{"id":90261,"date":"2017-07-06T06:30:06","date_gmt":"2017-07-05T22:30:06","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=90261"},"modified":"2017-07-05T22:29:24","modified_gmt":"2017-07-05T14:29:24","slug":"natl-sci-rev-%e5%88%98%e5%ba%84%e7%bb%bc%e8%bf%b0%ef%bc%9a%e8%82%bf%e7%98%a4%e9%85%b8%e6%80%a7%e5%be%ae%e7%8e%af%e5%a2%83%e5%93%8d%e5%ba%94%e6%80%a7%e7%ba%b3%e7%b1%b3%e8%af%8a%e7%96%97%e5%b9%b3","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=90261","title":{"rendered":"Natl. Sci. Rev.\u5218\u5e84\u7efc\u8ff0\uff1a\u80bf\u7624\u9178\u6027\u5fae\u73af\u5883\u54cd\u5e94\u6027\u7eb3\u7c73\u8bca\u7597\u5e73\u53f0\u7684\u6784\u5efa\u65b0\u601d\u8def"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u7531\u5927\u91cf\u65e0\u6c27\u7cd6\u9175\u89e3\u5f15\u8d77\u7684\u9178\u6027\u5fae\u73af\u5883\uff08TME\uff09\u662f\u6076\u6027\u80bf\u7624\u7684\u91cd\u8981\u7279\u5f81\u4e4b\u4e00\uff0c\u4e5f\u662f\u8bf1\u5bfc\u80bf\u7624\u53d1\u751f\u3001\u8f6c\u79fb\u4ee5\u53ca\u8010\u836f\u6027\u4ea7\u751f\u7684\u4e00\u4e2a\u91cd\u8981\u56e0\u7d20\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u5bf9\u9178\u6027TME\u7684\u7406\u89e3\u8d8a\u6765\u8d8a\u6df1\u523b\uff0c\u9178\u6027TME\u88ab\u8ba4\u4e3a\u662f\u80bf\u7624\u8bca\u65ad\u4e0e\u6cbb\u7597\u7684\u4e00\u4e2a\u65b0\u7684\u6807\u9776\uff0c\u8fd9\u79cd\u6807\u9776\u5bf9\u4e8e\u8bbe\u8ba1pH\u54cd\u5e94\u6027\u7eb3\u7c73\u836f\u7269\u53ca\u5176\u7eb3\u7c73\u8bca\u65ad\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u610f\u4e49\u3002<\/p>\n

\u8fd1\u65e5\uff0c\u82cf\u5dde\u5927\u5b66\u529f\u80fd\u7eb3\u7c73\u4e0e\u8f6f\u7269\u8d28\u7814\u7a76\u9662\u5218\u5e84\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u5728\u6700\u65b0\u7684\u7efc\u8ff0\u6587\u7ae0\u4e2d\u8be6\u7ec6\u4ecb\u7ecd\u4e86\u5177\u6709\u6807\u9776\u7279\u6b8a\u9178\u6027TME\u7684\u7eb3\u7c73\u836f\u7269\u53ca\u5176\u591a\u529f\u80fd\u7eb3\u7c73\u8bca\u7597\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u7cfb\u7edf\u5730\u603b\u7ed3\u4e86\u76ee\u524d\u7eb3\u7c73\u533b\u5b66\u9886\u57df\u6709\u5173\u80bf\u7624\u5fae\u9178\u54cd\u5e94\u6027\u7eb3\u7c73\u8bca\u7597\u5e73\u53f0\u7684\u6784\u5efa\u65b0\u601d\u8def\uff0c\u9610\u8ff0\u4e86\u80bf\u7624\u5fae\u9178\u54cd\u5e94\u6027\u4fe1\u53f7\u653e\u5927\u7b56\u7565\u5728\u80bf\u7624\u6210\u50cf\u9020\u5f71\u5242\u8bbe\u8ba1\u4e2d\u7684\u5e94\u7528\uff0c\u6307\u51fa\u8be5\u7b56\u7565\u53ef\u663e\u8457\u63d0\u9ad8\u6210\u50cf\u7684\u4fe1\u566a\u6bd4\uff0c\u5e76\u80fd\u8fdb\u4e00\u6b65\u63d0\u9ad8\u80bf\u7624\u65e9\u671f\u8bca\u65ad\u7684\u7cbe\u51c6\u6027\uff0c\u4ee5\u53ca\u5fae\u9178\u54cd\u5e94\u6027\u8868\u9762\u7535\u8377\u53cd\u8f6c\u3001\u7c92\u5f84\u53d8\u5316\u7b49\u7b56\u7565\u53ef\u6709\u6548\u63d0\u9ad8\u6750\u6599\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u5bcc\u96c6\u3001\u6269\u6563\u4e0e\u541e\u566c\u7b49\u884c\u4e3a\uff0c\u4e3a\u80bf\u7624\u7684\u5b89\u5168\u9ad8\u6548\u6cbb\u7597\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002\u8be5\u7efc\u8ff0\u6587\u7ae0\u4ee5\u201cThe Acidic Tumor Microenvironment: A Target for Smart Cancer Nano-theranostics\u201d<\/strong>\u4e3a\u9898\uff0c\u4e8e6\u670824\u65e5\u53d1\u8868\u5728\u300a\u56fd\u5bb6\u79d1\u5b66\u8bc4\u8bba\u300b\uff08National Science Review\uff0cNSR<\/strong>\uff09\u671f\u520a\u4e0a\u3002<\/p>\n

\"\"<\/p>\n

\u7efc\u8ff0\u603b\u89c8\u56fe<\/strong><\/p>\n

1<\/strong>\uff0e\u524d\u8a00<\/strong><\/p>\n

\u764c\u75c7\uff0c\u5373\u6076\u6027\u80bf\u7624\uff0c\u662f\u76ee\u524d\u5a01\u80c1\u4eba\u7c7b\u751f\u547d\u7684\u91cd\u8981\u75be\u75c5\u4e4b\u4e00\u3002\u76ee\u524d\u7684\u4e34\u5e8a\u5e38\u7528\u7684\u6cbb\u7597\u65b9\u6cd5\u6709\u624b\u672f\u3001\u5316\u5b66\u7597\u6cd5\u4ee5\u53ca\u653e\u5c04\u7597\u6cd5\uff0c\u4f46\u662f\u56e0\u4e3a\u80bf\u7624\u7ec6\u80de\u5177\u6709\u590d\u6742\u548c\u591a\u6837\u5316\u7684\u751f\u7269\u5b66\u6027\u8d28\uff0c\u8fd9\u51e0\u79cd\u6cbb\u7597\u65b9\u6cd5\u7684\u6548\u679c\u4e0d\u662f\u5f88\u7406\u60f3\u3002\u8fd1\u51e0\u5341\u5e74\uff0c\u7eb3\u7c73\u836f\u7269\u56e0\u4e3a\u5177\u6709\u5f3a\u5927\u7684\u7a7f\u900f\u6027\u548c\u6301\u7eed\u6027\uff08EPR\uff09\u7279\u6027\uff0c\u80fd\u6709\u6548\u6e17\u900f\u80bf\u7624\u8840\u7ba1\u5e76\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u5bcc\u96c6\uff0c\u8fbe\u5230\u589e\u5f3a\u836f\u6548\uff0c\u964d\u4f4e\u526f\u4f5c\u7528\uff0c\u6240\u4ee5\u5b83\u4e00\u76f4\u88ab\u8ba4\u4e3a\u662f\u8bca\u65ad\u548c\u6cbb\u7597\u764c\u75c7\u7684\u6700\u6709\u524d\u666f\u7684\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0cEPR\u6548\u679c\u867d\u7136\u80fd\u5728\u52a8\u7269\u80bf\u7624\u7ec6\u80de\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c\u4f46\u53ef\u80fd\u5728\u4eba\u4f53\u80bf\u7624\u7ec6\u80de\u4e2d\u5e76\u4e0d\u6709\u6548\uff0c\u6216\u8005\u5728\u4e0d\u540c\u4eba\u4f53\u3001\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4ee5\u53ca\u4e0d\u540c\u80bf\u7624\u9636\u6bb5\u6548\u679c\u90fd\u4f1a\u6709\u6240\u4e0d\u540c\u3002\u6240\u4ee5\uff0c\u5f88\u591a\u4e34\u5e8a\u5e94\u7528\u7eb3\u7c73\u836f\u7269\u7684\u6548\u679c\u5e76\u4e0d\u662f\u5f88\u597d\uff0c\u751a\u81f3\u4e3a\u4e86\u964d\u4f4e\u836f\u7269\u7684\u526f\u4f5c\u7528\u8fd8\u589e\u52a0\u4e86\u75c5\u4eba\u8eab\u4f53\u7684\u4e0d\u9002\u3002<\/p>\n

\u4e3a\u4e86\u6539\u8fdb\u7eb3\u7c73\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\uff0c\u8fd1\u51e0\u5e74\uff0c\u7814\u7a76\u4eba\u5458\u4e00\u76f4\u63a2\u7d22\u80bf\u7624\u7ec6\u80de\u7684\u6d3b\u6027\u6807\u9776\uff0c\u4f8b\u5982\u80bf\u7624\u7ec6\u80de\u7684\u7279\u6b8a\u57fa\u56e2\uff08\u6297\u4f53\u3001\u80bd\u3001\u5c0f\u5206\u5b50\uff09\uff0c\u8fd9\u79cd\u57fa\u56e2\u80fd\u8bc6\u522b\u7ecf\u8fc7\u80bf\u7624\u7ec6\u80de\uff08\u6216\u8005\u80bf\u7624\u8840\u7ba1\u7cfb\u7edf\uff09\u7684\u7eb3\u7c73\u836f\u7269\uff0c\u6210\u4e3a\u836f\u7269\u7684\u53d7\u4f53\u3002\u4f46\u662f\uff0c\u56e0\u4e3a\u4e0d\u540c\u60a3\u8005\u7684\u53d7\u4f53\u8868\u8fbe\u4e0d\u540c\uff0c\u4ee5\u53ca\u7eb3\u7c73\u836f\u7269\u5236\u5907\u7684\u590d\u6742\u6027\uff0c\u80bf\u7624\u6d3b\u6027\u6807\u9776\u7b56\u7565\u4e0d\u662f\u5f88\u6210\u529f\u3002<\/p>\n

\u8fc7\u53bb\u51e0\u5e74\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u7531\u80bf\u7624\u7ec6\u80de\u3001\u57fa\u8d28\u7ec6\u80de\u3001\u514d\u75ab\u7ec6\u80de\u4ee5\u53ca\u7ec6\u80de\u5916\u95f4\u8d28\u7ec4\u6210\u7684\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\uff0c\u4e0e\u6b63\u5e38\u7684\u7ec4\u7ec7\u76f8\u6bd4\uff0c\u5728\u8840\u7ba1\u751f\u6210\u3001\u6709\u6c27\u547c\u5438\u4ee5\u53ca\u4ee3\u8c22\u72b6\u6001\u7b49\u65b9\u9762\uff0c\u6709\u663e\u8457\u7684\u4e0d\u540c\u3002\u4e0e\u6b63\u5e38\u7ec6\u80de\u901a\u8fc7\u6c27\u5316\u78f7\u9178\u5316\u83b7\u53d6\u80fd\u91cf\u7684\u65b9\u5f0f\u4e0d\u540c\uff0c\u80bf\u7624\u7ec6\u80de\u56e0\u4e3a\u8109\u7ba1\u7cfb\u7edf\u5206\u5e03\u4e0d\u5747\u5300\uff08\u4e5f\u79f0\u74e6\u6c0f\u6548\u5e94\uff09\uff0c\u4f9b\u6c27\u91cf\u4e0d\u8db3\uff0c\u6240\u4ee5\u53ea\u80fd\u5229\u7528\u65e0\u6c27\u7cd6\u9175\u89e3\u4ea7\u751f\u7684\u80fd\u91cf\u3002\u56e0\u6b64\uff0c\u80bf\u7624\u7ec6\u80de\u4f1a\u4ea7\u751f\u5927\u91cf\u7684\u4e73\u9178\u3001\u6c22\u79bb\u5b50\u4ee5\u53ca\u4e8c\u6c27\u5316\u78b3\uff0c\u4ece\u800c\u5bfc\u81f4\u7ec6\u80de\u5916TME\u9178\u5316\uff0cpH\u503c\u57286.5-6.8\u4e4b\u95f4\uff0c\u4f7f\u80bf\u7624\u8f6c\u79fb\u7684\u98ce\u9669\u589e\u52a0\uff0c\u6cbb\u7597\u96be\u5ea6\u52a0\u5927\u3002<\/p>\n

\u7136\u800c\uff0c\u8bc1\u636e\u8868\u660e\uff0c\u8fd9\u79cd\u9178\u6027TME\u53ef\u4ee5\u4f5c\u4e3a\u80bf\u7624\u663e\u5f71\u548c\u6cbb\u7597\u7684\u6709\u6548\u9776\u6807\uff0c\u4e0e\u4f20\u7edf\u7684\u53d7\u4f53\uff0d\u914d\u4f53\u7684\u80bf\u7624\u6807\u9776\u65b9\u6cd5\u76f8\u6bd4\uff0c\u56e0\u4e3a\u5927\u591a\u6570\u6076\u6027\u80bf\u7624\u7684pH\u90fd\u5177\u6709\u9178\u6027\u7684\u7279\u70b9\uff0c\u6240\u4ee5\u524d\u8005\u4f18\u52bf\u975e\u5e38\u660e\u663e\u3002\u76ee\u524d\uff0c\u968f\u7740\u7eb3\u7c73\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u7814\u7a76\u4e86\u51e0\u79cd\u5177\u6709\u80bf\u7624\u9178\u6027\u54cd\u5e94\u6027\u7684\u7eb3\u7c73\u836f\u7269\uff0c\u5305\u62ec\u6709\u673a\u805a\u5408\u7269\u4ee5\u53ca\u65e0\u673a\u7eb3\u7c73\u6750\u6599\uff0c\u8fd9\u4e9b\u54cd\u5e94\u5305\u62ec\u7269\u5316\u6027\u8d28\uff08\u4f8b\u5982\u8868\u9762\u7535\u8377\u3001\u7c92\u5f84\u7b49\uff09\u53d1\u751f\u6539\u53d8\u3001\u5171\u4ef7\u952e\u65ad\u88c2\u4ee5\u53ca\u5206\u89e3\u7b49\u7b49\u3002\u800c\u4e14\uff0c\u5df2\u7ecf\u8bc1\u660e\uff0c\u8fd9\u79cd\u9178\u6027TEM\u54cd\u5e94\u6027\u7eb3\u7c73\u836f\u7269\u53ef\u4ee5\u5728\u7565\u4f4e\u4e8e\u6b63\u5e38\u751f\u7406pH\uff087.4\uff09\u7684\u6761\u4ef6\u4e0b\uff08pH\u4e3a6.5-6.8\uff09\uff0c\u901a\u8fc7\u653e\u5927\u663e\u5f71\u4fe1\u53f7\u3001\u589e\u5f3a\u836f\u7269\u5728\u80bf\u7624\u4e2d\u7684\u7d2f\u79ef\u3001\u589e\u5f3a\u836f\u7269\u7a7f\u900f\u6027\u7b49\u673a\u7406\uff0c\u63d0\u9ad8\u80bf\u7624\u663e\u5f71\u548c\u6cbb\u7597\u7684\u51c6\u786e\u6027\u548c\u6548\u7387\u3002<\/p>\n

2<\/strong>\uff0e\u9178\u6027<\/strong>TME<\/strong>\u54cd<\/strong>\u5e94\u6027\u7eb3\u7c73\u7597\u6cd5\u8bbe\u8ba1\u7684\u5206\u5b50\u673a\u7406<\/strong><\/p>\n

\u56e0\u4e3a\u65e0\u6c27\u7cd6\u89e3\u901f\u7387\u8f83\u9ad8\uff0c\u76f8\u6bd4\u4e8e\u6b63\u5e38\u7ec4\u7ec7\u7684pH\uff087.4\uff09\uff0c\u80bf\u7624\u7ec6\u80de\u5185\u7684pH\u8f83\u4f4e\uff086.5-6.8\uff09\u3002\u5c3d\u7ba1\u8fd9\u79cdpH\u5dee\u5f02\u8f83\u5c0f\uff0c\u4f46\u662f\u5f88\u591a\u6709\u673a\u529f\u80fd\u57fa\u56e2\u548c\u65e0\u673a\u6750\u6599\u5bf9\u6b64\u5dee\u5f02\u4ecd\u7136\u6709\u54cd\u5e94\uff0c\u88681\u4e2d\u5217\u51fa\u4e86\u4e0d\u540c\u7684\u9178\u6027TME\u54cd\u5e94\u6027\u7eb3\u7c73\u8bca\u7597\u6cd5\u7684\u5206\u5b50\u673a\u7406\u3002<\/p>\n

\u88681 \u4e0d\u540c\u7684\u9178\u6027TME\u54cd\u5e94\u7eb3\u7c73\u8bca\u7597\u6cd5\u5206\u5b50\u673a\u7406<\/strong><\/p>\n

\"\"<\/p>\n

3<\/strong>\uff0e<\/strong>\u9178\u6027<\/strong>TME<\/strong>\u663e\u5f71\u7684\u7eb3\u7c73\u63a2\u9488<\/strong><\/p>\n

\u5bf9\u4e0d\u540c\u80bf\u7624\u8fdb\u884c\u663e\u5f71\u5bf9\u4e8e\u764c\u75c7\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u975e\u5e38\u91cd\u8981\uff0c\u9274\u4e8e\u7ec6\u80de\u5916pH\u503c\u4e8e\u7cd6\u89e3\u901f\u7387\u6709\u5173\uff0c\u6d4b\u91cf\u7ec6\u80de\u5916pH\u503c\u5bf9\u4e8e\u80bf\u7624\u8bca\u65ad\u7684\u51c6\u786e\u6027\u5177\u6709\u91cd\u8981\u7684\u4f5c\u7528\u3002\u76ee\u524d\uff0c\u9664\u4e86\u63d2\u5165\u5f0f\u5fae\u7535\u6781\u663e\u5f71\u5916\uff0c\u8fd8\u6709\u5176\u4ed6\u4e00\u4e9b\u663e\u5f71\u65b9\u5f0f\uff0c\u5fc5\u5165MRS\u663e\u5f71\u3001CEST MR\u663e\u5f71\u3001PET\u663e\u5f71\u7b49\u3002\u8fd1\u51e0\u5e74\u968f\u7740\u7eb3\u7c73\u6280\u672f\u7684\u53d1\u5c55\uff0c\u7eb3\u7c73\u63a2\u9488\u663e\u5f71\u6280\u672f\u9010\u6b65\u88ab\u5e94\u7528\uff0c\u5305\u62ec\u8367\u5149\u663e\u5f71\u7eb3\u7c73\u63a2\u9488\u3001PA\u663e\u5f71\u63a2\u9488\u3001MR\u663e\u5f71\u63a2\u9488\u7b49\u7b49\u3002<\/p>\n

3.1 pH<\/strong>\u54cd\u5e94\u6027\u8367\u5149\u663e\u5f71\u7eb3\u7c73\u63a2\u9488<\/strong><\/p>\n

\u8367\u5149\u663e\u5f71\u662f\u6700\u5e38\u89c1\u7684\u4e00\u79cd\u663e\u5f71\u65b9\u5f0f\uff0c\u5b83\u7075\u660e\u5ea6\u9ad8\uff0c\u8272\u5f69\u9c9c\u660e\uff0c\u800c\u4e14\u6613\u64cd\u4f5c\u3002\u4f46\u662f\u4f20\u7edf\u8367\u5149\u663e\u5f71\u7531\u4e8e\u663e\u5f71\u63a2\u9488\u5bf9\u663e\u5f71\u80cc\u666f\u7684\u533a\u5206\u5ea6\u4e0d\u9ad8\uff0c\u6240\u4ee5\u663e\u5f71\u6548\u679c\u4e0d\u7406\u60f3\u3002\u6700\u8fd1pH\u54cd\u5e94\u6027\u8367\u5149\u663e\u5f71\u7eb3\u7c73\u63a2\u9488\u5f97\u5230\u4e86\u5feb\u901f\u7684\u53d1\u5c55\uff0c\u5982\u4e0b\u56fe\u6240\u793a\u3002<\/p>\n

\u56fe<\/strong>1 NIR<\/strong>\u8367\u5149\u663e\u5f71\u6280\u672f\u6307\u5bfc\u80bf\u7624\u624b\u672f\uff08\u542b\u6709<\/strong>pH<\/strong>\u54cd\u5e94\u548c<\/strong>ICG<\/strong>\u6280\u672f\u7684\u7eb3\u7c73\u611f\u5e94\u5668\uff09<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09pH\u4e3a6.9\u65f6\uff0cPINS\u54cd\u5e94\u5f00\u5173\u793a\u610f\u56fe\uff1bpH\u5c0f\u4e8e6.9\u65f6\uff0cPINS\u5206\u79bb\u6210\u8d28\u5b50\u5316\u9ad8\u8367\u5149\u5ea6\u7684\u5355\u805a\u4f53\uff1bpH\u5927\u4e8e6.9\u65f6\uff0cPINS\u7184\u706d\uff1b<\/p>\n

\uff08b\uff09\u80bf\u7624\u4ee3\u8c22\u663e\u5f71\u793a\u610f\u56fe\uff08PET\uff0bFDG\u663e\u5f71\u4e0eNIR\u8367\u5149\uff0bPINS\u663e\u5f71\u5bf9\u6bd4\uff09\uff1b<\/p>\n

\uff08c\uff09\u6709\u5927\u578bHN5\u80bf\u7624\uff08200mm3<\/sup>\uff09\u548c\u5c0f\u578bHN5\u80bf\u7624\uff0810mm3<\/sup>\uff09\u7684SCID\u9f20\uff1a\u663e\u5f71\u8868\u660e\uff0c\u76f8\u6bd4FDG-PET\uff0cPINS\u5728\u7075\u654f\u5ea6\u548c\u72ec\u7279\u6027\u65b9\u9762\u5177\u6709\u4f18\u52bf\uff1b\u9ed1\u7bad\u5934\u548c\u84dd\u7bad\u5934\u5206\u522b\u8868\u793aPET\u5bf9\u68d5\u8272\u8102\u80aa\u548c\u6a2a\u7eb9\u808c\u663e\u5f71\u5931\u6548\uff1b<\/p>\n

3.2 pH<\/strong>\u54cd\u5e94\u6027\u5149\u58f0\u663e\u5f71\u7eb3\u7c73\u63a2\u9488<\/strong><\/p>\n

\u5149\u58f0\u663e\u5f71\uff08PA\uff09\u53c8\u79f0\u4f5c\u70ed\u58f0\u663e\u5f71\uff0c\u4e0e\u4f20\u7edf\u5149\u5b66\u663e\u5f71\u76f8\u6bd4\uff0cPA\u80fd\u5bf9\u7ec4\u7ec7\u7ed3\u6784\u8fdb\u884c\u6df1\u5165\u7684\u68c0\u6d4b\u3002\u76ee\u524d\uff0c\u7ed3\u5408PA\u6280\u672f\uff0c\u5f88\u591a\u5177\u6709\u5f3aNIR\u5438\u6536\u7684\u80bf\u7624\u7eb3\u7c73\u68c0\u6d4b\u6280\u672f\u5f97\u5230\u53d1\u5c55\uff0c\u4f8b\u5982pH\u54cd\u5e94\u6027\u5149\u5b66\u663e\u5f71\uff0c\u5982\u4e0b\u56fe\u6240\u793a\u3002<\/p>\n

\u56fe<\/strong>2\u00a0<\/strong>\u5149\u58f0\u663e\u5f71\u63a2\u6d4b\u80bf\u7624<\/strong>pH<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09C-HAS-BPOx-IR825\u7684\u5f62\u6210\u8fc7\u7a0b\u53ca\u5176\u5e94\u7528\u793a\u610f\u56fe\uff08\u5728\u6bd4\u7387\u8367\u5149\u548c\u8367\u5149\u663e\u5f71\u7684\u6761\u4ef6\u4e0b\u7684pH\u54cd\u5e94\uff09\uff1b<\/p>\n

\uff08b\uff09pH\u964d\u4f4e\u65f6\uff0cBPOx<\/sub>\u914d\u4f53\u7684\u8d28\u5b50\u5316\u8fc7\u7a0b\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08c\uff09C-HAS-BPOx-IR825 \u7684UV-vis-NIR\u5438\u6536\u5149\u8c31\uff08600nm\u4e0b\u4e0d\u540cpH\u503c\u7684\u7f13\u51b2\u6db2\uff09\uff1b<\/p>\n

\uff08d\uff09C-HAS-BPOx<\/sub>-IR825\u7684PA\u663e\u5f71\uff08\u4e0d\u540cpH\u503c\u7684\u7f13\u51b2\u6db2\uff09\uff1b<\/p>\n

\uff08e\uff09\u5b9e\u9a8c\u9f20\u6ce8\u5c04C-HAS-BPOx-IR825\u540e\uff0c\u4e0d\u540c\u5c3a\u5bf8\u80bf\u7624\u7684PA\u663e\u5f71\uff08680nm\u548c825nm\u6761\u4ef6\uff09\uff1b<\/p>\n

\uff08f\uff09\u6839\u636e\uff08e\uff09\u4e2d\u7684PA\u663e\u5f71\u6570\u636e\uff0c\u80bf\u7624\u7684I<\/em>680<\/sub>\uff0fI<\/em>825<\/sub>\u4fe1\u53f7\u5f3a\u5ea6\u6bd4\u3002<\/p>\n

3.3 pH<\/strong>\u54cd\u5e94\u6027<\/strong>MR<\/strong>\u663e\u5f71\u7eb3\u7c73\u63a2\u9488<\/strong><\/p>\n

MR\u663e\u5f71\u56e0\u5206\u8fa8\u7387\u9ad8\u3001\u80fd\u5168\u8eab\u68c0\u6d4b\u800c\u88ab\u5e7f\u6cdb\u5e94\u7528\uff0c\u540c\u65f6\uff0cpH\u54cd\u5e94\u6027MR\u663e\u5f71\u4e5f\u8fbe\u5230\u4e86\u5feb\u901f\u53d1\u5c55\u3002\u76ee\u524d\uff0c\u5229\u7528\u9530\u6c27\u5316\u7269\u5bf9pH\u654f\u611f\u6613\u5206\u89e3\u7684\u7279\u70b9\uff0c\u542b\u6709Mn2+<\/sup>\u7eb3\u7c73\u7ed3\u6784MR\u663e\u5f71\u7eb3\u7c73\u63a2\u9488\u5df2\u7ecf\u88ab\u5f00\u53d1\u4e86\u51fa\u6765\uff0c\u5982\u4e0b\u56fe\u6240\u793a\u3002<\/p>\n

\u56fe<\/strong>3\u00a0<\/strong>\u975e\u63d2\u5165\u5f0f<\/strong>MR<\/strong>\u80bf\u7624\u663e\u5f71\u7684<\/strong>PEGMnCaP<\/strong>\u7eb3\u7c73\u7c92\u5b50\uff08\u5177\u6709\u4fe1\u53f7\u653e\u5927\u548c<\/strong>pH<\/strong>\u54cd\u5e94\uff09<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09PEGMnCaP\u7eb3\u7c73\u7c92\u5b50\u590d\u5408\u7ed3\u6784\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540cpH\u751f\u7406\u6761\u4ef6\u4e0b\uff0cPEGMnCaP\u7eb3\u7c73\u7c92\u5b50\u91ca\u653e\u66f2\u7ebf\u56fe\uff1b<\/p>\n

\uff08c\uff09\u4e0d\u540cpH\u4ee5\u53ca\u6709\uff0f\u65e0\u6c22\u79bb\u5b50\uff08\u4f8b\u5982HSA\uff09\u7684\u751f\u7406\u6761\u4ef6\u4e0b\uff0cPEGMnCaP\u7eb3\u7c73\u7c92\u5b50\u7684\u5f1b\u8c6b\u6548\u80fdr<\/em>1<\/sub>\u793a\u610f\u56fe\uff08PEGMnCaP\u91ca\u653e\u7684Mn2<\/sup>\uff0b<\/sup>\u4e0eHAS\u4f5c\u7528\u4f7f\u589e\u5927r<\/em>1<\/sub>\uff09\uff1b<\/p>\n

\uff08d\uff09\u75281T MRI\u68c0\u6d4b\u6709C26\u80bf\u7624\u5b9e\u9a8c\u9f20\u7684MR\u663e\u5f71\u56fe\uff08\u5de6\u56fe\u8868\u793a\u6ce8\u5c04PEGMnCaP\u524d\u540e\u7684\u663e\u5f71\u56fe\uff0c\u4e2d\u56fe\u8868\u793a\u6ce8\u5c04Gd-DTPA\u524d\u540e\u7684\u663e\u5f71\u56fe\uff0c\u53f3\u56fe\u8868\u793a\u6ce8\u5c04PEGMn2<\/sub>O3<\/sub>\u524d\u540e\u7684\u663e\u5f71\u56fe\uff09\uff1b<\/p>\n

\uff08e\uff09\u5b9e\u65bdPEGMnCaP\u3001Gd-DTPA\u548cPEGMn2<\/sub>O3<\/sub>\u540e\uff0cT\/N\u5bf9\u6bd4\u7387\uff1b<\/p>\n

\uff08f\uff09\u75287T MRI\u68c0\u6d4bC26\u80bf\u7624\u76843DMR\u663e\u5f71\u56fe\uff08\u6ce8\u5c04PEGMnCaP\u4e4b\u524d\uff09\uff1b<\/p>\n

\uff08g\uff09\u75287T MRI\u68c0\u6d4bC26\u80bf\u7624\u76843DMR\u663e\u5f71\u56fe\uff08\u6ce8\u5c04PEGMnCaP 1h\u4e4b\u540e\uff09\uff1b<\/p>\n

4<\/strong>\uff0e\u9178\u6027<\/strong>TME<\/strong>\u54cd\u5e94\u6027\u7eb3\u7c73\u7597\u6cd5<\/strong><\/p>\n

\u8fc7\u53bb\u51e0\u5e74\uff0c\u57fa\u4e8e\u9178\u6027TME\uff08pH\u4e3a6.5-6.8\uff09\u751a\u81f3\u9178\u6027\u66f4\u5f3a\u7684\u7ec6\u80de\u5185\u6eb6\u9176\u4f53\uff08pH\u4e3a5-6\uff09\uff0c\u5927\u91cf\u9178\u6027\u54cd\u5e94\u7684\u7eb3\u7c73\u836f\u7269\u8f93\u9001\u7cfb\u7edf\uff08NDDSs\uff09\u88ab\u5f00\u53d1\u4e86\u51fa\u6765\uff0c\u5df2\u7ecf\u6709\u4e86\u6709\u5f88\u591a\u5173\u4e8e\u7ec6\u80de\u5185\u9178\u6027\u5fae\u89c2\u73af\u5883\u54cd\u5e94\u6027NDDSs\u7684\u7efc\u8ff0\u3002\u56e0\u6b64\uff0c\u672c\u90e8\u5206\u4e3b\u8981\u4ecb\u7ecd\u9178\u6027TME\u54cd\u5e94\u6027\u7eb3\u7c73\u7c92\u5b50\u7597\u6cd5\u7684\u6700\u65b0\u8fdb\u5c55\u3002<\/p>\n

4.1 pH<\/strong>\u54cd\u5e94\u6027\u7535\u8377\u53ef\u53cd\u8f6c\u7684\u7eb3\u7c73\u7c92\u5b50<\/strong><\/p>\n

\u5728\u7eb3\u7c73\u836f\u7269\u9886\u57df\uff0c\u9178\u6027TME\u88ab\u8ba4\u4e3a\u662f\u5f00\u53d1\u667a\u80fdNDDSs\u80bf\u7624\u7597\u6cd5\u7684\u826f\u597d\u6807\u9776\uff0c\u7814\u7a76\u8868\u660eNDDSs\u7684\u5316\u7269\u7279\u6027\uff08\u4f8b\u5982NDDSs\u8868\u9762\u7684\u7535\u8377\u7279\u6027\u7b49\u7b49\uff09\u5728\u8840\u6db2\u5faa\u73af\u3001\u836f\u7269\u7a7f\u900f\u3001\u836f\u7269\u5bcc\u96c6\u7b49\u65b9\u9762\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5bf9pH\u54cd\u5e94\u6027NDDSs\u8868\u9762\u7535\u8377\u53cd\u8f6c\u7684\u7279\u6027\u5c55\u5f00\u4e86\u7814\u7a76\uff0c\u5982\u4e0b\u56fe\u6240\u793a\u3002<\/p>\n

\u56fe<\/strong>4\u00a0<\/strong>\u57fa\u4e8e<\/strong>DMMA<\/strong>\u7684\u9178\u6027<\/strong>TME<\/strong>\u54cd\u5e94\u6027\u80bf\u7624\u7eb3\u7c73\u7597\u6cd5\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u7eb3\u7c73PAMA-DMMA\u7684\u5236\u5907\uff0c\u8be5\u7eb3\u7c73\u6750\u6599\u5bf9\u80bf\u7624\u7ec6\u80de\u5916\u90e8pH\u54cd\u5e94\u6027\u4e14\u7535\u8377\u53ef\u53cd\u8f6c\uff1b<\/p>\n

\uff08b\uff09pH\u54cd\u5e94\u6027\u7535\u8377\u53ef\u53cd\u8f6c\u7684\u7535\u8377\u53ef\u9006\u4e0a\u53cd\u8f6c\u7eb3\u7c73\u7c92\u5b50\uff08UCNPs\uff09\u7684\u5236\u5907\u8fc7\u7a0b\uff0c\u8be5UCNPs\u5177\u6709\u9178\u6027TME\u54cd\u5e94PEG\u5c42\u6d88\u5931\u7684\u7279\u70b9\u3002<\/p>\n

\u56fe<\/strong>5\u00a0<\/strong>\u57fa\u4e8e<\/strong>CDM<\/strong>\u7684\u9178\u6027<\/strong>TME<\/strong>\u54cd\u5e94\u6027\u80bf\u7624\u7eb3\u7c73\u7597\u6cd5\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5728\u6c34\u6eb6\u6db2\u4e2d\uff0cPEG-Dlink<\/em>m<\/sub>-R9-PCL\u7684\u81ea\u7ec4\u88c5\u793a\u610f\u56fe\uff0cDm<\/sub>-NPsiRNA<\/sub>\u7684\u5f62\u6210\u53ca\u5176\u8f93\u9001\u81f3\u80bf\u7624\u7ec6\u80de\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09\u80bf\u7624\u9178\u6027\u5fae\u73af\u5883\u54cd\u5e94\u6027\u5206\u6563\u7eb3\u7c73\u7c92\u5b50\u7684\u5236\u5907\uff0c\u8be5\u7c92\u5b50\u5177\u6709\u7a7f\u900f\u6027\u5f3a\u3001\u6548\u7387\u9ad8\u7684\u7279\u70b9\u3002<\/p>\n

4.2 pH<\/strong>\u54cd\u5e94\u6027PEG<\/strong>\u5c42\u53ef\u6d88\u9664\u7eb3\u7c73\u7c92\u5b50<\/strong><\/p>\n

\u805a\u4e59\u4e8c\u9187\u5316\uff08PEGylated\uff09\u7684\u7eb3\u7c73\u7c92\u5b50\u5468\u56f4\u7684PEG\u5c42\uff0c\u4f7f\u7eb3\u7c73\u7c92\u5b50\u8868\u9762\u975e\u5e38\u7684\u654f\u611f\u3002\u9ad8\u5ea6PEGylated\u7684NDDSs\uff0c\u901a\u5e38\u4e0d\u5229\u4e8e\u80bf\u7624\u7ec6\u80de\u5bf9\u6297\u80bf\u7624\u836f\u7269\u7684\u5438\u6536\uff0c\u56e0\u6b64\u53ef\u4ee5\u8bbe\u8ba1\u667a\u80fdNDDSs\uff0c\u4f7f\u5176\u5177\u6709\u5bf9TME\u7684pH\u654f\u611f\u7684PEG\u5c42\u3002\u5176\u793a\u610f\u56fe\u5982\u56fe4\uff08b\uff09\u6240\u793a\u3002<\/p>\n

4.3 pH<\/strong>\u54cd\u5e94\u6027\u7c92\u5f84\u53ef\u53d8\u5316\u7684\u7eb3\u7c73\u7c92\u5b50<\/strong><\/p>\n

\u7eb3\u7c73\u7c92\u5b50\u7684\u7c92\u5f84\u5927\u5c0f\u5bf9\u5176\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u7a7f\u900f\u3001\u5bcc\u96c6\u6709\u91cd\u8981\u7684\u5f71\u54cd\uff0c\u56e0\u6b64\u4e5f\u5f71\u54cd\u7740NDDSs\u7684\u7eb3\u7c73\u8bca\u7597\u7684\u6548\u679c\uff0c\u5176\u793a\u610f\u56fe\u5982\u56fe\u56fe5\uff08b\uff09\u6240\u793a\u3002<\/p>\n

5<\/strong>\uff0e<\/strong>\u7ed3\u8bba\u548c\u5c55\u671b<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1a<\/strong>The Acidic Tumor Microenvironment: A Target for Smart Cancer Nano-theranostics<\/a>\uff08Natl. Sci. Rev., 2017. DOI:10.1093\/nsr\/nwx062\uff09<\/p>\n

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