{"id":87070,"date":"2017-06-20T06:30:05","date_gmt":"2017-06-19T22:30:05","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=87070"},"modified":"2017-06-19T21:56:23","modified_gmt":"2017-06-19T13:56:23","slug":"%e5%8d%97%e4%bd%9b%e7%bd%97%e9%87%8c%e8%be%be%e5%a4%a7%e5%ad%a6%e8%94%a1%e5%81%a5%e5%b3%b0%e5%9b%a2%e9%98%9f%e5%92%8c%e4%b8%ad%e5%8d%97%e5%a4%a7%e5%ad%a6%e5%be%90%e6%b5%b7%e5%9b%a2%e9%98%9fjacs","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=87070","title":{"rendered":"\u5357\u4f5b\u7f57\u91cc\u8fbe\u5927\u5b66\u8521\u5065\u5cf0\u56e2\u961f\u548c\u4e2d\u5357\u5927\u5b66\u5f90\u6d77\u56e2\u961fJACS\uff1a\u65b0\u578b\u53f3\u65cb\u87ba\u65cb\u591a\u80bd\u7684\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/b><\/strong><\/span><\/p>\n

\u4eba\u5de5\u5408\u6210\u7684\u65b0\u578b\u751f\u7269\u6a21\u62df\u7ed3\u6784\u53ef\u4ee5\u7528\u6765\u6a21\u62df\u591a\u80bd\u548c\u86cb\u767d\u7684\u9ad8\u7ea7\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u800c\u4e14\u5177\u5907\u6709\u663e\u8457\u63d0\u9ad8\u7684\u6297\u86cb\u767d\u964d\u89e3\u80fd\u529b\u53ca\u65e0\u7a77\u5c3d\u7684\u7ed3\u6784\u4fee\u9970\u591a\u6837\u5316\u7684\u4f18\u70b9\uff0c\u4f46\u662f\u5b83\u4eec\u7684\u8bbe\u8ba1\u548c\u5408\u6210\u6781\u5177\u6311\u6218\u6027\u3002\u57fa\u4e8e\u591a\u80bd\u9aa8\u67b6\u7684\u87ba\u65cb\u6a21\u62df\u7ed3\u6784\u5728\u751f\u7269\u6750\u6599\u3001\u50ac\u5316\u548c\u836f\u7269\u8bbe\u8ba1\u4e2d\u5c24\u4e3a\u7279\u522b\uff0c\u5b83\u4eec\u53ef\u4ee5\u8ddf\u86cb\u767d\u3001\u7ec6\u80de\u819c\u7b49\u591a\u79cd\u9776\u70b9\u7ed3\u5408\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5df2\u7ecf\u6709\u5305\u62ec \u03b2-peptides, peptoids, \u03b2-peptoids, oligoureas, azapeptides, \u03b1-aminoisobutyric acid foldamers, oligoproline, \u548caromatic amide foldamers\u7b49\u4eba\u5de5\u5408\u6210\u7684\u87ba\u65cb\u7ed3\u6784\u5728\u6587\u732e\u4e2d\u62a5\u9053\uff0c\u4e0e\u4e4b\u76f8\u5173\u7684\u5206\u5b50\u81ea\u7ec4\u88c5\u548c\u5206\u5b50\u8bc6\u522b\u4ee5\u53ca\u836f\u7269\u6d3b\u6027\u5206\u5b50\u5f00\u53d1\u7b49\u5e94\u7528\u4e5f\u76f8\u7ee7\u62a5\u9053\u3002\u4f46\u662f\uff0c\u57fa\u4e8e\u4e0d\u540c\u7c7b\u578b\u9aa8\u67b6\u7684\u87ba\u65cb\u7ed3\u6784\u4e0d\u5c3d\u76f8\u540c\uff0c\u52a0\u4e0a\u57fa\u4e8eD\u548cL\u578b\u7684\u4e8c\u7ea7\u7ed3\u6784\u5f88\u96be\u88ab\u51c6\u786e\u9884\u6d4b\uff0c\u56e0\u6b64\uff0c\u5f00\u53d1\u5177\u6709\u65b0\u578b\u7ed3\u6784\u7684\u4eba\u5de5\u5408\u6210\u751f\u7269\u6a21\u62df\u7269\u9aa8\u67b6\u4ecd\u7136\u975e\u5e38\u91cd\u8981\u3002<\/p>\n

\u3010\u6210\u679c\u4ecb\u7ecd\u3011<\/b><\/strong><\/span><\/p>\n

\u5357\u4f5b\u7f57\u91cc\u8fbe\u5927\u5b66<\/strong>\u7684\u8521\u5065\u5cf0\u6559\u6388<\/strong>\u7814\u7a76\u56e2\u961f\u4e0e\u4e2d\u5357\u5927\u5b66\u5316\u5b66\u5316\u5de5\u5b66\u9662\u5f90\u6d77\u526f\u6559\u6388<\/strong>\u7814\u7a76\u56e2\u961f\u5f00\u5c55\u5408\u4f5c\uff0c\u5728\u65b0\u578b\u751f\u7269\u6a21\u62df\u7269\u9aa8\u67b6\u5f00\u53d1\u4e0a\u53d6\u5f97\u7a81\u7834\uff0c\u4ed6\u4eec\u5408\u6210\u4e86\u4e00\u7cfb\u5217\u65b0\u7684\u591a\u80bd\u805a\u5408\u7269\uff0c\u901a\u8fc7\u9ad8\u5206\u8fa8X-\u5c04\u7ebf\u5355\u6676\u884d\u5c04\u65b9\u6cd5\u786e\u5b9a\u4e86\u5176\u4e8c\u7ea7\u7ed3\u6784\uff0c\u8868\u660e\u8fd9\u7c7b\u591a\u80bd\u7684\u7ed3\u6784\u66f4\u52a0\u7c7b\u4f3c\u4e8e\u751f\u7269\u4f53\u5185\u7684\u03c0-helix\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4ee5\u201cRight-Handed Helical Foldamers Consisting of de novo D- AApeptides\u201d\u4e3a\u9898\uff0c\u53d1\u8868\u5728\u5316\u5b66\u7c7b\u9876\u7ea7\u671f\u520aJACS\uff08J. Am. Chem. Soc., 2017, 139 (21), pp 7363\u20137369\uff0cIF=13.038\uff09\u4e0a\uff0c\u8be5\u5de5\u4f5c\u4e3b\u8981\u7531\u5357\u4f5b\u7f57\u91cc\u8fbe\u5927\u5b66\u535a\u58eb\u540e\u6ed5\u9e4f\u3001\u535a\u58eb\u751f\u9a6c\u5b81\u3001Darrell Cole Cerrato\u3001\u4f58\u5cf0\u5b87\u3001Timothy Odom\u548c\u4e2d\u5357\u5927\u5b662016\u7ea7\u7855\u58eb\u751f\u6c6a\u7fd4\u7b49\u5171\u540c\u5b8c\u6210\uff0c\u8521\u5065\u5cf0\u6559\u6388\u4e0e\u5f90\u6d77\u526f\u6559\u6388\u5171\u540c\u62c5\u4efb\u901a\u8baf\u4f5c\u8005\u3002<\/p>\n

\"\"<\/p>\n

\u03b1-peptides\u548c 2:1 \u03b1\/D-sulfono-\u03b3-AA peptides\u7b49\u7ed3\u6784\u793a\u610f\u56fe\u3002\u56fe\u7247\u6765\u6e90\uff1aJACS<\/i><\/em><\/p>\n

\u3010\u672c\u6587\u4eae\u70b9\u3011<\/b><\/strong><\/span><\/p>\n

AApeptide\u662f\u4e00\u4e2a\u65b0\u5174\u7684\u5408\u6210\u7c7b\u591a\u80bd\u7ed3\u6784\uff0c\u7814\u7a76\u8005\u5df2\u7ecf\u8bc1\u660e\u57fa\u4e8eAApeptide\u7684\u5316\u5408\u7269\u5177\u6709\u6f5c\u5728\u7684\u751f\u7269\u6750\u6599\u548c\u533b\u836f\u5e94\u7528\uff0c\u4f46\u662f\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u6240\u6709\u5df2\u62a5\u9053\u7684\u8be5\u7c7b\u7ed3\u6784\u90fd\u662f\u4ece\u5929\u7136L\u6784\u578b\u591a\u80bd\u4e3a\u8d77\u70b9\u5408\u6210\u5236\u5907\u7684\uff0c\u6700\u7ec8\u5f97\u5230L-AApeptide\u9aa8\u67b6\u5316\u5408\u7269\u3002\u4e0e\u4e4b\u7edd\u5bf9\u6784\u578b\u76f8\u53cd\u7684D-AApeptide\u9aa8\u67b6\u8fd8\u4ece\u672a\u89c1\u62a5\u9053\uff0c\u66f4\u4e0d\u7528\u63d0\u57fa\u4e8eD-AApeptide\u7684\u591a\u80bd\u4e8c\u7ea7\u7ed3\u6784\u3002\u4f5c\u8005\u5408\u6210\u4e86\u4e00\u7cfb\u5217\u57fa\u4e8eL-\u6c28\u57fa\u9178\u548cD-AApeptide\uff082:1\u6bd4\u4f8b\uff09\u7684\u6df7\u5408\u4f4e\u805a\u7269\uff0c\u9996\u6b21\u901a\u8fc7X-\u5c04\u7ebf\u5355\u6676\u884d\u5c04\u8bc1\u5b9e\u4e86\u8be5\u7c7b\u591a\u7c7b\u805a\u5408\u7269\u7684\u4e8c\u7ea7\u87ba\u65cb\u7ed3\u6784\uff0c\u5e76\u901a\u8fc7\u4e8c\u7ef4\u6838\u78c1\u3001\u5706\u4e8c\u8272\u8c31\u6cd5\u4ee5\u53ca\u7406\u8bba\u8ba1\u7b97\u5bf9\u5176\u5206\u5b50\u5c42\u9762\u7684\u7ed3\u6784\u8fdb\u884c\u4e86\u6df1\u5165\u7814\u7a76\u3002\u4ed6\u4eec\u7684\u6210\u679c\u4e3a\u8be5\u7c7b\u65b0\u578b\u591a\u80bd\u7684\u66f4\u9ad8\u7ea7\u7ed3\u6784\u548c\u5e94\u7528\u6253\u4e0b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/span><\/p>\n

\u4f5c\u8005\u5408\u6210\u4e866\u4e2a\u591a\u80bd\uff0c\u4ece\u4e2d\u5f97\u5230\u4e864\u4e2a\u591a\u80bd\u7684\u5355\u6676\u7ed3\u6784\u3002\u56fe1\u5c55\u793a\u4e86\u957f\u5ea6\u4e0d\u540c\u7684\u4e09\u4e2a\u5408\u6210\u80bd\u4f4e\u805a\u7269\u7684X-\u5c04\u7ebf\u5355\u6676\u7ed3\u6784\u3002\u4ee4\u4eba\u4fe1\u670d\u7684\u662f\uff0c\u5316\u5408\u72691\u4ec5\u5177\u6709\u76f8\u5f53\u4e8e14\u4e2a\u80bd\u952e\u7684\u957f\u5ea6\uff0c\u4e5f\u53ef\u4ee5\u91c7\u53d6\u975e\u5e38\u89c4\u5219\u7684\u87ba\u65cb\u7ed3\u6784\u3002\u4e09\u4e2a\u5316\u5408\u7269\u90fd\u53ef\u4ee5\u901a\u8fc7\u975e\u5e38\u6709\u5e8f\u768416\u221216\u221214\u2212\u5206\u5b50\u5185\u6c22\u952e\u6765\u7a33\u5b9a\u5176\u4e8c\u7ea7\u87ba\u65cb\u7ed3\u6784\uff0c\u5176\u4e2d\u5305\u62ec\u4e24\u7c7b\u5206\u5b50\u5185\u6c22\u952e\uff0c\u4ee5\u56fe2\u4e2d\u7684\u591a\u80bd3\u4e3a\u4f8b\uff0c\u5206\u522b\u5305\u62ec\u03b1-\u6c28\u57fa\u9178\u4e0a\u7684N-H\u548c\u56db\u4e2a\u57fa\u56e2\u4e4b\u524d\u7684\u03b1-\u6c28\u57fa\u9178\u4e0a\u7684C=O\u539f\u5b50\uff08A\u7c7b\u578b16-\u6c22\u952e\uff09\uff0c\u03b1-\u6c28\u57fa\u9178\u4e0a\u7684N-H\u548c\u56db\u4e2a\u57fa\u56e2\u4e4b\u524d\u7684D-sulfono-\u03b3-AA\u4e0a\u7684C=O\u539f\u5b50\uff08B\u7c7b\u578b16-\u6c22\u952e\uff09\uff0c\u4ee5\u53caD-sulfono-\u03b3-AA\u4e0a\u7684N-H\u539f\u5b50\u548c\u56db\u4e2a\u57fa\u56e2\u4e4b\u540e\u7684D-sulfono-\u03b3-AA\u4e0a\u7684C=O\u539f\u5b50\uff0814-\u6c22\u952e\uff09\uff0c\u6c22\u952e\u7684\u957f\u5ea6\u4e3a2.1 \u00c5\uff0c\u4f5c\u8005\u5c06\u8fd9\u7c7b\u53f3\u65cb\u87ba\u65cb\u4f53\u547d\u540d\u4e3a4.516\u221214 helix\u30024.516\u221214 helix\u7684\u4fa7\u94fe\u5806\u79ef\u6bd4\u4f20\u7edf\u7684\u03b1-helix\u548c310 helix\u76f8\u5bf9\u758f\u677e\uff0c\u4f46\u662f\u6bd4\u03c0-helix\u7684\u4fa7\u94fe\u5806\u79ef\u66f4\u52a0\u7d27\u5bc6\u3002\u901a\u8fc7\u5bf9\u6bd4\u6c22\u952e\u5305\u542b\u539f\u5b50\u6570\u76ee\u3001\u87ba\u65cb\u9876\u70b9\u7684\u8ddd\u79bb\u4ee5\u53ca\u87ba\u65cb\u7ed3\u6784\u7684\u534a\u5f84\uff0c\u4f5c\u8005\u8ba4\u4e3a4.516\u221214 helix\u7684\u7ed3\u6784\u4e0e\u03c0-helix\u7684\u7ed3\u6784\u66f4\u52a0\u76f8\u4f3c\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u79cd\u03c0-helix\u7684\u6a21\u62df\u7269\u8fdb\u800c\u5e94\u7528\u5728\u65b0\u7684\u836f\u7269\u6d3b\u6027\u5206\u5b50\u548c\u751f\u7269\u6750\u6599\u4ee5\u53ca\u751f\u7269\u50ac\u5316\u9886\u57df\u3002<\/p>\n

 <\/p>\n

\"\"<\/p>\n

\u56fe1. \u5316\u5408\u72691<\/b><\/strong>\u30013<\/b><\/strong>\u548c4<\/b><\/strong>\u7684X-\u5c04\u7ebf\u5355\u6676\u7ed3\u6784\u56fe\u3002\u56fe\u7247\u6765\u6e90\uff1aJACS<\/i><\/em><\/p>\n

\"\"<\/p>\n

\u56fe2. \u5316\u5408\u72693<\/b><\/strong>\u7684\u5206\u5b50\u5185\u6c22\u952e\u793a\u610f\u56fe\u3002\u56fe\u7247\u6765\u6e90\uff1aJACS<\/i><\/em><\/p>\n

\u4f5c\u8005\u53c8\u5229\u7528\u5206\u5b50\u52a8\u6001\u6a21\u62df\u6280\u672f\u8003\u5bdf\u4e86\u6db2\u6001\u4e2d\u8fd9\u7c7b\u5408\u6210\u591a\u80bd\u7684\u7a33\u5b9a\u6027\u3002\u5982\u56fe3\u6240\u793a\uff0c\u91cd\u539f\u5b50\u5747\u65b9\u6839\u504f\u5dee\uff08heavy atom root-mean-square deviation\uff0cRMSD\uff09\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u7c7b\u591a\u80bd\u805a\u5408\u7269\u5728300K\uff0827\u2103\uff09\u4e0b\u5728\u4e59\u8148\u6eb6\u6db2\u4e2d\u91c7\u53d6\u7edd\u5927\u591a\u6570\u7684\u7a33\u5b9a\u87ba\u65cb\u6784\u578b\uff0c\u8fd9\u8ddf\u56fa\u6001\u79cd\u7684\u5355\u6676\u6784\u578b\u7ed3\u6784\u975e\u5e38\u76f8\u4f3c\u3002<\/p>\n

\"\"<\/p>\n

\u56fe3. \u6eb6\u6db2\u4e2d\u5316\u5408\u72693<\/b><\/strong>\u7684\u5206\u5b50\u52a8\u6001\u6a21\u62df\u3002\u56fe\u7247\u6765\u6e90\uff1aJACS<\/i><\/em><\/p>\n

\u3010\u5c55\u671b\u3011<\/b><\/strong><\/span><\/p>\n

\u8be5\u8bba\u6587\u5728\u4eba\u5de5\u5408\u6210\u751f\u7269\u6a21\u62df\u7269\u9aa8\u67b6\u9886\u57df\u53c8\u8fdb\u884c\u4e86\u4e00\u6b21\u7a81\u7834\uff0c\u4e3a\u53f3\u65cb\u87ba\u65cb\u591a\u80bd\u6a21\u62df\u7269\u7684\u7814\u7a76\u6253\u4e0b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002\u76f8\u4fe1\u5728\u4e0d\u4e45\u4e4b\u540e\uff0c\u5404\u79cd\u8be5\u7c7b\u65b0\u578b\u591a\u80bd\u7684\u66f4\u9ad8\u7ea7\u7ed3\u6784\u5c06\u9646\u7eed\u88ab\u79d1\u7814\u5de5\u4f5c\u8005\u4eec\u5408\u6210\u548c\u68c0\u6d4b\u5e94\u7528\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a Right-Handed Helical Foldamers Consisting of de novo D- AApeptides<\/a>\uff08 J. Am. Chem. Soc., 2017,DOI: <\/b><\/strong>10.1021\/jacs.7b03007\uff09<\/p>\n

\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4Allen\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n

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