{"id":99414,"date":"2017-09-04T14:00:03","date_gmt":"2017-09-04T06:00:03","guid":{"rendered":"http:\/\/www.cailiaoniu.com\/?p=99414"},"modified":"2017-09-01T22:14:18","modified_gmt":"2017-09-01T14:14:18","slug":"adv-mater-%ef%bc%9a%e7%94%a8%e4%ba%8e%e5%85%8b%e6%9c%8d%e7%99%8c%e7%97%87%e4%b8%ad%e5%a4%9a%e9%87%8d%e8%80%90%e8%8d%af%e6%80%a7%e7%9a%84%e8%82%bf%e7%98%a4%e7%89%b9%e5%bc%82%e6%80%a7%e7%ba%a7","status":"publish","type":"post","link":"http:\/\/www.cailiaoniu.com\/?p=99414","title":{"rendered":"Adv. Mater. \uff1a\u7528\u4e8e\u514b\u670d\u764c\u75c7\u4e2d\u591a\u91cd\u8010\u836f\u6027\u7684\u80bf\u7624\u7279\u5f02\u6027\u7ea7\u8054\u6269\u589e\u836f\u7269\u91ca\u653e\u7eb3\u7c73\u7c92\u5b50"},"content":{"rendered":"<p><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n<p>\u5c3d\u7ba1\u4f5c\u4e3a\u4e34\u5e8a\u764c\u75c7\u6cbb\u7597\u7684\u652f\u67f1\uff0c\u5316\u7597\u4ecd\u4e25\u91cd\u53d7\u5230\u6bd2\u6027\u9ad8\uff0c\u80bf\u7624\u9009\u62e9\u6027\u5dee\u7b49\u4e25\u91cd\u526f\u4f5c\u7528\u7684\u9650\u5236\u3002\u4e3a\u4e86\u5c3d\u91cf\u51cf\u5c11\u526f\u4f5c\u7528\u5e76\u63d0\u9ad8\u5316\u5b66\u7597\u6cd5\u7684\u6cbb\u7597\u6548\u679c\uff0c\u8fc7\u53bb\u5341\u5e74\u6765\u4e00\u76f4\u5728\u52aa\u529b\u5f00\u53d1\u523a\u6fc0\u53cd\u5e94\u6027\u836f\u7269\u8f93\u9001\u7cfb\u7edf\uff08DDSs\uff09\u3002\u8fd9\u4e9bDDSs\u88ab\u5408\u7406\u8bbe\u8ba1\u4e3a\u5177\u6709\u9690\u5f62\u8868\u9762\u6750\u6599\uff08\u4f8b\u5982\u805a\uff08\u4e59\u4e8c\u9187\uff09\uff0cPEG\uff09\uff09\uff0c\u5e76\u4e14\u5177\u6709\u224820-250nm\u7684\u5178\u578b\u5c3a\u5bf8\u4ee5\u5728\u8840\u6db2\u4e2d\u5b9e\u73b0\u957f\u7684\u5faa\u73af\u65f6\u95f4\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u6d59\u6c5f\u5927\u5b66\u5510\u5efa\u658c\u6559\u6388\u3001\u9ad8\u5efa\u9752\u6559\u6388\u3001\u65af\u5766\u798f\u5927\u5b66Jianghong Rao\uff08\u5171\u540c\u901a\u8baf\uff09<\/strong>\u7b49\u4eba\u4ecb\u7ecd\u4e86\u7ea7\u8054\u6269\u589e\u91ca\u653e\u7eb3\u7c73\u9897\u7c92\uff08CARN\uff09\u662f\u901a\u8fc7\u5728\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u4e2d\u03b2-\u62c9\u5e15\u918c\u548c\u6d3b\u6027\u6c27\uff08ROS\uff09-\u53cd\u5e94\u6027\u963f\u9709\u7d20\uff08DOX\uff09\u524d\u836f\uff0cBDOX\u7684\u5171\u805a\u5408\u6765\u6784\u5efa\u7684\u3002\u9996\u5148\u4eceCARN\u4e2d\u91ca\u653e-\u62c9\u5e15\u918c\u901a\u8fc7NAD\uff08P\uff09H\uff1a\u918c\u6c27\u5316\u8fd8\u539f\u9176-1\uff08NQO1\uff09\u50ac\u5316\u9009\u62e9\u6027\u5730\u589e\u52a0\u764c\u7ec6\u80de\u4e2d\u7684ROS\u6c34\u5e73\uff0c\u5176\u8bf1\u5bfcDOX\u7684\u7ea7\u8054\u6269\u589e\u91ca\u653e\u5e76\u514b\u670d\u764c\u7ec6\u80de\u4e2d\u7684\u591a\u836f\u8010\u836f\u6027\uff08MDR\uff09\uff0c\u5bf9MDR\u80bf\u7624\u4ea7\u751f\u663e\u8457\u6539\u5584\u7684\u6cbb\u7597\u529f\u6548\uff0c\u526f\u4f5c\u7528\u5f88\u5c0f\u3002\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201c<strong>A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers<\/strong>\u201d\u53d1\u8868\u5728\u4e86<strong>Advanced Materials<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe1 \u524d\u836fBDOX\u548cCARN\u7684\u8868\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-99415\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/1-97.png\" alt=\"\" width=\"600\" height=\"566\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/1-97.png 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/1-97-300x283.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-99416\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/2-65.png\" alt=\"\" width=\"600\" height=\"431\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/2-65.png 600w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/2-65-300x216.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u5728NIH 3T3\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08A\uff09\uff0c\u5177\u6709\u9ad8NQO1\u8868\u8fbe\u7684\u764c\u7ec6\u80de\u5305\u62ec4T1\u4e73\u817a\u764c\u7ec6\u80de\uff08B\uff09MCF-7\u4e73\u817a\u764c\u7ec6\u80de\uff08C\uff09\u548cMCF-7 ADR\u591a\u836f\u8010\u836f\u7ec6\u80de\uff08D\uff09\u4e2d\u8d85\u8fc748\u5c0f\u65f6\u7684BDOX\uff0cDOX\u548cCARN\u6709\u6216\u6ca1\u6709NQO1\u6291\u5236\u5242dicoumarol\u7684\u7ec6\u80de\u6bd2\u6027\u6d4b\u5b9a<\/p>\n<p><strong>\u56fe3 CARNs\u7684\u8840\u6db2\u5faa\u73af\u548c\u751f\u7269\u5206\u5e03<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-99417\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/3-54.png\" alt=\"\" width=\"551\" height=\"693\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/3-54.png 551w, http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/3-54-239x300.png 239w\" sizes=\"(max-width: 551px) 100vw, 551px\" \/><\/p>\n<p>A\uff09\u8840\u6db2\u4e2d\u7684\u836f\u7269\u6d53\u5ea6\u4f5c\u4e3a\u65f6\u95f4\u7684\u51fd\u6570<\/p>\n<p>B\uff0924\u5c0f\u65f6\u5185\u7ec4\u7ec7\u4e2d\u603bDOX\u7684\u5206\u5e03\u60c5\u51b5<\/p>\n<p><strong>\u56fe4 \u6297\u80bf\u7624\u6d3b\u6027<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-99418\" src=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/4-45.png\" alt=\"\" width=\"600\" height=\"643\" srcset=\"http:\/\/www.cailiaoniu.com\/wp-content\/uploads\/2017\/08\/4-45.png 600w, 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href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adma.201702342\/full\" target=\"_blank\" rel=\"noopener\">A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers<\/a>\uff08Adv.Mater.,2017,DOI\uff1a10.1002\/adma.201702342\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4Allen\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"http:\/\/www.cailiaoniu.com\/25127.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n<p><strong>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong><a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u6d4b\u8bd5\u8c37<\/strong><\/a><strong>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 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