{"id":83833,"date":"2017-05-28T06:30:14","date_gmt":"2017-05-27T22:30:14","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=83833"},"modified":"2017-06-04T21:10:55","modified_gmt":"2017-06-04T13:10:55","slug":"%e9%99%88%e5%b0%8f%e5%85%83chem-soc-rev-%e7%bb%bc%e8%bf%b0%ef%bc%9a%e5%b0%86%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e7%9a%84%e7%ba%b3%e7%b1%b3%e7%b2%92%e5%ad%90%e8%ae%be%e8%ae%a1%e7%ad%96","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=83833","title":{"rendered":"\u9648\u5c0f\u5143Chem. Soc. Rev.\u7efc\u8ff0\uff1a\u5c06\u80bf\u7624\u5fae\u73af\u5883\u7684\u7eb3\u7c73\u7c92\u5b50\u8bbe\u8ba1\u7b56\u7565\u7528\u4e8e\u5f3a\u5316\u6297\u764c\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8bed\u3011<\/strong><\/p>\n

\u7eb3\u7c73\u8f7d\u4f53\u53ef\u4ee5\u6709\u6548\u5730\u8fd0\u8f7d\u8f93\u9001\u6297\u764c\u836f\u7269\u5230\u80bf\u7624\u4f4d\u70b9\u3002\u800c\u4e0e\u6b63\u5e38\u7ec4\u7ec7\u76f8\u6bd4\uff0c\u80bf\u7624\u5fae\u73af\u5883\u5177\u6709\u72ec\u7279\u7684\u6027\u8d28\uff0c\u5982\u8840\u7ba1\u5f02\u5e38\uff08vascular abnormalities\uff09\u3001\u4e4f\u6c27\uff08Hypoxia\uff09\u4ee5\u53ca\u9178\u6027pH\u7b49\u3002\u8fd1\u671f\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684\u9648\u5c0f\u5143\u6559\u6388\u4ee5\u53ca\u53a6\u95e8\u5927\u5b66\u7684\u5b59\u6653\u83b2\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\uff09<\/strong>\u7b49\u4eba\u5728Chemical Society Reviews<\/strong>\u4e0a\u53d1\u8868\u9898\u4e86\u4e3a\u201dNanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment\u201d<\/strong>\u7684\u7efc\u8ff0\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u603b\u7ed3\u6982\u8ff0\u4e86\u764c\u75c7\u7eb3\u7c73\u533b\u5b66\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u5e76\u91cd\u70b9\u5173\u6ce8\u4e86\u9488\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u523a\u6fc0\u54cd\u5e94\u6027\u7b56\u7565\u53d1\u5c55\u51fa\u7684\u7eb3\u7c73\u6280\u672f\u3002<\/strong><\/p>\n

\"\"<\/p>\n

\u7efc\u8ff0\u5bfc\u89c8\u56fe<\/strong><\/p>\n

1. \u6982\u51b5<\/strong><\/p>\n

\u764c\u75c7\u662f\u4e3b\u8981\u7684\u6b7b\u4ea1\u75c5\u56e0\u4e4b\u4e00\u3002\u4e00\u76f4\u4ee5\u6765\uff0c\u6765\u81ea\u4e0d\u540c\u9886\u57df\u7684\u7814\u7a76\u90fd\u5728\u81f4\u529b\u4e8e\u6709\u6548\u6cbb\u7597\u8fd9\u4e00\u75be\u75c5\u3002\u9274\u4e8e\u7eb3\u7c73\u6750\u6599\u62e5\u6709\u72ec\u7279\u7684\u7269\u5316\u6027\u8d28\uff0c\u5305\u62ec\u6709\u673a\u3001\u65e0\u673a\u548c\u751f\u7269\u5927\u5206\u5b50\u5728\u5185\u7684\u5404\u5f0f\u7eb3\u7c73\u6750\u6599\u76ee\u524d\u5728\u764c\u75c7\u8bca\u65ad\u548c\u6cbb\u7597\u9886\u57df\u5df2\u7ecf\u5b9e\u73b0\u4e86\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u5982\u78b3\u7eb3\u7c73\u6750\u6599\u3001\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\uff08UCNPs\uff09\u4ee5\u53ca\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\u7b49\u5229\u7528\u5176\u5404\u81ea\u7684\u7279\u70b9\u548c\u6027\u8d28\u53ef\u4f5c\u4e3a\u5355\/\u591a\u529f\u80fd\u8bca\u65ad\u4e0e\u6cbb\u7597\u7eb3\u7c73\u836f\u7269\u3002<\/p>\n

\u764c\u75c7\u6cbb\u7597\u7684\u4e00\u4e2a\u4e3b\u8981\u5173\u6ce8\u70b9\u662f\u6cbb\u7597\u5242\u5728\u4f53\u5185\u7684\u975e\u9776\u5411\u5206\u5e03\u3002\u5927\u591a\u6570\u4f20\u7edf\u7684\u836f\u7269\u90fd\u4e0d\u80fd\u533a\u522b\u6b63\u5e38\u7ec6\u80de\u548c\u764c\u75c7\u7ec6\u80de\u3002\u800c\u7eb3\u7c73\u7c92\u5b50\u7531\u4e8e\u9ad8\u901a\u900f\u6027\u548c\u6ede\u7559\u6548\u5e94\uff08EPR\uff09\u66f4\u503e\u5411\u4e8e\u5728\u80bf\u7624\u533a\u57df\u5bcc\u96c6\u3002\u800c\u53e6\u4e00\u65b9\u9762\uff0c\u4f53\u5185\u7684\u7269\u7406\u548c\u751f\u7269\u5b66\u5c4f\u969c\u4e5f\u5f71\u54cd\u7740\u7eb3\u7c73\u7c92\u5b50\u5728\u80bf\u7624\u533a\u7684\u5bcc\u96c6\u3002\u4f46\u662f\uff0c\u7edd\u5927\u591a\u6570\u7eb3\u7c73\u9897\u7c92\u5728\u5230\u8fbe\u80bf\u7624\u524d\u4f1a\u88ab\u7f51\u72b6\u5185\u76ae\u7cfb\u7edf\uff08RES\uff09\u9694\u7edd\uff0c\u8fd9\u4e0d\u4ec5\u6291\u5236\u4e86\u6750\u6599\u5728\u80bf\u7624\u7684\u5bcc\u96c6\u4e5f\u4f1a\u5bf9\u5bcc\u542b\u7f51\u72b6\u5185\u76ae\u7cfb\u7edf\u7684\u5668\u5b98\u9020\u6210\u635f\u4f24\u3002\u56e0\u6b64\uff0c\u9488\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u7279\u5f02\u6027\u54cd\u5e94\u7684\u7eb3\u7c73\u7c92\u5b50\u8bbe\u8ba1\u5bf9\u51cf\u5c11\u5065\u5eb7\u7ec4\u7ec7\u635f\u5bb3\u662f\u975e\u5e38\u6709\u610f\u4e49\u7684\u3002<\/p>\n

2. \u80bf\u7624\u5fae\u73af\u5883<\/strong><\/p>\n

\u5b9e\u4f53\u7624\u7531\u764c\u7ec6\u80de\u548c\u591a\u79cd\u57fa\u8d28\u7ec6\u80de\u7ec4\u6210\u3002\u8fd9\u4e9b\u7ec6\u80de\u5305\u62ec\u764c\u75c7\u76f8\u5173\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\u662f\u764c\u75c7\u57fa\u8d28\u7684\u4e3b\u8981\u6210\u5206\uff0c\u53ef\u5206\u6ccc\u5305\u62ec\u751f\u957f\u56e0\u5b50\u5728\u5185\u7684\u591a\u79cd\u7ec6\u80de\u5916\u57fa\u8d28\uff1b\u514d\u75ab\u7ec6\u80de\u53ef\u5206\u6ccc\u708e\u75c7\u4ecb\u8d28\u5f71\u54cd\u80bf\u7624\u5fae\u73af\u5883\uff0c\u5176\u4e2dT\u7ec6\u80de\u3001\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u3001\u6811\u7a81\u7ec6\u80de\u3001B\u7ec6\u80de\u7b49\u662f\u8d1f\u8d23\u5c40\u90e8\u523a\u6fc0\u7684\u4e3b\u8981\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\uff1b\u9ad3\u6e90\u6291\u5236\u6027\u7ec6\u80de\uff08MDSCs\uff09\u5219\u662f\u4e00\u7fa4\u6765\u6e90\u4e8e\u9aa8\u9ad3\u7684\u5f02\u8d28\u514d\u75ab\u7ec6\u80de\uff1b\u80bf\u7624\u5185\u76ae\u7ec6\u80de\uff08TECs\uff09\u4e0e\u6b63\u5e38\u5185\u76ae\u7ec6\u80de\u76f8\u6bd4\u53ef\u4ee5\u54cd\u5e94\u751f\u957f\u56e0\u5b50\u548c\u5404\u5f0f\u836f\u7269\u5206\u5b50\uff1b\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK cells\uff09\u4e0e\u81ea\u7136\u6740\u4f24T\u7ec6\u80de\uff08NKT cells\uff09\u5728\u8c03\u8282\u6297\u764c\u514d\u75ab\u65b9\u9762\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\uff1b\u5468\u76ae\u7ec6\u80de\u662f\u4e00\u7c7b\u5177\u6709\u6536\u7f29\u6027\u7684\u7ec6\u80de\uff0c\u80fd\u591f\u5305\u88f9\u8840\u7ba1\u7684\u5185\u76ae\u7ec6\u80de\uff1b\u80bf\u7624\u76f8\u5173\u4e2d\u6027\u7c92\u7ec6\u80de\uff08TANs\uff09\u5219\u662f\u901a\u8fc7\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u5728\u589e\u5f3a\u80bf\u7624\u4f4d\u70b9\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u6291\u5236\u65b9\u9762\u626e\u6f14\u7740\u91cd\u8981\u7684\u89d2\u8272\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>1<\/strong>\u80bf\u7624\u5fae\u73af\u5883\u7684\u4e3b\u8981\u7ec4\u6210<\/strong><\/p>\n

3. \u80bf\u7624\u8840\u7ba1\u5f02\u5e38<\/strong><\/p>\n

3.1 <\/strong>\u901a\u8fc7<\/strong>EPR<\/strong>\u6548\u5e94\u7684\u80bf\u7624\u88ab\u52a8\u9776\u5411<\/strong><\/p>\n

\u4e00\u5b9a\u5c3a\u5bf8\u8303\u56f4\u5185\u7684\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7EPR\u6548\u5e94\u66f4\u503e\u5411\u4e8e\u5728\u80bf\u7624\u7ec4\u7ec7\u5bcc\u96c6\u4e0e\u957f\u65f6\u95f4\u6ede\u7559\u3002\u8fd9\u5176\u4e2d\u7684\u539f\u56e0\u662f\u80bf\u7624\u8840\u7ba1\u5f02\u5e38\u63d0\u9ad8\u4e86\u8840\u7ba1\u6e17\u900f\u6027\uff0c\u5185\u76ae\u7ec6\u80de\u7684\u6392\u5217\u53d8\u5f97\u4e0d\u89c4\u6574\uff0c\u4f7f\u5f9720-200nm\u5c3a\u5bf8\u7684\u7eb3\u7c73\u7c92\u5b50\u66f4\u503e\u5411\u4e8e\u6e17\u900f\u8fdb\u7ec6\u80de\u95f4\u9699\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u80bf\u7624\u7ec4\u7ec7\u7f3a\u5c11\u6dcb\u5df4\u5f15\u6d41\u5bfc\u81f4\u7eb3\u7c73\u9897\u7c92\u5728\u7ec6\u80de\u95f4\u9699\u7684\u79fb\u52a8\u53d8\u5f97\u66f4\u52a0\u7f13\u6162\u3002\u7eb3\u7c73\u7c92\u5b50\u7684\u5f62\u8c8c\u548c\u8868\u9762\u6027\u8d28\u662f\u5f71\u54cd\u88ab\u52a8\u9776\u5411\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u7eb3\u7c73\u7c92\u5b50\u7684\u5c3a\u5bf8\u5e94\u8be5\u5927\u4e8e4-5nm\u4ee5\u907f\u514d\u80be\u810f\u8fc7\u6ee4\uff0c\u540c\u65f6\u5c3a\u5bf8\u8fd8\u5f97\u5c0f\u4e8e200nm\u4f7f\u5f97\u9897\u7c92\u53ef\u4ee5\u4ece\u6e17\u6f0f\u7684\u8109\u7ba1\u7cfb\u7edf\u4e2d\u6ea2\u51fa\u3002\u7eb3\u7c73\u7c92\u5b50\u7684\u751f\u7269\u5206\u5e03\u4e5f\u53d7\u5230\u7c92\u5b50\u5f62\u72b6\u548c\u786c\u5ea6\u7684\u5f71\u54cd\u3002\u8868\u9762\u6539\u6027\u4e5f\u53ef\u4ee5\u63d0\u9ad8\u6750\u6599\u7684\u8840\u6db2\u5faa\u73af\u80fd\u529b\u548c\u80bf\u7624\u5bcc\u96c6\u80fd\u529b\u3002\u5e26\u6b63\u7535\u7684\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u4e0e\u5e26\u8d1f\u7535\u7684\u8840\u7ba1\u7ed3\u5408\u5e76\u4ece\u8840\u6db2\u5faa\u73af\u4e2d\u88ab\u5feb\u901f\u6e05\u9664\uff0c\u800c\u5e26\u8d1f\u7535\u7684\u7eb3\u7c73\u7c92\u5b50\u4f1a\u7531\u4e8e\u7535\u8377\u9009\u62e9\u6027\u8fc7\u6ee4\u800c\u5bb9\u6613\u5728\u809d\u810f\u5bcc\u96c6\u3002\u53e6\u5916\uff0c\u5229\u7528PEG\u4fee\u9970\u7eb3\u7c73\u7c92\u5b50\u6216\u8005\u7ec6\u80de\u819c\u201c\u4f2a\u88c5\u201d\u7eb3\u7c73\u7c92\u5b50\u4e5f\u662f\u589e\u5f3a\u88ab\u52a8\u9776\u5411\u7684\u6709\u6548\u624b\u6bb5<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>2<\/strong> EPR<\/strong>\u6548\u5e94\u793a\u610f\u56fe<\/strong><\/p>\n

3.2 <\/strong>\u7eb3\u7c73\u7c92\u5b50\u7684\u4e3b\u52a8\u9776\u5411<\/strong><\/p>\n

\u867d\u7136\u7eb3\u7c73\u7c92\u5b50\u7531\u4e8eEPR\u6548\u5e94\u80fd\u591f\u88ab\u52a8\u9776\u5411\u80bf\u7624\u7ec4\u7ec7\uff0c\u4f46\u8fd9\u79cd\u9776\u5411\u4f9d\u8d56\u4e8e\u80bf\u7624\u8840\u7ba1\u751f\u6210\u548c\u518d\u751f\uff0c\u56e0\u6b64\u7f3a\u4e4f\u7279\u5f02\u6027\u548c\u4e00\u81f4\u6027\u3002\u80bf\u7624\u6a21\u578b\u79cd\u7c7b\u548c\u80bf\u7624\u72b6\u51b5\u90fd\u4f1a\u4e25\u91cd\u5f71\u54cd\u88ab\u52a8\u9776\u5411\u7684\u6709\u6548\u6027\u3002\u800c\u4e00\u4e9b\u914d\u4f53\u80fd\u591f\u4e0e\u80bf\u7624\u7ec6\u80de\u6216\u8005\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u8fc7\u5ea6\u8868\u8fbe\u53d7\u4f53\u7ed3\u5408\uff0c\u4e8e\u662f\u53ef\u5c06\u8fd9\u4e9b\u914d\u4f53\u4e0e\u7eb3\u7c73\u7c92\u5b50\u7ed3\u5408\u5e76\u7528\u4e8e\u80bf\u7624\u7684\u4e3b\u52a8\u9776\u5411\u3002\u8fd9\u4e9b\u9776\u5411\u7684\u4f4d\u70b9\u4e3b\u8981\u6709\u80bf\u7624\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08VEGFR\uff09\u3001\u6574\u5408\u7d20\u4ee5\u53ca\u8840\u7ba1\u7ec6\u80de\u7c98\u9644\u5206\u5b50\uff08VCAM-1\uff09\u3002<\/p>\n

4. \u80bf\u7624\u5fae\u73af\u5883\u8c03\u8282\u7eb3\u7c73\u6cbb\u7597<\/strong><\/p>\n

4.1 <\/strong>\u80bf\u7624\u4e4f\u6c27<\/strong><\/p>\n

\u80bf\u7624\u4e4f\u6c27\u610f\u5473\u7740\u80bf\u7624\u7ec4\u7ec7\u7684\u6c27\u6c14\u6c34\u5e73\u4f4e\u4e8e\u6b63\u5e38\u751f\u7406\u6c34\u5e73\u3002\u8fd9\u662f\u7531\u4e8e\u80bf\u7624\u7684\u5feb\u901f\u589e\u6b96\u4ee5\u53ca\u7ed3\u6784\u5f02\u5e38\u5bfc\u81f4\u6c27\u6c14\u96be\u4ee5\u6269\u6563\u4ea7\u751f\u7684\u3002\u56e0\u6b64\u4e4f\u6c27\u7ec6\u80de\u901a\u5e38\u8fdc\u79bb\u8840\u7ba1\uff0c\u6cbb\u7597\u836f\u7269\u96be\u4ee5\u5230\u8fbe\u3002\u4e3a\u4e86\u589e\u5f3a\u80bf\u7624\u6cbb\u7597\u6548\u529b\uff0c\u8bb8\u591a\u7814\u7a76\u90fd\u5c06\u5173\u6ce8\u70b9\u653e\u5728\u4e86\u8c03\u8282\u80bf\u7624\u6c27\u6c14\u6c34\u5e73\u4e0a\u3002\u5982\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u4f5c\u4e3a\u6c27\u6c14\u7684\u8f7d\u4f53\u6765\u8c03\u8282\u80bf\u7624\u6c27\u6c14\u6c34\u5e73\uff0c\u4ece\u800c\u66f4\u6709\u5229\u4e8e\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u7eb3\u7c73\u7c92\u5b50\u672c\u8eab\u53ef\u4ee5\u5728\u80bf\u7624\u5fae\u73af\u5883\u7684\u523a\u6fc0\u4e0b\u751f\u6210\u6c27\u6c14\u3002\u4e4f\u6c27\u7684\u73af\u5883\u8fd8\u80fd\u88ab\u5229\u7528\u5b9e\u73b0\u836f\u7269\u5728\u80bf\u7624\u7ec4\u7ec7\u7684\u91ca\u653e\u4ee5\u53ca\u524d\u836f\u7684\u6d3b\u5316\u7b49\u529f\u80fd\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>3<\/strong> \u6c27\u6c14\u81ea\u5bcc\u96c6\u5149\u52a8\u529b\u5b66\u6cbb\u7597<\/strong><\/p>\n

4.2<\/strong>\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u9178\u6027<\/strong>pH<\/strong><\/p>\n

\u80de\u5916\u9178\u6027pH\u662f\u5b9e\u4f53\u7624\u5fae\u73af\u5883\u7684\u91cd\u8981\u7279\u5f81\uff0c\u5176\u6570\u503c\u8303\u56f4\u5927\u6982\u57286.0-7.0\uff0c\u4e0e\u6b64\u540c\u65f6\uff0c\u6b63\u5e38\u7ec4\u7ec7\u548c\u8840\u7ba1\u7684pH\u5219\u662f7.4\u5de6\u53f3\u3002\u8fd9\u4e00\u7279\u5f81\u6027pH\u5e38\u88ab\u7528\u6765\u9009\u62e9\u6027\u89e6\u53d1\u4e00\u4e9b\u7eb3\u7c73\u8f7d\u4f53\u4ee5\u589e\u5f3a\u764c\u75c7\u6cbb\u7597\u6548\u529b\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u9178\u6027\u80de\u5916pH\u53ef\u4ee5\u6d3b\u5316\u6eb6\u9176\u4f53\u9176\u6765\u5e73\u8861pH\u3002\u6b64\u5916\uff0c\u9178\u6027\u73af\u5883\u53ef\u4ee5\u589e\u52a0\u8010\u836f\u6027\u5e76\u4e14\u5f71\u54cd\u80bf\u7624\u8f6c\u79fb\u3002\u4e3a\u4e86\u6d88\u9664\u8fd9\u4e9b\u4f5c\u7528\uff0c\u53d1\u5c55\u53ef\u4ee5\u8c03\u8282\u80de\u5916pH\u7684\u7eb3\u7c73\u7cfb\u7edf\u662f\u5f88\u91cd\u8981\u7684\u3002\u76ee\u524d\u6765\u8bf4\uff0c\u8fd9\u4e9b\u7cfb\u7edf\u5305\u62ec\u9178\u6eb6\u6027\u7eb3\u7c73\u9897\u7c92\u5982\u78b3\u9178\u9499\u3001\u78f7\u5316\u9499\u4ee5\u53ca\u4e8c\u6c27\u5316\u9530\u7eb3\u7c73\u7c92\u5b50\u7b49\uff1b\u591a\u6570\u6709\u673a\u7269\u5bf9\u4f4e\u9178\u6027\uff084.5-5.5\uff09\u6761\u4ef6\u90fd\u53ca\u5176\u654f\u611f\uff0c\u7136\u800c\u4f9d\u7136\u9700\u8981\u9009\u62e9\u5bf9\u80bf\u7624\u9178\u6027\u5fae\u73af\u5883\uff086.5-7.0\uff09\u54cd\u5e94\u7684\u6709\u673a\u7269\u7eb3\u7c73\u7c92\u5b50\u3002<\/p>\n

\u00a0\"\"<\/p>\n

\u56fe<\/strong>4 <\/strong>\u8d1f\u8f7d\u5149\u52a8\u529b\u5b66\u836f\u7269\u7684\u78b3\u9178\u9499\u7eb3\u7c73\u7c92\u5b50\u4f5c\u4e3a\u80bf\u7624\u6cbb\u7597\u7eb3\u7c73\u7cfb\u7edf<\/strong><\/p>\n

4.3\u00a0<\/strong>\u514d\u75ab\u53cd\u5e94<\/strong><\/p>\n

\u5229\u7528\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u53ef\u4ee5\u5bf9\u80bf\u7624\u8fdb\u884c\u6301\u7eed\u7279\u5f02\u6027\u7684\u514d\u75ab\u6297\u764c\u6cbb\u7597\u3002\u5bf9\u4e8e\u6709\u6548\u5730\u514d\u75ab\u6cbb\u7597\u6765\u8bf4\uff0c\u9996\u5148\u514d\u75ab\u7cfb\u7edf\u8981\u88ab\u6d3b\u5316\uff0c\u968f\u540e\u6548\u5e94\u7ec6\u80de\u6269\u6563\u5e76\u6d78\u6da6\u80bf\u7624\u7ec4\u7ec7\uff0c\u6700\u540e\u80bf\u7624\u7ec6\u80de\u4f1a\u88ab\u6740\u6b7b\u3002\u4f46\u662f\u764c\u7ec6\u80de\u80fd\u591f\u9003\u8131\u514d\u75ab\u53cd\u5e94\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4e5f\u80fd\u591f\u663e\u8457\u5730\u6291\u5236\u514d\u75ab\u8fc7\u7a0b\u3002\u800c\u7eb3\u7c73\u7c92\u5b50\u5219\u80fd\u591f\u4fc3\u8fdb\u6297\u764c\u514d\u75ab\u53cd\u5e94\u3002\u4e00\u65e6\u7eb3\u7c73\u7c92\u5b50\u88ab\u8f93\u8fd0\u5230\u80bf\u7624\u7ec4\u7ec7\uff0c\u5b83\u4eec\u5c31\u80fd\u591f\u8c03\u8282\u514d\u75ab\u6291\u5236\u7684\u80bf\u7624\u5fae\u73af\u5883\u4ece\u800c\u6fc0\u6d3b\u514d\u75ab\u5e94\u7b54\u3002\u800c\u5229\u7528\u7eb3\u7c73\u7c92\u5b50\u4f5c\u4e3a\u8f7d\u4f53\u4e5f\u53ef\u4ee5\u8f93\u8fd0\u6297\u539f\u5206\u5b50\u6216\u8005\u514d\u75ab\u523a\u6fc0\u836f\u7269\u6765\u5b9e\u73b0\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n

4.4\u00a0<\/strong>\u80bf\u7624\u75c5\u7406\u538b\u529b\u68af\u5ea6\uff08<\/strong>Tumour pathological pressure gradients<\/strong>\uff09<\/strong><\/p>\n

\u80bf\u7624\u75c5\u7406\u538b\u529b\u68af\u5ea6\u5728\u63a7\u5236\u7eb3\u7c73\u7c92\u5b50\u7624\u5185\u8f93\u8fd0\u65b9\u9762\u626e\u6f14\u7740\u4e0d\u53ef\u6216\u7f3a\u7684\u89d2\u8272\u3002\u538b\u529b\u68af\u5ea6\u5efa\u7acb\u5728\u4eba\u4f53\u5185\u95f4\u8d28\u6db2\u6d41\u52a8\u4ee5\u5b9e\u73b0\u8840\u6db2\u548c\u7ec6\u80de\u4e4b\u95f4\u7269\u8d28\u4ea4\u6362\u7684\u57fa\u7840\u4e4b\u4e0a\u3002\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\uff0c\u7ec4\u7ec7\u538b\u529b\u548c\u7ed3\u6784\u4e4b\u95f4\u5b58\u5728\u7740\u5e73\u8861\u4ee5\u6b64\u6765\u4fdd\u8bc1\u7ec6\u80de\u7684\u751f\u957f\u548c\u7ec4\u7ec7\u529f\u80fd\u7684\u6b63\u5e38\u8fd0\u4f5c\u3002\u800c\u5728\u5f02\u5e38\u7684\u80bf\u7624\u533a\u57df\u7ec4\u7ec7\u538b\u529b\u5219\u662f\u589e\u52a0\u7684\u3002\u8fd9\u662f\u7531\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u9ad8\u5bc6\u5ea6\u3001\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u9ad8\u6d53\u5ea6\u3001\u8840\u7ba1\u6e17\u6f0f\u4ee5\u53ca\u6dcb\u5df4\u7ba1\u5f02\u5e38\u9020\u6210\u7684\u3002\u80bf\u7624\u533a\u57df\u7684\u9ad8\u538b\u4f1a\u5bfc\u81f4\u7eb3\u7c73\u7c92\u5b50\u5728\u6cbb\u7597\u65f6\u7684\u5438\u6536\u6548\u7387\u53d8\u5f97\u4f4e\u4e0b\u3002\u4e8e\u662f\uff0c\u8c03\u8282\u7624\u5185\u538b\u529b\u68af\u5ea6\u662f\u589e\u5f3a\u7eb3\u7c73\u7c92\u5b50\u7684\u5916\u6e17\u548c\u6cbb\u7597\u6548\u529b\u7684\u65b0\u578b\u624b\u6bb5\u3002<\/p>\n

4.5\u00a0<\/strong>\u80bf\u7624\u7ec6\u80de\u5916\u57fa\u8d28\uff08<\/strong>ECM<\/strong>\uff09<\/strong><\/p>\n

\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u529f\u80fd\u662f\u5145\u5f53\u7ec4\u7ec7\u5f62\u6001\u751f\u957f\u652f\u67b6\uff0c\u5b83\u7684\u4e3b\u8981\u7ec4\u6210\u662f\u9ad8\u5ea6\u8fde\u901a\u80f6\u539f\u7ea4\u7ef4\u3001\u7cd6\u86cb\u767d\u4ee5\u53ca\u86cb\u767d\u591a\u7cd6\u7b49\u8d1f\u8d23\u7ec4\u7ec7\u7a33\u6001\u3001\u5668\u5b98\u53d1\u80b2\u7684\u86cb\u767d\u8d28\u7ec4\u7ec7\u3002\u7531\u4e8e\u9ad8\u5ea6\u80f6\u539f\u4ee3\u8c22\u3001\u589e\u9ad8\u7684\u8d56\u6c28\u9170\u6c27\u5316\u9176\u4ee5\u53ca\u5f3a\u5316\u7684\u6574\u5408\u7d20\u53d7\u4f53\uff0c\u5b9e\u4f53\u7624\u62e5\u6709\u6d53\u7a20\u7684\u7ec6\u80de\u5916\u57fa\u8d28\uff0c\u53ef\u4ee5\u963b\u6b62\u7eb3\u7c73\u7c92\u5b50\u7684\u6e17\u5165\uff0c\u964d\u4f4e\u80bf\u7624\u6cbb\u7597\u6548\u529b\u3002\u80bf\u7624ECM\u7684\u8c03\u5236\u80fd\u591f\u4e3a\u589e\u5f3a\u80bf\u7624\u6cbb\u7597\u63d0\u4f9b\u66ff\u4ee3\u7b56\u7565\u3002\u5176\u4e2d\u53ef\u4ee5\u7528\u900f\u660e\u8d28\u9178\u9176\u6216\u8005\u80f6\u539f\u86cb\u767d\u9176\u6765\u964d\u89e3\u57fa\u8d28\u7ed3\u6784\u3002\u800cMMPs\u53c8\u662f\u4e00\u7c7b\u4e0e\u80bf\u7624\u751f\u6210\u606f\u606f\u76f8\u5173\u7684\u86cb\u767d\u9176\uff0cMMP\u4ecb\u5bfc\u7684\u80bf\u7624\u7ec6\u80de\u5916\u57fa\u8d28\u964d\u89e3\u80fd\u591f\u5bfc\u81f4\u80bf\u7624\u7684\u4fb5\u88ad\u548c\u8f6c\u79fb\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>5 <\/strong>\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684<\/strong>MMPs<\/strong>\u54cd\u5e94\u7eb3\u7c73\u8f7d\u4f53<\/strong><\/p>\n

\u3010\u603b\u7ed3\u4e0e\u5c55\u671b\u3011<\/strong><\/p>\n

\u8fd9\u7bc7\u7efc\u8ff0\u8ba8\u8bba\u4e86\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u7eb3\u7c73\u7c92\u5b50\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u7684\u5f00\u53d1\u548c\u5229\u7528\u3002\u5177\u6709\u80bf\u7624\u5fae\u73af\u5883\u54cd\u5e94\u7684\u7eb3\u7c73\u7c92\u5b50\u5728\u764c\u75c7\u6cbb\u7597\u9886\u57df\u5177\u6709\u6f5c\u5728\u7684\u5e94\u7528\u60c5\u666f\u3002\u7406\u60f3\u7684\u6cbb\u7597\u578b\u7eb3\u7c73\u7c92\u5b50\u5e94\u8be5\u80fd\u591f\u5c06\u8d1f\u8f7d\u7269\u51c6\u786e\u9001\u8fbe\u80bf\u7624\u533a\u57df\uff0c\u5e76\u4e14\u80fd\u591f\u5728\u4f53\u5185\u964d\u89e3\u4e0d\u9020\u6210\u6bd2\u526f\u4f5c\u7528\u3002\u672a\u6765\u7684\u7814\u7a76\u5de5\u4f5c\u5e94\u8be5\u7ee7\u7eed\u56f4\u7ed5\u5f00\u53d1\u9488\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u7279\u5f02\u6027\u7684\u65b0\u578b\u7eb3\u7c73\u7c92\u5b50\u6765\u5c55\u5f00\u3002<\/p>\n

\u6587\u732e\u8fde\u63a5\uff1a<\/strong>Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumourmicroenvironment<\/a>(Chem. Soc. Rev., 2017, DOI:10.1039\/C6CS00592F)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u751f\u7269\u6750\u6599\u7ec4nanoCJ\u63d0\u4f9b\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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