219\u662f\u4e00\u9879\u91cd\u8981\u7684\u7814\u7a76\u8bfe\u9898\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4f26\u6566\u5e1d\u56fd\u5b66\u9662\u7684Molly Stevens\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u62a5\u9053\u4e86\u8be5\u8bfe\u9898\u7ec4\u5408\u6210\u7684\u03b2-\u7247\u80bd-\u03b3\u805a\u8c37\u6c28\u9178(\u03b3-PGA)\u6742\u5316\u6c34\u51dd\u80f6\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cSelf-Healing, Self-Assembled \u03b2\u2011Sheet Peptide\u2212Poly(\u03b3-glutamic acid) Hybrid Hydrogels<\/strong>\u201d\u53d1\u8868\u5728J. Am. Chem. Soc.<\/strong>\u4e0a\u3002\u8be5\u5de5\u4f5c\u901a\u8fc7\u4f18\u9009\u03b2-\u7247\u80bd\u7684\u63a5\u679d\u5bc6\u5ea6\u548c\u6d53\u5ea6\uff0c\u5f97\u5230\u4e86\u5177\u6709\u5e94\u529b\u7a33\u5b9a\u6027\u7684\u805a\u5408\u7269\u9aa8\u67b6\u7ed3\u6784\uff0c\u540c\u65f6\u901a\u8fc7\u8c03\u6574\u6240\u5f97\u7684\u6742\u5316\u6c34\u51dd\u80f6\u7684\u673a\u68b0\u6027\u80fd\uff0c\u4f7f\u5176\u80fd\u591f\u5e94\u7528\u5728\u5f88\u591a\u9886\u57df\u3002\u53e6\u5916\uff0c\u7531\u4e8e\u03b2-\u7247\u80bd\u975e\u5171\u4ef7\u952e\u4ea4\u8054\u65b9\u5f0f\u7684\u91cd\u7ec4\uff0c\u4f7f\u6742\u5316\u6c34\u51dd\u80f6\u5728\u5e94\u529b\u65ad\u88c2\u7684\u6761\u4ef6\u4e0b\u5177\u6709\u81ea\u4fee\u590d\u7684\u80fd\u529b\u3002\u56e0\u6b64\uff0c\u672c\u6587\u5408\u6210\u7684\u81ea\u4fee\u590d\u805a\u5408\u7269-\u03b2-\u7247\u80bd\u6742\u5316\u6c34\u51dd\u80f6\u80fd\u591f\u5728\u751f\u7269\u533b\u836f\u9886\u57df\u548c\u751f\u7269\u652f\u67b6\u6750\u6599\u65b9\u9762\u5f97\u5230\u8f83\u597d\u7684\u53d1\u5c55\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u81ea\u4fee\u590d\u3001\u81ea\u7ec4\u88c5\u6742\u5316\u6c34\u51dd\u80f6\u7684\u5236\u5907<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u56fe\u793a\u4e3a\u53e0\u6c2e\u4fee\u9970\u7684\u81ea\u7ec4\u88c5\u6750\u6599\u03b2-\u7247\u80bd(N3-D2I4D2)\u548c\u7094\u70c3\u529f\u80fd\u5316\u7684\u03b3-PGA\u751f\u7269\u529f\u80fd\u805a\u5408\u7269\uff1b<\/p>\n

(b) \u6742\u5316\u6c34\u51dd\u80f6\u7684\u5408\u6210\u548c\u81ea\u7ec4\u88c5\u662f\u5c06\u53e0\u6c2e\u5316\u7684\u591a\u80bd\u4e0e\u7094\u70c3\u529f\u80fd\u5316\u7684\u805a\u5408\u7269\u7ecf\u94dc\u50ac\u5316\u53d1\u751f\u5316\u5b66\u53cd\u5e94\uff1b<\/p>\n

(c) \u03b2-\u7247\u80bd\u7684\u81ea\u7ec4\u88c5\uff0c\u5f15\u53d1\u5f62\u6210\u6c34\u51dd\u80f6\u3002\u8fd9\u7c7b\u6c34\u51dd\u80f6\u7531\u03b2-\u7247\u80bd\u901a\u8fc7\u5171\u4ef7\u952e\u7ed3\u5408\u5230\u805a\u5408\u7269\u9aa8\u67b6\u4e0a\uff1b<\/p>\n

(d) \u4e0d\u540c\u6bd4\u4f8b\u5171\u4ef7\u952e\u7ed3\u5408\u7684\u03b2-\u7247\u80bd\u548c\u975e\u5171\u4ef7\u81ea\u7531\u6001\u7684\u03b2-\u7247\u80bd\u6df7\u5408\u6c34\u51dd\u80f6\u4f5c\u4e3a\u5bf9\u7167\u3002<\/p>\n

\u56fe2 \u6742\u5316\u6c34\u51dd\u80f6\u7684\u5149\u8c31\u7814\u7a76<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5706\u4e8c\u8272\u8c31\u56fe\u8868\u793a\u6742\u5316\u6c34\u51dd\u80f6\u5728220\u548c230 nm\u5904\u51fa\u73b0\u6700\u5c0f\u503c\uff0c\u901a\u5e38\u8868\u660e\u4e3a\u03b2-\u7247\u80bd\u7684\u6784\u8c61\uff1b<\/p>\n

(b) \u9170\u80faI\u7684\u7ea2\u5916\u8c31\u56fe\uff1b<\/p>\n

(c) \u786b\u78fa\u7d20T\u68c0\u6d4b\u6cd5\uff0c\u8868\u660e\u5b58\u5728\u03b2-\u7247\u80bd\u7684\u6c34\u51dd\u80f6\u53ef\u4ee5\u51cf\u5c11\u76d0\u9178\u80cd\u7684\u542b\u91cf\uff1b\u6240\u6709\u6c34\u51dd\u80f6\u90fd\u662f\u7531\u8d28\u91cf\u5206\u6570\u4e3a7.5%\u7684\u6742\u5316\u6c34\u51dd\u80f6\u6784\u6210\uff0cFT-IR\u8868\u5f81\u91c7\u7528\u51bb\u5e72\u7684\u6c34\u51dd\u80f6\u3002<\/p>\n

\u56fe3 \u6742\u5316\u6c34\u51dd\u80f6\u7684\u673a\u68b0\u6027\u80fd\u6d4b\u8bd5<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e0d\u540c\u6d53\u5ea6(5\uff0c7.5\u548c10 wt%)\u7684\u03b3-PGA-10%\u03b2C\u6742\u5316\u6c34\u51dd\u80f6\u626b\u9891\u548c\u6768\u6c0f\u6a21\u91cf\u7684\u5173\u7cfb\uff1b<\/p>\n

(b) \u6742\u5316\u6c34\u51dd\u80f6\u7684\u673a\u68b0\u6027\u80fd\uff0c\u5bf9\u7167\u8bd5\u9a8c\u5305\u62ec\u4e0d\u540c\u63a5\u679d\u5bc6\u5ea6\u548c\u4e0d\u540c\u03b2-\u7247\u80bd\u7684\u4ea4\u8054\u7ed3\u5408\u6bd4\u4f8b\uff1b<\/p>\n

(c) \u4ece0\u52300.01%\uff0c1%\uff0c2%\uff0c5%\uff0c10%\uff0c15%\uff0c20%\uff0c30%\uff0c50%\u548c100%\u4e0d\u65ad\u589e\u52a0\u5e94\u529b\u7684\u5faa\u73af\u626b\u63cf\uff0c\u56fe\u4e2d\u7684\u70b9\u4ee3\u8868\u6bcf\u4e2a\u5e94\u529b\u626b\u63cf\u7684\u7ed3\u675f\u70b9\uff1b<\/p>\n

(d) \u4ece0\u5230200%\u5e94\u529b\u7684\u4e09\u7ec4\u91cd\u590d\u5e94\u529b\u626b\u63cf\uff0c\u626b\u63cf\u632f\u8361\u9891\u7387\u4e3a6.283 rads-1\uff0c\u6240\u6709\u7684\u6742\u5316\u6c34\u51dd\u80f6\u6bcf\u6b21\u626b\u63cf\u540e\u670930 min\u6062\u590d\u65f6\u95f4\uff0c\u4ece\u56fe\u4e2d\u53ef\u4ee5\u770b\u51fa\u6742\u5316\u6c34\u51dd\u80f6\u80fd\u591f\u5728\u65ad\u88c2\u540e\u6062\u590d\u5176\u673a\u68b0\u6027\u80fd\uff0c\u6240\u6709\u6d4b\u8bd5\u6837\u54c1\u90fd\u662f\u75317.5%\u7684\u6742\u5316\u6c34\u51dd\u80f6\u6784\u6210\u7684\u3002<\/p>\n

\u56fe4 \u6742\u5316\u6c34\u51dd\u80f6\u7684\u8868\u9762\u5f62\u8c8c<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u03b3-PGA-5%\u03b2C\u6750\u6599\u7684SEM\uff1b<\/p>\n

(b) \u03b3-PGA-10%\u03b2C\u6750\u6599\u7684SEM\uff1b<\/p>\n

(c) \u03b3-PGA-15%\u03b2C\u6750\u6599\u7684SEM\uff1b<\/p>\n

(d) \u03b3-PGA-10%\u03b2C+5%\u03b2F\u6750\u6599\u7684SEM\uff0c\u6240\u6709\u6c34\u51dd\u80f6\u90fd\u662f\u7531\u8d28\u91cf\u5206\u6570\u4e3a7.5%\u7684\u6742\u5316\u6c34\u51dd\u80f6\u7ec4\u6210\uff0c\u56fe\u4e2d\u7684\u6807\u5c3a\u4e3a1 \u00b5m\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u901a\u8fc7\u63a5\u679d\u03b2-\u7247\u80bd\u5230\u03b3-\u805a\u8c37\u6c28\u9178\u805a\u5408\u7269\u9aa8\u67b6\u4e0a\uff0c\u5408\u6210\u4e86\u4e00\u79cd\u80bd-\u805a\u5408\u7269\u7684\u6742\u5316\u6c34\u51dd\u80f6\u3002\u901a\u8fc7\u8c03\u6574\u03b2-\u7247\u80bd\u7684\u63a5\u679d\u5bc6\u5ea6\uff0c\u6539\u53d8\u6c34\u51dd\u80f6\u672c\u4f53\u7684\u6d53\u5ea6\u548c\u5171\u4ef7\u7ed3\u5408\u591a\u80bd\u7684\u6bd4\u4f8b\u5f97\u5230\u4e86\u5177\u6709\u8f83\u597d\u673a\u68b0\u6027\u80fd\u7684\u6c34\u51dd\u80f6\u3002\u540c\u65f6\uff0c\u672c\u6587\u5408\u6210\u7684\u6c34\u51dd\u80f6\u5728\u5177\u6709\u76f8\u540c\u7684\u6768\u6c0f\u6a21\u91cf\u65f6\u53ef\u4ee5\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u5bf9\u5e94\u529b\u54cd\u5e94\u7684\u673a\u68b0\u6027\u80fd\u3002\u03b2-\u7247\u80bd\u4f5c\u4e3a\u5f88\u597d\u7684\u7269\u7406\u4ea4\u8054\u5242\uff0c\u80fd\u591f\u5728\u5e94\u529b\u589e\u52a0\u523020%\u65f6\uff0c\u7ef4\u6301\u6c34\u51dd\u80f6\u7684\u673a\u68b0\u6027\u80fd\u4e0d\u53d8\uff0c\u5e76\u4e14\u53ef\u4ee5\u5728\u5e94\u529b\u7834\u574f\u540e\uff0c\u57fa\u4e8e\u5176\u81ea\u8eab\u7684\u81ea\u7ec4\u88c5\u7279\u6027\u8fdb\u884c\u81ea\u4fee\u590d\u3002\u53e6\u5916\uff0c\u672c\u6587\u91c7\u7528\u4e0d\u540c\u7684\u5149\u8c31\u6280\u672f\u7814\u7a76\u4e86\u6742\u5316\u6c34\u51dd\u80f6\u7684\u4e8c\u7ea7\u7ed3\u6784\u7684\u53d8\u5316\uff0c\u8868\u660e\u5176\u5185\u90e8\u542b\u6709\u03b2-\u7247\u80bd\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5: Self-Healing, Self-Assembled \u03b2\u2011Sheet Peptide\u2212Poly(\u03b3-glutamic acid) Hybrid Hydrogels<\/a><\/strong>\u00a0(J. Am. Chem. Soc., 2017, DOI: 10.1021\/jacs.7b00528)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u9ad8\u5206\u5b50\u5c0f\u7ec4\u70b9\u70b9\u63d0\u4f9b\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002\u53c2\u4e0e\u9ad8\u5206\u5b50\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u9ad8\u5206\u5b50\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u9ad8\u5206\u5b50\u4ea4\u6d41\u7fa4\uff08298064863\uff09\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a><\/strong>\uff01<\/p>\n

<\/p>\n

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