厦大Nat. Commun.:3D打印一体化探针用于核磁共振检测


【研究背景】

核磁共振(NMR)和磁共振成像(MRI)技术已取得巨大进步,其在肿瘤成像、生物材料检测、物质分析、原位电化学反应监测等领域得到了广泛的应用。射频线圈作为磁共振系统的核心部件之一,对磁共振实验结果的质量有着重要的影响。传统的磁流变线圈通常采用手工缠绕和印刷电路板光刻技术制造,这通常需要劳动密集型制造和二维制造工艺。因此,对于复杂或不规则的三维结构的线圈,尤其是在小型化的要求下,制造线圈是不精确和耗时的。此外,一些非常规核磁共振实验,如微升级样品检测和生化反应监测,需要定制的三维微流控样品结构与射频线圈集成。对于不同形状和尺寸的MRI样品或微流控系统,很难精确地拟合射频均匀区域,由于填充因子较低,导致信噪比(SNR)降低。

【成果简介】

近日,厦门大学陈忠教授、游学秋副研究员、孙惠军工程师(共同通讯作者)等人报道了利用3D打印和液态金属填充技术来制作用于磁共振实验的集成射频探头前端。具有微米精度的三维打印探头前端一般由液态金属线圈、定制的样品腔和射频电路接口组成。结合不同的金属颗粒,对不同配比的液态金属和金属颗粒进行了优化。三维打印探头能够进行常规和非常规磁共振实验,包括原位电化学分析、连续流顺磁颗粒和离子分离的原位反应监测以及小体积样本磁共振成像。由于三维打印技术的灵活性和精确性,可以允许在微米尺度上精确地获得复杂的线圈几何形状,缩短了制作时间,扩展了应用场景。该研究利用高精度3D打印和液态金属灌注技术制备出包含有射频线圈和定制化样品管道结构在内的一体化磁共振射频探头前端,克服了传统磁共振三维微型线圈成型困难、与样品腔匹配程度差等问题,提高了探头的信噪比,为定制化的磁共振检测提供了新思路。该文章近日以题为“3D-printed integrative probeheads for magnetic resonance”发表在知名期刊Nature Communications,第一作者为厦门大学博士研究生谢君尧博士。

【图文导读】

图一、不同场景的一体化MR探头3D打印和制造流程

(a-c)根据仿真设计,采用(a)熔融沉积建模(FDM)和(b)立体光刻外观(SLA)技术,逐层制作完整的探针头(c)。

(d)液态金属通过注入孔灌注到模型中,形成射频线圈。

(e)射频线圈通过两条铜条连接到匹配电路,形成一个完整的探头。

(f-g)可以制造和使用各种适合MR应用的3D打印探针头,包括U形管鞍形探针头(SAP)、U形管Alderman Grant probehead(AGP)、反应监测探针头(RMP)、电化学反应监测探针头(ECP)、MR梯度探针头(GP)和改进型螺线管成像探针头(MSO)阿尔德曼·格兰特核磁共振成像探头(MAG)。

图二、LM浆料的多比例电性能和温度相关特性测量

(a)由金微粒和镓组成的LM浆料在不同配比下的电导率。

(b)金微粒在镓中不同混合比电导率的温度依赖性。

图三、鞍形线圈和改型Alderman-Grant线圈的射频磁场模拟

马鞍形线圈和改进的Alderman Grant线圈均在500 MHz频率下进行模拟。

图四、原位核磁共振系统及实验结果

(a)核磁共振仪和探针头示意图。

(b-c)乙醇氧化反应过程中乙醇、乙酸和二氧化碳浓度的原位1H-NMR谱和时间分辨变化。

图五、CFSP的内部结构和分离原理

(a)CFSP的内部结构。

(b)原位过滤和分离顺磁性颗粒的原理。

(c)在强磁场下洛伦兹力分离顺磁性离子的原理。

图六、CFSPMn2+分离效率和原位分离结果

(a)通过半峰宽(FWHM)显示了不同流速下的顺磁性离子(0.01 mol L-1 Mn2+)的洛伦兹力分离效率。

(b)乙醇氧化反应过程中的原位1H-NMR谱图。

【结论展望】

综上所述,作者利用3D打印熔融沉积制造和光敏树脂选择性固化技术精确加工出一体化磁共振探头前端,使用常温液态金属填充线圈模型管路形成射频线圈,搭建出稳定的一体化磁共振射频探头。打印材料和液态金属种类均经过系统性的优选和优化,提升了常规材料的电磁特性,保证了探头的基本性能。为了进一步验证该设计在传统磁共振系统中的可用性,作者使用定制的三维打印探针头进行了相关的核磁共振和核磁共振实验。实验结果表明,该方法灵活、有效地满足了磁共振实验的要求,扩大了实际应用范围。下一步工作需要进一步提高探针头的性能,包括优化材料性能、改进设计结构和扩大应用领域。该方法为核磁共振研究和临床核磁共振检测提供了一个定制探针头的基础,为磁共振系统开辟了一个新的应用领域。

文献链接:3D-printed integrative probeheads for magnetic resonance (Nature Communications, 2020, DOI: 10.1038/s41467-020-19711-y)

陈忠教授简介:

陈忠博士,厦门大学电子科学与技术学院(国家示范性微电子学院)院长,厦门大学电子科学系博士生导师、闽江学者特聘教授,享受国务院政府特殊津贴,主要从事生物医学电子学、光电照明与显示研究。

中国物理学会理事,中国波谱学专业委员会副主任委员,厦门大学国家集成电路产教融合创新平台执行主任,福建省等离子和磁共振研究重点实验室主任、福建省半导体照明工程技术研究中心主任、福建省半导体照明与显示行业开发基地主任;已主持国家高新技术计划、国家科技支撑计划子课题、国家自然科学基金科学仪器专项和重点等重要科研项目30多项。发表论文中SCI收录460余篇;参与撰写国际科研专著3部章和合作编写教材5部;授权发明专利110项(其中美国专利2项);研究成果获得省部级科学技术一等奖3项,二等奖5项。是Journal of Magnetic Resonance、Magnetic Resonance in Chemistry、Concepts in Magnetic Resonance Part A & B编委,是《波谱学杂志》和Magnetic Resonance Letters副主编,《厦门大学学报》、《现代物理知识》和《功能与分子影像学》编委。

游学秋副研究员简介:

  1. 个人信息

姓名:游学秋    性别:男    民族:汉族

地址:厦门市思明区厦门大学海韵园物理机电大楼343

电子邮件:youxueqiu.qqq@hotmail.com

电话:13357639860,18250839386

  1. 教育经历

2008.09-2013.08  韩国高丽大学电子电气计算机学院,博士

2004.09-2008.08  哈尔滨工业大学电气工程及其自动化专业, 学士

  1. 工作经历

2014.03-2016.10    韩国国家基础科学研究院,研究员

2013.08-2014.09    韩国高丽大学, 微纳米系统研究所,研究教授

2012.02-2013.02    美国伊利诺伊州立大学香槟-厄班纳分校,微纳米技术研究所,访问学者 

2008.09-2013.09    韩国高丽大学,微纳米系统研究所,研究助理

2007.09-2008.06    哈尔滨工业大学西门子自动化实验室,研究助理

2006.02-2006.05    哈尔滨工业大学罗克韦尔自动化实验室,研究助理

2005.10-2006 .06   哈尔滨工业大学军用电器和车辆电器研究所,研究助理

2016.11-2019.11          厦门大学电子科学与技术学院,特任副研究员

2017.08-今          厦门薇针医药科技有限公司,创始人

  1. 中国发明专利:

[1] 一种丝素微针系统和丝素纳米颗粒及其制备方法, 专利号 201210048238.2

[2] 一种孔状生物传感器、制作及应用方法, 专利号 201210025394.7

[3] 石墨烯晶体管及其生物传感器的制作与应用方法, 专利号201210025405.1

[4] 基于倾斜铸模的微针制作方法, 专利号201410248519.1

[5]异平面微针阵列及其制作方法,专利号201410266984.8

[6] 一种异平面微针阵列,专利号201420319587.8

[7] 一种可分离式微针系统,专利号201420363489.4

[8] 空气微纳颗粒过滤净化设备,专利号201410035875.5

[9] 一种空气微纳颗粒过滤净化设备,专利号201410035875.5

[10] 三维连通弯曲石墨烯及其制备方法,专利号201410072066.1

[11] 可分离式微针系统及其制备方法,专利号 201410312539.0

[12]二维材料膜的批量大面积制备方法及其制备设备,专利号01410072066.1

[13]一种二维材料膜的批量大面积制备设备,专利号20140705402

[14]适用HPLC-NMR联用的微型核磁共振线圈及其制备,专利号2017110767066

[15]3D打印的一体化核磁共振射频探头前端及其制备方法,专利号2017110767352

[16]  微针注射弹及其制备方法和微针注射设备,专利号201510556515.4

[17]  射流微针注射系统,专利号201610953804.2

[18] 可分离式微针系统及其制造方法,专利号201410312539.0

[19]  一种医疗核磁共振成像仪的升降台装置,专利号201810102509.5

[20] 智能陪伴香薰净化机器人,专利号201810257592.1

 [21] 一种原位分离检测核磁共振射频探头前端及其制备方法,专利号202010191495.6

 [22] 一种核磁共振仪可插拔式滚印线圈探头及其设计方法,专利号202010191495.6

 [23] 一种语音控制空间移动的磁悬浮系统,专利号201811589445.2

 [24]  超导脉冲核磁共振波谱仪微流控平面梯度线圈及安装支架,专利号 201811486776.3;

 [25]   智能净化机器人,专利号201821622516.

 [26]  可溶解微针注射装置,专利号201810933522.5

 [27]  一种宽带信号合成器的厚膜电路,专利号201821349648

 [28]  一种蛋白延时表达开关及其在葡萄糖二酸生产中应用,专利号201911330031

 [29]  医疗核磁共振成像仪的升降台装置,专利号 201820179300

 [30]   一种蛋白动态表达调控系统及其在莽草酸生产中的应用,专利号 201911331142

 [31] 宽带信号合成器的厚膜电路,专利号201810954611

[32] 一种医疗核磁共振成像仪的升降台装置,专利号 201810102509.5

[33] 一种十六元大环内酯类化合物及其制备方法与应用,专利号201911263557.3

[34]  一种大环内酯类化合物及其制备方法与应用,专利号201911263537.6

  1. 国际发明专利:

[1] “A method to fabricate semiconductor nanosheets,” James Jungho Pak, Xueqiu You,10-2013-0104665

[2] “Graphene-iron oxide nanoparticle composite buckypaper fabrication method and H2O2 sensor,” James Jungho Pak, Xueqiu You, 10-2013-0024053

[3] “Metal oxide nanowires growth method,” James Jungho Pak, Xueqiu You, 2010-0077389

[4] “A solder self-assembly pattern based electronic package method,” James Jungho Pak, Jong-hyeon Chang, Xueqiu You, 2010-0003932

[5] “Graphene oxide synthesis method,” James Jungho Pak, Xueqiu You, 2009-0122680

[6] “Large area grapheme transfer method, ”  YouXueqiu, Rodney Ruoff, United States Patent Application 20160137507

  1. 近年主要论著:

国际期刊 (SCIs):

[1] Junyao Xie , Xueqiu You* , Yuqing Huang , Zurong Ni , Xinchang Wang , Xingrui Li , Prof. Chaoyong James Yang , Dechao Zhang , Huijun Sun,Chenzhong*, 3D-printed integrative probeheads for magnetic resonance,Nature Communications,(2020) (通讯)

[2] Xueqiu You,Dechao Zhang,Kaiwen Yao,Yuqing Huang,Min Liu,Junyao Xie,Tienmo Shih,Huijun Sun,Zhong Chen,Ultrasensitive and fast detection of pathogens using Europium-containing polystyrene nanospheres in a homemade portable NMR diagnostic system,Sensors and actuators B: Chemical,320, 128370,(2020)(IF 7.1)

[3] Jiangli Wang,Xueqiu You,Chi Xiao,Xiaoping Zhang,ShuhuiCai, Wenlong Jiang, Shengshi Guo, Shuohui Cao, Zhong Chen, Small-sized Pt nanoparticles supported on hybrid structures of MoS2 nanoflowers/graphene nanosheets: Highly active composite catalyst toward efficient ethanol oxidation reaction studied by in situ electrochemical NMR spectroscopy,Applied Catalysis B: Environmental, 259. 118060, (2019) (IF 16.68)

[4] Jiangli Wang, Xinrui Cao, Lei Fang, Xueqiu You*, Kester Wong, Shuohui Cao, Chi Xiao, Shuhui Cai, Yuqing Huang, Xiaoping Zhang, Zhong Chen*, MoS2 nanoflower supported Pt nanoparticle as an efficient electrocatalyst for ethanol oxidation reaction, International Journal of Hydrogen Energy, 44, 16411, (2019) (IF 4.2) (共同通讯)

[5] Yuqing Huang,Haolin Zhan,Xueqiu You,Yu Yang,Zhong Chen,A Pure Shift-Based NMR Method for Transverse Relaxation Measurements on Complex Samples,IEEE Transactions on Instrumentation and Measurement,69, 201(2019)(IF 3.658)

[6] Xiao-Ping Zhang, Wen-Long Jiang, Shuo-Hui Cao, Hui-Jun Sun , Xueqiu You, Shu-Hui Cai, Jiang-Li Wang, Cheng-Sen Zhao, Xin Wang, Zhong Chen, NMR spectroelectrochemistry in studies of hydroquinone oxidation by polyaniline thin films,Electrochimica Acta, 273,300–306 ,(2018) (IF 6.2)

 

[7] Da Luo, Xueqiu You, Bao-Wen Li, Xianjue Chen, Hyo Ju Park, Minbok Jung, Taeg Yeoung Ko, Kester Wong, Masood Yousaf, Xiong Chen, Ming Huang, Sun Hwa Lee, Zonghoon Lee, Hyung-Joon Shin, Sunmin Ryu, Sang Kyu Kwak, Noejung Park, Revathi R. Bacsa, Wolfgang Bacsa, and Rodney S. Ruoff,Role of Graphene in Water-Assisted Oxidation of Copper in Relation to Dry Transfer of Graphene,Chemistry of Materials,  29 (10),4546–4556,(2017 )(IF10.2)

[8] Jiangli Wang, Xueqiu You, Shuohui Cao, Jianming Lin, Jihuai Wu,Zhong Chen, Enhancement of Photovoltaic Properties in Dye‐sensitized Solar Cells using Y0.80Yb0.18Er0.02OF Nanorods,Energy Technology,10.1002/ente.201700589,(2017 )(IF 3.16)

[9] Xueqiu You, James Jungho Pak , Electrostatically Gated Graphene-Zinc Oxide Nanowire Heterojunction,Journal of Nanoscience and Nanotechnology,15,2040,(2015)

[10]     Xueqiu You, James Jungho Pak , Flexible and Conductive Graphene-Poly (diallyldimethylammoniumchloride) Buckypaper,Journal of Nanoscience and Nanotechnology,15 (3), 2001-2008,(2015)

[11]     Huang Ming,Fei Li, Xiao Li,Da Luo, Xueqiu You, Yuxin Zhang, Hierarchical ZnO@MnO2 Core-Shell Pillar Arrays on Ni Foam for Binder-Free Supercapacitor Electrodes,ElectrochimicaActa,152,172,(2015)

[12]     Xueqiu You, James Jungho Pak , Graphene-based field effect transistor enzymatic glucose biosensor using silk protein for enzyme immobilization and device substrate,Sensors and actuators B: Chemical,202,1357,(2014)

[13]     Xueqiu You,J Park,Y Jang,Y Nam,JK Min , James Jungho Pak,  ZnO nanorod matrix based electrochemical immunosensors for sensitivity enhanced detection of Legionellapneumophila,Sensors and actuators B: Chemical,200,173,(2014),(共同一作)

[14]     Xueqiu You, James Jungho Pak , Preparation and application of PDDA-Graphene-iron oxide NPs buckypaper for hydrogen peroxide detection, Journal of Nanoscience and Nanotechnology,13,7349,(2014)

[15]     Xueqiu You, James Jungho Pak , An electrochemical route to MoS2 nanosheets for device applications,Material letters, 121,31, (2014)

[16]     Xueqiu You, James H. Pikul, William P. King, James Jungho Pak, “Inverse opal ZnO based Glucose Biosensors”, Applied Physics Letter, 102,253103, (2013)

[17]     Xueqiu You, Jeejung Kim, James Jungho Pak,“Preparation and application of Graphene-Poly(diallyldimethylammoniumchloride)-Iron Oxide Nanoparticles  buckypaper for hydrogen peroxide detection”, Journal of Nanoscience and Nanotechnology, 13, 7349-7357 (2013)

[18]     Shouvik Banerjee, Jiwook Shim, Jose Rivera, Xiaozhong Jin, David Estrada, Vita Solovyeva, Xueqiu You, James Pak, Eric Pop, Narayana Aluru, Rashid Bashir, “Electrochemistry at the edge of a single graphene layer in a nanopore”, ACS Nano, 3, 834-843, (2013)

[19]     Xueqiu You, Jong-hyeon Chang, Byeong Kwon Ju, James Jungho Pak, “Rapidly dissolving fibroin microneedles for transdermal drug delivery”, Materials Science and Engineering: C, 31(8), 1632-1636, (2011)

[20]     Xueqiu You, Jong-Hyeon Chang, Byeong Kwon Ju, James Jungho Pak, “An Electrochemical Route to Graphene Oxide”, Journal of Nanoscience and Nanotechnology, 11, 5965-5968, (2011)

[21]     Jae Hoon Choi, Xueqiu You, Jong-Hyeon Chang, Byeong Kwon Ju, James Jungho Pak, “Wettability Control of a Transparent Substrate Using ZnO Nanorods”, Journal of Nanoscience and Nanotechnology, 11, 5944-5948, (2011)

[22]     Xueqiu You, Jungil Park, Jae-hoon Choi, James J. Pak, “Thermo-electrochemical selective growth of ZnO nanorods on any noble metal electrodes”, Superlattices and Microstructures, 48, 365-372, (2010)

[23]     Jae-hoon Choi, Xueqiu You, Chul Kim, Jungil Park, James Jungho Pak, “Power Generating Characteristics of Zinc Oxide Nanorods Grown on a Flexible Substrate by a Hydrothermal Method”, Journal of Electrical Engineering & Technology, 5, 511-671, (2010)

  1. 国际会议论文:

[1] Xueqiu You, Junyao Xie, and Zhong Chen, “NMN 3D-printed integrative RF probehead for nuclear magnetic resonance”, National Magnetic Resonance Conference (2018)

[2] Xueqiu You, Jiangli Wang, and Zhong Chen, “Studying on the ethanol oxidation process using in situ EC-NMR”, National Magnetic Resonance Conference (2018)

[3] Xueqiu You, Jiahe Chen, and Zhong Chen, “High-resolution CMOM NMR detector for picoliter samples” National Magnetic Resonance Conference (2018)

[4] Xueqiu You, Dechao Zhang, and Zhong Chen, “Fabricating Ag microcoils on capillaries for high resolution NMR on nanoliter volumes using a stamp printing method”, National Magnetic Resonance Conference (2018)

[5] Taeheon Kim, Xueqiu You, Jeehoon Han, and James Jungho Pak, “An Effective Hydrothermal ZnO Nanowire Growth with Dispersion for Power Nanogenerator Application”, Fusion science and Technologies (ISFT2015), Huntra campus, Thailand (2015)

[6] Xueqiu You, James Jungho Pak “Preconcentration device in a single microchannel using patterned ion-selective nafion membrane” The 7th International Conference on Transducers and Micro/Nano Technologies, Daegu. Korea (2014)

[7] Taeheon Kim, Xueqiu You, Jeehoon Han, and James Jungho Pak, “An Effective Hydrothermal ZnO Nanowire Growth with Dispersion for Power Nanogenerator Application”, Fusion science and Technologies (ISFT2015), Huntra campus, Thailand (2015) (最佳论文奖)

[8] Xueqiu You, James Jungho Pak “Silk stabilized graphene FET enzymatic biosensor”, The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Barcelona. Spain (2013)

[9] Xueqiu You, Inyoung Woo, James Jungho Pak “Flexible conductive graphene-PDDA buckypaper”, NanoKorea, Seoul, Korea (2012)

[10]     Xueqiu You, James Jungho Pak “Graphene-ZnO nanowires triode devices”, NanoKorea, Seoul, Korea (2012)

[11]     Shouvik Banerjee, Jiwook Shim, Jose Rivera, Xiaozhong Jin, David Estrada, Vita Solovyeva, Xueqiu You, James Pak, Eric Pop, Narayana Aluru, Rashid Bashir, “Electrochemistry of Graphene Edge Embedded Nanopores”, American Physical Society APS March Meeting,Volume 58, Number 1 (2013)

[12]     Xueqiu You, Taeheon Kim, James Jungho Pak “Fabrication and Analysis Method of Solidstate Nanopore by Using Focused Electron Beam of Transmission Electron Microscope” Korean Institude Electrical Engineering Conference (2012), Kangwon land, Korea,

[13]     Xueqiu You, Jeejung Kim, James Jungho Pak, “Graphene-iron oxide NPs buckypaper for hydrogen peroxide detection”, NanoKorea, Seoul, Korea (2012)

[14]     Jeejung Kim, Xueqiu You, Jungo Kim, Seongjin Son, and James Jungho Pak, “Electrochemical hydrogen peroxide sensor using copper oxide nanoflower structure”, The 6th Asia-Pacific Conference on Transducers and Micro-Nano Technology, Nanjing, China (2012)

[15]     Jang, Yunseok, Yoonkyung Nam, Xueqiu You, Electrochemical immunosensor based on zinc oxide nanorods for High selectively detecting h1N1 swin influenza, The 6th Asia-Pacific Conference on Transducers and Micro-Nano Technology, Nanjing, China (2012)

[16]     Xueqiu You, James Jungho Pak, “Lithography Free Fabrication of Bistability Graphene FET Biosensor”, IEEE Nano 2011, Portland, Oregon, USA (2011)

[17]     Jong-hyeon Chang, Xueqiu You, Ji-jung Kim “Mechanical Reliability of The Solder Joints Created from The Self-arranged Solder Balls”, 13th KMEMS 2011, Jeju, Korea (2011)

[18]     Xueqiu You, Jong-hyeon Chang, James Jungho Pak, “Electrochemical method to exfoliate graphene oxide from graphite” Nano Korea 2010, KINTEX, South Korea (2010)

[19]     Jae-hoon Choi, Xueqiu You, Jong-hyeon Chang, James Jungho Pak, “Wettability control of a transparent substrate using ZnO nanorods” Nano Korea 2010, KINTEX, South Korea (2010)

[20]     Xueqiu You, Jong-hyeon Chang, James Jungho Pak, “An electrochemical route to graphene oxide” The 5th Asia-Pacific Conference on Transducers and Micro-Nano Technology, Perth, Western Australia (2010)

[21]     Jae-hoon Choi, Xueqiu You, Jungil Park, and Jungho Pak, “Characteristics of ZnO Nanorods Grown on a Flexible Substrate by a Hydrothermal Method”, 12th KMEMS 2010, Busan, South Korea (2010)

[22]     Xueqiu You, Jungil Park, Yunseok Jang , James Jungho Pak, "Enzymatic Glucose Biosensor Based On Porous ZnO/Au Electrodes", 4th IEEE-NANOMED 2010, Hong Kong, China (2010)

[23]     Xueqiu You, Jong-hyeon Chang, James Jungho Pak, “Dissolving Silk Protein Microneedles For Transdermal Drug Delivery”, 4th IEEE-NANOMED 2010, Hong Kong, China (2010)

[24]     Jong-hyeon Chang, Dae-Young Choi, Xueqiu You, and James Jungho Pak, “Low Voltage Electrowetting on Atomic-Layer- Deposited Aluminum Oxide”, 2010 5th IEEE NEMS, Xiamen, China (2010)

  1. 书籍:

物联网导论:智能医疗【I S B N 】978-7-5084-9932-1,中国水利水电出版社

  1. 主持或参与的科研项目

[1] 适用于活细胞代谢研究的高灵敏度高分辨率微型核磁共振探头关键技术研究,中国国家自然科学基金青年科学基金项目,项目批准号:61801411,29万(2018.9~今)(主持)

[2] 微型核磁共振和色谱分析谱仪的关键技术研究,中国国家自然科学基金博士后基金,项目编号:K8317001, 5万(2017.12~今)(主持)

[3] 等离子体储备池神经拟态计算研究,中国国家自然科学基金面上项目,项目批准号: 61875169,61万(2018.9~今)

[4] 毛囊再生移植关键技术开发,XDHT2019423A, 40万 (2019.09.21~今)(主持)

[5] ZnO NWs-graphene composite based nanogenerators for automobile energy harvesting, Hyundai motor company, (2013.10~now)

[6] T1101991, Water pollution detection system for semiconductor manufacturing industry, Samsung electronics company, (2011.10.1 ~2012.9.30)

[7] 2011-0008474, Electrochemical High Resolution Nano-Bio Immunosensor and Measurement System for Detecting Novel Swine-Origin Influenza A (H1N1) and Variable Influenza Virus, National Resarch Foundation of Korea, (2010.05.01~ 2013.04.30)

[8] Graphene-Al2O3 hybrid Nanopore based DNA sensors, Brain Korea 21 program (2012, 01.20~2012.12.30)

[9] K20903001812-11E0100-01710, Biosensors for Early Diagnosis of Acute Respiratory Infections and Severe Sepsis, KICOS project grant (Bathel-.Korea University) from the Korean Ministry of Education, Science and Technology. (2011.07.01~ 2012.06.30)

[10]     2009-0075886, Digital Micro-pumps for Lab-on-a-chip Applications by using electrowetting, National Resarch Foundation of Korea, (2009.05,01~2010.04.30)

  1. 获奖情况

[1] 厦门大学电子科学与技术学院2019年度研究生教学先进个人

[2]厦门大学电子科学与技术学院2018年度研究生培养先进个人

[3] “兆易创新杯”第十四届中国研究生电子设计竞赛二等奖,第一指导老师

[4] “兆易创新杯”第十三届中国研究生电子设计竞赛三等奖,第一指导老师

 

团队在该领域工作汇总:

针对传统磁共振线圈在制作过程中遇到的困难,研究团队不断尝试与新技术相融合,在三维微线圈加工领域提出了一系列各具特色的新方法。其中,将高精度3D打印与液态金属灌注技术相结合,用以制作一体化的磁共振探头前端,可实现灵活的定制设计加工。一体化探头可用于多种磁共振测试应用,简化和改善了实验流程,丰富和扩展了磁共振检测的应用领域。

相关优质文献推荐:

Wu, SY., Yang, C., Hsu, W. et al. 3D-printed microelectronics for integrated circuitry and passive wireless sensors. Microsyst Nanoeng 1, 15013 (2015). https://doi.org/10.1038/micronano.2015.13

Giraso Keza Monia Kabandana, Curtis G. Jones, Sahra Khan Sharifi, and Chengpeng Chen. 3D-Printed Microfluidic Devices for Enhanced Online Sampling and Direct Optical Measurements. ACS Sensors 2020 5 (7), 2044-2051. https://doi.org/10.1021/acssensors.0c00507

Yin, M., Xiao, L., Liu, Q., Kwon, S.‐Y., Zhang, Y., Sharma, P. R., Jin, L., Li, X., Xu, B., 3D Printed Microheater Sensor‐Integrated, Drug‐Encapsulated Microneedle Patch System for Pain Management. Adv. Healthcare Mater. 2019, 8, 1901170. https://doi.org/10.1002/adhm.201901170

Varga M, Mehmann A, Marjanovic J, Reber J, Vogt C, Pruessmann KP, Tröster G. Adsorbed Eutectic GaIn Structures on a Neoprene Foam for Stretchable MRI Coils. Adv Mater. 2017 Nov;29(44). https://doi.org/10.1002/adma.201703744

Daalkhaijav, U., Yirmibesoglu, O. D., Walker, S., Mengüç, Y., Rheological Modification of Liquid Metal for Additive Manufacturing of Stretchable Electronics. Adv. Mater. Technol. 2018, 3, 1700351. https://doi.org/10.1002/admt.201700351

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